#CancerDiscov
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erictopol.bsky.social
This is big. The first vaccine tested to PREVENT pancreatic cancer in high-risk individuals
aacrjournals.org/cancerdiscov...
First-in-human testing of a mutant KRAS vaccine for pancreatic cancer interception in high-risk cohorts
Abstract. Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a mino...
aacrjournals.org
July 16, 2026 at 5:47 PM
bild.bsky.social
aacrjournals.org/cancerdiscov...
September 23, 2026 at 7:19 AM
sailorrooscout.bsky.social
You can read all this and more here:
• aacrjournals.org/cancerdiscov...
• aacrjournals.org/cancerdiscov...
• www.hopkinsmedicine.org/news/newsroo...
• www.aacr.org/blog/2026/07...
• www.insideprecisionmedicine.com/topics/oncol...
• www.technologynetworks.com/tn/news/kras...
September 8, 2026 at 10:45 PM
nlbigas.bsky.social
Tackling Cancer through Global Team Science

aacrjournals.org/cancerdiscov...
March 5, 2025 at 8:09 PM
erictopol.bsky.social
We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment.
aacrjournals.org/cancerdiscov...
May 21, 2026 at 3:57 PM
itaiyanai.bsky.social
What were the most inspiring 2024 discoveries in cancer?
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...
December 3, 2024 at 3:46 PM
scinews.bsky.social
Study uncovers genetic drivers of aggressive prostate cancer

"The Germline and Somatic Origins of Prostate Cancer Heterogeneity"

aacrjournals.org/cancerdiscov...
March 4, 2025 at 9:32 AM
tme-caf-ecm.bsky.social
Check out this seminal study @theaacr.bsky.social by the one and only @marasherman.bsky.social

aacrjournals.org/cancerdiscov...

& the commentary about its importance to gain understanding on the inherent tumor-suppressive #PancreaticCancer #TME (by yours truly)

aacrjournals.org/cancerdiscov...
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression
Normal pancreatic mesenchyme expresses stem cell factor (KITL), which is lost in the cancer-associated fibroblast state during tumorigenesis and restrains pancreatic inflammation, epithelial identity,...
aacrjournals.org
May 2, 2025 at 6:01 PM
texwiller.bsky.social
aacrjournals.org/cancerdiscov...
Primo vaccino per il tumore pancreatico con mutazione KRAS.
Vorrei vedere un #novax predisposto a tale malattia che lo rifiutasse
First-in-human testing of a mutant KRAS vaccine for pancreatic cancer interception in high-risk cohorts
Abstract. Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a mino...
aacrjournals.org
July 17, 2026 at 3:24 PM
timwitney.bsky.social
'CTR-FAPI PET Enables Precision Management of Medullary Thyroid Carcinoma', published today in @theaacr.bsky.social Cancer Discovery: aacrjournals.org/cancerdiscov...

Read my commentary on this great work here: aacrjournals-org.kcl.idm.oclc.org/cancerdiscov...
February 7, 2025 at 12:32 PM
elizsmckenna.bsky.social
The April (and #AACR25) issue of Cancer Discovery is now online! The cover features work by Ling Cai, Nia Hammond, @faubert.bsky.social, @rjdlab.bsky.social & colleagues showing high glucose contribution to the TCA cycle is a feature of aggressive NSCLC - more here: aacrjournals.org/cancerdiscov...
April 2, 2025 at 8:34 PM
apccc.bsky.social
High-purity CTC RNA sequencing identifies #ProstateCancer lineage phenotypes prognostic for clinical outcomes out in CANCER DISCOVERY

aacrjournals.org/cancerdiscov...

@silkegillessen.bsky.social
@aureliusomlin.bsky.social
@barbaramelao.bsky.social
@achoud72.bsky.social
@yukselurun.bsky.social
February 7, 2025 at 9:56 AM
landau.bsky.social
Happy new year/paper!

A new tech (scG2P) maps genotype (DNA) to phenotype (RNA) in single cells, bringing together the worldviews of genetic & transcriptional heterogeneity. With scG2P we define how mosaicism drivers increase clonal fitness in the aging esophagus

aacrjournals.org/cancerdiscov...
January 7, 2026 at 4:18 PM
ankuroncofetal.bsky.social
Very cool work on Notch signaling’s role in drives sexually dimorphic responses in HCC by @amaialujambio.bsky.social & co. in Cancer Discovery
aacrjournals.org/cancerdiscov...
November 20, 2024 at 8:16 PM
drjonlim.bsky.social
#AACRBlog ▶️ Intersting read re: "Peto’s paradox" 🐘...and the recent #CancerDiscovery story from Compton et al. re: cancer prevalence across vertebrates!

aacrjournals.org/cancerdiscov...
November 20, 2024 at 1:48 AM
elizsmckenna.bsky.social
The January issue of Cancer Discovery is now online! The cover features "Cancer Prevalance across Vertebrates" by @zacharytcompton.bsky.social and colleagues - read that and much more: aacrjournals.org/cancerdiscov...
January 14, 2025 at 6:44 PM
oawlab.bsky.social
Excited to announce a new paper in ‪@aacrjournals.bsky.social‬ with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies:
aacrjournals.org/cancerdiscov...
August 12, 2025 at 5:09 PM
pozniakjoanna.bsky.social
Big thanks to Cancer Discovery and the authors of this commentary for highlighting our work!

Really cool to see our research featured here! ☺️

aacrjournals.org/cancerdiscov...

#CancerResearch #Immunology #NKCells @marinelab.bsky.social
The Dark Side of NK Cells in Cancer Immunotherapy
Summary:. NK cells are a subset of innate lymphoid cells originally identified in mice and humans based on their ability to mediate cytotoxicity against transformed cells. However, two recent back-to-...
aacrjournals.org
September 9, 2025 at 2:01 PM
labwaggoner.bsky.social
Mitochondrial Complex I at the Crossroads of NK cell Dysfunction in Glioblastoma
aacrjournals.org/cancerdiscov...

aacrjournals.org/cancerdiscov...
September 2, 2026 at 7:54 PM
haoyin.bsky.social
#Polyploidy
#HNSCC

TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma

Cool CosMx single-cell spatial (64-plex) immunophenotyping🤠

#CancerDiscov 2024
aacrjournals.org/cancerdiscov...
September 24, 2026 at 12:08 PM
batllelab.bsky.social
🧵1/17

📣Thrilled to share our latest study just out in Cancer Discovery!

➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 23, 2025 at 6:07 PM
scinews.bsky.social
Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis

Open Access
aacrjournals.org/cancerdiscov...

#TIC2025 #Oncology #CancerResearch
June 18, 2025 at 1:44 AM
elizsmckenna.bsky.social
A little travel reading for those heading to #AACR25: the recent collections of special commentaries published in Cancer Discovery! Read them here: aacrjournals.org/cancerdiscov... aacrjournals.org/cancerdiscov...
April 24, 2025 at 6:42 PM
christophertape.bsky.social
Important new paper from @batllelab.bsky.social showing how the KRAS-G12D inhibitor (RMC-9945) triggers rapid stem cell switching in CRC.

This switch happens in just a few hours — similar to what we see with tumour cell responses to CAFs.

aacrjournals.org/cancerdiscov...
October 25, 2025 at 1:16 PM