A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
October 29, 2026 at 1:13 PM
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
October 29, 2026 at 5:10 AM
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
October 29, 2026 at 2:45 AM
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
October 28, 2026 at 11:59 AM
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
October 28, 2026 at 4:45 AM
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
October 28, 2026 at 2:04 AM
A Comprehensive Mitochondrial Cytochrome c Oxidase Subunit II Gene (cox2)-Based Framework for Genotyping and Phylogenetic Analysis of Pythium insidiosum and Related Taxa https://pubmed.ncbi.nlm.nih.gov/42943539/
The authors included RRIDs in their in Cell Reports paper! Thanks for making your methods matter! #OpenResearch #accelerateopenscience #ReproducibleResearch
The COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-dependent STING activation
Read the full paper: The COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-dependent STING activation
doi.org
October 18, 2026 at 7:00 AM
The authors included RRIDs in their in Cell Reports paper! Thanks for making your methods matter! #OpenResearch #accelerateopenscience #ReproducibleResearch
Yes, a repeat of the COX2 story would be a bad one.
September 21, 2026 at 6:13 PM
Yes, a repeat of the COX2 story would be a bad one.
2/2 Warum kein NSAID/ COX2-Hemmer bei Polyarthrose (Kontraindikationen, Begleiterkrankungen)?
September 5, 2026 at 9:12 PM
2/2 Warum kein NSAID/ COX2-Hemmer bei Polyarthrose (Kontraindikationen, Begleiterkrankungen)?
Warum bei Polyarthrose keine Antiinflammatorischen Maßnahmen (Cox 1/2 oder selektive Cox2)?
Metamizol zur schnellwirksamen Therapie von akuten Peaks als Tropfen.
2/2
Metamizol zur schnellwirksamen Therapie von akuten Peaks als Tropfen.
2/2
September 5, 2026 at 9:59 PM
Warum bei Polyarthrose keine Antiinflammatorischen Maßnahmen (Cox 1/2 oder selektive Cox2)?
Metamizol zur schnellwirksamen Therapie von akuten Peaks als Tropfen.
2/2
Metamizol zur schnellwirksamen Therapie von akuten Peaks als Tropfen.
2/2
مين قالك اني مجمعاهم ف وقت واحد؟ both are cox1 & cox2 inh. so no further advantage in combining both.
Acetaminophen is metabolised in liver not the kidney
Keyoprofen is more toxic because it's more potent and its toxicity depends on the dose, duration of treatment & the patient condition
Acetaminophen is metabolised in liver not the kidney
Keyoprofen is more toxic because it's more potent and its toxicity depends on the dose, duration of treatment & the patient condition
July 18, 2025 at 6:15 AM
مين قالك اني مجمعاهم ف وقت واحد؟ both are cox1 & cox2 inh. so no further advantage in combining both.
Acetaminophen is metabolised in liver not the kidney
Keyoprofen is more toxic because it's more potent and its toxicity depends on the dose, duration of treatment & the patient condition
Acetaminophen is metabolised in liver not the kidney
Keyoprofen is more toxic because it's more potent and its toxicity depends on the dose, duration of treatment & the patient condition
More FtL = less NF-κB/p65 nuclear translocation = less TNFα, IL-6, iNOS and COX2. Knock FtL down and the inflammatory storm explodes. The iron cage is also a fire extinguisher.
May 19, 2026 at 2:28 PM
More FtL = less NF-κB/p65 nuclear translocation = less TNFα, IL-6, iNOS and COX2. Knock FtL down and the inflammatory storm explodes. The iron cage is also a fire extinguisher.
Puget sound, the Salish Sea and all the islands make this area sailboat heaven. When the orcas come up to my boat I grab a package of herring out of the freezer to feed them. Often they'll stick their heads out of the water and open their mouths so I can toss them in.
www.youtube.com/watch?v=COx2...
www.youtube.com/watch?v=COx2...
The FAMOUS Killer Whales of Puget Sound!
YouTube video by AquaTerra
www.youtube.com
July 20, 2025 at 3:01 AM
Puget sound, the Salish Sea and all the islands make this area sailboat heaven. When the orcas come up to my boat I grab a package of herring out of the freezer to feed them. Often they'll stick their heads out of the water and open their mouths so I can toss them in.
www.youtube.com/watch?v=COx2...
www.youtube.com/watch?v=COx2...
5/ Now this is where it get's interesting - the immune response is out of balance in m.5019A>G macrophages ⚖️
-> Elevated type I IFN (IFN-I) & nitric oxide (NO) after stimulation ⬆️
-> IL-6, IL-1β (pro-inflammatory cytokines), and COX2-dependent oxylipins ⬇️
-> Elevated type I IFN (IFN-I) & nitric oxide (NO) after stimulation ⬆️
-> IL-6, IL-1β (pro-inflammatory cytokines), and COX2-dependent oxylipins ⬇️
January 10, 2025 at 7:48 AM
5/ Now this is where it get's interesting - the immune response is out of balance in m.5019A>G macrophages ⚖️
-> Elevated type I IFN (IFN-I) & nitric oxide (NO) after stimulation ⬆️
-> IL-6, IL-1β (pro-inflammatory cytokines), and COX2-dependent oxylipins ⬇️
-> Elevated type I IFN (IFN-I) & nitric oxide (NO) after stimulation ⬆️
-> IL-6, IL-1β (pro-inflammatory cytokines), and COX2-dependent oxylipins ⬇️
One COX2-driven axis suppresses T cells, NK cells, cDC1s, and the myeloid compartment simultaneously, through a single cAMP-dependent mechanism. New Owkin blog: the mechanistic case for triple EP2/EP4/DP1 blockade with OKN4395. www.owkin.com/blogs-case-s...
June 26, 2026 at 9:05 AM
One COX2-driven axis suppresses T cells, NK cells, cDC1s, and the myeloid compartment simultaneously, through a single cAMP-dependent mechanism. New Owkin blog: the mechanistic case for triple EP2/EP4/DP1 blockade with OKN4395. www.owkin.com/blogs-case-s...
Long noncoding RNAs (lncRNAs) are crucial players in autoimmune and inflammatory disorders. This study investigated the expression of lnc-EGFR, SNHG1, and lincRNA-Cox2 in RRMS patients during active relapses and in remission.
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
Altered Lnc-EGFR, SNHG1, and LincRNA-Cox2 Profiles in Patients with Relapsing-Remitting Multiple Sclerosis: Impact on Disease Activity and Progression
Long noncoding RNAs (lncRNAs) are crucial players in autoimmune and inflammatory disorders. This study investigated the expression of lnc-EGFR, SNHG1, and lincRNA-Cox2 in RRMS patients during active r
gregory-ms.com
July 25, 2025 at 2:40 PM
Long noncoding RNAs (lncRNAs) are crucial players in autoimmune and inflammatory disorders. This study investigated the expression of lnc-EGFR, SNHG1, and lincRNA-Cox2 in RRMS patients during active relapses and in remission.
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #NeuroSkyence
www.youtube.com/watch?v=COx2... i know mouselook is basically sacrilegious but i played doom 2 on a sim which had it by default so i was just kinda used to it... i really like how it looked in this vid of my favorite sigil level i think it makes me feel like a panicking wild beast
Sigil E5M4 - Paths of Wretchedness
YouTube video by NARFNra
www.youtube.com
December 14, 2025 at 7:58 AM
www.youtube.com/watch?v=COx2... i know mouselook is basically sacrilegious but i played doom 2 on a sim which had it by default so i was just kinda used to it... i really like how it looked in this vid of my favorite sigil level i think it makes me feel like a panicking wild beast
Activating Gli2 in a murine colorectal cancer model also led to similar Cox2 and Wnt5a upregulation. In vivo, subcutanous implantation of this line similarly altered the immune microenvironment, excluding CD8 T cells while enriched in MDSCs.
February 24, 2025 at 7:02 PM
Activating Gli2 in a murine colorectal cancer model also led to similar Cox2 and Wnt5a upregulation. In vivo, subcutanous implantation of this line similarly altered the immune microenvironment, excluding CD8 T cells while enriched in MDSCs.
We again found the inverse to be true, genetic knockout or Gant61 suppresses COX2. We showed that Ptgs2 is directly regulated by Gli2 using ChIP-qPCR in both the active and KO lines.
February 24, 2025 at 7:02 PM
We again found the inverse to be true, genetic knockout or Gant61 suppresses COX2. We showed that Ptgs2 is directly regulated by Gli2 using ChIP-qPCR in both the active and KO lines.
In our bulk tumor RNAseq data, we noted an upregulation of Ptgs2, which encodes COX2, the primary enzyme synthesizing prostaglandin E2. I had thought this was due to the influx of Ptgs2 producing MDSCs into Gli2 active tumors, but it was the cancer cells themselves!
February 24, 2025 at 7:02 PM
In our bulk tumor RNAseq data, we noted an upregulation of Ptgs2, which encodes COX2, the primary enzyme synthesizing prostaglandin E2. I had thought this was due to the influx of Ptgs2 producing MDSCs into Gli2 active tumors, but it was the cancer cells themselves!
Cryptic sponge with bizarre, GC-rich mitogenome (missing cox2) found in a Haliclona–Plakortis symbiosis. Resembles H. plakophila, but genetic + morphological data reveal a new Haplosclerida lineage, highlighting hidden diversity 🧽🧬 @makhaki.bsky.social @dlavrov.bsky.social
doi.org/10.1093/jeb/...
doi.org/10.1093/jeb/...
Hidden in plain sight: a novel symbiotic haplosclerid sponge species revealed by its mitochondrial genome
Abstract. Sponges (phylum Porifera) are known to form symbiotic relationships with a variety of organisms, including other sponges. Recently, such symbiosi
doi.org
May 26, 2026 at 10:29 AM
Cryptic sponge with bizarre, GC-rich mitogenome (missing cox2) found in a Haliclona–Plakortis symbiosis. Resembles H. plakophila, but genetic + morphological data reveal a new Haplosclerida lineage, highlighting hidden diversity 🧽🧬 @makhaki.bsky.social @dlavrov.bsky.social
doi.org/10.1093/jeb/...
doi.org/10.1093/jeb/...
Not disagreeing with you, but 325mg is not exactly a gigadose of COX2 inhibition. It’s the standard adult dose for fever, analgesia, etc.
If he does have a stroke after having his HHS secretary relieve the NINDS director of duty, that may be karmic. But he’s not chowing down on them like pez 🤷♂️
If he does have a stroke after having his HHS secretary relieve the NINDS director of duty, that may be karmic. But he’s not chowing down on them like pez 🤷♂️
January 1, 2026 at 6:01 PM
Not disagreeing with you, but 325mg is not exactly a gigadose of COX2 inhibition. It’s the standard adult dose for fever, analgesia, etc.
If he does have a stroke after having his HHS secretary relieve the NINDS director of duty, that may be karmic. But he’s not chowing down on them like pez 🤷♂️
If he does have a stroke after having his HHS secretary relieve the NINDS director of duty, that may be karmic. But he’s not chowing down on them like pez 🤷♂️
This study identifies #Quercetin, #Kaempferol, & #Naringenin as promising compounds in SZKJT, a Chinese herbal formulation, targeting #COX2, #TNF, #BCL2, & #Caspase3 to suppress #TumorGrowth, #Inflammation, & #OxidativeStress in OSCC. #medsky
Read: link.springer.com/article/10.1...
Read: link.springer.com/article/10.1...
December 2, 2025 at 6:00 AM
This study identifies #Quercetin, #Kaempferol, & #Naringenin as promising compounds in SZKJT, a Chinese herbal formulation, targeting #COX2, #TNF, #BCL2, & #Caspase3 to suppress #TumorGrowth, #Inflammation, & #OxidativeStress in OSCC. #medsky
Read: link.springer.com/article/10.1...
Read: link.springer.com/article/10.1...
Ibuprofen is a non-steroidal anti-inflammatory drug. It acts through stopping the creation of certain prostaglandins, while control inflammation, pain, fever. Ibuprofen action mechanism is a non-selective, reversible inhibition of the cyclooxygenase enzymes COX1 e COX2. Can cause damage to kidneys.
April 13, 2024 at 3:46 AM
Ibuprofen is a non-steroidal anti-inflammatory drug. It acts through stopping the creation of certain prostaglandins, while control inflammation, pain, fever. Ibuprofen action mechanism is a non-selective, reversible inhibition of the cyclooxygenase enzymes COX1 e COX2. Can cause damage to kidneys.
薬局で痛み止め買おうと店員と話してたけど、
NSAIDsやCOX2って専門用語使っても反応イマイチだったな
アスピリンをピリン系って言ってた気がするし、薬剤師ではなく登録販売員だったのかな？
素人が専門用語使ってわかった気になるなと言われそうだけど(-∀-｀;)
NSAIDsやCOX2って専門用語使っても反応イマイチだったな
アスピリンをピリン系って言ってた気がするし、薬剤師ではなく登録販売員だったのかな？
素人が専門用語使ってわかった気になるなと言われそうだけど(-∀-｀;)
April 14, 2024 at 7:24 AM
薬局で痛み止め買おうと店員と話してたけど、
NSAIDsやCOX2って専門用語使っても反応イマイチだったな
アスピリンをピリン系って言ってた気がするし、薬剤師ではなく登録販売員だったのかな？
素人が専門用語使ってわかった気になるなと言われそうだけど(-∀-｀;)
NSAIDsやCOX2って専門用語使っても反応イマイチだったな
アスピリンをピリン系って言ってた気がするし、薬剤師ではなく登録販売員だったのかな？
素人が専門用語使ってわかった気になるなと言われそうだけど(-∀-｀;)