Fun Fact: The action of cisplatin, now used in chemotherapy treatment for testicular, bladder, lung, stomach & ovarian #cancers, was discovered in 1965 by MSU scientists.
The discovery & FDA approval of cisplatin was made possible by #NIH & NSF funding.
🧪 innovationcenter.msu.edu/msus-cisplat...
The discovery & FDA approval of cisplatin was made possible by #NIH & NSF funding.
🧪 innovationcenter.msu.edu/msus-cisplat...
MSU’s cisplatin cancer drug wins national award - MSU Innovation Center
In 1965, a group of Michigan State University researchers accidentally discovered a new cancer-fighting drug: cisplatin. Since then, cisplatin has become the
innovationcenter.msu.edu
September 29, 2025 at 10:36 PM
Fun Fact: The action of cisplatin, now used in chemotherapy treatment for testicular, bladder, lung, stomach & ovarian #cancers, was discovered in 1965 by MSU scientists.
The discovery & FDA approval of cisplatin was made possible by #NIH & NSF funding.
🧪 innovationcenter.msu.edu/msus-cisplat...
The discovery & FDA approval of cisplatin was made possible by #NIH & NSF funding.
🧪 innovationcenter.msu.edu/msus-cisplat...
Testicular cancer was fatal in ~95% of cases before cisplatin was developed in the 1970s.
Today, survival exceeds 95%, even when cancer has metastasized.
That’s thanks to:
Chemotherapies
Scientific research
Biopharmaceutical therapies
Evidence-based medicine
1/
Today, survival exceeds 95%, even when cancer has metastasized.
That’s thanks to:
Chemotherapies
Scientific research
Biopharmaceutical therapies
Evidence-based medicine
1/
May 1, 2025 at 10:28 PM
Testicular cancer was fatal in ~95% of cases before cisplatin was developed in the 1970s.
Today, survival exceeds 95%, even when cancer has metastasized.
That’s thanks to:
Chemotherapies
Scientific research
Biopharmaceutical therapies
Evidence-based medicine
1/
Today, survival exceeds 95%, even when cancer has metastasized.
That’s thanks to:
Chemotherapies
Scientific research
Biopharmaceutical therapies
Evidence-based medicine
1/
"I don't have cancer but I injected myself with cisplatin and now I feel awful and can't understand why I am puking 18 times a day"
Man without ADHD tries uppers for the first time:
I mean honestly we're scraping the barrel on this now surely. I'm not diabetic. If I took insulin the affects would be far worse.
I mean honestly we're scraping the barrel on this now surely. I'm not diabetic. If I took insulin the affects would be far worse.
August 12, 2026 at 1:17 PM
"I don't have cancer but I injected myself with cisplatin and now I feel awful and can't understand why I am puking 18 times a day"
May 26, 2026 at 3:24 PM
Other things that will be cancelled because they're #TooDEI
Non-Binary Coding
Trans Siberian Railway
The Pontiac Trans Am
Gaylussite
Cisplatin
Black Holes
Non-Binary Coding
Trans Siberian Railway
The Pontiac Trans Am
Gaylussite
Cisplatin
Black Holes
Soon to be cancelled:
Marvin Gaye’s music
and… worse still for anaesthetists: Gay-Lussac's law 😱! How will we work without it‽
Marvin Gaye’s music
and… worse still for anaesthetists: Gay-Lussac's law 😱! How will we work without it‽
March 8, 2025 at 9:33 AM
Other things that will be cancelled because they're #TooDEI
Non-Binary Coding
Trans Siberian Railway
The Pontiac Trans Am
Gaylussite
Cisplatin
Black Holes
Non-Binary Coding
Trans Siberian Railway
The Pontiac Trans Am
Gaylussite
Cisplatin
Black Holes
I am thrilled that our latest work exploring how cisplatin exposure dysregulates insulin secretion in mice is now online at Diabetes! This project was led by the amazing @laharibasu.bsky.social, with important contributions from many other trainees and collaborators. doi.org/10.2337/db24...
Cisplatin exposure dysregulates insulin secretion in male and female mice
Cancer survivors have an increased risk of developing Type 2 diabetes compared to the general population. Patients treated with cisplatin, a common chemoth
doi.org
January 14, 2025 at 10:19 PM
I am thrilled that our latest work exploring how cisplatin exposure dysregulates insulin secretion in mice is now online at Diabetes! This project was led by the amazing @laharibasu.bsky.social, with important contributions from many other trainees and collaborators. doi.org/10.2337/db24...
But someone tell Thiel to take cisplatin every day to keep the tumours away
February 19, 2026 at 5:06 PM
But someone tell Thiel to take cisplatin every day to keep the tumours away
bacteria living in superheated water at the bottom of the ocean (PCR)
jellyfish glowing in the dark (GFP)
weird effects of sticking metal bars into Petri dishes (cisplatin, a common chemotherapy drug)
most technology comes from curiosity-driven discovery
mostly you don’t know what you don’t know
jellyfish glowing in the dark (GFP)
weird effects of sticking metal bars into Petri dishes (cisplatin, a common chemotherapy drug)
most technology comes from curiosity-driven discovery
mostly you don’t know what you don’t know
February 9, 2025 at 5:59 PM
bacteria living in superheated water at the bottom of the ocean (PCR)
jellyfish glowing in the dark (GFP)
weird effects of sticking metal bars into Petri dishes (cisplatin, a common chemotherapy drug)
most technology comes from curiosity-driven discovery
mostly you don’t know what you don’t know
jellyfish glowing in the dark (GFP)
weird effects of sticking metal bars into Petri dishes (cisplatin, a common chemotherapy drug)
most technology comes from curiosity-driven discovery
mostly you don’t know what you don’t know
The power of tinkering and curiosity-driven research. This 2001 piece could not be more timely. Did not know this is how cisplatin was discovered. Amazing story
December 7, 2024 at 11:56 AM
The power of tinkering and curiosity-driven research. This 2001 piece could not be more timely. Did not know this is how cisplatin was discovered. Amazing story
Nothing more metal than beating Stage III cancer.
August 1, 2023 at 10:08 AM
Nothing more metal than beating Stage III cancer.
Fun Fact: The action of cisplatin, now used in chemotherapy treatment for testicular, bladder, lung, stomach & ovarian #cancers, was discovered in 1965 by MSU scientists.
The discovery & FDA approval of cisplatin was made possible by #NIH & NSF funding.
🧪 innovationcenter.msu.edu/msus-cisplat...
The discovery & FDA approval of cisplatin was made possible by #NIH & NSF funding.
🧪 innovationcenter.msu.edu/msus-cisplat...
MSU’s cisplatin cancer drug wins national award - MSU Innovation Center
In 1965, a group of Michigan State University researchers accidentally discovered a new cancer-fighting drug: cisplatin. Since then, cisplatin has become the
innovationcenter.msu.edu
September 30, 2025 at 5:56 AM
Because Barnett Rosenberg wanted to study the effects of electrical fields on bacterial cell division and chose to use platinum electrodes, we have a curative therapy for testicular cancer.
www.cancer.gov/research/pro...
www.cancer.gov/research/pro...
Discovery – Cisplatin and The Treatment of Testicular and Other Cancers
Prior to the discovery of cisplatin in 1965, men with testicular cancer had few medical options. Now, thanks to NCI research, cisplatin and similar chemotherapy drugs are known for curing testicular a...
www.cancer.gov
December 5, 2024 at 7:39 AM
Because Barnett Rosenberg wanted to study the effects of electrical fields on bacterial cell division and chose to use platinum electrodes, we have a curative therapy for testicular cancer.
www.cancer.gov/research/pro...
www.cancer.gov/research/pro...
Permanent hearing loss and tinnitus are frequent side effects of cisplatin chemotherapy 👂
Strategies to prevent hearing loss focus on protecting sensory hair cells from cisplatin induced death. ☠️
But are surviving hair cells really ok?
Spoiler- no, they’re not! 🤕
Come see Poster #55
#IZFC2025
Strategies to prevent hearing loss focus on protecting sensory hair cells from cisplatin induced death. ☠️
But are surviving hair cells really ok?
Spoiler- no, they’re not! 🤕
Come see Poster #55
#IZFC2025
July 12, 2025 at 8:16 PM
Permanent hearing loss and tinnitus are frequent side effects of cisplatin chemotherapy 👂
Strategies to prevent hearing loss focus on protecting sensory hair cells from cisplatin induced death. ☠️
But are surviving hair cells really ok?
Spoiler- no, they’re not! 🤕
Come see Poster #55
#IZFC2025
Strategies to prevent hearing loss focus on protecting sensory hair cells from cisplatin induced death. ☠️
But are surviving hair cells really ok?
Spoiler- no, they’re not! 🤕
Come see Poster #55
#IZFC2025
So free you can't say biodiversity or cisplatin 🙃
March 15, 2025 at 2:50 AM
So free you can't say biodiversity or cisplatin 🙃
#FluorescenceFriday
Live image of green macrophages in a 6-day-old zebrafish responding to dying sensory hair cells following treatment with the chemotherapy drug cisplatin 👂🐟⚕️
Live image of green macrophages in a 6-day-old zebrafish responding to dying sensory hair cells following treatment with the chemotherapy drug cisplatin 👂🐟⚕️
December 20, 2024 at 3:40 PM
#FluorescenceFriday
Live image of green macrophages in a 6-day-old zebrafish responding to dying sensory hair cells following treatment with the chemotherapy drug cisplatin 👂🐟⚕️
Live image of green macrophages in a 6-day-old zebrafish responding to dying sensory hair cells following treatment with the chemotherapy drug cisplatin 👂🐟⚕️
Cisplatin for chemotherapy.
August 22, 2025 at 8:10 AM
Cisplatin for chemotherapy.
had cancer, now I don't, primary chemo drug (cisplatin) was first approved in 1978
pretty good achievement I'd say
pretty good achievement I'd say
I like this brainstorm: greatest achievements since 1969.
Number one for me: eradicating smallpox
What else?
Number one for me: eradicating smallpox
What else?
I get it from a narrative perspective.
Kitty Hawk to Apollo 11 was 66 years; many people experienced both in their lifetime (and everything between).
66 years from 1969 is 2035 and the triumphs just aren’t as narratively simple.
Kitty Hawk to Apollo 11 was 66 years; many people experienced both in their lifetime (and everything between).
66 years from 1969 is 2035 and the triumphs just aren’t as narratively simple.
July 31, 2026 at 8:31 PM
had cancer, now I don't, primary chemo drug (cisplatin) was first approved in 1978
pretty good achievement I'd say
pretty good achievement I'd say
Cisplatin causes neuronal death by activating nucleotide excision repair (NER), which paradoxically promotes damage instead of protecting neurons. #Neurotoxicity PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2
No description available
www.cell.com
September 26, 2026 at 9:00 PM
Cisplatin causes neuronal death by activating nucleotide excision repair (NER), which paradoxically promotes damage instead of protecting neurons. #Neurotoxicity PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
5 years ago I had cancer and had Cisplatin in my chemo cocktail, known to cause hearing loss, recently I noticed that I have had problems hearing people on my phone, so I made an appointment with an audiologist. I just bought a brand new iPhone, it arrived yesterday, I can hear perfectly well now…
January 4, 2025 at 3:58 PM
5 years ago I had cancer and had Cisplatin in my chemo cocktail, known to cause hearing loss, recently I noticed that I have had problems hearing people on my phone, so I made an appointment with an audiologist. I just bought a brand new iPhone, it arrived yesterday, I can hear perfectly well now…
Interesting paper @asnpublications.bsky.social
SGLT2 inhibitors prevent kidney magnesium loss caused by cisplatin
#flozins improve Mg reabsorption in the thick ascending limb and distal convoluted tubule
VA by @corinateodosiu.bsky.social
#nephsky #medsky
journals.lww.com/jasn/abstrac...
SGLT2 inhibitors prevent kidney magnesium loss caused by cisplatin
#flozins improve Mg reabsorption in the thick ascending limb and distal convoluted tubule
VA by @corinateodosiu.bsky.social
#nephsky #medsky
journals.lww.com/jasn/abstrac...
April 3, 2025 at 9:57 AM
Interesting paper @asnpublications.bsky.social
SGLT2 inhibitors prevent kidney magnesium loss caused by cisplatin
#flozins improve Mg reabsorption in the thick ascending limb and distal convoluted tubule
VA by @corinateodosiu.bsky.social
#nephsky #medsky
journals.lww.com/jasn/abstrac...
SGLT2 inhibitors prevent kidney magnesium loss caused by cisplatin
#flozins improve Mg reabsorption in the thick ascending limb and distal convoluted tubule
VA by @corinateodosiu.bsky.social
#nephsky #medsky
journals.lww.com/jasn/abstrac...
Cisplatin in Cancer Treatment: Mechanism, Resistance, Toxicity, and Future Directions
oncodaily.com/drugs/cispla...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Cisplatin #Immunotherapy #Mechanism #Pharmacology #Resistance #Toxicity
oncodaily.com/drugs/cispla...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Cisplatin #Immunotherapy #Mechanism #Pharmacology #Resistance #Toxicity
Cisplatin in Cancer Treatment: Mechanism, Resistance, Toxicity, and Future Directions - OncoDaily
Explore how cisplatin, a cornerstone platinum-based chemotherapy, works to treat cancer. Learn about its mechanism of action, clinical applications, resistance pathways, side effects, and future direc...
oncodaily.com
July 10, 2025 at 6:38 PM
Cisplatin in Cancer Treatment: Mechanism, Resistance, Toxicity, and Future Directions
oncodaily.com/drugs/cispla...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Cisplatin #Immunotherapy #Mechanism #Pharmacology #Resistance #Toxicity
oncodaily.com/drugs/cispla...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Cisplatin #Immunotherapy #Mechanism #Pharmacology #Resistance #Toxicity
Now online! DNA repair drives cisplatin-induced neuronal death
DNA repair drives cisplatin-induced neuronal death
In neurons, cisplatin-induced DNA damage is repaired by NER, but low dNTP pools cause NER to promote death rather than survival. Deoxynucleoside supplementation or genetic upregulation of dNTP synthesis replenishes nucleotides and protects neurons from cisplatin, suggesting nucleoside therapy may mitigate chemotherapy-induced neurotoxicity.
dlvr.it
June 11, 2026 at 12:41 PM
Now online! DNA repair drives cisplatin-induced neuronal death
Given that I'd have hit my failure state at 35 if not for cisplatin...I'll take my chances on dying from a tired spleen at 97.
September 1, 2026 at 11:12 PM
Given that I'd have hit my failure state at 35 if not for cisplatin...I'll take my chances on dying from a tired spleen at 97.
New review 🧬 Cisplatin doesn't just harm kidneys/nerves — it directly causes skeletal muscle atrophy via ↑MuRF1/atrogin-1 and ↓IGF-1/Akt/mTORC1 signaling, an overlooked toxicity distinct from cancer cachexia.
www.jstage.jst.go.jp/article/jts/...
www.jstage.jst.go.jp/article/jts/...
Protein homeostasis disruption in cisplatin-induced skeletal muscle atrophy: toxicological insights from experimental studies
Cisplatin is a widely used platinum-based chemotherapeutic agent whose dose-limiting toxicities, including nephrotoxicity, neurotoxicity, and myelosup …
www.jstage.jst.go.jp
September 17, 2026 at 3:17 AM
New review 🧬 Cisplatin doesn't just harm kidneys/nerves — it directly causes skeletal muscle atrophy via ↑MuRF1/atrogin-1 and ↓IGF-1/Akt/mTORC1 signaling, an overlooked toxicity distinct from cancer cachexia.
www.jstage.jst.go.jp/article/jts/...
www.jstage.jst.go.jp/article/jts/...