Out of Screamfest 2026, 'Postmortem' is written and directed by Andrés Beltrán and stars Odette Annable and Tony Revolori.

Abstract. Host–guest binding can be classified into two well-separated modes, i.e., reversible binding under thermodynamic control and permanent encapsulat

The hippocampus and neocortex are thought to undergo reorganization to incorporate new information during learning. How can we identify network states that indicate learning is occurring? In the hippocampus, one network signature with these properties is the sharp wave–ripple (SWR), which occurs more frequently during initial learning. However, it remains unclear which neural signatures track changes in neocortical networks during learning. We therefore recorded local field potentials simultaneously from the dorsal hippocampus (CA1) and prefrontal cortex (PFC) as male rats learned spatial navigation tasks. After animals reached goal locations, we found beta frequency (∼20 Hz) oscillations in PFC that increased in power with improvements in performance across days of training. In contrast, the rate and size of hippocampal SWRs decreased over the same period. Furthermore, goal-entry beta in PFC but not in CA1 was correlated with reward likelihood. Our results suggest that neocortical beta oscillations develop gradually as learning occurs, which stands in contrast to the reduction in hippocampal SWRs as the task becomes familiar. We hypothesize that PFC beta oscillations and hippocampal SWRs are complementary markers of experience-dependent change in hippocampal–neocortical networks during learning.

Tirzepatide, sold as Mounjaro and Zepbound, is our most potent weight-loss drug, but it can have an even greater effect when combined with a complementary medicine

LLM-based multi-agent collaboration is increasingly used to solve complex tasks by dividing work among specialized agents and integrating complementary expertise. Yet existing systems and evaluations largely rest on an implicit perfect-colleague assumption: collaborators provide correct and complet…