Wee1-AS, a #lncRNA, protects against #MASLD by repressing #Wee1 and stabilizing #CYCLINB1 to activate CDK1-driven mitochondrial #FattyAcidOxidation, while WEE1 inhibition or the human homolog LNC106435.1 similarly improves mitochondrial function.
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
February 23, 2026 at 5:20 PM
Wee1-AS, a #lncRNA, protects against #MASLD by repressing #Wee1 and stabilizing #CYCLINB1 to activate CDK1-driven mitochondrial #FattyAcidOxidation, while WEE1 inhibition or the human homolog LNC106435.1 similarly improves mitochondrial function.
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
TET2 aggravates podocyte mitotic catastrophe and renal injury in diabetic nephropathy via m5C-dependent downregulation of Wee1 and acti…
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · Feng et al.
doi.org/10.1007/s00011-026-02346-y
#RNAsky #RNAmods
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · Feng et al.
doi.org/10.1007/s00011-026-02346-y
#RNAsky #RNAmods
TET2 aggravates podocyte mitotic catastrophe and renal injury in diabetic nephropathy via m5C-dependent downregulation of Wee1 and activation of CDK1-cyclinB1 signaling
Here, we explored whether TET2 mediates podocyte MC in DN using Adriamycin (ADM) and high glucose (HG) in vitro, and both STZ-induced and db/db diabetic mouse models in vivo.
doi.org
September 6, 2026 at 9:06 PM
TET2 aggravates podocyte mitotic catastrophe and renal injury in diabetic nephropathy via m5C-dependent downregulation of Wee1 and acti…
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · Feng et al.
doi.org/10.1007/s00011-026-02346-y
#RNAsky #RNAmods
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · Feng et al.
doi.org/10.1007/s00011-026-02346-y
#RNAsky #RNAmods