David Mason, Raphaël Lévy: Sticky-flares: real-time tracking of mRNAs... or of endosomes? https://hal.science/hal-05726513v1 [sdv]
October 9, 2026 at 3:00 AM
David Mason, Raphaël Lévy: Sticky-flares: real-time tracking of mRNAs... or of endosomes? https://hal.science/hal-05726513v1 [sdv]
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
@currentbiology.bsky.social from @samreckpeterson.bsky.social
with @kellerlab.bsky.social
www.cell.com/current-biol...
@currentbiology.bsky.social from @samreckpeterson.bsky.social
with @kellerlab.bsky.social
www.cell.com/current-biol...
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
Kumar, Allen, Oster et al. show that motility of PxdA-marked early endosomes in Aspergillus
nidulans is required for light-responsive development and production of secondary
metabolites. In the pathog...
www.cell.com
October 8, 2026 at 7:12 AM
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
@currentbiology.bsky.social from @samreckpeterson.bsky.social
with @kellerlab.bsky.social
www.cell.com/current-biol...
@currentbiology.bsky.social from @samreckpeterson.bsky.social
with @kellerlab.bsky.social
www.cell.com/current-biol...
A dsRNA Virus Converts Early Endosomes into Stable Replication Organelles Through Maturation Arrest and Retrograde Transport https://www.biorxiv.org/content/10.64898/2026.10.02.756243v1
October 6, 2026 at 8:30 AM
A dsRNA Virus Converts Early Endosomes into Stable Replication Organelles Through Maturation Arrest and Retrograde Transport https://www.biorxiv.org/content/10.64898/2026.10.02.756243v1
A dsRNA Virus Converts Early Endosomes into Stable Replication Organelles Through Maturation Arrest and Retrograde Transport https://www.biorxiv.org/content/10.64898/2026.10.02.756243v1
October 6, 2026 at 8:30 AM
A dsRNA Virus Converts Early Endosomes into Stable Replication Organelles Through Maturation Arrest and Retrograde Transport https://www.biorxiv.org/content/10.64898/2026.10.02.756243v1
EPHA2/CD44-directed trafficking enhances endosomal leakiness and antisense therapy delivery rupress.org/jcb/article/...
EPHA2/CD44-directed trafficking enhances endosomal leakiness and antisense therapy delivery
A scavenger receptor (CD44) and a receptor tyrosine kinase (EPHA2) join forces to mediate internalization of therapeutic ASOs into endosomes, which are the
rupress.org
October 3, 2026 at 9:46 PM
EPHA2/CD44-directed trafficking enhances endosomal leakiness and antisense therapy delivery rupress.org/jcb/article/...
One particularly exciting finding: the FERRY complex, previously studied primarily in neurons in the context of localized mRNA transport and translation, assembles on early endosomes in macrophages and is dynamically remodeled following TLR4 activation.
October 2, 2026 at 7:52 PM
One particularly exciting finding: the FERRY complex, previously studied primarily in neurons in the context of localized mRNA transport and translation, assembles on early endosomes in macrophages and is dynamically remodeled following TLR4 activation.
The -other- participants of the study:
@nadlerlab.bsky.social
@pavelbarahtjan.bsky.social
@susananunes.bsky.social
@sascha-kuhn.bsky.social
Kristin Böhlig
Aditya Chhatre
Radek Šachl
Lior Moneta
Wan Yee Yau
Juan Iglesias
Martin Hof
Lukáš Opálka
Carl Modes
Alf Honigmann
@mpi-cbg.de
www.nature.com
@nadlerlab.bsky.social
@pavelbarahtjan.bsky.social
@susananunes.bsky.social
@sascha-kuhn.bsky.social
Kristin Böhlig
Aditya Chhatre
Radek Šachl
Lior Moneta
Wan Yee Yau
Juan Iglesias
Martin Hof
Lukáš Opálka
Carl Modes
Alf Honigmann
@mpi-cbg.de
www.nature.com
October 2, 2026 at 5:40 AM
The -other- participants of the study:
@nadlerlab.bsky.social
@pavelbarahtjan.bsky.social
@susananunes.bsky.social
@sascha-kuhn.bsky.social
Kristin Böhlig
Aditya Chhatre
Radek Šachl
Lior Moneta
Wan Yee Yau
Juan Iglesias
Martin Hof
Lukáš Opálka
Carl Modes
Alf Honigmann
@mpi-cbg.de
www.nature.com
@nadlerlab.bsky.social
@pavelbarahtjan.bsky.social
@susananunes.bsky.social
@sascha-kuhn.bsky.social
Kristin Böhlig
Aditya Chhatre
Radek Šachl
Lior Moneta
Wan Yee Yau
Juan Iglesias
Martin Hof
Lukáš Opálka
Carl Modes
Alf Honigmann
@mpi-cbg.de
www.nature.com
For example, while MDVs have been described to deliver mtDNA to lysosomes, maybe they also deliver mtDNA to endosomes...
September 30, 2026 at 12:58 PM
For example, while MDVs have been described to deliver mtDNA to lysosomes, maybe they also deliver mtDNA to endosomes...
At this point it is important to note that other groups have described mtDNA release through endosomes (@dplamartin.bsky.social and @lauraenewmanphd.bsky.social in Gerry Shadel's lab at the time) as well as mtDNA release through MDVs (@prudentlab.bsky.social and
@mitodynamics.bsky.social).
@mitodynamics.bsky.social).
September 30, 2026 at 12:58 PM
At this point it is important to note that other groups have described mtDNA release through endosomes (@dplamartin.bsky.social and @lauraenewmanphd.bsky.social in Gerry Shadel's lab at the time) as well as mtDNA release through MDVs (@prudentlab.bsky.social and
@mitodynamics.bsky.social).
@mitodynamics.bsky.social).
In addition to the endosomal mtDNA release linked to myopathy. We also saw that some cell lines had smaller mtDNA puncta that were outside of the mitochondrial network but were not inside of endosomes.
It turns out these smaller mtDNA puncta were inside of mitochondrial derived vesicles (MDVs).
It turns out these smaller mtDNA puncta were inside of mitochondrial derived vesicles (MDVs).
September 30, 2026 at 12:58 PM
In addition to the endosomal mtDNA release linked to myopathy. We also saw that some cell lines had smaller mtDNA puncta that were outside of the mitochondrial network but were not inside of endosomes.
It turns out these smaller mtDNA puncta were inside of mitochondrial derived vesicles (MDVs).
It turns out these smaller mtDNA puncta were inside of mitochondrial derived vesicles (MDVs).
In the second paper (doi.org/10.64898/202...), we show that MFN2 variants that cause myopathy promote mtDNA release via endosomes, which leads to increased inflammation via TLR9 and cGAS-STING pathways. We believe this inflammation is what drives the myopathy in the patients.
doi.org
September 30, 2026 at 12:58 PM
In the second paper (doi.org/10.64898/202...), we show that MFN2 variants that cause myopathy promote mtDNA release via endosomes, which leads to increased inflammation via TLR9 and cGAS-STING pathways. We believe this inflammation is what drives the myopathy in the patients.
Rhymes et al. report that ciliary neurotrophic factor selectively slows the retrograde transport of signalling endosomes in motor neurons in vivo, highlighting the specificity with which neurotrophic factors shape axonal transport and motor neuron connectivity.
Read it at 👉https://buff.ly/jfwxif1
Read it at 👉https://buff.ly/jfwxif1
September 27, 2026 at 3:02 PM
Rhymes et al. report that ciliary neurotrophic factor selectively slows the retrograde transport of signalling endosomes in motor neurons in vivo, highlighting the specificity with which neurotrophic factors shape axonal transport and motor neuron connectivity.
Read it at 👉https://buff.ly/jfwxif1
Read it at 👉https://buff.ly/jfwxif1
Open Access UCL Research: Ciliary neurotrophic factor slows axonal transport of signalling endosomes discovery.ucl.ac.uk/id/eprint/10...
Ciliary neurotrophic factor slows axonal transport of signalling endosomes
-
UCL Discovery
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
September 25, 2026 at 2:09 PM
Open Access UCL Research: Ciliary neurotrophic factor slows axonal transport of signalling endosomes discovery.ucl.ac.uk/id/eprint/10...
Effect of HSV-1 ICP0 E3 ubiquitin ligase on CIN85 endosomes https://www.biorxiv.org/content/10.64898/2026.09.21.753399v1
September 24, 2026 at 4:16 AM
Effect of HSV-1 ICP0 E3 ubiquitin ligase on CIN85 endosomes https://www.biorxiv.org/content/10.64898/2026.09.21.753399v1
Effect of HSV-1 ICP0 E3 ubiquitin ligase on CIN85 endosomes https://www.biorxiv.org/content/10.64898/2026.09.21.753399v1
September 24, 2026 at 4:16 AM
Effect of HSV-1 ICP0 E3 ubiquitin ligase on CIN85 endosomes https://www.biorxiv.org/content/10.64898/2026.09.21.753399v1
CROP2, a Retriever–PROPPIN complex mediating protein export from endosomes to the plasma membrane in human cells
CROP2, a Retriever–PROPPIN complex mediating protein export from endosomes to the plasma membrane in human cells
Endosomes operate several exit routes that sort protein cargo and depend on pathway-specific associations of a PROPPIN with the responsible protein coat, such as the here identified CROP2, to support...
buff.ly
September 23, 2026 at 10:28 PM
CROP2, a Retriever–PROPPIN complex mediating protein export from endosomes to the plasma membrane in human cells
Yes, if the big purple cavern is a nucleus then the cilia would be short, but plausible. PCD can do that. It would mean the scale bar’s too small though; mammalian nuclei in tissue are usually 10 um diameter, or smaller. The “nuclei” would likely be over-interpreted and wrong-colored endosomes.
September 23, 2026 at 11:23 AM
Yes, if the big purple cavern is a nucleus then the cilia would be short, but plausible. PCD can do that. It would mean the scale bar’s too small though; mammalian nuclei in tissue are usually 10 um diameter, or smaller. The “nuclei” would likely be over-interpreted and wrong-colored endosomes.
NIEHS, 22 MHV-infected mice plus cell models, found coronaviruses depend on host inositol phosphate signaling.
UNC7844 trapped virions in late endosomes and cut viral RNA by over 10,000-fold in cells.
www.biorxiv.org/content/10.6...
UNC7844 trapped virions in late endosomes and cut viral RNA by over 10,000-fold in cells.
www.biorxiv.org/content/10.6...
Host soluble inositol phosphate signaling promotes coronavirus replication
Coronaviruses rely extensively on host pathways for replication, making host-directed therapies an attractive strategy for broad-spectrum antivirals with reduced risk of viral resistance. Here we iden...
www.biorxiv.org
September 16, 2026 at 5:09 PM
NIEHS, 22 MHV-infected mice plus cell models, found coronaviruses depend on host inositol phosphate signaling.
UNC7844 trapped virions in late endosomes and cut viral RNA by over 10,000-fold in cells.
www.biorxiv.org/content/10.6...
UNC7844 trapped virions in late endosomes and cut viral RNA by over 10,000-fold in cells.
www.biorxiv.org/content/10.6...
WO2026178657A1 describes pH-responsive amphipathic peptides that become cationic in acidic endosomes, promoting cytosolic cargo release. In mRNA-LNPs, 1% FSP003D-CLS increased liver/spleen reporter output ~18×/~20×, with no obvious distribution shift. Escape and toxicity remain to be confirmed.
September 13, 2026 at 6:52 AM
WO2026178657A1 describes pH-responsive amphipathic peptides that become cationic in acidic endosomes, promoting cytosolic cargo release. In mRNA-LNPs, 1% FSP003D-CLS increased liver/spleen reporter output ~18×/~20×, with no obvious distribution shift. Escape and toxicity remain to be confirmed.
In a #BriefReview authors discuss the role of lysosomes in immune cells and their potential for developing targeted therapeutic strategies and for enhancing the safety and efficacy of novel biological entities (NBEs). Find the full article in The JI: https://ow.ly/Aofs50ZLyaL.
September 11, 2026 at 6:20 PM
In a #BriefReview authors discuss the role of lysosomes in immune cells and their potential for developing targeted therapeutic strategies and for enhancing the safety and efficacy of novel biological entities (NBEs). Find the full article in The JI: https://ow.ly/Aofs50ZLyaL.
ASOs can be used to treat central nervous system diseases. Here intrathecal injections are used to cross the blood brain barrier. ASO uptake by CNS cells happens after surface interaction and macropinocytosis. ASOs end up in the endosomes, where they either are degraded in lysosomes, or...
September 10, 2026 at 8:46 AM
ASOs can be used to treat central nervous system diseases. Here intrathecal injections are used to cross the blood brain barrier. ASO uptake by CNS cells happens after surface interaction and macropinocytosis. ASOs end up in the endosomes, where they either are degraded in lysosomes, or...
New paper:
Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles.
Neutral at physiological pH, charge-switching #LNP become positively charged in endosomes, enabling efficient nucleic acid delivery with reduced inflammatory responses.
www.nature.com/articles/s41...
Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles.
Neutral at physiological pH, charge-switching #LNP become positively charged in endosomes, enabling efficient nucleic acid delivery with reduced inflammatory responses.
www.nature.com/articles/s41...
Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles - Nature Nanotechnology
Charge-switching S-lipids generate S-lipid nanoparticles that are neutral or negative at physiological pH but become cationic in acidic endosomes, enabling nucleic acid delivery with reduced inflammat...
www.nature.com
September 8, 2026 at 9:47 AM
New paper:
Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles.
Neutral at physiological pH, charge-switching #LNP become positively charged in endosomes, enabling efficient nucleic acid delivery with reduced inflammatory responses.
www.nature.com/articles/s41...
Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles.
Neutral at physiological pH, charge-switching #LNP become positively charged in endosomes, enabling efficient nucleic acid delivery with reduced inflammatory responses.
www.nature.com/articles/s41...
Left England with no voice and a head full of ideas! What a wonderful conference on endosomes!
The 93 Harden Conference concludes after several days of insightful talks, brilliant discussions and lots of networking. Thank you to all programme coordinators, speakers, presenters and attendees for a very successful meeting!
September 6, 2026 at 7:17 PM
Left England with no voice and a head full of ideas! What a wonderful conference on endosomes!