Puntos de corte de las imágenes PET para positividad convergen alrededor de 18 a 27 centiloides, y las imágenes en el rango de 11 a 26 centiloides deben interpretarse con atención al contexto de uso #centiloids #scans #Alzheimer jamanetwork.com/journals/jam...
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease
This individual participant data meta-analysis seeks to establish robust data-driven Centiloid positivity cutoffs using Centiloid values collected from multiple existing datasets with retrospective, i...
jamanetwork.com
October 7, 2026 at 7:50 AM
Puntos de corte de las imágenes PET para positividad convergen alrededor de 18 a 27 centiloides, y las imágenes en el rango de 11 a 26 centiloides deben interpretarse con atención al contexto de uso #centiloids #scans #Alzheimer jamanetwork.com/journals/jam...
🧵 2/3
They bind tau differently. MK-6240 was always one step ahead, by 20 to 30 centiloids, roughly 3 to 5 years sooner.
A 10-year study found cortical thickness can briefly rise before it declines, so a scan can read reassuring at the wrong time (Qiu, IND 2025).
They bind tau differently. MK-6240 was always one step ahead, by 20 to 30 centiloids, roughly 3 to 5 years sooner.
A 10-year study found cortical thickness can briefly rise before it declines, so a scan can read reassuring at the wrong time (Qiu, IND 2025).
October 4, 2026 at 9:10 PM
🧵 2/3
They bind tau differently. MK-6240 was always one step ahead, by 20 to 30 centiloids, roughly 3 to 5 years sooner.
A 10-year study found cortical thickness can briefly rise before it declines, so a scan can read reassuring at the wrong time (Qiu, IND 2025).
They bind tau differently. MK-6240 was always one step ahead, by 20 to 30 centiloids, roughly 3 to 5 years sooner.
A 10-year study found cortical thickness can briefly rise before it declines, so a scan can read reassuring at the wrong time (Qiu, IND 2025).
📣 HABS-HD R8 measures for sMRI & amyloid and tau PET are now available on the LONI IDA!
New from our lab:
🧠 Centiloids for global amyloid.
🧠 Tau SUVR in the mesial temporal lobe region we used to tau positivity (doi: 10.1162/IMAG.a.41).
🧠 Detailed analysis protocols.
@uscini.bsky.social
New from our lab:
🧠 Centiloids for global amyloid.
🧠 Tau SUVR in the mesial temporal lobe region we used to tau positivity (doi: 10.1162/IMAG.a.41).
🧠 Detailed analysis protocols.
@uscini.bsky.social
April 20, 2026 at 8:22 PM
📣 HABS-HD R8 measures for sMRI & amyloid and tau PET are now available on the LONI IDA!
New from our lab:
🧠 Centiloids for global amyloid.
🧠 Tau SUVR in the mesial temporal lobe region we used to tau positivity (doi: 10.1162/IMAG.a.41).
🧠 Detailed analysis protocols.
@uscini.bsky.social
New from our lab:
🧠 Centiloids for global amyloid.
🧠 Tau SUVR in the mesial temporal lobe region we used to tau positivity (doi: 10.1162/IMAG.a.41).
🧠 Detailed analysis protocols.
@uscini.bsky.social
(Wild: in simulating measured centiloids of amyloid, there was not much published data to reference on noise in measuring this entity.)
June 25, 2025 at 2:37 PM
(Wild: in simulating measured centiloids of amyloid, there was not much published data to reference on noise in measuring this entity.)
TODAY at 11A US ET, #MELODEM brings you @relajoie.bsky.social and Ganna Blazhenets presenting:
"Harmonization of #amyloid-PET quantification for #ADRD research: putting #Centiloids to the test"
More deets on MELODEM & how to hop on the distribution list:
sites.bu.edu/melodem/
"Harmonization of #amyloid-PET quantification for #ADRD research: putting #Centiloids to the test"
More deets on MELODEM & how to hop on the distribution list:
sites.bu.edu/melodem/
Methods for Longitudinal Studies in Dementia (MELODEM)
sites.bu.edu
February 20, 2025 at 1:16 PM
TODAY at 11A US ET, #MELODEM brings you @relajoie.bsky.social and Ganna Blazhenets presenting:
"Harmonization of #amyloid-PET quantification for #ADRD research: putting #Centiloids to the test"
More deets on MELODEM & how to hop on the distribution list:
sites.bu.edu/melodem/
"Harmonization of #amyloid-PET quantification for #ADRD research: putting #Centiloids to the test"
More deets on MELODEM & how to hop on the distribution list:
sites.bu.edu/melodem/
Working in this paper was a really fun collaboration with folks at AMYPAD, Lyduine Collij, Ariane Bollack, Gill Farrar and many others.
This should be a helpful piece for people who want to understand Centiloids!
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
This should be a helpful piece for people who want to understand Centiloids!
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
November 21, 2024 at 3:55 PM
Working in this paper was a really fun collaboration with folks at AMYPAD, Lyduine Collij, Ariane Bollack, Gill Farrar and many others.
This should be a helpful piece for people who want to understand Centiloids!
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
This should be a helpful piece for people who want to understand Centiloids!
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Meta-analysis: #Centiloid values <11 or >26 on #AmyloidPET scans provide high diagnostic confidence for the absence or presence of amyloid in #AlzheimerDisease, while values between 11 and 26 indicates uncertainty and may require further assessment. #AAIC26
ja.ma/3RxLxz6
ja.ma/3RxLxz6
July 13, 2026 at 3:05 PM
Meta-analysis: #Centiloid values <11 or >26 on #AmyloidPET scans provide high diagnostic confidence for the absence or presence of amyloid in #AlzheimerDisease, while values between 11 and 26 indicates uncertainty and may require further assessment. #AAIC26
ja.ma/3RxLxz6
ja.ma/3RxLxz6
#ADPD2025 continues for us in Vienna! 🇦🇹
Don't forget to stop by booth 10 and check out poster 403, which showcases an example of leveraging the GAAIN platform to conduct a large scale meta-analysis comparing amyloid load between cohorts 🧠
#Centiloids #datasharing
Don't forget to stop by booth 10 and check out poster 403, which showcases an example of leveraging the GAAIN platform to conduct a large scale meta-analysis comparing amyloid load between cohorts 🧠
#Centiloids #datasharing
April 4, 2025 at 12:27 PM
#ADPD2025 continues for us in Vienna! 🇦🇹
Don't forget to stop by booth 10 and check out poster 403, which showcases an example of leveraging the GAAIN platform to conduct a large scale meta-analysis comparing amyloid load between cohorts 🧠
#Centiloids #datasharing
Don't forget to stop by booth 10 and check out poster 403, which showcases an example of leveraging the GAAIN platform to conduct a large scale meta-analysis comparing amyloid load between cohorts 🧠
#Centiloids #datasharing
60 centiloids. Fascinating. www.alzforum.org/news/confere...
Your Amyloid Load Determines When, and How Fast, Tangles Spread | ALZFORUM
www.alzforum.org
April 17, 2026 at 4:56 PM
60 centiloids. Fascinating. www.alzforum.org/news/confere...
From #AAIC2026 - Researchers have identified amyloid PET positivity thresholds #AlzheimerDisease to be around 18 to 27 Centiloids, based on a combination of data-driven methods and visual reads.
👉️ buff.ly/HoP56Ol
#MedNews
👉️ buff.ly/HoP56Ol
#MedNews
Centiloid thresholds for amyloid PET positivity in Alzheimer disease defined
Researchers have identified amyloid PET positivity thresholds to be around 18 to 27 Centiloids, based on a combination of data-driven methods and visual reads.
www.springermedicine.com
July 26, 2026 at 6:25 PM
From #AAIC2026 - Researchers have identified amyloid PET positivity thresholds #AlzheimerDisease to be around 18 to 27 Centiloids, based on a combination of data-driven methods and visual reads.
👉️ buff.ly/HoP56Ol
#MedNews
👉️ buff.ly/HoP56Ol
#MedNews
Amyloid PET Quantification with Centiloids: Concepts, Thresholds, and Interpretation
Renaud La Joie, PhD
&
David Soleimani-Meigooni, MD
University of California, San Francisco
Memory and Aging Center Grand Rounds
Monday, Oct. 6, 10-11am PT
register 👉
Renaud La Joie, PhD
&
David Soleimani-Meigooni, MD
University of California, San Francisco
Memory and Aging Center Grand Rounds
Monday, Oct. 6, 10-11am PT
register 👉
Memory and Aging Center Grand Rounds
Amyloid PET Quantification with Centiloids: Concepts, Thresholds, and Interpretation Renaud La Joie, PhD Assistant Professor of Neurology University of California, San Francisco David…
buff.ly
September 30, 2025 at 5:03 PM
Amyloid PET Quantification with Centiloids: Concepts, Thresholds, and Interpretation
Renaud La Joie, PhD
&
David Soleimani-Meigooni, MD
University of California, San Francisco
Memory and Aging Center Grand Rounds
Monday, Oct. 6, 10-11am PT
register 👉
Renaud La Joie, PhD
&
David Soleimani-Meigooni, MD
University of California, San Francisco
Memory and Aging Center Grand Rounds
Monday, Oct. 6, 10-11am PT
register 👉
#PRTA Prothena Provides Update on PRX012 and Announces Results from the Phase 1 ASCENT Clinical Program
https://www.stocktitan.net/news/PRTA/prothena-provides-update-on-prx012-and-announces-results-from-the-chbug6hiksjm.html
https://www.stocktitan.net/news/PRTA/prothena-provides-update-on-prx012-and-announces-results-from-the-chbug6hiksjm.html
Prothena Provides Update on PRX012 and Announces Results from the Phase 1 ASCENT Clinical Program
Prothena (NASDAQ:PRTA) has announced results from its Phase 1 ASCENT clinical program for PRX012, their anti-amyloid beta antibody for early symptomatic Alzheimer's disease. The study demonstrated that PRX012 achieved dose- and time-dependent reductions in amyloid plaque, with the 400mg dose showing mean reduction to 27.47 centiloids at month 12.While PRX012 showed positive aspects including stable pharmacokinetics, low anti-drug antibodies, and low injection site reactions (4.1%), it demonstrated higher overall ARIA-E rates compared to FDA-approved anti-Aβ antibodies. Due to this non-competitive safety profile, Prothena plans to explore partnership opportunities to advance both PRX012 and its preclinical PRX012-TfR antibody variant.
www.stocktitan.net
August 27, 2025 at 8:05 PM
#PRTA Prothena Provides Update on PRX012 and Announces Results from the Phase 1 ASCENT Clinical Program
https://www.stocktitan.net/news/PRTA/prothena-provides-update-on-prx012-and-announces-results-from-the-chbug6hiksjm.html
https://www.stocktitan.net/news/PRTA/prothena-provides-update-on-prx012-and-announces-results-from-the-chbug6hiksjm.html
Building on the success of Centiloids for #Alzheimers, researchers present the "Centamine scale" holds promise for the harmonized quantification of dopaminergic neuronal imaging markers for #Parkinsons & related synucleinopathies
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
January 29, 2026 at 9:39 PM
Building on the success of Centiloids for #Alzheimers, researchers present the "Centamine scale" holds promise for the harmonized quantification of dopaminergic neuronal imaging markers for #Parkinsons & related synucleinopathies
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Puntos de corte de positividad de las PET con amiloide en los casos de demencia convergen alrededor de 18 y 27 centiloides, y las imágenes en el rango de 11 a 26 deben interpretarse con cuidado dependiendo del contexto #PET #centiloids #AD jamanetwork.com/journals/jam...
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease
This individual participant data meta-analysis seeks to establish robust data-driven Centiloid positivity cutoffs using Centiloid values collected from multiple existing datasets with retrospective, i...
jamanetwork.com
July 14, 2026 at 5:38 AM
Puntos de corte de positividad de las PET con amiloide en los casos de demencia convergen alrededor de 18 y 27 centiloides, y las imágenes en el rango de 11 a 26 deben interpretarse con cuidado dependiendo del contexto #PET #centiloids #AD jamanetwork.com/journals/jam...
MK6240 reaches tau positivity at lower amyloid burden than flortaucipir. The Centiloid threshold for 50% probability of medial temporal tau positivity was 53 for MK6240 vs 81 for Flortaucipir. In the neocortex, 129 vs 171 Centiloids.
May 29, 2026 at 6:36 PM
MK6240 reaches tau positivity at lower amyloid burden than flortaucipir. The Centiloid threshold for 50% probability of medial temporal tau positivity was 53 for MK6240 vs 81 for Flortaucipir. In the neocortex, 129 vs 171 Centiloids.