#CTSS
A 2026 Targetome study by Xinzhi Wang’s team (China Pharmaceutical University) reports that celastrol suppresses CTSS-dependent autophagy impairment, promotes protective iNKT1 polarization, and reduces cholestasis and fibrosis.
#Mitophagy #Cathepsin S
Details: doi.org/10.48130/tar...
September 17, 2026 at 3:05 PM
"Elle a communié avec le public": Céline Dion donne un deuxième concert à la hauteur des espérances de ses fans
https://l.bfmtv.com/cTsS
September 17, 2026 at 1:08 PM
RRID:AB_2134500 from @dshb-antibodies.bsky.social was used by authors in their Journal of Neuroinflammation paper. We value the author's support of reproducibility. #OpenResearch #methodsmatter #ReproducibleResearch
Estrogen deprivation exacerbates Alzheimer’s disease pathology through neuronal CTSS signaling
Read the full paper: Estrogen deprivation exacerbates Alzheimer’s disease pathology through neuronal CTSS signaling
doi.org
September 16, 2026 at 7:38 PM
Estrogen deprivation exacerbates Alzheimer’s disease pathology through neuronal CTSS signaling

link.springer.com/article/10.1...
Estrogen deprivation exacerbates Alzheimer’s disease pathology through neuronal CTSS signaling - Journal of Neuroinflammation
Alzheimer’s disease (AD) exhibits a pronounced sex bias, with women facing disproportionately higher risk and more severe pathology. Postmenopausal estrogen decline is implicated in this vulnerability...
link.springer.com
September 15, 2026 at 5:01 PM
The Compatible Time-Sharing System (CTSS), developed in 1961 at MIT, introduced the first true command-line interpreter.

For the first time, a user could type a command like LOGIN or PRINT, and a dedicated program (the supervisor) would parse that text and execute the corresponding function […]
Original post on mastodon.nu
mastodon.nu
September 10, 2026 at 5:50 AM
At InventingEliza.com you can talk to the most accurate reproduction of DOCTOR running on the ELIZA platform and find loads of other content, including code and context. Anthony Hay built this faithful recreation, featured at the Jeu de Paume in Paris!

#ArtificialIntelligence #computerhistory
September 2, 2026 at 1:19 PM
10/11 Ultimately, we want to understand the regulatory effects of disease alleles. Dynema helped uncover new potential mechanisms! We found that the IBD-associated variant near CTSS had a strong eQTL effect specific to activated T cells—which are just 2% of blood T cells!
August 31, 2026 at 3:42 PM
JMIR Mental Health: Experiences and Perceptions of Crisis Text Services: Interview Study Among Young Adults With Suicidal Ideation #MentalHealth #CrisisIntervention #SuicidePrevention #YoungAdults #CrisisTextServices
Experiences and Perceptions of Crisis Text Services: Interview Study Among Young Adults With Suicidal Ideation
Background: Suicide remains a leading cause of death among young adults aged 18 to 25 years. Young adults experiencing suicidal ideation (SI) are increasingly using crisis text services (CTSs), a free and accessible option for crisis intervention. Little is known about CTSs from the young adult perspective. Objective: This study aimed to characterize young adults’ experiences with and perceptions of CTSs for SI. Methods: We conducted in-depth interviews, by phone, Zoom, or text, with young adults (n=39) in the United States who had a lifetime history of SI. Participants included those who had or had not engaged with CTSs for SI. Semistructured interviews were conducted from January to July 2024. The data were analyzed using a modified grounded theory #Approach. Results: We constructed 5 key themes to characterize young adults’ perceptions of and experiences with CTSs for SI. Young adults perceived CTSs as a unique component of their #MentalHealth crisis management. They #Appreciated CTSs’ technological features, particularly the privacy they provided and the ability to reflect on and edit responses. However, they expressed dissatisfaction with the nonspecific nature of many CTS interactions. The perceived anonymity of CTSs served multiple functions, both as a motivator for CTS use and as a potential point of vulnerability, should it be lost during a CTS interaction. Participants’ perceptions of CTSs’ impact varied; some viewed them as beneficial, whereas others reported neutral or inconsistent effects over time. Conclusions: Among young adults with SI, CTSs are a key yet imperfect resource. Quality improvement and evaluation efforts may be needed to understand how responders can better tailor responses to improve conversational quality and consistency for young adult texters.
dlvr.it
August 26, 2026 at 9:12 PM
Becker County's Human Services budget faces tough decisions as a contract renegotiation saves money, but SNAP cuts could raise property taxes!

Get the details!

#BeckerCounty #MN #CitizenPortal #HumanServices #MentalHealth #BudgetTransparency
Human services budget tight as Lakeland contract is trimmed and SNAP admin cut hits county
Human Services reported both Child Protection and Income Maintenance met performance criteria; commissioners learned that a proposed 10% increase from Lakeland Mental Health was reduced by removing CTSS services, saving about $3,000, and discussed a SNAP administration cut of $155,565 that will raise levy needs.
citizenportal.ai
August 22, 2026 at 9:25 AM
Calling all Year 2 CTSS counseling teams! Bring your administrators and join us to work on your Gold-level submissions with individualized guidance. Leave with concrete next steps and a strong start to the school year. Learn more & register today - kinl.cc/CCevents #EduSky
August 11, 2026 at 1:25 PM
Here in the US Trump mob control fuel prices,stock markets, as MF everything else and in between , and the font give a ctss as p about what Americans have to say !
August 7, 2026 at 1:51 AM
7️⃣/9️⃣

A partir de aquí hemos realizado en Ciencia en el XXI una reconstrucción histórica para que cualquiera pueda experimentar cómo era utilizar ELIZA.

No es un clon moderno. No usa IA generativa.

Reproduce incluso el arranque del sistema CTSS antes de iniciar la conversación
August 6, 2026 at 5:31 PM
The start of the school year moves fast. Let us help you find the time to focus on your CTSS Year 2 goals and Gold recognition. Bring your counseling team for a morning of expert guidance and productive planning. Learn more and register today - kinl.cc/CCevents #EduSKy
August 6, 2026 at 4:25 PM
Don't let early-year deadlines overwhelm your team! Join us at CIESC for a focused, half-day work session. Get expert coaching and dedicated time to tackle your CTSS Year 2 data requirements and Gold submissions. Register now! kinl.cc/CCevents #EduSky
July 29, 2026 at 3:10 PM
I am impressed by their "Try Eliza" page: https://findingeliza.org/try.html (Though it does show how bad this chatbot is, by contemporary standards)

It's a Javascript implementation, with source here […]

[Original post on hcommons.social]
July 25, 2026 at 7:56 AM
I am impressed by their "Try Eliza" page: findingeliza.org/try.html (Though it does show how bad this chatbot is, by contemporary standards)

It's a Javascript implementation, with source here: github.com/anthay/antha...

The "doctor script" is fascinating: "(WHAT DOES THAT DREAM SUGGEST TO YOU)".
July 25, 2026 at 7:56 AM
#BreakingKindSongs
#MusicChallenge

July 1️⃣5️⃣ - You can only take a Greatest Hits CD on a road trip. Share a track from that CD.

One of my favourite best of 💿 🎶✌️🖖🤘🕊️🎶

www.youtube.com/watch?v=CtSS...
Downtown Came Uptown
YouTube video by David Wilcox - Topic
www.youtube.com
July 15, 2026 at 12:50 PM
#OTD in 1926, 1990 #ACMTuringAward recipient Fernando J. Corbato was born. He received it for his pioneering work organizing the concepts and leading the development of the general-purpose, large-scale, time-sharing and resource-sharing computer systems, CTSS and Multics. youtu.be/xIyEkljD9FI?...
July 1, 2026 at 12:45 PM
Meet Kelly S. Davison RN, CPMHN(C), CTSS (he/him)
IALH Student Affiliate
PhD Candidate, School of Health Information Science, UVic

For more information about the SGWG, explore here: infocentral.infoway-inforoute.ca/en/collabora...
June 25, 2026 at 7:56 PM
CTSS is looking at the 2026 state of the art when it comes to GPU timesharing and is like "Y'all live like this?!"
June 12, 2026 at 1:08 PM
CTSS(Compatible Time-Sharing System)のコンパチブルの意味を Wikipedia で知る。
June 12, 2026 at 12:53 AM
The Virtual OS Museum

https://virtualosmuseum.org

Want to see the earliest resident monitors? The ancestor of all modern OSes (CTSS)? The earliest versions of Unix? The first OS with a desktop metaphor GUI (Xerox Star Pilot/ViewPoint)? Early versions of mainstream OSes? If you want to explore […]
Original post on fediscience.org
fediscience.org
June 7, 2026 at 3:03 PM
#Targetome
Celastrol ameliorates cholestatic liver injury by inhibiting CTSS and restoring autophagy, shifting iNKT cells from pathogenic iNKT17 to protective iNKT1 polarization.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0018
#DrugDiscovery #Pharmacology
May 29, 2026 at 3:45 AM
🚀 https://ow.ly/4xEO50Z3AHV 📦 Pre-installed OS & emulators, snapshot tool, hypervisor installers for Windows, macOS & Linux. Explore CTSS, early Unix, Xerox Star GUI hassle-free! Full offline or lite version with auto updates. #RetroTech #Emulation
May 24, 2026 at 2:32 PM