#Component1
Pfft my Wii is still hooked up to Component1
July 18, 2023 at 4:53 AM
January 15, 2026 at 11:48 AM
Rare genetic variants in exome data from 8,895 individuals unveil high ADHD risk, highlighting neuronal biology. A new dimension to this prevalent disorder! PMID:41224997, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-09702-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology | Nature
Attention deficit hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder with a large genetic component1. It affects around 5% of children and 2.5% of adults2, and is associated with several severe outcomes3–11. Common genetic variants associated with the disorder have been identified12,13, but the role of rare variants in ADHD is mostly unknown. Here, by analysing rare coding variants in exome-sequencing data from 8,895 individuals with ADHD and 53,780 control individuals, we identify three genes (MAP1A, ANO8 and ANK2; P < 3.07 × 10−6; odds ratios 5.55–15.13) that are implicated in ADHD. The protein–protein interaction networks of these three genes were enriched for rare-variant risk genes of other neurodevelopmental disorders, and for genes involved in cytoskeleton organization, synapse function and RNA processing. Top associated rare-variant risk genes showed increased expression across pre- and postnatal brain developmental stages and in several neur
doi.org
November 22, 2025 at 8:00 PM
Based on the above:
src/
├── user/
│ ├── queries.ts
│ ├── mutations.ts
│ ├── component1.tsx
│ ├── use-something.ts
│ └── sub-domain/
│ └── queries.ts
└── routes/
└── user <- imports from user vertical primarily + any others
├── user.index.ts
└── $userId.tsx
July 23, 2026 at 2:07 PM