🫀🧬 This review examines the transcriptional and epigenetic mechanisms linking ART to alterations in cardiogenic gene regulation during embryogenesis. #InVitroFertilization #Cardiogenesis
www.mdpi.com/2227-9059/13...
www.mdpi.com/2227-9059/13...
September 28, 2026 at 12:57 AM
🫀🧬 This review examines the transcriptional and epigenetic mechanisms linking ART to alterations in cardiogenic gene regulation during embryogenesis. #InVitroFertilization #Cardiogenesis
www.mdpi.com/2227-9059/13...
www.mdpi.com/2227-9059/13...
extraordinarily deep investigation of the human fetal heart with spatial and single cell approaches. With a comment by postdoc Lisa Iwamoto-Stohl and I. www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatiotemporal gene expression and cellular dynamics of the developing human heart - Nature Genetics
The authors use spatial and single-cell transcriptomics to examine spatial dynamics during early human cardiogenesis, yielding insights into the development of the cardiac pacemaker-conduction system,...
www.nature.com
October 29, 2025 at 2:07 PM
extraordinarily deep investigation of the human fetal heart with spatial and single cell approaches. With a comment by postdoc Lisa Iwamoto-Stohl and I. www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 6:12 AM
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
There is a huge difference between biochemically defined motifs and real life chromatin sites. In our 2016 paper we found all sorts of TFBS variants that would have never showed up in any database www.sciencedirect.com/science/arti...
Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis
Transcription factors (TFs) are thought to function with partners to achieve specificity and precise quantitative outputs. In the developing heart, he…
www.sciencedirect.com
January 13, 2025 at 3:00 AM
There is a huge difference between biochemically defined motifs and real life chromatin sites. In our 2016 paper we found all sorts of TFBS variants that would have never showed up in any database www.sciencedirect.com/science/arti...
Here's our paper on which this was inspired www.nature.com/articles/s41...
Brahma safeguards canalization of cardiac mesoderm differentiation - Nature
The BAF chromatin-remodelling complex ATPase gene Brm safeguards cell identity during directed cardiogenesis of mouse embryonic stem cells.
www.nature.com
February 22, 2026 at 1:43 AM
Here's our paper on which this was inspired www.nature.com/articles/s41...
TAK1 is a vital signalling molecule at cilia level regulating cardiogenesis
📸 Canan Doganli, Oskar Kaaber Thomsen, Daniel A. Baird & Yeasmeen Ali et al University of Copenhagen in
@plosbiology.org
➡️ bpod.org.uk/archive/2026...
📸 Canan Doganli, Oskar Kaaber Thomsen, Daniel A. Baird & Yeasmeen Ali et al University of Copenhagen in
@plosbiology.org
➡️ bpod.org.uk/archive/2026...
August 14, 2026 at 8:50 AM
TAK1 is a vital signalling molecule at cilia level regulating cardiogenesis
📸 Canan Doganli, Oskar Kaaber Thomsen, Daniel A. Baird & Yeasmeen Ali et al University of Copenhagen in
@plosbiology.org
➡️ bpod.org.uk/archive/2026...
📸 Canan Doganli, Oskar Kaaber Thomsen, Daniel A. Baird & Yeasmeen Ali et al University of Copenhagen in
@plosbiology.org
➡️ bpod.org.uk/archive/2026...
New Online! Coordination of cardiogenesis in vivo and in vitro
Coordination of cardiogenesis in vivo and in vitro
Nature Reviews Molecular Cell Biology, Published online: 24 September 2025; doi:10.1038/s41580-025-00878-5The development of a functional heart depends on the specification of multiple cell types, including pacemaker cells, and complex tissue re-organization. This Review discusses recent insights into these processes from in vivo studies and cardiac organoid models.
bit.ly
September 24, 2025 at 4:48 PM
New Online! Coordination of cardiogenesis in vivo and in vitro
Excited to share some new work from our group - www.biorxiv.org/content/10.1...
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 4:43 PM
Excited to share some new work from our group - www.biorxiv.org/content/10.1...
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
ICYMI: New Online! Coordination of cardiogenesis in vivo and in vitro
Coordination of cardiogenesis in vivo and in vitro
Nature Reviews Molecular Cell Biology, Published online: 24 September 2025; doi:10.1038/s41580-025-00878-5The development of a functional heart depends on the specification of multiple cell types, including pacemaker cells, and complex tissue re-organization. This Review discusses recent insights into these processes from in vivo studies and cardiac organoid models.
bit.ly
September 27, 2025 at 4:49 PM
ICYMI: New Online! Coordination of cardiogenesis in vivo and in vitro
💐 Congratulations to our 2025 KLI fellow, Nina Kraus @ninakraus.bsky.social, on her new publication in the Journal of Experimental Biology on
"Environmentally dependent developmental induction as a potential driver of heart evolution"!
👏👏👏
📃 doi.org/10.1242/jeb....
"Environmentally dependent developmental induction as a potential driver of heart evolution"!
👏👏👏
📃 doi.org/10.1242/jeb....
January 30, 2026 at 12:40 PM
💐 Congratulations to our 2025 KLI fellow, Nina Kraus @ninakraus.bsky.social, on her new publication in the Journal of Experimental Biology on
"Environmentally dependent developmental induction as a potential driver of heart evolution"!
👏👏👏
📃 doi.org/10.1242/jeb....
"Environmentally dependent developmental induction as a potential driver of heart evolution"!
👏👏👏
📃 doi.org/10.1242/jeb....
Beautiful and important work by the group of @yichenglong.bsky.social at Weill Cornell on the molecular determinants that direct epigenetic repression by Polycomb complexes. www.biorxiv.org/content/10.1... #epigenetics #stemcells #cardiogenesis #polycomb
Macromolecular interactions dictate Polycomb-mediated epigenetic repression
The dynamic regulation of epigenetic states relies on complex macromolecular interactions. PRC2, the methyltransferase complex responsible for depositing H3K27me3, interacts with distinct accessory pr...
www.biorxiv.org
May 16, 2025 at 10:58 AM
Beautiful and important work by the group of @yichenglong.bsky.social at Weill Cornell on the molecular determinants that direct epigenetic repression by Polycomb complexes. www.biorxiv.org/content/10.1... #epigenetics #stemcells #cardiogenesis #polycomb
Our new preprint, full of exciting data, is now available. Have a look!
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 8, 2025 at 6:32 AM
Our new preprint, full of exciting data, is now available. Have a look!
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
www.biorxiv.org/content/10.1...
Very excited to share the culmination of this wonderful collaborative effort, which reveals a mechanism by which QKI facilitates exon inclusion at transcripts with ‘weak’ 5’ splice sites during cardiogenesis, providing new insight into RBP-mediated splicing regulation www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 6:08 PM
Very excited to share the culmination of this wonderful collaborative effort, which reveals a mechanism by which QKI facilitates exon inclusion at transcripts with ‘weak’ 5’ splice sites during cardiogenesis, providing new insight into RBP-mediated splicing regulation www.biorxiv.org/content/10.1...
....but guilty also. Our 2016 paper (pubmed.ncbi.nlm.nih.gov/26875865/) was ten years in our lab, ten years in Müller lab in parallel. In vivo to chromatin to crystal structure.
Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis - PubMed
Transcription factors (TFs) are thought to function with partners to achieve specificity and precise quantitative outputs. In the developing heart, heterotypic TF interactions, such as between the T-b...
pubmed.ncbi.nlm.nih.gov
June 22, 2026 at 10:01 PM
....but guilty also. Our 2016 paper (pubmed.ncbi.nlm.nih.gov/26875865/) was ten years in our lab, ten years in Müller lab in parallel. In vivo to chromatin to crystal structure.
He has deep expertise ranging from nitty-gritty of single cell data analysis (was a co-lead of the ENCODE single cell multi-ome atlas resource) to really insightful modeling of the data (he has a super cool project on regulatory evolution of cardiogenesis which is in the works). 2/
March 5, 2025 at 10:11 PM
He has deep expertise ranging from nitty-gritty of single cell data analysis (was a co-lead of the ENCODE single cell multi-ome atlas resource) to really insightful modeling of the data (he has a super cool project on regulatory evolution of cardiogenesis which is in the works). 2/
Cardiogenesis is the complex, highly regulated embryonic development of the heart, forming the first functional organ from mesodermal progenitors.
en.wikipedia.org/wiki/Heart_d...
en.wikipedia.org/wiki/Heart_d...
Heart development - Wikipedia
en.wikipedia.org
March 8, 2026 at 2:40 AM
Cardiogenesis is the complex, highly regulated embryonic development of the heart, forming the first functional organ from mesodermal progenitors.
en.wikipedia.org/wiki/Heart_d...
en.wikipedia.org/wiki/Heart_d...
Loredana Cirillo from @westernuresearch.bsky.social explored how gestational #diabetes affects planar cell polarity and cardiogenesis, early #heart development, using mouse gastruloids, stem-cell-derived models of the early embryo #DOHaDCanada2026
June 3, 2026 at 8:27 PM
Loredana Cirillo from @westernuresearch.bsky.social explored how gestational #diabetes affects planar cell polarity and cardiogenesis, early #heart development, using mouse gastruloids, stem-cell-derived models of the early embryo #DOHaDCanada2026
Here U go my dear!
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites.
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites.
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5′ splice sites (5′SS) yet are spliced with high precision,...
www.biorxiv.org
September 19, 2025 at 8:38 AM
Here U go my dear!
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites.
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites.
www.biorxiv.org/content/10.1...
A paper using RRID:Addgene_198058 was just published in eLife see "GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis". We appreciate the author's support of reproducibility. #methodsmatter #ReproducibleResearch
doi.org
April 5, 2025 at 7:01 AM
A paper using RRID:Addgene_198058 was just published in eLife see "GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis". We appreciate the author's support of reproducibility. #methodsmatter #ReproducibleResearch
Nicole Graham and colleagues demonstrate the regulatory relationship between cardiogenic factor GATA4 and its target genes TBX2 and PRDM1, discovered in Xenopus, is conserved in human cardiogenesis. doi.org/10.1242/bio....
July 25, 2026 at 4:02 PM
Nicole Graham and colleagues demonstrate the regulatory relationship between cardiogenic factor GATA4 and its target genes TBX2 and PRDM1, discovered in Xenopus, is conserved in human cardiogenesis. doi.org/10.1242/bio....
Authors published a paper in Biorxiv, they used MATLAB in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #reproducibility
Conserved roles of GATA4 and its target gene TBX2 in regulation of human cardiogenesis
www.biorxiv.org
March 3, 2026 at 1:00 PM
Authors published a paper in Biorxiv, they used MATLAB in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #reproducibility
Authors published a paper in Biorxiv, they used MATLAB in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
Conserved roles of GATA4 and its target gene TBX2 in regulation of human cardiogenesis
www.biorxiv.org
March 2, 2026 at 1:01 PM
Authors published a paper in Biorxiv, they used MATLAB in the study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
How to make a ❤️ in a dish? This very comprehensive review from the lab of Gergana Dobreva discusses everything you need to know, from the chemical signalling to mechanical signalling that governs cardiogenesis, to the current protocols of how to make this organ in vitro.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
May 15, 2026 at 3:28 PM
How to make a ❤️ in a dish? This very comprehensive review from the lab of Gergana Dobreva discusses everything you need to know, from the chemical signalling to mechanical signalling that governs cardiogenesis, to the current protocols of how to make this organ in vitro.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis
A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis
(Cell Stem Cell 22, 893–908.e1–e6; June 1, 2018)
dlvr.it
September 3, 2026 at 4:00 PM
A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis
RRID:AB_2535732 from @thermofishersci.bsky.social was used by authors in their Scientific Reports paper. We value the author's support of reproducibility. #OpenScience #RRID #accelerateopenscience
A miR-200b–Filamin A axis drives epicardial contribution to cardiogenesis - Scientific Reports
Read the full paper: A miR-200b–Filamin A axis drives epicardial contribution to cardiogenesis
doi.org
August 28, 2026 at 7:01 AM
RRID:AB_2535732 from @thermofishersci.bsky.social was used by authors in their Scientific Reports paper. We value the author's support of reproducibility. #OpenScience #RRID #accelerateopenscience