Optimized amyloid‐β PET centiloid and cognitive cutoffs predict progression from mild cognitive impairment to Alzheimer's dementia #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71892?af=R
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71892?af=R
November 6, 2026 at 11:04 AM
Optimized amyloid‐β PET centiloid and cognitive cutoffs predict progression from mild cognitive impairment to Alzheimer's dementia #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71892?af=R
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71892?af=R
New paper out: Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.: Blazhenets, Ganna; Soleimani-Meigooni, David N; Chiotis, Konstantinos; et al.
The journal of the American Medical… | Thanks for sharing #dzne #papers
The journal of the American Medical… | Thanks for sharing #dzne #papers
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.
Blazhenets, Ganna; Soleimani-Meigooni, David N; Chiotis, Konstantinos; et al.
The journal of the American Medical Association Vol. 336, no. 13, p. 1135 -
Amyloid positron emission tomography (PET) is increasingly used in research and clinical settings to determine the etiology of cognitive decline and eligibility for amyloid-targeting therapies. To assist with amyloid PET evaluation and to guide clinical decision-making, images can be quantified in a
dlvr.it
October 25, 2026 at 10:53 AM
🧠 What is the optimal Centiloid cutoff for amyloid PET positivity?
Check out this new meta-analysis of 53 studies including AMYPAD.
📊 AMYPAD PNHS data are available on the AD Workbench.
👏 Congrats to all authors!
jamanetwork.com/journals/jam...
Check out this new meta-analysis of 53 studies including AMYPAD.
📊 AMYPAD PNHS data are available on the AD Workbench.
👏 Congrats to all authors!
jamanetwork.com/journals/jam...
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease
This individual participant data meta-analysis seeks to establish robust data-driven Centiloid positivity cutoffs using Centiloid values collected from multiple existing datasets with retrospective, i...
jamanetwork.com
October 15, 2026 at 10:41 AM
🧠 What is the optimal Centiloid cutoff for amyloid PET positivity?
Check out this new meta-analysis of 53 studies including AMYPAD.
📊 AMYPAD PNHS data are available on the AD Workbench.
👏 Congrats to all authors!
jamanetwork.com/journals/jam...
Check out this new meta-analysis of 53 studies including AMYPAD.
📊 AMYPAD PNHS data are available on the AD Workbench.
👏 Congrats to all authors!
jamanetwork.com/journals/jam...
In preclinical #AlzheimerDisease screening, higher plasma phosphorylated tau 217 percentage was associated with higher amyloid #PET across racial groups. ja.ma/3VFP0xm
October 12, 2026 at 3:30 PM
In preclinical #AlzheimerDisease screening, higher plasma phosphorylated tau 217 percentage was associated with higher amyloid #PET across racial groups. ja.ma/3VFP0xm
Puntos de corte de las imágenes PET para positividad convergen alrededor de 18 a 27 centiloides, y las imágenes en el rango de 11 a 26 centiloides deben interpretarse con atención al contexto de uso #centiloids #scans #Alzheimer jamanetwork.com/journals/jam...
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease
This individual participant data meta-analysis seeks to establish robust data-driven Centiloid positivity cutoffs using Centiloid values collected from multiple existing datasets with retrospective, i...
jamanetwork.com
October 7, 2026 at 7:50 AM
Puntos de corte de las imágenes PET para positividad convergen alrededor de 18 a 27 centiloides, y las imágenes en el rango de 11 a 26 centiloides deben interpretarse con atención al contexto de uso #centiloids #scans #Alzheimer jamanetwork.com/journals/jam...
When Is Amyloid Really Cleared? Substantial Discordance Between Centiloid Quantification and Visual Reads of Amyloid PET after Amyloid-Targeting Therapy #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.10.03.26364642v1
https://www.medrxiv.org/content/10.64898/2026.10.03.26364642v1
October 6, 2026 at 4:02 PM
When Is Amyloid Really Cleared? Substantial Discordance Between Centiloid Quantification and Visual Reads of Amyloid PET after Amyloid-Targeting Therapy #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.10.03.26364642v1
https://www.medrxiv.org/content/10.64898/2026.10.03.26364642v1
A data-driven regional amyloid PET score predicts cognitive decline beyond Centiloid #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.08.26.26360248v1
https://www.medrxiv.org/content/10.64898/2026.08.26.26360248v1
August 31, 2026 at 7:02 PM
A data-driven regional amyloid PET score predicts cognitive decline beyond Centiloid #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.08.26.26360248v1
https://www.medrxiv.org/content/10.64898/2026.08.26.26360248v1
A data-driven regional amyloid PET score predicts cognitive decline beyond Centiloid https://www.medrxiv.org/content/10.64898/2026.08.26.26360248v1
August 31, 2026 at 5:10 PM
A data-driven regional amyloid PET score predicts cognitive decline beyond Centiloid https://www.medrxiv.org/content/10.64898/2026.08.26.26360248v1
Open Access UCL Research: Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis discovery.ucl.ac.uk/id/eprint/10...
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis
-
UCL Discovery
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
August 26, 2026 at 2:50 PM
Open Access UCL Research: Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis discovery.ucl.ac.uk/id/eprint/10...
The Centiloid (CL) scale gives doctors a standardized way to measure amyloid plaques on brain scans. Combined with visual interpretation, it can improve diagnosis, guide treatment decisions, and help monitor Alzheimer's disease over time. #Alzheimers
July 13, 2026 at 11:02 AM
The Centiloid (CL) scale gives doctors a standardized way to measure amyloid plaques on brain scans. Combined with visual interpretation, it can improve diagnosis, guide treatment decisions, and help monitor Alzheimer's disease over time. #Alzheimers
🧠 Great to see the AMYPAD dataset continuing to advance #Alzheimers research!
New in JAMA: a global meta-analysis pooling data from 53 studies "𝗪𝗵𝗮𝘁 𝗖𝗲𝗻𝘁𝗶𝗹𝗼𝗶𝗱 𝗰𝘂𝘁𝗼𝗳𝗳 𝘀𝗵𝗼𝘂𝗹𝗱 𝗱𝗲𝗳𝗶𝗻𝗲 𝗮𝗻 𝗮𝗺𝘆𝗹𝗼𝗶𝗱-𝗽𝗼𝘀𝗶𝘁𝗶𝘃𝗲 𝗣𝗘𝗧 𝘀𝗰𝗮𝗻?" 👇
jamanetwork.com/journals/jam...
New in JAMA: a global meta-analysis pooling data from 53 studies "𝗪𝗵𝗮𝘁 𝗖𝗲𝗻𝘁𝗶𝗹𝗼𝗶𝗱 𝗰𝘂𝘁𝗼𝗳𝗳 𝘀𝗵𝗼𝘂𝗹𝗱 𝗱𝗲𝗳𝗶𝗻𝗲 𝗮𝗻 𝗮𝗺𝘆𝗹𝗼𝗶𝗱-𝗽𝗼𝘀𝗶𝘁𝗶𝘃𝗲 𝗣𝗘𝗧 𝘀𝗰𝗮𝗻?" 👇
jamanetwork.com/journals/jam...
jamanetwork.com
July 15, 2026 at 8:16 AM
🧠 Great to see the AMYPAD dataset continuing to advance #Alzheimers research!
New in JAMA: a global meta-analysis pooling data from 53 studies "𝗪𝗵𝗮𝘁 𝗖𝗲𝗻𝘁𝗶𝗹𝗼𝗶𝗱 𝗰𝘂𝘁𝗼𝗳𝗳 𝘀𝗵𝗼𝘂𝗹𝗱 𝗱𝗲𝗳𝗶𝗻𝗲 𝗮𝗻 𝗮𝗺𝘆𝗹𝗼𝗶𝗱-𝗽𝗼𝘀𝗶𝘁𝗶𝘃𝗲 𝗣𝗘𝗧 𝘀𝗰𝗮𝗻?" 👇
jamanetwork.com/journals/jam...
New in JAMA: a global meta-analysis pooling data from 53 studies "𝗪𝗵𝗮𝘁 𝗖𝗲𝗻𝘁𝗶𝗹𝗼𝗶𝗱 𝗰𝘂𝘁𝗼𝗳𝗳 𝘀𝗵𝗼𝘂𝗹𝗱 𝗱𝗲𝗳𝗶𝗻𝗲 𝗮𝗻 𝗮𝗺𝘆𝗹𝗼𝗶𝗱-𝗽𝗼𝘀𝗶𝘁𝗶𝘃𝗲 𝗣𝗘𝗧 𝘀𝗰𝗮𝗻?" 👇
jamanetwork.com/journals/jam...
👉 NEW AMYPAD paper presenting the AMYPAD approach to address data acquisition, processing, interpretation and data sharing challenges!
Congratulations to all authors👏
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Congratulations to all authors👏
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Implementing robust amyloid PET quantification in multi‐center studies: AMYPAD approach to address data acquisition, processing, interpretation and data sharing challenges
INTRODUCTION Amyloid-positron emission tomography (PET) is pivotal to Alzheimer's management, with the Centiloid standardizing measurements across tracers. AMYPAD trials (Diagnostic and Patient Mana...
alz-journals.onlinelibrary.wiley.com
January 5, 2026 at 8:51 AM
👉 NEW AMYPAD paper presenting the AMYPAD approach to address data acquisition, processing, interpretation and data sharing challenges!
Congratulations to all authors👏
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Congratulations to all authors👏
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Today, @ihieurope.bsky.social hosted a webinar on regulatory impact. On behalf of AMYPAD, Gill Farrar presented how we succeeded in the Biomarker Qualification Opinion application for our Centiloid work!
#RegulatoryScience #HorizonEurope #ResearchImpact
#RegulatoryScience #HorizonEurope #ResearchImpact
December 10, 2025 at 2:23 PM
Today, @ihieurope.bsky.social hosted a webinar on regulatory impact. On behalf of AMYPAD, Gill Farrar presented how we succeeded in the Biomarker Qualification Opinion application for our Centiloid work!
#RegulatoryScience #HorizonEurope #ResearchImpact
#RegulatoryScience #HorizonEurope #ResearchImpact
🌟Good morning #ECCN25!
Join us tomorrow for the AMYPAD satellite symposium "What does AMYPAD study reveal about centiloid relevance for the future clinical setting?"
We're looking forward to seeing you!
Join us tomorrow for the AMYPAD satellite symposium "What does AMYPAD study reveal about centiloid relevance for the future clinical setting?"
We're looking forward to seeing you!
March 24, 2025 at 10:08 AM
🌟Good morning #ECCN25!
Join us tomorrow for the AMYPAD satellite symposium "What does AMYPAD study reveal about centiloid relevance for the future clinical setting?"
We're looking forward to seeing you!
Join us tomorrow for the AMYPAD satellite symposium "What does AMYPAD study reveal about centiloid relevance for the future clinical setting?"
We're looking forward to seeing you!
If you are attending next week #ECCN25 in Madrid, don’t miss the AMYPAD satellite symposium on Tuesday, 25th March at 12:30.
This session will explore the AMYPAD study's impact on centiloid relevance and its implications for future clinical practices.
This session will explore the AMYPAD study's impact on centiloid relevance and its implications for future clinical practices.
March 17, 2025 at 10:08 AM
If you are attending next week #ECCN25 in Madrid, don’t miss the AMYPAD satellite symposium on Tuesday, 25th March at 12:30.
This session will explore the AMYPAD study's impact on centiloid relevance and its implications for future clinical practices.
This session will explore the AMYPAD study's impact on centiloid relevance and its implications for future clinical practices.
The 13th European Conference on Clinical Neuroimaging #ECCN25 will be held in Madrid next month!
We're pleased to held a symposium exploring the AMYPAD study's impact on centiloid relevance & its implications for future clinical practices.
We can’t wait to see you in Madrid!
We're pleased to held a symposium exploring the AMYPAD study's impact on centiloid relevance & its implications for future clinical practices.
We can’t wait to see you in Madrid!
February 24, 2025 at 10:08 AM
The 13th European Conference on Clinical Neuroimaging #ECCN25 will be held in Madrid next month!
We're pleased to held a symposium exploring the AMYPAD study's impact on centiloid relevance & its implications for future clinical practices.
We can’t wait to see you in Madrid!
We're pleased to held a symposium exploring the AMYPAD study's impact on centiloid relevance & its implications for future clinical practices.
We can’t wait to see you in Madrid!
📢 Check out this recent opinion piece on the use of Centiloid threshold for anti-amyloid therapy published in The Journal of Prevention of Alzheimer's Disease.
Many AMYPAD collaborators are acknowledged for sharing their input on the topic!
doi.org/10.1016/j.tj...
Many AMYPAD collaborators are acknowledged for sharing their input on the topic!
doi.org/10.1016/j.tj...
February 4, 2025 at 11:56 AM
📢 Check out this recent opinion piece on the use of Centiloid threshold for anti-amyloid therapy published in The Journal of Prevention of Alzheimer's Disease.
Many AMYPAD collaborators are acknowledged for sharing their input on the topic!
doi.org/10.1016/j.tj...
Many AMYPAD collaborators are acknowledged for sharing their input on the topic!
doi.org/10.1016/j.tj...
[Last 3 sentences]: The minimum sample size required per study group to detect a 25% drug effect was 610 for the CU Aβ-positive and 664 for the CI Aβ-positive group. Notably, selecting individuals with intermediate Aβ levels (Centiloid 20-40) yielded higher effect sizes
4/5
4/5
February 15, 2026 at 2:07 AM
[Last 3 sentences]: The minimum sample size required per study group to detect a 25% drug effect was 610 for the CU Aβ-positive and 664 for the CI Aβ-positive group. Notably, selecting individuals with intermediate Aβ levels (Centiloid 20-40) yielded higher effect sizes
4/5
4/5
Open Access UCL Research: AI-enhanced Centiloid quantification of amyloid PET images discovery.ucl.ac.uk/id/eprint/10...
AI-enhanced Centiloid quantification of amyloid PET images
-
UCL Discovery
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
February 18, 2026 at 11:43 AM
Open Access UCL Research: AI-enhanced Centiloid quantification of amyloid PET images discovery.ucl.ac.uk/id/eprint/10...
New [₁₈F] tau scan detects tau accumulation at significantly earlier stages of Alzheimer's Disease. #Medsky www.thelancet.com/action/showP...
![Cumulative tau MTL and neocortical positivity of [18F]flortaucipir and [¹⁸F] MK6240 as a function of Aβ burden (Centiloid) in cognitively unimpaired (A) and cognitively impaired (B) participants. (C) The number of individuals required to detect one tau-positive case and NND one extra tau positive case stratified by diagnostic and Aβ status. Neocortical region is composed of Braak V and VI regions. p values indicate whether detection of tau positivity differs between [¹⁸F]MK6240 and [¹⁸F]flortaucipir. Error bars indicate 95% CI. Asterisks indicate NND estimates for which the 95% CI of the paired absolute risk difference did not include zero. Participants with Alzheimer’s disease dementia were, by definition, Aβ-positive. Analysis accounted for Centiloid, age, sex, and study site. Aβ+=amyloid-β positive. PR=prevalence ratio. MCI=mild cognitive impairment. MTL=medial temporal lobe. Neo=neocortex. NND=number needed to detect. tau+=tau positive.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:sij7wzttoxd3ujhhnptqb3c5/bafkreihwvg3rnbjidt5hftblkbci2rq3f5zpp2a37kqomnba43q5z3bzf4)
June 1, 2026 at 4:45 PM
New [₁₈F] tau scan detects tau accumulation at significantly earlier stages of Alzheimer's Disease. #Medsky www.thelancet.com/action/showP...
Meta-analysis: #Centiloid values <11 or >26 on #AmyloidPET scans provide high diagnostic confidence for the absence or presence of amyloid in #AlzheimerDisease, while values between 11 and 26 indicates uncertainty and may require further assessment.
ja.ma/4pkRxHW
ja.ma/4pkRxHW
July 16, 2026 at 10:00 AM
Meta-analysis: #Centiloid values <11 or >26 on #AmyloidPET scans provide high diagnostic confidence for the absence or presence of amyloid in #AlzheimerDisease, while values between 11 and 26 indicates uncertainty and may require further assessment.
ja.ma/4pkRxHW
ja.ma/4pkRxHW
💬 Editorial: Meta-analysis of #AlzheimerDisease amyloid PET scans validates Centiloid thresholds for classifying amyloid status and supports their integration into clinical workflows, w/ adaptation to cohort- and site-specific factors recommended.
#AAIC26
ja.ma/4f0Vpum
#AAIC26
ja.ma/4f0Vpum
July 13, 2026 at 4:11 PM
💬 Editorial: Meta-analysis of #AlzheimerDisease amyloid PET scans validates Centiloid thresholds for classifying amyloid status and supports their integration into clinical workflows, w/ adaptation to cohort- and site-specific factors recommended.
#AAIC26
ja.ma/4f0Vpum
#AAIC26
ja.ma/4f0Vpum
Meta-analysis: #Centiloid values <11 or >26 on #AmyloidPET scans provide high diagnostic confidence for the absence or presence of amyloid in #AlzheimerDisease, while values between 11 and 26 indicates uncertainty and may require further assessment. #AAIC26
ja.ma/3RxLxz6
ja.ma/3RxLxz6
July 13, 2026 at 3:05 PM
Meta-analysis: #Centiloid values <11 or >26 on #AmyloidPET scans provide high diagnostic confidence for the absence or presence of amyloid in #AlzheimerDisease, while values between 11 and 26 indicates uncertainty and may require further assessment. #AAIC26
ja.ma/3RxLxz6
ja.ma/3RxLxz6
💬 Viewpoint: #Amyloid PET quantification with Centiloid values provides objective context for #Alzheimer disease diagnosis, prognosis, and management, especially for amyloid-targeting therapies.
ja.ma/4aFvYMk
ja.ma/4aFvYMk
July 10, 2026 at 11:00 AM
💬 Viewpoint: #Amyloid PET quantification with Centiloid values provides objective context for #Alzheimer disease diagnosis, prognosis, and management, especially for amyloid-targeting therapies.
ja.ma/4aFvYMk
ja.ma/4aFvYMk
💬 Viewpoint: #Amyloid PET quantification with Centiloid values provides objective context for #Alzheimer disease diagnosis, prognosis, and management, especially for amyloid-targeting therapies.
ja.ma/4vdNxdJ
ja.ma/4vdNxdJ
July 3, 2026 at 3:12 PM
💬 Viewpoint: #Amyloid PET quantification with Centiloid values provides objective context for #Alzheimer disease diagnosis, prognosis, and management, especially for amyloid-targeting therapies.
ja.ma/4vdNxdJ
ja.ma/4vdNxdJ