Super happy to see our latest work on the opposite effects of DOT1L on gene expression published !
#chromatin #DOT1L #sexchromosomes #malegermcells
www.nature.com/articles/s42...
#chromatin #DOT1L #sexchromosomes #malegermcells
www.nature.com/articles/s42...
Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells - Communications Biology
Epigenomic and transcriptomic analyses reveal that, during mouse spermatogenesis, the H3K79 methyltransferase DOT1L has opposite effects on autosomal and X-linked gene expression depending on local ch...
www.nature.com
January 29, 2025 at 8:29 AM
Super happy to see our latest work on the opposite effects of DOT1L on gene expression published !
#chromatin #DOT1L #sexchromosomes #malegermcells
www.nature.com/articles/s42...
#chromatin #DOT1L #sexchromosomes #malegermcells
www.nature.com/articles/s42...
H3K79me2/3 is sufficient to antagonise PRC1 www.nature.com/articles/s41...
DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology
Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...
www.nature.com
February 3, 2026 at 10:30 PM
H3K79me2/3 is sufficient to antagonise PRC1 www.nature.com/articles/s41...
☕Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia.
bit.ly/46MZ3Di
bit.ly/46MZ3Di
DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology
Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...
bit.ly
February 13, 2026 at 6:15 PM
☕Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia.
bit.ly/46MZ3Di
bit.ly/46MZ3Di
www.nature.com/articles/s41...
happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis
happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis
DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology
Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...
www.nature.com
February 3, 2026 at 9:29 PM
www.nature.com/articles/s41...
happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis
happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat
academic.oup.com
February 20, 2025 at 1:38 PM
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
Fantastic day for the Korb lab with Marissa defending her thesis on DOT1L function in the brain and passing the torch to Annastelle who passed her qualifying exam on testing mechanisms of DOT1L regulation of chromatin in neurons! May 20th shall henceforth be known as National DOT1L Day.
May 20, 2025 at 9:50 PM
Fantastic day for the Korb lab with Marissa defending her thesis on DOT1L function in the brain and passing the torch to Annastelle who passed her qualifying exam on testing mechanisms of DOT1L regulation of chromatin in neurons! May 20th shall henceforth be known as National DOT1L Day.
Epigenetics Update - DOT1L provides transcriptional memory through PRC1.1 antagonism go.nature.com/4qh5aXB
Chen Davidovich and Omer Gilan (Monash University) reporting in Nat Cell Biol
#Epigenetics #DOT1L #PolyComb
---
Gain deeper insights into gene regulation; epigenometech.com
Chen Davidovich and Omer Gilan (Monash University) reporting in Nat Cell Biol
#Epigenetics #DOT1L #PolyComb
---
Gain deeper insights into gene regulation; epigenometech.com
February 6, 2026 at 12:50 PM
Epigenetics Update - DOT1L provides transcriptional memory through PRC1.1 antagonism go.nature.com/4qh5aXB
Chen Davidovich and Omer Gilan (Monash University) reporting in Nat Cell Biol
#Epigenetics #DOT1L #PolyComb
---
Gain deeper insights into gene regulation; epigenometech.com
Chen Davidovich and Omer Gilan (Monash University) reporting in Nat Cell Biol
#Epigenetics #DOT1L #PolyComb
---
Gain deeper insights into gene regulation; epigenometech.com
Looking forward to speaking next week @fnucleosome.bsky.social seminar! #FragileNucleosome #chromatin #DOT1L #germcells
⚡Next Wednesday! In our next #FragileNucleosome seminar session, we are delighted to host, @baluapuri.bsky.social and @juliecocquet.bsky.social!
If you've registered to one of our previous 2025 sessions, you can use the same link to join our next session. If not:
us06web.zoom.us/webinar/regi...
If you've registered to one of our previous 2025 sessions, you can use the same link to join our next session. If not:
us06web.zoom.us/webinar/regi...
May 1, 2025 at 7:36 PM
Looking forward to speaking next week @fnucleosome.bsky.social seminar! #FragileNucleosome #chromatin #DOT1L #germcells
www.nature.com/articles/s41...
@studerl.bsky.social
An epigenetic modulators affect timing of human neuronal maturation. Transient inhibition of EZH2, EHMT1 and EHMT2 or DOT1L, at progenitor stage primes newly born neurons to rapidly acquire mature properties upon differentiation.
2/n
@studerl.bsky.social
An epigenetic modulators affect timing of human neuronal maturation. Transient inhibition of EZH2, EHMT1 and EHMT2 or DOT1L, at progenitor stage primes newly born neurons to rapidly acquire mature properties upon differentiation.
2/n
An epigenetic barrier sets the timing of human neuronal maturation - Nature
The slow maturation of human neurons is regulated by epigenetic modification in nascent neurons, mediated by EZH2, EHMT1, EHMT2 and DOT1L.
www.nature.com
December 29, 2024 at 12:30 PM
www.nature.com/articles/s41...
@studerl.bsky.social
An epigenetic modulators affect timing of human neuronal maturation. Transient inhibition of EZH2, EHMT1 and EHMT2 or DOT1L, at progenitor stage primes newly born neurons to rapidly acquire mature properties upon differentiation.
2/n
@studerl.bsky.social
An epigenetic modulators affect timing of human neuronal maturation. Transient inhibition of EZH2, EHMT1 and EHMT2 or DOT1L, at progenitor stage primes newly born neurons to rapidly acquire mature properties upon differentiation.
2/n
OUT NOW: ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L rdcu.be/eEVKR @mskcancercenter.bsky.social @natureportfolio.nature.com #SawyersLabMSKCC
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L
Nature Genetics - Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an...
rdcu.be
September 8, 2025 at 3:38 PM
OUT NOW: ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L rdcu.be/eEVKR @mskcancercenter.bsky.social @natureportfolio.nature.com #SawyersLabMSKCC
They found that targeting the epigenetic proteins Menin or DOT1L can permanently ‘switch off’ cancer-causing genes in leukemia
#auspol #AusResearch
#auspol #AusResearch
February 20, 2026 at 8:11 AM
They found that targeting the epigenetic proteins Menin or DOT1L can permanently ‘switch off’ cancer-causing genes in leukemia
#auspol #AusResearch
#auspol #AusResearch
#SmoothMuscleCell DOT1L, H3K79 methyltransferase, KO🐭
⏬lesion burden, Mφ
⏫plaque stability
DOT1L ⬆️in SMC+PDGFBB, 👤carotid #Atherosclerosis, 👤popliteal arterial aneursym
shDOT1L in SMC➡️
⏫contractile phenotype
75% 1-h PDGFBB-activated genes are H3K79me2+
#EHJ 2022
academic.oup.com/eurheartj/ar...
⏬lesion burden, Mφ
⏫plaque stability
DOT1L ⬆️in SMC+PDGFBB, 👤carotid #Atherosclerosis, 👤popliteal arterial aneursym
shDOT1L in SMC➡️
⏫contractile phenotype
75% 1-h PDGFBB-activated genes are H3K79me2+
#EHJ 2022
academic.oup.com/eurheartj/ar...
October 18, 2025 at 7:20 PM
#SmoothMuscleCell DOT1L, H3K79 methyltransferase, KO🐭
⏬lesion burden, Mφ
⏫plaque stability
DOT1L ⬆️in SMC+PDGFBB, 👤carotid #Atherosclerosis, 👤popliteal arterial aneursym
shDOT1L in SMC➡️
⏫contractile phenotype
75% 1-h PDGFBB-activated genes are H3K79me2+
#EHJ 2022
academic.oup.com/eurheartj/ar...
⏬lesion burden, Mφ
⏫plaque stability
DOT1L ⬆️in SMC+PDGFBB, 👤carotid #Atherosclerosis, 👤popliteal arterial aneursym
shDOT1L in SMC➡️
⏫contractile phenotype
75% 1-h PDGFBB-activated genes are H3K79me2+
#EHJ 2022
academic.oup.com/eurheartj/ar...
Two new druggable targets in ERG-driven prostate cancer - KMT2A and DOT1L www.nature.com/articles/s41...
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L - Nature Genetics
Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an enrichment for STAT3 ch...
www.nature.com
September 1, 2025 at 11:43 AM
Two new druggable targets in ERG-driven prostate cancer - KMT2A and DOT1L www.nature.com/articles/s41...
🚨Paper Alert!
👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!
🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.
A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!
🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.
A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat
academic.oup.com
March 18, 2025 at 5:08 PM
🚨Paper Alert!
👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!
🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.
A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!
🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.
A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
We have just published our latest work about the different regulatory roles of DOT1L in male germ cells 🎉 find all details on @juliecocquet.bsky.social ‘s thread below 👇🏻
Super happy to see our latest work on the opposite effects of DOT1L on gene expression published !
#chromatin #DOT1L #sexchromosomes #malegermcells
www.nature.com/articles/s42...
#chromatin #DOT1L #sexchromosomes #malegermcells
www.nature.com/articles/s42...
Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells - Communications Biology
Epigenomic and transcriptomic analyses reveal that, during mouse spermatogenesis, the H3K79 methyltransferase DOT1L has opposite effects on autosomal and X-linked gene expression depending on local ch...
www.nature.com
January 29, 2025 at 12:03 PM
We have just published our latest work about the different regulatory roles of DOT1L in male germ cells 🎉 find all details on @juliecocquet.bsky.social ‘s thread below 👇🏻
ICR researchers have found that the drug could work better when combined with another targeted drug, a DOT1L inhibitor.
A DOT1L inhibitor drug is already in clinical trials, so the team hope the combination could benefit blood cancer patients sooner.
Learn more ⬇️
www.icr.ac.uk/about-us/icr...
A DOT1L inhibitor drug is already in clinical trials, so the team hope the combination could benefit blood cancer patients sooner.
Learn more ⬇️
www.icr.ac.uk/about-us/icr...
June 12, 2025 at 4:02 PM
ICR researchers have found that the drug could work better when combined with another targeted drug, a DOT1L inhibitor.
A DOT1L inhibitor drug is already in clinical trials, so the team hope the combination could benefit blood cancer patients sooner.
Learn more ⬇️
www.icr.ac.uk/about-us/icr...
A DOT1L inhibitor drug is already in clinical trials, so the team hope the combination could benefit blood cancer patients sooner.
Learn more ⬇️
www.icr.ac.uk/about-us/icr...
Great to see this out!
Following on from our earlier work revealing DOT1L was essential for humoral responses, here we determine the importance of H3K79me2 at multiple stages of B cell biology
👏 to Liam for tenaciously driving this study
👏 to collabs incl @sjturn.bsky.social + those not on bsky
Following on from our earlier work revealing DOT1L was essential for humoral responses, here we determine the importance of H3K79me2 at multiple stages of B cell biology
👏 to Liam for tenaciously driving this study
👏 to collabs incl @sjturn.bsky.social + those not on bsky
DOT1L-mediated H3K79me2 directs B-cell repertoire establishment, marginal zone development, and germinal center function @jimmunol.bsky.social @kimljacobson.bsky.social @monashuniversity.bsky.social
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
September 18, 2025 at 8:37 PM
Great to see this out!
Following on from our earlier work revealing DOT1L was essential for humoral responses, here we determine the importance of H3K79me2 at multiple stages of B cell biology
👏 to Liam for tenaciously driving this study
👏 to collabs incl @sjturn.bsky.social + those not on bsky
Following on from our earlier work revealing DOT1L was essential for humoral responses, here we determine the importance of H3K79me2 at multiple stages of B cell biology
👏 to Liam for tenaciously driving this study
👏 to collabs incl @sjturn.bsky.social + those not on bsky
🔊The decline of transplant for relapsed myeloma; DDAVP response in bleeding disorders; dual DOT1L/EZH2 targeting in DLBCL 🎧 buff.ly/KMpSvaC
#hemesky
#hemesky
April 18, 2025 at 6:01 PM
🔊The decline of transplant for relapsed myeloma; DDAVP response in bleeding disorders; dual DOT1L/EZH2 targeting in DLBCL 🎧 buff.ly/KMpSvaC
#hemesky
#hemesky
From Kim Good-Jacobson and team, new data demonstrate a vital role for disruptor of telomeric silencing 1-like (DOT1L) during B-cell lymphopoiesis, marginal zone B-cell generation, and germinal center B-cell biology. Read this #EditorChoice article: https://ow.ly/Oa0750Yn56n
March 7, 2026 at 4:00 PM
From Kim Good-Jacobson and team, new data demonstrate a vital role for disruptor of telomeric silencing 1-like (DOT1L) during B-cell lymphopoiesis, marginal zone B-cell generation, and germinal center B-cell biology. Read this #EditorChoice article: https://ow.ly/Oa0750Yn56n
The latest publication from our lab is online in @narjournal.bsky.social . Congratulations to @marcelwerner.bsky.social and Manuel Trauner for developing a novel system in mammalian cells to study Transcription-Replication conflicts and pointing DOT1L as a transcription mediator at TRC sites!
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat
academic.oup.com
February 20, 2025 at 3:45 PM
The latest publication from our lab is online in @narjournal.bsky.social . Congratulations to @marcelwerner.bsky.social and Manuel Trauner for developing a novel system in mammalian cells to study Transcription-Replication conflicts and pointing DOT1L as a transcription mediator at TRC sites!
Immunology updates: Newly discovered role of DOT1L in shaping the defense system
www.thailandmedical.news/news/immunol...
www.thailandmedical.news/news/immunol...
Immunology updates: Newly discovered role of DOT1L in shaping the defense system - Thailand Medical News
www.thailandmedical.news
June 20, 2024 at 4:44 AM
Immunology updates: Newly discovered role of DOT1L in shaping the defense system
www.thailandmedical.news/news/immunol...
www.thailandmedical.news/news/immunol...
DOT1L-mediated H3K79me2 directs B-cell repertoire establishment, marginal zone development, and germinal center function @jimmunol.bsky.social @kimljacobson.bsky.social @monashuniversity.bsky.social
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
September 17, 2025 at 11:32 PM
DOT1L-mediated H3K79me2 directs B-cell repertoire establishment, marginal zone development, and germinal center function @jimmunol.bsky.social @kimljacobson.bsky.social @monashuniversity.bsky.social
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
Don’t miss next week’s Fragile Nucleosome seminar featuring @juliecocquet.bsky.social ⭐️ cool discussion about #DOT1L, #chromatin dynamics & #spermatogenesis guaranteed!
⚡Next Wednesday! In our next #FragileNucleosome seminar session, we are delighted to host, @baluapuri.bsky.social and @juliecocquet.bsky.social!
If you've registered to one of our previous 2025 sessions, you can use the same link to join our next session. If not:
us06web.zoom.us/webinar/regi...
If you've registered to one of our previous 2025 sessions, you can use the same link to join our next session. If not:
us06web.zoom.us/webinar/regi...
May 1, 2025 at 11:25 AM
Don’t miss next week’s Fragile Nucleosome seminar featuring @juliecocquet.bsky.social ⭐️ cool discussion about #DOT1L, #chromatin dynamics & #spermatogenesis guaranteed!
Inactivation of the epigenetic writer DOT1L boosts the tumor cell killing potential of T cells
www.science.org/doi/10.1126/...
@fredvanleeuwen.co.uk @nkinl.bsky.social
www.science.org/doi/10.1126/...
@fredvanleeuwen.co.uk @nkinl.bsky.social
December 12, 2025 at 8:28 PM
Inactivation of the epigenetic writer DOT1L boosts the tumor cell killing potential of T cells
www.science.org/doi/10.1126/...
@fredvanleeuwen.co.uk @nkinl.bsky.social
www.science.org/doi/10.1126/...
@fredvanleeuwen.co.uk @nkinl.bsky.social
There is a lot of redundancy in protein methylation. Here is our method to track individual enzyme activity. Exemplified for DOT1L, but could be more broadly applied in the future. Out now in Communications Chemistry. Congrats Nicole and Harry! #chemsky #epigenetics 🧪 www.nature.com/articles/s42...
Tracking DOT1L methyltransferase activity by stable isotope labelling using a selective synthetic co-factor - Communications Chemistry
Histone methylation by histone lysine methyltransferases (HKMTs) is a vital post-translational modification regulating gene expression, however, selective mapping of methylation by proteomics analysis...
www.nature.com
June 27, 2024 at 8:18 PM
There is a lot of redundancy in protein methylation. Here is our method to track individual enzyme activity. Exemplified for DOT1L, but could be more broadly applied in the future. Out now in Communications Chemistry. Congrats Nicole and Harry! #chemsky #epigenetics 🧪 www.nature.com/articles/s42...