Just had my first experience with CycloneSEQ data and shared my findings in this blog post:
rrwick.github.io/2024/12/17/c...
How does CycloneSEQ compare to @nanoporetech.com? I looked at both read-level and consensus-level accuracy. Check it out!
rrwick.github.io/2024/12/17/c...
How does CycloneSEQ compare to @nanoporetech.com? I looked at both read-level and consensus-level accuracy. Check it out!
A first look at CycloneSEQ data
a blog for miscellaneous bioinformatics stuff
rrwick.github.io
December 16, 2024 at 9:57 PM
Just had my first experience with CycloneSEQ data and shared my findings in this blog post:
rrwick.github.io/2024/12/17/c...
How does CycloneSEQ compare to @nanoporetech.com? I looked at both read-level and consensus-level accuracy. Check it out!
rrwick.github.io/2024/12/17/c...
How does CycloneSEQ compare to @nanoporetech.com? I looked at both read-level and consensus-level accuracy. Check it out!
Is CycloneSeq infringing on ONTs patents? open.substack.com/pub/albertvi...
Is CycloneSeq infringing on ONTs patents?
As reported by GenomeWeb, explained in plain terms below:
open.substack.com
August 5, 2025 at 8:52 AM
Is CycloneSeq infringing on ONTs patents? open.substack.com/pub/albertvi...
A paper using the CycloneSEQ NGS method, similar to Oxford @nanoporetech.com in concept, but with a Q-score of 14-15. onlinelibrary.wiley.com/doi/10.1002/...
Rapid reconstruction of multidrug‐resistant bacterial genomes using CycloneSEQ nanopore sequencing
Multidrug-resistant (MDR) bacteria commonly harbor highly complex genomes enriched with mobile elements and resistance islands, which are challenging to resolve using short-read sequencing. Here, we ...
onlinelibrary.wiley.com
October 31, 2025 at 10:24 AM
A paper using the CycloneSEQ NGS method, similar to Oxford @nanoporetech.com in concept, but with a Q-score of 14-15. onlinelibrary.wiley.com/doi/10.1002/...
CycloneSEQ: BGI's new single-molecule nanopore sequencing platform https://www.biorxiv.org/content/10.1101/2024.08.19.608720v1?rss=1
August 21, 2024 at 9:32 AM
CycloneSEQ: BGI's new single-molecule nanopore sequencing platform https://www.biorxiv.org/content/10.1101/2024.08.19.608720v1?rss=1
I was expecting this kind of data and feedback about #CycloneSEQ, the long read sequencing technology developed by #MGI
Just had my first experience with CycloneSEQ data and shared my findings in this blog post:
rrwick.github.io/2024/12/17/c...
How does CycloneSEQ compare to @nanoporetech.com? I looked at both read-level and consensus-level accuracy. Check it out!
rrwick.github.io/2024/12/17/c...
How does CycloneSEQ compare to @nanoporetech.com? I looked at both read-level and consensus-level accuracy. Check it out!
A first look at CycloneSEQ data
a blog for miscellaneous bioinformatics stuff
rrwick.github.io
December 16, 2024 at 10:18 PM
I was expecting this kind of data and feedback about #CycloneSEQ, the long read sequencing technology developed by #MGI
When CycloneSEQ meets Oxford Nanopore Technologies: a performance comparison of contemporary nanopore DNA sequencing platforms https://www.biorxiv.org/content/10.64898/2026.01.14.699587v1
January 15, 2026 at 5:47 PM
When CycloneSEQ meets Oxford Nanopore Technologies: a performance comparison of contemporary nanopore DNA sequencing platforms https://www.biorxiv.org/content/10.64898/2026.01.14.699587v1
🧬 CycloneSEQ #nanopore sequencing rapidly reconstructs multidrug-resistant bacterial genomes!
⚙️ 96.16% read accuracy, 99.98% assembly accuracy.
💡 Complete genomes with just 15× long reads or 5× hybrid data.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #BGI
⚙️ 96.16% read accuracy, 99.98% assembly accuracy.
💡 Complete genomes with just 15× long reads or 5× hybrid data.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #BGI
October 30, 2025 at 3:20 PM
🧬 CycloneSEQ #nanopore sequencing rapidly reconstructs multidrug-resistant bacterial genomes!
⚙️ 96.16% read accuracy, 99.98% assembly accuracy.
💡 Complete genomes with just 15× long reads or 5× hybrid data.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #BGI
⚙️ 96.16% read accuracy, 99.98% assembly accuracy.
💡 Complete genomes with just 15× long reads or 5× hybrid data.
🔗 onlinelibrary.wiley.com/doi/10.1002/...
#Bioinformatics #BGI
When publishing the first benchmarking data for a new sequencing technology like CycloneSeq, it's great having @protocolsio.bsky.social to share the protocols in a transparent manner.
CycloneSEQ Library Construction and Sequencing Protocol for Isolated Bacteria. dx.doi.org/10.17504/pro...
CycloneSEQ Library Construction and Sequencing Protocol for Isolated Bacteria. dx.doi.org/10.17504/pro...
Bring structure to your research - protocols.io
A secure platform for developing and sharing reproducible methods.
protocols.io
May 2, 2025 at 8:30 AM
When publishing the first benchmarking data for a new sequencing technology like CycloneSeq, it's great having @protocolsio.bsky.social to share the protocols in a transparent manner.
CycloneSEQ Library Construction and Sequencing Protocol for Isolated Bacteria. dx.doi.org/10.17504/pro...
CycloneSEQ Library Construction and Sequencing Protocol for Isolated Bacteria. dx.doi.org/10.17504/pro...
The authors included RRIDs in their Gigabyte paper! RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #ReproducibleResearch
Efficiently constructing complete genomes with CycloneSEQ to fill gaps in bacterial draft assemblies
doi.org
May 28, 2025 at 7:00 AM
The authors included RRIDs in their Gigabyte paper! RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #ReproducibleResearch
Sign up for our webinar on Tuesday 26th August on how new long read technologies (including the first CycloneSeq vertebrate genomes) are helping elucidate the sex determination of sex-changing reptiles cassyni.com/events/SWHRe...
August 22, 2025 at 11:56 AM
Sign up for our webinar on Tuesday 26th August on how new long read technologies (including the first CycloneSeq vertebrate genomes) are helping elucidate the sex determination of sex-changing reptiles cassyni.com/events/SWHRe...
And the paper: gigabytejournal.com/articles/154
Efficiently constructing complete genomes with CycloneSEQ to fill gaps in bacterial draft assemblies
Efficiently constructing complete genomes with CycloneSEQ to fill gaps in bacterial draft assemblies
gigabytejournal.com
May 2, 2025 at 4:54 PM
And the paper: gigabytejournal.com/articles/154
"CycloneSEQ’s accuracy is not yet competitive with ONT. However, ONT’s accuracy improved dramatically over the course of its history, so I anticipate that CycloneSEQ may follow a similar trajectory."
December 18, 2024 at 8:05 PM
"CycloneSEQ’s accuracy is not yet competitive with ONT. However, ONT’s accuracy improved dramatically over the course of its history, so I anticipate that CycloneSEQ may follow a similar trajectory."
Efficiently Constructing Complete Genomes with CycloneSEQ to Fill Gaps in Bacterial Draft Assemblies https://www.biorxiv.org/content/10.1101/2024.09.05.611410v1
Efficiently Constructing Complete Genomes with CycloneSEQ to Fill Gaps in Bacterial Draft Assemblies https://www.biorxiv.org/content/10.1101/2024.09.05.611410v1
Current microbial sequencing relies on short-read platforms like Illumina and DNBSEQ, favored for th
www.biorxiv.org
September 8, 2024 at 3:31 AM
Efficiently Constructing Complete Genomes with CycloneSEQ to Fill Gaps in Bacterial Draft Assemblies https://www.biorxiv.org/content/10.1101/2024.09.05.611410v1
FYI The peer reviewed final version of the paper is out now:
doi.org/10.46471/gig...
With more in GigaBlog on how it was openly reviewed and benchmarked: gigasciencejournal.com/blog/open-cy...
doi.org/10.46471/gig...
With more in GigaBlog on how it was openly reviewed and benchmarked: gigasciencejournal.com/blog/open-cy...
Open CycloneSeq Benchmarking For Complete Bacterial Genomes - GigaBlog
gigasciencejournal.com
April 28, 2025 at 8:50 PM
FYI The peer reviewed final version of the paper is out now:
doi.org/10.46471/gig...
With more in GigaBlog on how it was openly reviewed and benchmarked: gigasciencejournal.com/blog/open-cy...
doi.org/10.46471/gig...
With more in GigaBlog on how it was openly reviewed and benchmarked: gigasciencejournal.com/blog/open-cy...
QHap reformulates haplotype phasing as a Max-Cut problem solved via GPU-accelerated ballistic simulated bifurcation, achieving 4–20× speedup over HapCUT2/WhatsHap with zero switch error on MHC region across CycloneSEQ, HiFi, and ONT platforms.
#QuantumInspired #HaplotypePhasing #Bioinformatics
#QuantumInspired #HaplotypePhasing #Bioinformatics
QHap: GPU-Accelerated Quantum-Inspired Haplotype Phasing via Max-Cut Optimization
iq.fp2.dev
March 30, 2026 at 2:27 PM
QHap reformulates haplotype phasing as a Max-Cut problem solved via GPU-accelerated ballistic simulated bifurcation, achieving 4–20× speedup over HapCUT2/WhatsHap with zero switch error on MHC region across CycloneSEQ, HiFi, and ONT platforms.
#QuantumInspired #HaplotypePhasing #Bioinformatics
#QuantumInspired #HaplotypePhasing #Bioinformatics
First in-the-flesh look at the @MGI_Technology CycloneSeq-WT02 #nanopore sequencer at #AGTA24
Oddly familiar vibes, but the flowcells are slightly larger, heavier and feel solid. 4k pores, which are derived from a thermophilic microbe identified during a Mariana Trench expedition
Oddly familiar vibes, but the flowcells are slightly larger, heavier and feel solid. 4k pores, which are derived from a thermophilic microbe identified during a Mariana Trench expedition
December 3, 2024 at 5:27 AM
Oxford Nanopore wins injunction against MGI Tech in Europe
Oxford Nanopore wins injunction against MGI Tech in Europe
The Unified Patent Court barred MGI Tech from selling its CycloneSEQ sequencing systems across eight European jurisdictions after ruling they infringe two Oxford Nanopore patents.
dlvr.it
September 16, 2026 at 7:55 AM
Oxford Nanopore wins injunction against MGI Tech in Europe
The other CYCLONESEQ instrument has a single, larger flow cell, presumably the higher throughput version.
July 29, 2025 at 9:46 AM
The other CYCLONESEQ instrument has a single, larger flow cell, presumably the higher throughput version.
Back to CYCLONESEQ, one instrument type seems to have a 2-bay A+B configuration, presumably for the smaller flow cell type.
July 29, 2025 at 9:46 AM
Back to CYCLONESEQ, one instrument type seems to have a 2-bay A+B configuration, presumably for the smaller flow cell type.
Another bit of info is the CYCLONESEQ technology, very similar in format to Oxford @nanoporetech.com sequencing. They have two size instruments, both similar to the ONT P2 Solo and P2I in size.
July 29, 2025 at 9:43 AM
Another bit of info is the CYCLONESEQ technology, very similar in format to Oxford @nanoporetech.com sequencing. They have two size instruments, both similar to the ONT P2 Solo and P2I in size.
And then there are of course the nanopore copycats that will come online now that patents are expiring.
CycloneSEQ, for example.
en.cyclone-seq.com/corChip
CycloneSEQ, for example.
en.cyclone-seq.com/corChip
CycloneSEQ
杭州华大序风科技有限公司（简称华大序风）致力于通过纳米孔单分子测序技术的创新研发及落地应用，将这一硬核科技从实验室推向产业应用的前沿。公司专注于为全球生命科学研究者及应用转化领域提供一站式、高精准、高效率的全流程工具解决方案。
en.cyclone-seq.com
May 19, 2026 at 2:23 PM
And then there are of course the nanopore copycats that will come online now that patents are expiring.
CycloneSEQ, for example.
en.cyclone-seq.com/corChip
CycloneSEQ, for example.
en.cyclone-seq.com/corChip
So... has the accuracy of CycloneSEQ improved in the interim?
April 28, 2025 at 9:38 PM
So... has the accuracy of CycloneSEQ improved in the interim?
New toy in town: youtu.be/3W3omYxjCQo
CycloneSEQ-WT02 Nanopore Gene Sequencer
YouTube video by MGI
youtu.be
September 11, 2024 at 9:58 PM
New toy in town: youtu.be/3W3omYxjCQo