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rnadoctor.bsky.social
Mostafiz presented a poster entitled: "Splicing-Dependent Modulation of CaV1.3 Calcium Channels: Implications for Neurological Disease and Therapeutic Targeting".

#ionchannel
#calciumchannel
#CACNA1D
#AlternativeSplicing
#RNAsplicing
#RNA
#splicing
April 24, 2026 at 6:26 PM
bcmfromthelabs.bsky.social
This discovery could one day improve outcomes in children with #epilepsy and related #neurodevelopmentalDisorders. J Noebels, S. Thompson, Q-L Miao et al. @bcmhouston.bsky.social #bcmneurology #Neuron @cellpress.bsky.social #calciumChannel blogs.bcm.edu/2026/04/03/f...
Study reveals how calcium channel mutations disrupt early brain development in childhood epilepsy
This discovery opens new possibilities that could one day improve outcomes in children with epilepsy and related neurodevelopmental disorders.
blogs.bcm.edu
April 3, 2026 at 3:32 PM
rnadoctor.bsky.social
Congratulations to my PhD student Md Mostafizur Rahman for winning an award at St. John's University Student Research Conference 2026 with his poster entitled: "Alternative Splicing as a Driver of CaV1.3 Functional Diversity"🏆

#ionchannel
#calciumchannel
#CACNA1D
#AlternativeSplicing
#RNAsplicing
April 23, 2026 at 2:41 PM
gimjournal.bsky.social
Beyond #spinocerebellar ataxia phenotypic expansion of #pathogenic variants in #CACNA1G bit.ly/3CA6zWu #cerebellum #neurodevelopment #calciumchannel
Screenshot of Figure 3: Genotype-phenotype correlations for Cav3.1 variants. A. Radar plots illustrating the distribution of the clinical features of the representative phenotypes in the 32 patients (new and previously reported) examined in this study (upper panel), in the 13 patients carrying the p.(Ala961Thr) variant (lower-left panel), and in the 6 patients carrying the p.(Met1531Val) variant (lower-right panel). Note that the cerebellar phenotype (motor delay, cerebellar atrophy, and ataxia) found in all p.(Ala961Thr) and p.(Met1531Val) patients was not retrieved consistently in patients carrying the other variants. Note also that one major difference is the near-complete absence of seizure phenotype in p.(Ala961Thr) patients (1 of 13), compared with p.(Met1531Val) patients (6 of 6).
February 4, 2025 at 9:20 PM
rnadoctor.bsky.social
We uncover an unexpected synergy between RNA editing & alternative splicing in the CaV1.3 calcium channel. This mechanism fine-tunes neuronal Ca²⁺ entry & may protect against excitotoxicity.

#IonChannels #CalciumChannel #CACNA1D #ExcitoToxicity
October 14, 2025 at 2:39 PM
mainzuniversity.bsky.social
#CalciumChannel subunits play a major role in autistic disorders: Fine-tuning of calcium channel subunits is essential for ensuring a physiological balance between inhibitory and excitatory nerve cells https://www.uni-mainz.de/presse/aktuell/11867_ENG_HTML.php #autism...
December 12, 2024 at 3:47 PM