Silva and colleagues refine an EV isolation method to optimize recovery of cancer-derived large oncosomes (LOs). This approach enables high-yield profiling by mass spectrometry and bulk/single-LO RNA-...

Kowala et al. demonstrate a clinically relevant transplantation strategy synergizing engineered human myogenic cells and hydrogel-mediated delivery in a dystrophic mouse model. Upon long-term engraftm...

Excellent news — assuming it pans out… Newly discovered antibody protects against all COVID-19 variants @utaustin @CellRepMed https://t.co/3ni1mvR5tB — Medical Xpress (@medical_xpress) September 3, 20...

Excellent news — assuming it pans out… Newly discovered antibody protects against all COVID-19 variants @utaustin @CellRepMed https://t.co/3ni1mvR5tB — Medical Xpress (@medical_xpress) September 3, 20...

Here, Fang et al. highlight emerging and established benefits of GLP-1 medicines in neurological and psychiatric disorders. These medicines exert direct and indirect effects on the brain, improving ne...

Komaki et al. show that brogidirsen, a dual-targeting antisense oligonucleotide, shows promising safety and dose-dependent dystrophin restoration in a phase 1/2 trial for Duchenne muscular dystrophy. Potential biomarkers and motor function stabilization are observed. High efficacy is validated through patient-derived cell-based assays, warranting a subsequent trial to confirm its therapeutic potential.

Bai et al. establish a rhesus monkey model for DMD with exon 50 mutations, closely mimicking human pathology. Using this model, they develop and evaluate a single-cut gene therapy targeting exon 51 of...

Djalalvandi et al. show that blockers of Opa1-targeting microRNAs found upregulated in diseased skeletal muscle can restore mitochondrial architecture and muscle performance in mitochondrial myopathy ...

Malignant rhabdoid tumor (MRT) is an aggressive childhood cancer with limited treatment options. Using patient-derived tumor organoids (tumoroids), Kes et al. identify nucleotide biosynthesis as a vulnerability in MRT. Treatment with methotrexate (MTX) and BAY-2402234 reduced nucleotide levels and induced apoptosis in vitro, with MTX demonstrating reduced MRT growth in vivo.

Histopathological evaluation is a cornerstone of cancer identification but often involves time-consuming labeling processes (∼days per sample) and exp…

De Nardo et al. profile the plasma and liver-secreted proteome from obese individuals spanning the spectrum of MASLD. They identify biomarkers for MASH in persons with obesity and develop and validate...

Gubatan et al. demonstrate vitamin D’s immunoregulatory role on host immune-microbe interactions in patients with inflammatory bowel disease. Vitamin D alters the profiles of IgA- and IgG-bound gut…