#Effector
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flolfiest.bsky.social
Added an independent option for pieces to stick to the effector.
November 13, 2026 at 1:21 AM
eff.org
What happens when the government outsources medical treatment approval to private AI companies? Find out more with our latest issue of EFFector: www.eff.org/deeplinks/2...
🤕 Medicare's AI Experiment | EFFector 38.20
When we need medical care, we expect decisions about our treatment to be made by our doctors, not a tech company's algorithm. But in January, the federal government launched a program that uses AI to
www.eff.org
November 13, 2026 at 8:58 PM
eff.org
We sued for answers on Medicare's AI experiment. What we found were problems on top of problems.

Learn more with the latest EFFector newsletter and podcast: www.eff.org/deeplinks/2...
🤕 Medicare's AI Experiment | EFFector 38.20
When we need medical care, we expect decisions about our treatment to be made by our doctors, not a tech company's algorithm. But in January, the federal government launched a program that uses AI to
www.eff.org
November 11, 2026 at 6:39 PM
eff.org
Tune into the latest EFFector podcast: "We Sued for Answers on Medicare's AI Experiment."

This time, we're talking about what happens when the government outsources treatment approval to private AI companies—without sufficient transparency, testing, or legal limits.
www.eff.org/deeplinks/2...
🤕 Medicare's AI Experiment | EFFector 38.20
When we need medical care, we expect decisions about our treatment to be made by our doctors, not a tech company's algorithm. But in January, the federal government launched a program that uses AI to
www.eff.org
November 12, 2026 at 7:56 PM
jibarrondo.bsky.social
Differentiation of stem-like CD4+ T cells modulates early effector responses in colorectal cancer | Science www.science.org/doi/10.1126/... 🧪
Differentiation of stem-like CD4+ T cells modulates early effector responses in colorectal cancer
Strategies to improve cancer immunotherapy have largely focused on the intratumor immunosuppressive microenvironment, whereas approaches to amplify peripheral T cells and promote tumor recruitment hav...
www.science.org
November 13, 2026 at 8:12 PM
sciences.skyfleet.blue
Differentiation of stem-like CD4+ T cells modulates early effector responses in colorectal cancer
Differentiation of stem-like CD4+ T cells modulates early effector responses in colorectal cancer
Science, Volume 394, Issue 6825 , November 2026.
www.science.org
November 12, 2026 at 8:41 PM
labwaggoner.bsky.social
TOX and PD-1 preserve a CXCR5+TCF-1+CD62L+CD4 progenitor population that replenishes CD4 effector cells during chronic viral infection
www.science.org/doi/10.1126/...
November 13, 2026 at 9:46 PM
sheencr.bsky.social
super interesting study showing that some patients with severe covid make antibodies to a an important anti-viral protection mechanisms - interferons- in effect shutting off an important effector arm of the immune response to covid
November 11, 2026 at 3:49 PM
keihiruma.bsky.social
Our work is out.We identified a fungal effector required for root colonization. Its expression tracks host phosphate status and is repressed by the fungal phosphate starvation regulator. Fungi may balance colonization and low-phosphate adaptation. Congrats Jacy!
www.sciencedirect.com/science/arti...
www.sciencedirect.com
November 12, 2026 at 7:30 AM
plosbiology.org
How does Cryptosporidium invade intestinal cells and build its intracellular niche? This study shows that its single rhoptry, a secretory organelle, is repurposed during invasion to form the host–parasite interface and extract host metabolites.
🧪 #AcademicSky #pathogens
plos.io/3UKiEBy
Updated model for Cryptosporidium invasion and effector secretion. A. We propose the following model for Cryptosporidium invasion and effector secretion and establish the timing of selected events above the cartoon. First, the parasite establishes stable contact with the host cell and inserts its apical end into an invagination in the host cell membrane. Then, rhoptry discharge and host actin accumulation at the site of attachment occurs rapidly, within 5 s of initial contact. The dense granules then migrate to the apical end, a process which takes about 10 s. They fuse at the apical end and are secreted into the host-parasite interface. Once the interface has been established, the parasite engages the host plasma membrane and forms its parasitophorous vacuole (PV). The parasite further rounds up and matures. The rhoptry membrane then develops into the feeder organelle starting at 3–4 hours after invasion. B. Model of the evolution of intracellular parasitism in Apicomplexa. Colpodella is a predator of other protists, feeding by cellular vampirism or myzocytosis. Siedeleckia is a gregarine parasite of marine worms that inserts an apical holdfast and feeding structure called the mucron into its host cell but remains largely extracellular, and Toxoplasma is a fully intracellular parasite growing within a PV in the cytoplasm of the host cell. All these organisms feature a rhoptry (red). In Toxoplasma this is solely an invasion organelle, but it appears to have evolved from an organelle that combined host penetration with nutrient acquisition.
November 14, 2026 at 1:02 PM
biorxiv-microbiol.bsky.social
EveD, a vesicle-associated rhizobial candidate effector shaping nodulation competitiveness and host genotype responses https://www.biorxiv.org/content/10.64898/2026.11.12.766089v1
November 13, 2026 at 6:20 PM
plosbiology.org
How does Cryptosporidium invade intestinal cells and build its intracellular niche? This study shows that its single rhoptry, a secretory organelle, is repurposed during invasion to form the host–parasite interface and extract host metabolites.
🧪 #AcademicSky #pathogens
plos.io/3UKiEBy
Updated model for Cryptosporidium invasion and effector secretion. A. We propose the following model for Cryptosporidium invasion and effector secretion and establish the timing of selected events above the cartoon. First, the parasite establishes stable contact with the host cell and inserts its apical end into an invagination in the host cell membrane. Then, rhoptry discharge and host actin accumulation at the site of attachment occurs rapidly, within 5 s of initial contact. The dense granules then migrate to the apical end, a process which takes about 10 s. They fuse at the apical end and are secreted into the host-parasite interface. Once the interface has been established, the parasite engages the host plasma membrane and forms its parasitophorous vacuole (PV). The parasite further rounds up and matures. The rhoptry membrane then develops into the feeder organelle starting at 3–4 hours after invasion. B. Model of the evolution of intracellular parasitism in Apicomplexa. Colpodella is a predator of other protists, feeding by cellular vampirism or myzocytosis. Siedeleckia is a gregarine parasite of marine worms that inserts an apical holdfast and feeding structure called the mucron into its host cell but remains largely extracellular, and Toxoplasma is a fully intracellular parasite growing within a PV in the cytoplasm of the host cell. All these organisms feature a rhoptry (red). In Toxoplasma this is solely an invasion organelle, but it appears to have evolved from an organelle that combined host penetration with nutrient acquisition.
November 13, 2026 at 9:00 AM
labwaggoner.bsky.social
Central role of IκBζ in orchestrating the ILC2 effector program in different tissues in health and disease @natcomms.nature.com
www.nature.com/articles/s41...
November 10, 2026 at 7:40 PM
edelplopez.bsky.social
What a great time at Wooster! 🌱🔬

Thank you Andrés for hosting me, and to the amazing faculty, USDA scientists, and students who took the time to connect!

Loved sharing our research on clubroot genomics and effector biology!

Some legendary figures in plant pathology have walked these halls! 😉🌿
November 14, 2026 at 2:49 AM
glosal-riot-korp.bsky.social
🤕 Medicare's AI Experiment | EFFector 38.20
https://www.eff.org/deeplinks/2026/11/medicares-ai-experiment-effector-3820 [1/3]
November 11, 2026 at 7:03 PM
gutsyliberal.com
If you’re tempted to assume this is a good idea—even with its assurances of human validation—check out how the regime’s rollout of AI for Medicare is going: www.eff.org/deeplinks/20...
🤕 Medicare's AI Experiment | EFFector 38.20
When we need medical care, we expect decisions about our treatment to be made by our doctors, not a tech company's algorithm. But in January, the federal government launched a program that uses AI to ...
www.eff.org
November 12, 2026 at 10:47 PM
rridrobot.bsky.social
The authors included RRIDs in their in Cell Reports paper! Thanks for making your methods matter! #OpenScience #accelerateopenscience #reproducibility
Uncoupling hypersensitive cell death response and disease resistance activated by effector-triggered immunity
Read the full paper: Uncoupling hypersensitive cell death response and disease resistance activated by effector-triggered immunity
doi.org
November 15, 2026 at 8:00 AM
kinetoplastpapers.bsky.social
EBI3-Dependent Pathways Coordinate Regulatory and Effector Immunity During Cutaneous Leishmaniasis pubmed.ncbi.nlm.nih.gov/43014342/
November 12, 2026 at 2:18 PM
biorxivpreprint.bsky.social
EveD, a vesicle-associated rhizobial candidate effector shaping nodulation competitiveness and host genotype responses https://www.biorxiv.org/content/10.64898/2026.11.12.766089v1
November 13, 2026 at 6:20 PM
tridibmahata.bsky.social
🎉New paper alert:
GAPS4 protects bacteria against a broad range of phages by degrading host DNA.
The trigger? DNA damage by phages, antibiotics, DNase effector from rival bacteria.
A guardian of genome integrity that works like a double edged sword.
More in the thread below👇
November 10, 2026 at 4:17 PM
⚖️ **🤕 Medicare's AI Experiment | EFFector 38.20**

When we need medical care, we expect decisions about our treatment to be made by our doctors, not a tech company's algorithm. But in January, the federal government launched a program that uses AI […]

[Original post on igeek.gamer-geek-news.com]
Image for: 🤕 Medicare's AI Experiment | EFFector 38.20
November 13, 2026 at 6:58 PM
rridrobot.bsky.social
A paper using RRID:AB_2876881 from @proteintech.bsky.social was just published in Current Biology. RRIDs improve reproducibility in scientific research. #reproducibility #RRID #BetterScience
A CONSTANS-like transcriptional co-activator couples ethylene signaling to jasmonate biosynthesis and is targeted by a fungal effector
Read the full paper: A CONSTANS-like transcriptional co-activator couples ethylene signaling to jasmonate biosynthesis and is targeted by a fungal effector
doi.org
November 15, 2026 at 8:00 AM
jsabatino37.bsky.social
Lowering the Barr
Rethinking Causality in Complex Autoimmunity Through Epstein-Barr Virus in Multiple Sclerosis

www.neurology.org/doi/10.1212/...
Lowering the Barr | Neurology Neuroimmunology & Neuroinflammation
Classical autoimmune postulates were developed for diseases driven by a dominant antigen or transferable effector mechanism. Multiple sclerosis (MS), despite compelling evidence of immune-mediated pat...
www.neurology.org
November 15, 2026 at 2:57 AM
beanhowitzer.bsky.social
nobody makes cruise missiles anymore it’s always something like a “one way effector multidomain strike drone”
November 6, 2026 at 7:45 PM