This Week in Research💫: Combination treatment offers a promising therapeutic approach for prostate tumors exhibiting lineage plasticity. Storck et al. report combined BET bromodomain & DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer: doi.org/10.1172/jci....
September 26, 2026 at 1:00 PM
This Week in Research💫: Combination treatment offers a promising therapeutic approach for prostate tumors exhibiting lineage plasticity. Storck et al. report combined BET bromodomain & DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer: doi.org/10.1172/jci....
Combination treatment offers a promising therapeutic approach for prostate tumors exhibiting lineage plasticity: doi.org/10.1172/jci....
Storck et al. report Combined BET bromodomain and DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer.
Storck et al. report Combined BET bromodomain and DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer.
September 23, 2026 at 4:05 PM
Combination treatment offers a promising therapeutic approach for prostate tumors exhibiting lineage plasticity: doi.org/10.1172/jci....
Storck et al. report Combined BET bromodomain and DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer.
Storck et al. report Combined BET bromodomain and DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer.
#EPI
Obesity-associated DNMT downregulation drives oncogenic pathway hypomethylation in endometrioid endometrial cancer, implicating INPP5F in metabolic-epigenetic crosstalk.
Details: https://www.maxapress.com/article/doi/10.48130/epi-0026-0007
#DNMT #EndometrialCancer
Obesity-associated DNMT downregulation drives oncogenic pathway hypomethylation in endometrioid endometrial cancer, implicating INPP5F in metabolic-epigenetic crosstalk.
Details: https://www.maxapress.com/article/doi/10.48130/epi-0026-0007
#DNMT #EndometrialCancer
September 16, 2026 at 12:38 AM
#EPI
Obesity-associated DNMT downregulation drives oncogenic pathway hypomethylation in endometrioid endometrial cancer, implicating INPP5F in metabolic-epigenetic crosstalk.
Details: https://www.maxapress.com/article/doi/10.48130/epi-0026-0007
#DNMT #EndometrialCancer
Obesity-associated DNMT downregulation drives oncogenic pathway hypomethylation in endometrioid endometrial cancer, implicating INPP5F in metabolic-epigenetic crosstalk.
Details: https://www.maxapress.com/article/doi/10.48130/epi-0026-0007
#DNMT #EndometrialCancer
The female autosomal genome is consistently hypermethylated across tissues, concentrated at Polycomb-repressed regions and their regulators. We hypothesize that this may extend from the sustained Polycomb/DNMT activity that represses the inactive X in females.
September 3, 2026 at 8:33 AM
The female autosomal genome is consistently hypermethylated across tissues, concentrated at Polycomb-repressed regions and their regulators. We hypothesize that this may extend from the sustained Polycomb/DNMT activity that represses the inactive X in females.
currently trying to teach myself to play bass guitar ITS FUN im having a lot of fun. this is the first song im learning to play along to www.youtube.com/watch?v=dnMt...
Izzat Love? (2015 Remaster)
YouTube video by Todd Rundgren - Topic
www.youtube.com
August 28, 2026 at 10:56 PM
currently trying to teach myself to play bass guitar ITS FUN im having a lot of fun. this is the first song im learning to play along to www.youtube.com/watch?v=dnMt...
夏幽霊 covered by とうめいのくに【Official Video】
YouTube video by とうめいのくに🕊 / Toumeinokuni
youtube.com
August 25, 2026 at 11:43 AM
A BET bromodomain inhibitor plus a DNMT inhibitor suppressed transdifferentiated prostate tumor growth better than either drug alone, in cell lines and in mice. Which genes drive the effect remains unclear. doi.org/hcgfsk
New drug combination may help treat advanced prostate cancer
About 1 in 8 men are diagnosed with prostate cancer during their lifetime. Although many survive, it can develop into metastatic disease.
medicalxpress.com
August 21, 2026 at 4:00 PM
A BET bromodomain inhibitor plus a DNMT inhibitor suppressed transdifferentiated prostate tumor growth better than either drug alone, in cell lines and in mice. Which genes drive the effect remains unclear. doi.org/hcgfsk
Congratulations to this year’s winners.
Very proud to be a trustee on DNMT.
#LottaWorkFerCharidee etc.
Very proud to be a trustee on DNMT.
#LottaWorkFerCharidee etc.
We're delighted to announce the winner of this year's DNMT New Comedy Writing competition is Paul Carey! Congratulations are also in order for runners-up Lewis Brierly and Indigo Hinton. Thanks to our judges Andy Hamilton, Holly Walsh and Lucy Lumsden.
July 24, 2026 at 12:43 PM
Congratulations to this year’s winners.
Very proud to be a trustee on DNMT.
#LottaWorkFerCharidee etc.
Very proud to be a trustee on DNMT.
#LottaWorkFerCharidee etc.
Winner announced. beyondthejoke.co.uk/content/1767...
Winners Of The David Nobbs Memorial Trust Writing Competition Revealed
The David Nobbs Memorial Trust (DNMT) has announced the 2026 winners of its prestigious annual comedy writing competition. Paul Carey has won £1,000 cash prize, alongside a meeting with two comedy ind...
beyondthejoke.co.uk
July 23, 2026 at 9:23 AM
Winner announced. beyondthejoke.co.uk/content/1767...
We're delighted to announce the winner of this year's DNMT New Comedy Writing competition is Paul Carey! Congratulations are also in order for runners-up Lewis Brierly and Indigo Hinton. Thanks to our judges Andy Hamilton, Holly Walsh and Lucy Lumsden.
July 23, 2026 at 7:08 AM
We're delighted to announce the winner of this year's DNMT New Comedy Writing competition is Paul Carey! Congratulations are also in order for runners-up Lewis Brierly and Indigo Hinton. Thanks to our judges Andy Hamilton, Holly Walsh and Lucy Lumsden.
Can you believe next year the DNMT will be 10! Since our launch we’ve run a panel at the Edinburgh Film Festival, met some of you at the Manchester Women in Comedy Festival with the Writers’ Guild and joined John O’Farrell for talks in London. Where shall we go next?
Animated Ten XFOVH from BFB
ALT: Animated Ten XFOVH from BFB
static.klipy.com
July 14, 2026 at 5:12 PM
Can you believe next year the DNMT will be 10! Since our launch we’ve run a panel at the Edinburgh Film Festival, met some of you at the Manchester Women in Comedy Festival with the Writers’ Guild and joined John O’Farrell for talks in London. Where shall we go next?
The authors included RRIDs in their in Biochemical Pharmacology paper! RRIDs improve reproducibility in scientific research. #reproducibility #OpenScience #BetterScience
Dual inhibition of tubulin and DNMT by the novel letermovir derivative H62 blocks leukemia
Read the full paper: Dual inhibition of tubulin and DNMT by the novel letermovir derivative H62 blocks leukemia
doi.org
June 30, 2026 at 7:00 AM
The authors included RRIDs in their in Biochemical Pharmacology paper! RRIDs improve reproducibility in scientific research. #reproducibility #OpenScience #BetterScience
#JuneKnowWhatIMean #MusicChallenge #MusicSky
Day 21 - Song with a Question
Todd Rundgren - Izzat Love?
www.youtube.com/watch?v=dnMt...
Day 21 - Song with a Question
Todd Rundgren - Izzat Love?
www.youtube.com/watch?v=dnMt...
Izzat Love? (2015 Remaster)
YouTube video by Todd Rundgren - Topic
www.youtube.com
June 22, 2026 at 2:21 PM
#JuneKnowWhatIMean #MusicChallenge #MusicSky
Day 21 - Song with a Question
Todd Rundgren - Izzat Love?
www.youtube.com/watch?v=dnMt...
Day 21 - Song with a Question
Todd Rundgren - Izzat Love?
www.youtube.com/watch?v=dnMt...
Meet this year’s DNMT New Comedy Writing Competition shortlist! Congratulations to Indigo Hinton, Anina Grostern, Sid Sagar, Craig Hazell & Tom Holmes, Lewis Brierly and Paul Carey
June 19, 2026 at 8:49 AM
Meet this year’s DNMT New Comedy Writing Competition shortlist! Congratulations to Indigo Hinton, Anina Grostern, Sid Sagar, Craig Hazell & Tom Holmes, Lewis Brierly and Paul Carey
Hi Lennart, yes it's a bit convoluted for a short post 😅. There are a lot of ATAC peaks that don't close properly in Dnmt KOs. Motifs for this set of peaks are enriched in methyl-specific binding TFs. We reason that 5mC might be required to help them close. Just an insight at this point. Thanks!
June 15, 2026 at 7:01 AM
Hi Lennart, yes it's a bit convoluted for a short post 😅. There are a lot of ATAC peaks that don't close properly in Dnmt KOs. Motifs for this set of peaks are enriched in methyl-specific binding TFs. We reason that 5mC might be required to help them close. Just an insight at this point. Thanks!
We also took advantage of the genetics in the EpiLC system. We reasoned that if active enhancers required 5mC, they would lose activity in the Dnmt KO. We could find examples, but they were rare (11/13)
June 15, 2026 at 6:13 AM
We also took advantage of the genetics in the EpiLC system. We reasoned that if active enhancers required 5mC, they would lose activity in the Dnmt KO. We could find examples, but they were rare (11/13)
What about the mutants? The Dnmt KO ATAC landscape was broadly misregulated. In the Tet KO, we could see an increase in 5mC (indicating Tet activity), but only subtle effects on accessibility (5/13)
June 15, 2026 at 6:13 AM
What about the mutants? The Dnmt KO ATAC landscape was broadly misregulated. In the Tet KO, we could see an increase in 5mC (indicating Tet activity), but only subtle effects on accessibility (5/13)
From its onset, our lab has been using the ESC-EpiLC transition to study the requirements of 5mC, as it is resilient to mutations in Dnmt or Tet machinery. Priscillia and I thought this would be an excellent system to employ her tools to study enhancer dynamics (3/13)
June 15, 2026 at 6:13 AM
From its onset, our lab has been using the ESC-EpiLC transition to study the requirements of 5mC, as it is resilient to mutations in Dnmt or Tet machinery. Priscillia and I thought this would be an excellent system to employ her tools to study enhancer dynamics (3/13)
This🔥new study by Hai et al. illustrates how different mechanisms have together promoted the #evolutionary dynamic and functional #divergence of different DNMT duplicates in extant Poaceae species.
doi.org/10.1111/jse....
@wileyecology.bsky.social
#JSE #PlantSci #grass #DNA #evolution
doi.org/10.1111/jse....
@wileyecology.bsky.social
#JSE #PlantSci #grass #DNA #evolution
Evolutionary dynamics and functional divergence of DNA methyltransferase in Poaceae
In this study, we aimed to address the copy number variation and transcriptional dynamics of different DNMT duplicates in extant Poaceae species, and elucidate the evolutionary mechanisms underlying ...
doi.org
June 11, 2026 at 1:36 PM
This🔥new study by Hai et al. illustrates how different mechanisms have together promoted the #evolutionary dynamic and functional #divergence of different DNMT duplicates in extant Poaceae species.
doi.org/10.1111/jse....
@wileyecology.bsky.social
#JSE #PlantSci #grass #DNA #evolution
doi.org/10.1111/jse....
@wileyecology.bsky.social
#JSE #PlantSci #grass #DNA #evolution
DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.06.05.730343v1
https://www.biorxiv.org/content/10.64898/2026.06.05.730343v1
June 8, 2026 at 7:00 AM
DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.06.05.730343v1
https://www.biorxiv.org/content/10.64898/2026.06.05.730343v1
DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma https://www.biorxiv.org/content/10.64898/2026.06.05.730343v1
June 8, 2026 at 4:16 AM
DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma https://www.biorxiv.org/content/10.64898/2026.06.05.730343v1