Long-term cocaine use, as well as acute cocaine use, is associated with adverse cardiovascular consequences, including arrhythmias, angina, myocardial infarction, heart failure, and other conditions. ...

The clinical utility of doxorubicin is limited by dose-dependent cardiotoxicity. Yang et al. identify an integrated stress response (ISR)-driven ATF4-METTL1-NLRP3 axis underlying this injury. ISRIB tr...

Three priorities for AYA cancer survivorship: (1) Systematic cardiotoxicity & late-effects screening; (2) Pre-treatment fertility counselling & reproductive health support; (3) Plan…

We identify the maladaptive ATF4-dependent integrated stress response (ISR) program as a central driver of this pathology.

Trastuzumab, an epidermal growth factor receptor 2 (HER2) targeting humanized monoclonal antibody, has been approved for the treatment HER2-positive breast cancer and HER2-positve metastatic gastric c...

Doxorubicin affects topoisomerase IIb (Topo IIb) activity. To identify downstream targets of doxorubicin, Topo IIb ChIP-seq was performed in neonatal rat ventricular cardiomyocytes (NRVM), that were treated with doxorubicin. We were able to identify genomic regions significantly gaining Topo IIb enrichment after doxorubicin treatment (n = 211 peaks, FDR < 0.1), indicative of a specific response to double-strand breaks. These regions comprise cardiomyocyte-specific promoters, e.g., of Myh7, Myl2 and Actc1 (Fig. 1A–E, Supplementary Fig. 1A–D) and share a high enrichment of the transcription factor myocyte enhancer factor 2 (MEF2), which is known to be a major mediator of pathological cardiac remodeling (Fig. 1A, E). From 1148 called peaks in Doxo-treated NRVMs (at least in one replicate), we found 1012 (88%) peaks overlapping with at least one MEF2-peak. A total of 180 peaks were recalled in all replicates of Topo IIb- and MEF2-ChIP-seq as common targets (Fig. 1F). Target genes are regulated in doxorubicin-treated hiPSC To verify transcriptional dysregulation of the identified genes in human samples, we re-analyzed the publicly available RNA-seq dataset of hiPSC-derived cardiomyocytes exposed for 16 h to vehicle, 1 µM or 2.5 µM doxorubicin (2 sets of duplicate samples per condition, GEO ID GSE10629721) (Fig. 1G). We...

Utrecht University is offering a PhD position in Neurotoxicity of Herbal Supplements. The four-year research project focuses on in vitro toxicity testing, neuronal effects, the blood-brain barrier and cardiotoxicity. The salary is €3,204–€4,051 per month, with applications due September 13, 2026.

Three priorities for AYA cancer survivorship: (1) Systematic cardiotoxicity & late-effects screening; (2) Pre-treatment fertility counselling & reproductive health support; (3) Plan…

Patients with breast and lung cancer are at increased risk of cardiotoxicity, or heart-related damage caused by cancer treatments, because of the proximity of the heart, lungs and breasts. Cardiotoxicity increases the risk of heart attacks, heart failure and other cardiac conditions. Looking for evidence of cardiac disease in these patients requires reading through hundreds of patients' health records, which is often too time-consuming to be practical.

Read the full paper: AKT (Ser473) suppression mediates ceritinib cardiotoxicity through autophagic flux impairment and mitochondrial injury

UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

Adolescents & young adults surviving cancer face complex long-term health risks—from cardiotoxicity to infertility. A new Canadian Medical Association Journal practice review ou…

Abstract Doxorubicin is one of the most widely used anthracycline chemotherapeutic agents in modern oncology and remains a cornerstone treatment for numerous h