Citrobacter freundii ain't ever been a friend of ours... now becoming even more hostile!
#IDSky #ClinMicro #AMR #MedSky
@lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #AMR #MedSky
@lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Global emergence and transmission dynamics of carbapenemase-producing Citrobacter freundii sequence type 22 high-risk international clone: a retrospective, genomic, epidemiological study
Our study provides evidence to suggest that Citrobacter species are emerging carriers
of carbapenem-resistance genes. These findings provide insight into the population
structure of CPC species and hi...
www.thelancet.com
July 21, 2025 at 7:57 AM
Citrobacter freundii ain't ever been a friend of ours... now becoming even more hostile!
#IDSky #ClinMicro #AMR #MedSky
@lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #AMR #MedSky
@lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.
Convergent evolution of distinct D-ribulose utilisation pathways in attaching and effacing pathogens - Nature Communications
Cottam et al. identify distinct pathways for D-ribulose utilisation in pathogenic Escherichia coli and Citrobacter rodentium, providing mechanistic details and suggesting convergent evolution towards ...
www.nature.com
July 30, 2025 at 9:24 AM
Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.
#phagesky #microsky #phage defence #microbiome
CRISPR-cas activated by anoxia and regulated by Fnr in Citrobacter rodentium
www.nature.com/articles/s41...
CRISPR-cas activated by anoxia and regulated by Fnr in Citrobacter rodentium
www.nature.com/articles/s41...
Anoxia activates CRISPR–Cas immunity in the mouse intestine - Nature Microbiology
The Citrobacter rodentium CRISPR–Cas system is activated by the oxygen-responsive transcriptional regulator Fnr in the anoxic environment of the mouse gut.
www.nature.com
October 30, 2025 at 8:05 AM
#phagesky #microsky #phage defence #microbiome
CRISPR-cas activated by anoxia and regulated by Fnr in Citrobacter rodentium
www.nature.com/articles/s41...
CRISPR-cas activated by anoxia and regulated by Fnr in Citrobacter rodentium
www.nature.com/articles/s41...
New preprint from our lab www.biorxiv.org/content/10.1...! Andrea Dos Santos and Clément Vulin combine experiments and models showing how adding glucose can strengthen negative interactions between microbial species. This can be used in tandem with antibiotic treatment to inhibit pathogens!
December 2, 2025 at 1:12 PM
New preprint from our lab www.biorxiv.org/content/10.1...! Andrea Dos Santos and Clément Vulin combine experiments and models showing how adding glucose can strengthen negative interactions between microbial species. This can be used in tandem with antibiotic treatment to inhibit pathogens!
🚨New paper from our lab!🚨
We show that disrupting mucin sugar utilization in Citrobacter rodentium causes the build-up of a sugar phosphate, which compromises bacterial growth, colonization, and pathogenesis. A metabolic bottleneck with big virulence consequences.
journals.asm.org/doi/10.1128/...
We show that disrupting mucin sugar utilization in Citrobacter rodentium causes the build-up of a sugar phosphate, which compromises bacterial growth, colonization, and pathogenesis. A metabolic bottleneck with big virulence consequences.
journals.asm.org/doi/10.1128/...
April 13, 2026 at 10:14 PM
🚨New paper from our lab!🚨
We show that disrupting mucin sugar utilization in Citrobacter rodentium causes the build-up of a sugar phosphate, which compromises bacterial growth, colonization, and pathogenesis. A metabolic bottleneck with big virulence consequences.
journals.asm.org/doi/10.1128/...
We show that disrupting mucin sugar utilization in Citrobacter rodentium causes the build-up of a sugar phosphate, which compromises bacterial growth, colonization, and pathogenesis. A metabolic bottleneck with big virulence consequences.
journals.asm.org/doi/10.1128/...
Latest paper out today with the IPC team in Birmingham.
Where we show the 2m splash zone of a hospital sink is awash with Gram negs, including a Citrobacter containing our Birmingham KPC-2 plasmid pQEB1
www.sciencedirect.com/science/arti...
Where we show the 2m splash zone of a hospital sink is awash with Gram negs, including a Citrobacter containing our Birmingham KPC-2 plasmid pQEB1
www.sciencedirect.com/science/arti...
What grows in the sink splash zone
The hospital sink drain microbiome can harbour opportunistic pathogens and antimicrobial resistance genes. Patients may be exposed to waterborne patho…
www.sciencedirect.com
May 5, 2026 at 7:46 AM
Latest paper out today with the IPC team in Birmingham.
Where we show the 2m splash zone of a hospital sink is awash with Gram negs, including a Citrobacter containing our Birmingham KPC-2 plasmid pQEB1
www.sciencedirect.com/science/arti...
Where we show the 2m splash zone of a hospital sink is awash with Gram negs, including a Citrobacter containing our Birmingham KPC-2 plasmid pQEB1
www.sciencedirect.com/science/arti...
#NewResearch
Anoxia activates CRISPR–Cas immunity in the mouse intestine
www.nature.com/articles/s41...
#microsky
Anoxia activates CRISPR–Cas immunity in the mouse intestine
www.nature.com/articles/s41...
#microsky
Anoxia activates CRISPR–Cas immunity in the mouse intestine - Nature Microbiology
The Citrobacter rodentium CRISPR–Cas system is activated by the oxygen-responsive transcriptional regulator Fnr in the anoxic environment of the mouse gut.
www.nature.com
November 5, 2025 at 3:41 PM
#NewResearch
Anoxia activates CRISPR–Cas immunity in the mouse intestine
www.nature.com/articles/s41...
#microsky
Anoxia activates CRISPR–Cas immunity in the mouse intestine
www.nature.com/articles/s41...
#microsky
Citrobacter braakii urinary tract infection in chronic kidney disease url: connectsci.au/ma/article/4...
Citrobacter braakii urinary tract infection in chronic kidney disease
We report urinary tract infection caused by Citrobacter braakii in an 83-old female patient with chronic kidney disease. The isolate was confirmed with bac
connectsci.au
March 20, 2026 at 12:21 AM
Citrobacter braakii urinary tract infection in chronic kidney disease url: connectsci.au/ma/article/4...
Und den ganzen anderen Mist, den man bekommt, weil das Immunsystem kaputt ist, möchte ich auch nicht bekommen.
December 2, 2024 at 10:46 PM
Und den ganzen anderen Mist, den man bekommt, weil das Immunsystem kaputt ist, möchte ich auch nicht bekommen.
Citrobacter rodentium infection activates colonic lamina propria ILC2
doi.org/10.1101/2025...
doi.org/10.1101/2025...
February 23, 2025 at 3:12 AM
Citrobacter rodentium infection activates colonic lamina propria ILC2
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Shelf the Cefepime! Check out this week’s KASIC pearl to learn about a Species Spotlight: Citrobacter koseri & Citrobacter amalonaticus kymdro.org/kasic/?p=8592
#IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs
#IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs
October 4, 2025 at 3:32 PM
Shelf the Cefepime! Check out this week’s KASIC pearl to learn about a Species Spotlight: Citrobacter koseri & Citrobacter amalonaticus kymdro.org/kasic/?p=8592
#IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs
#IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs
Fitness determinants during mice infection for enterotoxigenic Escherichia coli, Salmonella typhimurium, Shigella flexneri and Citrobacter rodentium. #microsky 🦠 www.nature.com/articles/s41...
Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice - Nature Microbiology
InducTn-seq, a method for inducible mutagenesis followed by transposon insertion site sequencing, enables temporal control of transposition to bypass population bottlenecks and enable the quantificati...
www.nature.com
April 2, 2025 at 7:34 AM
Fitness determinants during mice infection for enterotoxigenic Escherichia coli, Salmonella typhimurium, Shigella flexneri and Citrobacter rodentium. #microsky 🦠 www.nature.com/articles/s41...
#IDSky @idsainfo.bsky.social @cidjournal.bsky.social @ofidjournal.bsky.social @sidpharm.bsky.social @davidvanduin.bsky.social @jac-amr.bsky.social
🚨 #AMRrounds: Citrobacter koseri is intrinsically resistant to amoxicillin/ampicillin by which chromosomal Bla-enzyme?
A. AmpC
B. CKO
C. SHV
D. TEM
🚨 #AMRrounds: Citrobacter koseri is intrinsically resistant to amoxicillin/ampicillin by which chromosomal Bla-enzyme?
A. AmpC
B. CKO
C. SHV
D. TEM
February 9, 2025 at 4:59 PM
#IDSky @idsainfo.bsky.social @cidjournal.bsky.social @ofidjournal.bsky.social @sidpharm.bsky.social @davidvanduin.bsky.social @jac-amr.bsky.social
🚨 #AMRrounds: Citrobacter koseri is intrinsically resistant to amoxicillin/ampicillin by which chromosomal Bla-enzyme?
A. AmpC
B. CKO
C. SHV
D. TEM
🚨 #AMRrounds: Citrobacter koseri is intrinsically resistant to amoxicillin/ampicillin by which chromosomal Bla-enzyme?
A. AmpC
B. CKO
C. SHV
D. TEM
Researchers fail to replicate previous work suggesting that repeated gastrointestinal infection with Citrobacter rodentium can induce #Parkinsons-like motor dysfunction in Pink1 knockout mice
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
July 1, 2026 at 8:15 AM
Researchers fail to replicate previous work suggesting that repeated gastrointestinal infection with Citrobacter rodentium can induce #Parkinsons-like motor dysfunction in Pink1 knockout mice
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Our September issue is now online:
www.thelancet.com/journals/lan...
Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #HIV #Pneumocystis #tuberculosis #TB #gonorrhoea #Citrobacter #AMR #Salmonella
#IDSky #ClinMicro #OA
www.thelancet.com/journals/lan...
Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #HIV #Pneumocystis #tuberculosis #TB #gonorrhoea #Citrobacter #AMR #Salmonella
#IDSky #ClinMicro #OA
![Cover of The Lancet Microbe's September issue with a "Light micrograph of a lung sample from an AIDS patient showing cysts of Pneumocystis [jirovecii]".](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:yhddktxw22k3ylm2zzzwlbqt/bafkreibdxhb2lrv7iaw5e4boui2mhodgmydw3olw3vfivknge3h6xgasnu)
September 9, 2025 at 8:35 AM
Our September issue is now online:
www.thelancet.com/journals/lan...
Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #HIV #Pneumocystis #tuberculosis #TB #gonorrhoea #Citrobacter #AMR #Salmonella
#IDSky #ClinMicro #OA
www.thelancet.com/journals/lan...
Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #HIV #Pneumocystis #tuberculosis #TB #gonorrhoea #Citrobacter #AMR #Salmonella
#IDSky #ClinMicro #OA
#BacterioMed Uncommon antibiotype for Citrobacter farmeri, showing a hyper OXY-like profile.
C. farmeri belongs to the Citrobacter amalonaticus group.
⚠️ Beware: immunochromatographic tests may misidentify it as CTX-M. This resistance in C. farmeri is chromosomally encoded.
doi.org/10.1016/j.di...
C. farmeri belongs to the Citrobacter amalonaticus group.
⚠️ Beware: immunochromatographic tests may misidentify it as CTX-M. This resistance in C. farmeri is chromosomally encoded.
doi.org/10.1016/j.di...
September 21, 2025 at 12:25 PM
#BacterioMed Uncommon antibiotype for Citrobacter farmeri, showing a hyper OXY-like profile.
C. farmeri belongs to the Citrobacter amalonaticus group.
⚠️ Beware: immunochromatographic tests may misidentify it as CTX-M. This resistance in C. farmeri is chromosomally encoded.
doi.org/10.1016/j.di...
C. farmeri belongs to the Citrobacter amalonaticus group.
⚠️ Beware: immunochromatographic tests may misidentify it as CTX-M. This resistance in C. farmeri is chromosomally encoded.
doi.org/10.1016/j.di...
Antigen location shapes T cell memory: one epitope, injected by the mouse pathogen Citrobacter rodentium into colon lining cells, drew robust CD4 T cell responses and epithelium-resident memory T cells; kept inside the bacteria, it drew limited ones.
@cgarrettwilson.bsky.social #MicroSky
@cgarrettwilson.bsky.social #MicroSky
Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigens | Frontier
Where an antigen sits (antigen compartmentalization) is known to influence how CD4 and CD8 T cells recognize it, but how it shapes immune responses to the…
frontierresearch.co
October 7, 2026 at 10:00 PM
Antigen location shapes T cell memory: one epitope, injected by the mouse pathogen Citrobacter rodentium into colon lining cells, drew robust CD4 T cell responses and epithelium-resident memory T cells; kept inside the bacteria, it drew limited ones.
@cgarrettwilson.bsky.social #MicroSky
@cgarrettwilson.bsky.social #MicroSky
April 22, 2025 at 5:31 PM
A manuscript that we published this past summer. This work was carried out in the context of our global objective to examine whether infections could represent a trigger of Parkinson's disease. @asapresearch.parkinsonsroadmap.org journals.plos.org/plospathogen...
A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal...
Author summary We hypothesize that immune system activation is linked to the development of Parkinson’s disease (PD). Previous work revealed that repeated gastrointestinal infections with Citrobacter ...
journals.plos.org
September 16, 2026 at 12:49 PM
A manuscript that we published this past summer. This work was carried out in the context of our global objective to examine whether infections could represent a trigger of Parkinson's disease. @asapresearch.parkinsonsroadmap.org journals.plos.org/plospathogen...
E. coli, Klebsiella spp, Enterococcus spp, S. pneumo, and Coagulase-negative staph were the most prevalent infections.
Pseudomonas, Enterobacter, Serratia, Citrobacter, Strep anginosus were among the least prevalent (3-6 patients each).
Looking forward to future studies! #MedSky #IMsky #IDsky
Pseudomonas, Enterobacter, Serratia, Citrobacter, Strep anginosus were among the least prevalent (3-6 patients each).
Looking forward to future studies! #MedSky #IMsky #IDsky
November 24, 2024 at 1:20 AM
Team Desjardins tested whether mild gastrointestinal infection can affect blood-brain barrier integrity and brain inflammation in Pink1 knockout and wild-type mice.
bit.ly/4gSsAQy
bit.ly/4gSsAQy
September 21, 2026 at 3:00 PM
Team Desjardins tested whether mild gastrointestinal infection can affect blood-brain barrier integrity and brain inflammation in Pink1 knockout and wild-type mice.
bit.ly/4gSsAQy
bit.ly/4gSsAQy
These AmpC hyper producers have their own mnemonic now, that your audience may want to know about: HECK-YES:
Hafnia alvei
Enterobacter cloacae
Citrobacter freundii
Klebsiella aerogenes
YErSinia
(The last one’s a bit of a fudge, and Hafnia isn’t very common, it’s the middle 3 that matter)
Hafnia alvei
Enterobacter cloacae
Citrobacter freundii
Klebsiella aerogenes
YErSinia
(The last one’s a bit of a fudge, and Hafnia isn’t very common, it’s the middle 3 that matter)
August 23, 2025 at 10:26 AM
These AmpC hyper producers have their own mnemonic now, that your audience may want to know about: HECK-YES:
Hafnia alvei
Enterobacter cloacae
Citrobacter freundii
Klebsiella aerogenes
YErSinia
(The last one’s a bit of a fudge, and Hafnia isn’t very common, it’s the middle 3 that matter)
Hafnia alvei
Enterobacter cloacae
Citrobacter freundii
Klebsiella aerogenes
YErSinia
(The last one’s a bit of a fudge, and Hafnia isn’t very common, it’s the middle 3 that matter)
Acho bom avisar porque SP consome muita ostra de SC: cbntotal.com.br/cotidiano/os...
Ostra com superbactéria crítica para OMS é encontrada em SC
A superbactéria Citrobacter telavivensis foi encontrada em ostras vendidas em Santa Catarina. É a primeira vez que o organismo é identificado no país. Com
cbntotal.com.br
June 5, 2026 at 3:03 PM
Acho bom avisar porque SP consome muita ostra de SC: cbntotal.com.br/cotidiano/os...
🧫 The scars of war also appear in the antibiogram. #BacterioMed
A Ukrainian war-injured patient, with a Citrobacter freundii osteitis producing a carbapenemase. The first-line antibiogram offered almost no therapeutic options.
#AntimicrobialResistance #WarAndHealth #GlobalHealth
A Ukrainian war-injured patient, with a Citrobacter freundii osteitis producing a carbapenemase. The first-line antibiogram offered almost no therapeutic options.
#AntimicrobialResistance #WarAndHealth #GlobalHealth
October 8, 2025 at 5:27 PM
🧫 The scars of war also appear in the antibiogram. #BacterioMed
A Ukrainian war-injured patient, with a Citrobacter freundii osteitis producing a carbapenemase. The first-line antibiogram offered almost no therapeutic options.
#AntimicrobialResistance #WarAndHealth #GlobalHealth
A Ukrainian war-injured patient, with a Citrobacter freundii osteitis producing a carbapenemase. The first-line antibiogram offered almost no therapeutic options.
#AntimicrobialResistance #WarAndHealth #GlobalHealth
Data identify an essential role for STAT3 in mediating effective control of bacterial infection and suggest it is regulated by modulation of autocrine IL-6 signaling in macrophages. Read more about it in The JI: https://ow.ly/ExQH50YNxUH.
April 30, 2026 at 2:05 PM
Data identify an essential role for STAT3 in mediating effective control of bacterial infection and suggest it is regulated by modulation of autocrine IL-6 signaling in macrophages. Read more about it in The JI: https://ow.ly/ExQH50YNxUH.