Researchers have identified a subset of regulatory T cells enriched in the decidua that promote maternal-fetal immune tolerance during early pregnancy.
Learn more in #ScienceImmunology: scim.ag/44Pt7Ot
Learn more in #ScienceImmunology: scim.ag/44Pt7Ot
CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy
Decidual CCR8+ dTreg cells, with a highly activated and immunosuppressive phenotype, are crucial for maternal-fetal immune tolerance.
scim.ag
April 30, 2025 at 4:09 PM
Researchers have identified a subset of regulatory T cells enriched in the decidua that promote maternal-fetal immune tolerance during early pregnancy.
Learn more in #ScienceImmunology: scim.ag/44Pt7Ot
Learn more in #ScienceImmunology: scim.ag/44Pt7Ot
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www.youtube.com/watch?v=CCR8...
www.youtube.com/watch?v=CCR8...
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January 29, 2025 at 9:41 PM
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www.youtube.com/watch?v=CCR8...
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Decidual CCR8+ dTreg cells, with a highly activated and immunosuppressive phenotype, are crucial for maternal-fetal immune tolerance @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
April 18, 2025 at 8:18 PM
Decidual CCR8+ dTreg cells, with a highly activated and immunosuppressive phenotype, are crucial for maternal-fetal immune tolerance @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Molecular heterogeneity and clonal origin of CCR8+ effector regulatory T cells in human cancer @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2026 at 9:03 PM
Molecular heterogeneity and clonal origin of CCR8+ effector regulatory T cells in human cancer @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy | Science Immunology www.science.org/doi/10.1126/...
CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy
Decidual CCR8+ dTreg cells, with a highly activated and immunosuppressive phenotype, are crucial for maternal-fetal immune tolerance.
www.science.org
April 26, 2025 at 2:53 AM
CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy | Science Immunology www.science.org/doi/10.1126/...
Allergen sensitization drives CCR8-dependent trafficking of ILC2s to lymph nodes, where they provide early IL-4 signals that selectively promote Tfh13 cells www.cell.com/immunity/ful... @cp-immunity.bsky.social @gowthaman.bsky.social @umasschan.bsky.social
May 19, 2026 at 8:34 PM
Allergen sensitization drives CCR8-dependent trafficking of ILC2s to lymph nodes, where they provide early IL-4 signals that selectively promote Tfh13 cells www.cell.com/immunity/ful... @cp-immunity.bsky.social @gowthaman.bsky.social @umasschan.bsky.social
Autoantibody landscape and functional role of anti-CCR8 autoantibodies in systemic sclerosis: post-hoc analysis of a B-cell depletion trial
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com
December 5, 2025 at 1:27 AM
Autoantibody landscape and functional role of anti-CCR8 autoantibodies in systemic sclerosis: post-hoc analysis of a B-cell depletion trial
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com
"Suppressive activity is enriched among CD4+ Tconv cells marked by expression of CCR8, which are found in mouse & human tumors. Upon Treg cell depletion, CCR8+ Tconv cells undergo systemic & intratumoral activation & expansion, and mediate IL-10–dependent suppression of antitumor immunity."
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depl...
CCR8+ Tconv cells undergo expansion and activation upon Treg cell depletion and limit antitumor immunity through production of IL-10.
www.science.org
December 24, 2023 at 12:44 AM
"Suppressive activity is enriched among CD4+ Tconv cells marked by expression of CCR8, which are found in mouse & human tumors. Upon Treg cell depletion, CCR8+ Tconv cells undergo systemic & intratumoral activation & expansion, and mediate IL-10–dependent suppression of antitumor immunity."
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August 29, 2025 at 1:02 PM
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January 3, 2026 at 10:15 PM
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Tune in on Oct. 22 for our Development of Anti-CCR8 Ab - Mechanisms and Clinical Results Webinar!
We will address the novel therapeutic target C-C chemokine receptor 8 (CCR8), its role in regulatory T cell (Treg) activity and immunosuppression.
Register: www.sitcancer.org/edu/webinars... 🧪
We will address the novel therapeutic target C-C chemokine receptor 8 (CCR8), its role in regulatory T cell (Treg) activity and immunosuppression.
Register: www.sitcancer.org/edu/webinars... 🧪
September 24, 2025 at 3:21 PM
Tune in on Oct. 22 for our Development of Anti-CCR8 Ab - Mechanisms and Clinical Results Webinar!
We will address the novel therapeutic target C-C chemokine receptor 8 (CCR8), its role in regulatory T cell (Treg) activity and immunosuppression.
Register: www.sitcancer.org/edu/webinars... 🧪
We will address the novel therapeutic target C-C chemokine receptor 8 (CCR8), its role in regulatory T cell (Treg) activity and immunosuppression.
Register: www.sitcancer.org/edu/webinars... 🧪
The 2025 Nobel Prize in Physiology or Medicine honored the discovery and characterization of Tregs. Tomorrow's Deep Dive Webinar will explore CCR8 and #Tregs, building on this groundbreaking area of research. There's still time to register: https://ow.ly/bNTG50XfxAV
October 21, 2025 at 1:30 PM
The 2025 Nobel Prize in Physiology or Medicine honored the discovery and characterization of Tregs. Tomorrow's Deep Dive Webinar will explore CCR8 and #Tregs, building on this groundbreaking area of research. There's still time to register: https://ow.ly/bNTG50XfxAV
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #STMpublishing #RRID #BetterScience
Pharmacological Inhibition of Plasmacytoid Dendritic Cell Chemotaxis via CCR8 as a Therapeutic Strategy for IgG4-Related Disease
Read the full paper: Pharmacological Inhibition of Plasmacytoid Dendritic Cell Chemotaxis via CCR8 as a Therapeutic Strategy for IgG4-Related Disease
doi.org
April 10, 2026 at 7:03 AM
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #STMpublishing #RRID #BetterScience
Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8 https://www.biorxiv.org/content/10.1101/2023.12.30.573520v1
Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8 https://www.biorxiv.org/content/10.1101/2023.12.30.573520v1
The C-C motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has emerged a
www.biorxiv.org
January 2, 2024 at 12:52 AM
Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8 https://www.biorxiv.org/content/10.1101/2023.12.30.573520v1
#CHRS #BMY #ZLAB #CCR8 LM-108? >>depletion of CCR8+Treg cells combined with PD1 inhibitor extremely increased interleukin-12 secretion by the JAK-STAT pathway activation on CCL5+ DCs, thereby promoting cytotoxic activity of CD8+ T cells<< www.sciencedirect.com/science/arti....
Selective depletion of CCR8+Treg cells enhances anti-tumor immunity of cytotoxic T cells in lung cancer via dendritic cells
Accumulation of regulatory T (Treg) cells, an immunosuppressive population, limits the efficacy of immunotherapy in non-small cell lung cancer (NSCLC)…
www.sciencedirect.com
March 7, 2025 at 4:16 PM
#CHRS #BMY #ZLAB #CCR8 LM-108? >>depletion of CCR8+Treg cells combined with PD1 inhibitor extremely increased interleukin-12 secretion by the JAK-STAT pathway activation on CCL5+ DCs, thereby promoting cytotoxic activity of CD8+ T cells<< www.sciencedirect.com/science/arti....
Teresita Arenzana Delfino has been issued a US Patent!
Anti-C-C motif chemokine receptor 8 (CCR8) antibodies and methods of use
Anti-C-C motif chemokine receptor 8 (CCR8) antibodies and methods of use
March 23, 2025 at 1:56 PM
Teresita Arenzana Delfino has been issued a US Patent!
Anti-C-C motif chemokine receptor 8 (CCR8) antibodies and methods of use
Anti-C-C motif chemokine receptor 8 (CCR8) antibodies and methods of use
Online now: Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation
Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation
T follicular helper 13 (Tfh13) cells are required for anaphylactic IgE responses, yet how these cells arise is unclear. Lee et al. show that allergen sensitization drives CCR8-dependent trafficking of ILC2s to lymph nodes, where they provide early IL-4 signals that selectively promote Tfh13 cells, revealing differentiation requirements distinct from Tfh2 cells.
dlvr.it
May 19, 2026 at 7:56 PM
Online now: Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation
"CCL1/ #CCR8 may be the pathway between NECs and Tregs in vitro and may play a key role in the immune network of AR"... pmc.ncbi.nlm.nih.gov/articles/PMC...
Interaction between nasal epithelial cells and Tregs in allergic rhinitis responses to allergen via CCL1/CCR8
The airway epithelial barrier is the first defence against aeroallergens. Nasal epithelial cells (NECs) are vital in regulating innate and adaptive mucosal immunity in allergic rhinitis (AR). Tregs pr...
pmc.ncbi.nlm.nih.gov
March 10, 2025 at 7:43 PM
"CCL1/ #CCR8 may be the pathway between NECs and Tregs in vitro and may play a key role in the immune network of AR"... pmc.ncbi.nlm.nih.gov/articles/PMC...
Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8+ Treg cells #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.05.14.653926v1
https://www.biorxiv.org/content/10.1101/2025.05.14.653926v1
May 17, 2025 at 4:00 PM
Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8+ Treg cells #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.05.14.653926v1
https://www.biorxiv.org/content/10.1101/2025.05.14.653926v1