#ChemicalProbes
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mads-chem.bsky.social
Huge congratulations to the first MSc #graduate from the Kavanagh lab (and future #PhD ) @leidenscience.bsky.social @led3hub.bsky.social Could not be more proud of Jakob and his hard work pushing forward the development of #chemicalprobes to modulate #immunology #chembio #STEMed
March 13, 2025 at 6:50 PM
chemicalprobes.org
We provide a new checklist for selecting & using chemical probes—valuable for researchers, journal editors, reviewers, and vendors. Ensure best practices in chemical biology! 🧪✅

🔗 Supplementary material: ars.els-cdn.com/content/imag...

#ChemicalProbes #DrugDiscovery #ChemicalBiology
ars.els-cdn.com
March 2, 2025 at 9:14 AM
chemicalprobes.org
Excited about tomorrow!
A full house at @crick.ac.uk for the 9th Chemical Probe Hackathon, with experts from GSK, @icr.ac.uk & TheCrick
working with PhDs & postdocs to review chemical probes and improve research quality.

#ChemicalProbes #ChemBio #OpenScience #Hackathon
February 5, 2026 at 3:18 PM
chemicalprobes.org
We brought together 22 researchers & 6 experts for a full day of evaluating GPCR and ion channel probes — and completed 26 reviews!
Lots of learning, laughter, and deep discussions about what makes a great chemical probe.

#ChemicalProbes #OpenScience #DrugDiscovery #GPCR #IonChannels
October 20, 2025 at 8:56 AM
mads-chem.bsky.social
Can't wait for 4 days of #chembiol #medchem #chemicalprobes #drugdiscovery and #chemoproteomics
@RACInational
#MCCB2025 Great line of #science and catching up with old friends in #NT
bit.ly/3PNkUl6
January 25, 2025 at 3:25 PM
mads-chem.bsky.social
Save the date! 15th Activity Based Protein Profiling meeting #ABPP2027 is in Leiden, 2-4th June 2027. Join the mailing list for program updates and rego: www.universiteitleiden.nl/en/science/led3/abpp2027
#chembiol #proteomics #ABPs #Chemicalprobes @led3hub.bsky.social @leidenscience.bsky.social
ABPP2027
The 15th International Activity-Based Protein Profiling Meeting will be held in Naturalis, Leiden, The Netherlands from June 2nd to 4th, 2027. This meeting will discuss the latest advancements in prot...
www.universiteitleiden.nl
March 2, 2026 at 9:44 PM
chemicalprobes.org
The 10th #ChemicalProbes Hackathon was a great success in Naples!

👥 20 participants
🎓 7 expert reviewers
📝 16 new probe reviews produced
⏰ All in just 4 hours

Thanks to @EUFEPS and SITELF for hosting—and for the real Italian espresso machine at coffee break! ☕🇮🇹
June 3, 2026 at 8:37 AM
stephanhacker2.bsky.social
#ChemicalProbes #ChemicalProteomics #ProteoProbes #ChemSky #ChemBio #Ligandability #Cysteine #CovalentInhibitor
May 9, 2026 at 11:34 AM
chemicalprobes.org
🚨 New publication alert! 🚨
Our latest update on the Chemical Probes Portal is live! 🎉

📜 Read the paper: doi.org/10.1093/nar/...

🔍 Learn about our expanded content + improved functionality in the 2024 Nucleic Acids Research Database Issue.

#ChemicalProbes #BiomedicalResearch #OpenScience
The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research
Abstract. The Chemical Probes Portal (www.chemicalprobes.org) is a free, public resource, based on expert-reviews, that supports the assessment, selection
doi.org
November 21, 2024 at 9:33 AM
chemicalprobes.org
Registration: chemicalprobes.org/hackathons/eufeps2025

📧 Questions? hackathon@chemprobes.org

@Chemical_probes
#ChemicalProbes #Hackathon #ScientificResearch #EUFEPS
Hackathon | Chemical Probes Portal
Chemical Probes Portal Hackathon
chemicalprobes.org
January 28, 2025 at 9:29 AM
chemicalprobes.org
Breakthrough Aurora A PROTAC on the Chemical Probes Portal ⭐⭐⭐⭐

CCT400028 @icr.ac.uk London overcomes the hook effect, delivers >120h stability, is highly selective, and includes a matched inactive control.

Powering paediatric cancer research.
#ChemicalProbes #PROTAC

Read more 👇
Researchers overcome major obstacle in targeted protein degradation
Researchers overcome major obstacle in targeted protein degradation
www.icr.ac.uk
March 2, 2026 at 9:40 AM
chemicalprobes.org
We’re in Oxford today for the 1st UK Chemical Probes Hackathon! 🎯
Postdocs & PhD students join experts to assess GPCR probes and improve research quality.
Hosted by @ChemProbes + @UniofOxford
#ChemicalProbes #GPCRs #DrugDiscovery
October 14, 2025 at 5:08 AM
chemicalprobes.org
A successful PROTAC Hackathon hosted at the@crick.ac.uk:

• 34 participants
• 24 reviews generated
• 100% reported improved understanding

Organised by the Chemical Probes Portal with academic & industry collaboration.

Next Hackathon: EUFEPS–SITELF 2026 in Naples 🇮🇹

#ChemicalProbes #PROTACs #EUFEPS
February 12, 2026 at 11:38 AM
chemicalprobes.org
The Chemical Probes Portal now covers 601 protein targets, expanding resources for chemical biology & drug discovery! 🧪🔬 New high-quality probes target DCTPP1, MASTL, HCN1, plus E3 ligases & PROTACs for protein degradation. Learn more: www.chemicalprobes.org/news/600-tar... #ChemicalProbes
March 5, 2025 at 9:37 AM
aledmedwards.bsky.social
More than 25 years after FXR agonist GW4604 was described by now @thesgc.bsky.social scientist Tim Willson, it is still being used in cutting edge papers. High quality #ChemicalProbes are expensive to discover, but they’re the gift that keeps on giving.

www.nature.com/articles/s41...
Host metabolism balances microbial regulation of bile acid signalling - Nature
A family of host-derived bile acid–methylcysteamine conjugates functions as FXR antagonists, forming part of a microbiota-dependent metabolic network that regulates FXR-dependent physiology.
www.nature.com
February 5, 2025 at 6:20 PM
chemicalprobes.org
Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes
February 28, 2025 at 7:34 AM
mads-chem.bsky.social
Last chance to register for #ABPP2025 ! Don't miss an incredible line up of talks on #proteomics #chemicalprobes #drugdiscovery #immunology #cancer plus an #earlycareer research. 30th March - 2nd April in London. Registration www.eventcreate.com/e/abpp2025/
ABPP2025: The 14th International Activity Based Protein Profiling Meeting | March 30, 2025 - April 02, 2025
Join us on March 30
www.eventcreate.com
January 20, 2025 at 8:53 PM
pwk2024.bsky.social
#PhD opportunity: Multifunctional #ChemicalProbes for mapping protein networks at Manchester Metropolitan University (UK) ref: SciEng-2024-Multifunctional-Chemical-Probes-PhD closing: 14-Oct-2024 #ChemBiol #SynChem #ChemPhD #chemsky 🧪
www.findaphd.com/phds/project...
Multifunctional Chemical Probes for Molecular Mapping of Cellular and Subcellular Protein Networks at Manchester Metropolitan University on FindAPhD.com
PhD Project - Multifunctional Chemical Probes for Molecular Mapping of Cellular and Subcellular Protein Networks at Manchester Metropolitan University, listed on FindAPhD.com
www.findaphd.com
October 3, 2024 at 7:33 AM
aledmedwards.bsky.social
Designing compounds with robots and AI will not accelerate drug discovery says @dereklowe.bsky.social (agreed). But designing great #ChemicalProbes using AI (eventually) and putting them in the hands of biologists just might. #Target2035

www.chemistryworld.com/opinion/robo...
Robots queuing up to fail
Claims of an AI revolution in drug discovery are missing the biggest problem
www.chemistryworld.com
January 17, 2025 at 4:50 PM
milkakostic.bsky.social
What do you get when you put @aledmedwards.bsky.social and me in front of a microphone? You get a great conversation about #openscience, #ChemicalProbes, and a crazy goal about creating tool compounds and probes for every protein in the human proteome by 2035. creators.spotify.com/pod/show/tar...
Episode 2: Why Open Science with Aled Edwards? by Target 2035 Podcast series
What if the greatest breakthroughs in research were locked away, inaccessible to the world? For Aled Edwards, this wasn’t just a hypothetical but a reality he encountered early in his career. In this ...
creators.spotify.com
January 22, 2025 at 5:30 PM
dbkonrad.bsky.social
Congratulations to all co-authors and collaborators involved in this work!

#Chemoproteomics #ChemicalBiology #ABPP #ProteinProfiling #Cysteine #Bioconjugation #Proteomics #MedicinalChemistry #ChemicalProbes #OpenScience #ProteoProbes
June 18, 2026 at 1:12 PM
chiosislabmskcc.bsky.social
🔍Specialized #ChemicalProbes are central to dfPPI, capturing dysfunctional interactions—trapping thousands of protein interactors, enabling precise identification of disease-driven interactome changes. #MassSpec #Proteomics (4)
April 25, 2025 at 3:11 PM
chemicalprobes.org
🎉 The Chemical Probes Portal turns 10!
We’re honoured to be featured in Dr Dan Erlanson’s latest Practical Fragments blog, reflecting on a decade of advancing chemical biology and open science.

🔗 Read the blog: practicalfragments.blogspot.com/2025/08/the-...
#ChemicalProbes #Target2035
The Chemical Probes Portal turns ten. Use it!
Last week we highlighted a new tool to computationally predict whether a molecule might aggregate, thereby causing false positives. This do...
practicalfragments.blogspot.com
August 7, 2025 at 11:34 AM
chemicalprobes.org
🧪 As a complement to CCT251545 and CCT251921, the study also highlights MSC2530818 as a valuable orthogonal CDK8/19 probe, further strengthening confidence in on-target effects and enabling robust mechanistic studies.
#ChemicalProbes #CDK8 #TargetValidation
July 4, 2025 at 10:59 AM
chemicalprobes.org
New @ACSChemBio study provides strong evidence that the effects of CDK8/19 inhibitors CCT251545 and CCT251921 are on-target.
Using CRISPR knockouts + phosphoproteomics, authors show transcriptional & antitumor effects depend on CDK8/19.
🔗 pubs.acs.org/doi/10.1021/...
#ChemicalProbes #CDK8 #OnTarget
Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer
The Mediator complex is a regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is controlled by a protein kinase module, which inclu...
pubs.acs.org
July 3, 2025 at 1:38 PM