In a striking advance that could reshape our understanding of placental biology and oxidative stress regulation, Lu and colleagues have unveiled the critical role of DCTPP1 in maintaining oxidative homeostasis within human villous trophoblasts. Published in Cell Death Discovery, this groundbreaking study elucidates how DCTPP1, through its interaction with the RNA-binding protein AUF1, orchestrates a molecular defense against oxidative stress—a phenomenon implicated in a vast array of pregnancy complications and pathological conditions.

In a new research report, scientists at Johns Hopkins University School of Medicine and Johns Hopkins Kimmel Cancer Center say they have found a potential therapeutic target that can boost the potency of a chemotherapy drug used to treat certain cancers.

DCTPP1 modulates dNTP pool balance, which is disrupted in TK2d and related syndromes, and shows promise as a therapeutic target in MNGIE.

While nucleoside DNA methyltransferase inhibitors (DNMTi) such as decitabine and azacitidine are eff

While nucleoside DNA methyltransferase inhibitors (DNMTi) such as decitabine and azacitidine are eff