www.biorxiv.org/content/10.6...
Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo
Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo
November 10, 2026 at 12:18 PM
www.biorxiv.org/content/10.6...
Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo
Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo
New paper from the lab has just been published online showing that cellular contractility can activate ELKIN1 dependent signalling: www.nature.com/articles/s44...
ELKIN1-dependent Ca++ flickers in melanoma cells depend on acto-myosin contractility - npj Biological Physics and Mechanics
npj Biological Physics and Mechanics - ELKIN1-dependent Ca++ flickers in melanoma cells depend on acto-myosin contractility
www.nature.com
November 6, 2026 at 12:08 AM
New paper from the lab has just been published online showing that cellular contractility can activate ELKIN1 dependent signalling: www.nature.com/articles/s44...
www.nature.com/articles/s41...
Engineering filamentous myosins for optical control of contractility
cool new work from Zev Bryant's lab on light-inducible myosin filament formation!!
Engineering filamentous myosins for optical control of contractility
cool new work from Zev Bryant's lab on light-inducible myosin filament formation!!
November 6, 2026 at 12:51 PM
www.nature.com/articles/s41...
Engineering filamentous myosins for optical control of contractility
cool new work from Zev Bryant's lab on light-inducible myosin filament formation!!
Engineering filamentous myosins for optical control of contractility
cool new work from Zev Bryant's lab on light-inducible myosin filament formation!!
YAP reads contractility in the embryo 🐭 Asymmetric divisions give early blastomeres different contractility, which sorts them inside or outside. Contractility controls where Yap sits, and cells that lose it take on inner-cell-mass markers wherever they are.
doi.org/10.1038/natu...
doi.org/10.1038/natu...
November 8, 2026 at 8:00 AM
YAP reads contractility in the embryo 🐭 Asymmetric divisions give early blastomeres different contractility, which sorts them inside or outside. Contractility controls where Yap sits, and cells that lose it take on inner-cell-mass markers wherever they are.
doi.org/10.1038/natu...
doi.org/10.1038/natu...
𝗧𝗵𝗶𝗻𝗸 𝘆𝗼𝘂 𝗸𝗻𝗼𝘄 𝗺𝗶𝘁𝗼𝘀𝗶𝘀?
Nuclear rotation before mitosis is thought to be caused by actin contractility, and the interaction of hydrodynamic forces. What else might we be missing from static images?
Imaging info: x.sfmsg.co/adZA_FoXu
Nuclear rotation before mitosis is thought to be caused by actin contractility, and the interaction of hydrodynamic forces. What else might we be missing from static images?
Imaging info: x.sfmsg.co/adZA_FoXu
November 9, 2026 at 3:11 PM
𝗧𝗵𝗶𝗻𝗸 𝘆𝗼𝘂 𝗸𝗻𝗼𝘄 𝗺𝗶𝘁𝗼𝘀𝗶𝘀?
Nuclear rotation before mitosis is thought to be caused by actin contractility, and the interaction of hydrodynamic forces. What else might we be missing from static images?
Imaging info: x.sfmsg.co/adZA_FoXu
Nuclear rotation before mitosis is thought to be caused by actin contractility, and the interaction of hydrodynamic forces. What else might we be missing from static images?
Imaging info: x.sfmsg.co/adZA_FoXu
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #STMpublishing #ReproducibleResearch #reproducibility
PES-8 is required for Cytoskeletal Organization and Contractility in the C. elegans Spermatheca
Read the full paper: PES-8 is required for Cytoskeletal Organization and Contractility in the C. elegans Spermatheca
doi.org
November 11, 2026 at 8:00 AM
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #STMpublishing #ReproducibleResearch #reproducibility
YAP is a general-purpose mechanosensor 📖 YAP/TAZ read stiffness, shape, stretch, shear and contractility and turn them into cell-specific gene programmes, with roles from embryos and stem cells to regeneration, fibrosis and cancer.
doi.org/10.1038/nrm....
doi.org/10.1038/nrm....
November 8, 2026 at 8:00 AM
YAP is a general-purpose mechanosensor 📖 YAP/TAZ read stiffness, shape, stretch, shear and contractility and turn them into cell-specific gene programmes, with roles from embryos and stem cells to regeneration, fibrosis and cancer.
doi.org/10.1038/nrm....
doi.org/10.1038/nrm....
Cells frequently cross between compartments, yet persistent mispositioning remains rare.
Rather than preventing errors, these tissues continuously correct them. Differences in adhesion and contractility bias misplaced cells back toward their compartment, preserving tissue organization.
Rather than preventing errors, these tissues continuously correct them. Differences in adhesion and contractility bias misplaced cells back toward their compartment, preserving tissue organization.
November 9, 2026 at 2:32 PM
Cells frequently cross between compartments, yet persistent mispositioning remains rare.
Rather than preventing errors, these tissues continuously correct them. Differences in adhesion and contractility bias misplaced cells back toward their compartment, preserving tissue organization.
Rather than preventing errors, these tissues continuously correct them. Differences in adhesion and contractility bias misplaced cells back toward their compartment, preserving tissue organization.
Endurance training: การปรับตัวด้านหัวใจ & การหายใจ ไม่เฉพาะเพศ
->Maximal intensity: ↑Q max (จาก ↑SVmax ผ่าน ↑preload, contractility), ↑muscle blood flow, ↑capillary density, ↑maximal ventilation
->Submaximal intensity: Qคงเดิม, ↑SV, ↓HR
->Maximal intensity: ↑Q max (จาก ↑SVmax ผ่าน ↑preload, contractility), ↑muscle blood flow, ↑capillary density, ↑maximal ventilation
->Submaximal intensity: Qคงเดิม, ↑SV, ↓HR
November 9, 2026 at 5:49 PM
Endurance training: การปรับตัวด้านหัวใจ & การหายใจ ไม่เฉพาะเพศ
->Maximal intensity: ↑Q max (จาก ↑SVmax ผ่าน ↑preload, contractility), ↑muscle blood flow, ↑capillary density, ↑maximal ventilation
->Submaximal intensity: Qคงเดิม, ↑SV, ↓HR
->Maximal intensity: ↑Q max (จาก ↑SVmax ผ่าน ↑preload, contractility), ↑muscle blood flow, ↑capillary density, ↑maximal ventilation
->Submaximal intensity: Qคงเดิม, ↑SV, ↓HR
🧬 New publication by @kanishka03.bsky.social et al. in @embopress.org @emboreports.org on an unexpected role of #CDK4 beyond #cell-cycle regulation, linking cell-cycle signalling to #cytoskeletal organisation, cellular mechanics, and #cancer cell migration.
🔗 link.springer.com/article/10.1...
🔗 link.springer.com/article/10.1...
CDK4 maintains cytoskeletal homeostasis by restraining actomyosin contractility - EMBO Reports
Cyclin-dependent kinase 4 (CDK4) is best known for its canonical role in cell-cycle control, yet how CDK4 activity intersects with cellular architecture remains poorly defined. Here, we uncover a non-...
link.springer.com
November 9, 2026 at 8:39 AM
🧬 New publication by @kanishka03.bsky.social et al. in @embopress.org @emboreports.org on an unexpected role of #CDK4 beyond #cell-cycle regulation, linking cell-cycle signalling to #cytoskeletal organisation, cellular mechanics, and #cancer cell migration.
🔗 link.springer.com/article/10.1...
🔗 link.springer.com/article/10.1...
The authors included RRIDs in their in npj Biological Physics and Mechanics paper! We value the author's support of reproducibility. #OpenResearch #RRID #accelerateopenscience
ELKIN1-dependent Ca++ flickers in melanoma cells depend on acto-myosin contractility - npj Biological Physics and Mechanics
Read the full paper: ELKIN1-dependent Ca++ flickers in melanoma cells depend on acto-myosin contractility
doi.org
November 7, 2026 at 8:01 AM
The authors included RRIDs in their in npj Biological Physics and Mechanics paper! We value the author's support of reproducibility. #OpenResearch #RRID #accelerateopenscience
Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo https://www.biorxiv.org/content/10.64898/2026.11.04.764377v1
November 6, 2026 at 12:30 PM
Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo https://www.biorxiv.org/content/10.64898/2026.11.04.764377v1
Titin acts as a mechano-signaling hub in uterine smooth muscle
Myh11-Cre;Ttn Mex1-2 KO🐭(M-band kinase deficiency)
👉⏫Oxytocin-induced uterine contractility
👉⏬Bulk uterine wall motion
👉Impaired implantation site distribution
#iScience 2026
www.cell.com/iscience/ful...
Myh11-Cre;Ttn Mex1-2 KO🐭(M-band kinase deficiency)
👉⏫Oxytocin-induced uterine contractility
👉⏬Bulk uterine wall motion
👉Impaired implantation site distribution
#iScience 2026
www.cell.com/iscience/ful...
November 5, 2026 at 1:10 PM
Titin acts as a mechano-signaling hub in uterine smooth muscle
Myh11-Cre;Ttn Mex1-2 KO🐭(M-band kinase deficiency)
👉⏫Oxytocin-induced uterine contractility
👉⏬Bulk uterine wall motion
👉Impaired implantation site distribution
#iScience 2026
www.cell.com/iscience/ful...
Myh11-Cre;Ttn Mex1-2 KO🐭(M-band kinase deficiency)
👉⏫Oxytocin-induced uterine contractility
👉⏬Bulk uterine wall motion
👉Impaired implantation site distribution
#iScience 2026
www.cell.com/iscience/ful...
Mechano-chemical Pericyte-to-Endothelial cell communication
R-Ras acts as a pro-wrapping & pro-contractile factor in Pericyte
R-Ras activation in pericyte
⏫Cell contractility
⏫αv integrin- & Myosin (MYL9/MLCK)-dependent active TGFβ1 secretion
⏫EC quiescence
#PNAS 2026
www.pnas.org/doi/10.1073/...
R-Ras acts as a pro-wrapping & pro-contractile factor in Pericyte
R-Ras activation in pericyte
⏫Cell contractility
⏫αv integrin- & Myosin (MYL9/MLCK)-dependent active TGFβ1 secretion
⏫EC quiescence
#PNAS 2026
www.pnas.org/doi/10.1073/...
November 10, 2026 at 1:04 PM
Mechano-chemical Pericyte-to-Endothelial cell communication
R-Ras acts as a pro-wrapping & pro-contractile factor in Pericyte
R-Ras activation in pericyte
⏫Cell contractility
⏫αv integrin- & Myosin (MYL9/MLCK)-dependent active TGFβ1 secretion
⏫EC quiescence
#PNAS 2026
www.pnas.org/doi/10.1073/...
R-Ras acts as a pro-wrapping & pro-contractile factor in Pericyte
R-Ras activation in pericyte
⏫Cell contractility
⏫αv integrin- & Myosin (MYL9/MLCK)-dependent active TGFβ1 secretion
⏫EC quiescence
#PNAS 2026
www.pnas.org/doi/10.1073/...
Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo https://www.biorxiv.org/content/10.64898/2026.11.04.764377v1
November 6, 2026 at 12:30 PM
Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo https://www.biorxiv.org/content/10.64898/2026.11.04.764377v1
Interestingly, we find that calcium flashes drive the localized, pulsatile actomyosin contractility required for efficient tricellular zipping.
Calbae Calcium
ALT: Calbae Calcium
static.klipy.com
November 4, 2026 at 4:58 PM
Interestingly, we find that calcium flashes drive the localized, pulsatile actomyosin contractility required for efficient tricellular zipping.
Amaury Korb, et al.: Myosin-binding protein composition tunes vertebrate superfast contractility https://pasteur.hal.science/pasteur-05846575v1 [sdv]
November 4, 2026 at 3:01 AM
Amaury Korb, et al.: Myosin-binding protein composition tunes vertebrate superfast contractility https://pasteur.hal.science/pasteur-05846575v1 [sdv]
Missed highlighting my choice last week in @science.org
Elevated contractility drives implantation failure in mouse embryos from aged females
www.nature.com/articles/s41...
Elevated contractility drives implantation failure in mouse embryos from aged females
www.nature.com/articles/s41...
October 30, 2026 at 4:59 PM
Missed highlighting my choice last week in @science.org
Elevated contractility drives implantation failure in mouse embryos from aged females
www.nature.com/articles/s41...
Elevated contractility drives implantation failure in mouse embryos from aged females
www.nature.com/articles/s41...
“We propose that spatial patterning of HA-mediated extracellular forces, acting together with tissue geometry and junctional mechanics, provides a common physical framework capable of generating distinct tissue architectures”
Hyaluronic acid over-expression drives tissue architecture in both healthy and diseased states
Tissue architecture is shaped by a variety of biomechanical and biochemical mechanisms, including morphogen patterning, differential growth, and spatial variations in cellular contractility. These mec...
arxiv.org
November 2, 2026 at 10:21 AM
“We propose that spatial patterning of HA-mediated extracellular forces, acting together with tissue geometry and junctional mechanics, provides a common physical framework capable of generating distinct tissue architectures”
PDGFD-induced pericyte contractility drives pathological neoangiogenesis https://www.biorxiv.org/content/10.64898/2026.10.28.762436v1
October 30, 2026 at 10:30 PM
PDGFD-induced pericyte contractility drives pathological neoangiogenesis https://www.biorxiv.org/content/10.64898/2026.10.28.762436v1
PDGFD-induced pericyte contractility drives pathological neoangiogenesis https://www.biorxiv.org/content/10.64898/2026.10.28.762436v1
October 30, 2026 at 10:30 PM
PDGFD-induced pericyte contractility drives pathological neoangiogenesis https://www.biorxiv.org/content/10.64898/2026.10.28.762436v1
We discuss several other examples (in chick, mouse and Drosophila) where metabolic states regulate cellular behaviour, affecting mechanical transitions including increased contractility, tissue stiffening and epithelial-to-mesenchymal transition.
October 26, 2026 at 2:16 PM
We discuss several other examples (in chick, mouse and Drosophila) where metabolic states regulate cellular behaviour, affecting mechanical transitions including increased contractility, tissue stiffening and epithelial-to-mesenchymal transition.
@thermofishersci.bsky.social's resource, RRID:AB_2533438, was just reported to be used in the paper. We value the author's support of reproducibility. #OpenScience #ReproducibleResearch #RRID
FGD1 restrains actomyosin contractility to promote suprabasal junction maturation in stratified keratinocytes
Read the full paper: FGD1 restrains actomyosin contractility to promote suprabasal junction maturation in stratified keratinocytes
doi.org
October 23, 2026 at 7:03 AM
@thermofishersci.bsky.social's resource, RRID:AB_2533438, was just reported to be used in the paper. We value the author's support of reproducibility. #OpenScience #ReproducibleResearch #RRID
I’m not surprised this study was neutral and wouldn’t have been that surprised if CI-guided treatment led to harm. Lots to unpack.
In simple terms, the investigators have increased CI by increasing RA pressure (fluids), increasing contractility and reducing SVR (dobutamine).
Is this sensible?
In simple terms, the investigators have increased CI by increasing RA pressure (fluids), increasing contractility and reducing SVR (dobutamine).
Is this sensible?
October 20, 2026 at 6:15 AM
I’m not surprised this study was neutral and wouldn’t have been that surprised if CI-guided treatment led to harm. Lots to unpack.
In simple terms, the investigators have increased CI by increasing RA pressure (fluids), increasing contractility and reducing SVR (dobutamine).
Is this sensible?
In simple terms, the investigators have increased CI by increasing RA pressure (fluids), increasing contractility and reducing SVR (dobutamine).
Is this sensible?