Enteric neurons doing enteric neuron things #drosophila
November 21, 2024 at 11:36 AM
Enteric neurons doing enteric neuron things #drosophila
“It’s afraid!” is going to haunt my enteric nervous system for days
February 9, 2025 at 3:16 AM
“It’s afraid!” is going to haunt my enteric nervous system for days
Early-life enteric infection is a driver of long-lasting neuroimmune imbalance @pnas.org @gareaulab.bsky.social @ucdavis.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
September 27, 2026 at 6:46 PM
Early-life enteric infection is a driver of long-lasting neuroimmune imbalance @pnas.org @gareaulab.bsky.social @ucdavis.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Happy to share that our latest work is out now!
BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development @thedrjam.bsky.social @rodrigomorec.bsky.social anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development @thedrjam.bsky.social @rodrigomorec.bsky.social anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development
During early enteric nervous system development, BMP signaling pathway members and target genes are enriched within neural crest, enteric progenitor, and enteric neuron populations. BMP signaling pl...
anatomypubs.onlinelibrary.wiley.com
March 4, 2025 at 2:45 PM
Happy to share that our latest work is out now!
BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development @thedrjam.bsky.social @rodrigomorec.bsky.social anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development @thedrjam.bsky.social @rodrigomorec.bsky.social anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
📣First preprint of the lab📣 Did that really happen?😅
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Genetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity
Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...
www.biorxiv.org
January 11, 2026 at 3:32 PM
📣First preprint of the lab📣 Did that really happen?😅
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Another paper from our awesome lab out today @nature.com. Led by 🌟 PD Jihye Yeon with fantastic collaborators. We show how an ionotropic receptor (related to insect sensory IRs) in a single pharyngeal enteric neuron senses ingested salts and protects the worm from high salt stress.
rdcu.be/fbd4a
rdcu.be/fbd4a
An enteric neuron ionotropic receptor regulates salt stress resistance
Nature - The I3 pharyngeal enteric neuron in Caenorhabditis elegans detects high-salt conditions, and the GLR-9 ionotropic salt receptor expressed specifically in I3 regulates genes related to salt...
rdcu.be
April 1, 2026 at 8:39 PM
Another paper from our awesome lab out today @nature.com. Led by 🌟 PD Jihye Yeon with fantastic collaborators. We show how an ionotropic receptor (related to insect sensory IRs) in a single pharyngeal enteric neuron senses ingested salts and protects the worm from high salt stress.
rdcu.be/fbd4a
rdcu.be/fbd4a
🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...
www.science.org
May 23, 2025 at 1:26 AM
🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
The "second brain" of the body—the gut (enteric) nervous system—can tamp down inflammation of the gut lining via release of a neuropeptide, a discovery that may help vs inflammatory bowel disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 16, 2025 at 6:33 PM
The "second brain" of the body—the gut (enteric) nervous system—can tamp down inflammation of the gut lining via release of a neuropeptide, a discovery that may help vs inflammatory bowel disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#MedSky🧪 #IDSky #PedSky #Immunosky #publichealth Overview The Enteric Viruses , #SARSCoV2 & Their Pathogenesis in Intestinal Epithelial Cell Infection esp Norovirus ,A persistent threat for childrens in 🇬🇧 this winter
www.mdpi.com/2227-9059/12...
www.mdpi.com/2227-9059/12...
Overview of the Trending Enteric Viruses and Their Pathogenesis in Intestinal Epithelial Cell Infection
Enteric virus infection is a major public health issue worldwide. Enteric viruses have become epidemic infectious diseases in several countries. Enteric viruses primarily infect the gastrointestinal t...
www.mdpi.com
December 8, 2024 at 4:14 PM
#MedSky🧪 #IDSky #PedSky #Immunosky #publichealth Overview The Enteric Viruses , #SARSCoV2 & Their Pathogenesis in Intestinal Epithelial Cell Infection esp Norovirus ,A persistent threat for childrens in 🇬🇧 this winter
www.mdpi.com/2227-9059/12...
www.mdpi.com/2227-9059/12...
From EID: Potentially Zoonotic Enteric Infections in Gorillas and Chimpanzees, Cameroon and Tanzania
#IDSky 🧪
#IDSky 🧪
Potentially Zoonotic Enteric Infections in Gorillas and Chimpanzees, Cameroon and Tanzania
Enteric Infections in Gorillas and Chimpanzees
wwwnc.cdc.gov
February 25, 2024 at 11:02 PM
From EID: Potentially Zoonotic Enteric Infections in Gorillas and Chimpanzees, Cameroon and Tanzania
#IDSky 🧪
#IDSky 🧪
ONCE a medicine is approved by the FDA after said clinical trials, that medicine is available.
SOMETIMES there are updates to a medicine, like:
Adding an enteric coating.
Changing manufacturing facility.
Making a generic version.
Altering a stabilizer.
Updating a virus strain in a vaccine.
3/
SOMETIMES there are updates to a medicine, like:
Adding an enteric coating.
Changing manufacturing facility.
Making a generic version.
Altering a stabilizer.
Updating a virus strain in a vaccine.
3/
May 5, 2025 at 12:25 AM
ONCE a medicine is approved by the FDA after said clinical trials, that medicine is available.
SOMETIMES there are updates to a medicine, like:
Adding an enteric coating.
Changing manufacturing facility.
Making a generic version.
Altering a stabilizer.
Updating a virus strain in a vaccine.
3/
SOMETIMES there are updates to a medicine, like:
Adding an enteric coating.
Changing manufacturing facility.
Making a generic version.
Altering a stabilizer.
Updating a virus strain in a vaccine.
3/
It is International Day of Women and Girls in Science.
Gagandeep Kang’s research on enteric infections has contributed to the rotavirus vaccine rollout in #India, protecting millions of children and shaping a healthier future. for all.
🔬 #WomenInScience #WomenInSTEM
Gagandeep Kang’s research on enteric infections has contributed to the rotavirus vaccine rollout in #India, protecting millions of children and shaping a healthier future. for all.
🔬 #WomenInScience #WomenInSTEM
February 11, 2025 at 11:46 AM
It is International Day of Women and Girls in Science.
Gagandeep Kang’s research on enteric infections has contributed to the rotavirus vaccine rollout in #India, protecting millions of children and shaping a healthier future. for all.
🔬 #WomenInScience #WomenInSTEM
Gagandeep Kang’s research on enteric infections has contributed to the rotavirus vaccine rollout in #India, protecting millions of children and shaping a healthier future. for all.
🔬 #WomenInScience #WomenInSTEM
'However, how the ∼500 million enteric neurons that reside in the GI tract sense and respond to force remains unknown. Herein, we establish that the mechanosensor Piezo1 is functionally expressed in cholinergic enteric neurons.'
#Immunology
www.cell.com/cell/abstrac...
#Immunology
www.cell.com/cell/abstrac...
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
Expression and functional analysis define how Piezo1-dependent cholinergic responses
by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation
in mice.
www.cell.com
March 29, 2025 at 9:51 AM
'However, how the ∼500 million enteric neurons that reside in the GI tract sense and respond to force remains unknown. Herein, we establish that the mechanosensor Piezo1 is functionally expressed in cholinergic enteric neurons.'
#Immunology
www.cell.com/cell/abstrac...
#Immunology
www.cell.com/cell/abstrac...
The CDC has finally acknowledged that SARS-CoV-2 is not a typical “winter” respiratory virus, and COVID-19 is a threat that can surge throughout the year.
Source: www.cdc.gov/ncird/whats-...
Source: www.cdc.gov/ncird/whats-...
July 4, 2024 at 4:48 PM
The CDC has finally acknowledged that SARS-CoV-2 is not a typical “winter” respiratory virus, and COVID-19 is a threat that can surge throughout the year.
Source: www.cdc.gov/ncird/whats-...
Source: www.cdc.gov/ncird/whats-...
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
www.science.org
September 24, 2025 at 8:17 PM
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
More detailed functional interrogation of enteric neuron subpopulations www.cell.com/cell/abstrac...
Properties and functions of transcriptionally distinct enteric neurons
Developing genetic access to transcriptionally distinct enteric neurons in vivo enables
the examination of morphological heterogeneity across cell types as well as cell-type-specific
influences on GI ...
www.cell.com
November 26, 2025 at 11:15 AM
More detailed functional interrogation of enteric neuron subpopulations www.cell.com/cell/abstrac...
April 25, 2026 at 5:30 PM
There is a dashboard run by what's left of the CDC that can answer the question "what's going around?".
www.cdc.gov/nrevss/php/d...
www.cdc.gov/nrevss/php/d...
The National Respiratory and Enteric Virus Surveillance System (NREVSS)
NREVSS is a laboratory-based system that monitors respiratory and enteric virus activity.
www.cdc.gov
September 23, 2026 at 1:52 AM
There is a dashboard run by what's left of the CDC that can answer the question "what's going around?".
www.cdc.gov/nrevss/php/d...
www.cdc.gov/nrevss/php/d...
As my blatant tour of self-promotion continues.. macrophages are so much more than just cells that eat things! Yet, even the eating can be very cool. Here, we showed that macrophages in gut shape the nervous system, and this makes 💩 happen correctly in adulthood: www.nature.com/articles/s41...
Dedicated macrophages organize and maintain the enteric nervous system - Nature
Resident macrophages of the muscularis externa refine the enteric nervous system (ENS) early in life by pruning synapses and phagocytosing enteric neurons, and later switch to a neuro-supportive funct...
www.nature.com
November 13, 2024 at 5:19 PM
As my blatant tour of self-promotion continues.. macrophages are so much more than just cells that eat things! Yet, even the eating can be very cool. Here, we showed that macrophages in gut shape the nervous system, and this makes 💩 happen correctly in adulthood: www.nature.com/articles/s41...
Nature research paper: Nutrients activate distinct patterns of small-intestinal enteric neurons
go.nature.com/4lr616y
go.nature.com/4lr616y
Nutrients activate distinct patterns of small-intestinal enteric neurons - Nature
Calcium imaging of the mouse jejunum shows that specific nutrients in the intestinal lumen are detected by epithelial cells, which activate specific sets of enteric neurons through a serotonin-mediated signalling process.
go.nature.com
July 10, 2025 at 7:13 PM
Nature research paper: Nutrients activate distinct patterns of small-intestinal enteric neurons
go.nature.com/4lr616y
go.nature.com/4lr616y
'Using transcriptomic aging clocks, we measured biological age in Drosophila melanogaster infected with four enteric RNA viruses spanning a broad pathogenicity range (i.e., reduction of host lifespan). All pathogenic infections accelerated aging & the magnitude of acceleration tracked pathogenicity'
Enteric viral infections promote systemic accelerated aging in Drosophila
Enteric viruses act as age-distorters, with infection severity tied to aging hallmarks and consequences.
www.science.org
August 25, 2026 at 12:13 AM
'Using transcriptomic aging clocks, we measured biological age in Drosophila melanogaster infected with four enteric RNA viruses spanning a broad pathogenicity range (i.e., reduction of host lifespan). All pathogenic infections accelerated aging & the magnitude of acceleration tracked pathogenicity'
Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans
-in @currentbiology.bsky.social
www.cell.com/current-biol...
-in @currentbiology.bsky.social
www.cell.com/current-biol...
Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans
Estrem et al. show that bacterial polysaccharides, including peptidoglycans, activate
the enteric sensory neuron NSM to regulate feeding and locomotion in C. elegans, while
pathogen-derived metabolite...
www.cell.com
April 24, 2026 at 9:27 AM
Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans
-in @currentbiology.bsky.social
www.cell.com/current-biol...
-in @currentbiology.bsky.social
www.cell.com/current-biol...
Out Now! Prophage-encoding engineered bacteria enable prophylactic lytic phage therapy for enteric infection in mice #MicroSky
Prophage-encoding engineered bacteria enable prophylactic lytic phage therapy for enteric infection in mice
Nature Microbiology, Published online: 16 September 2026; doi:10.1038/s41564-026-02484-3An engineered non-pathogenic bacterium produces lytic phages and is protective in mouse models of Salmonella infection.
go.nature.com
September 16, 2026 at 1:09 PM
Out Now! Prophage-encoding engineered bacteria enable prophylactic lytic phage therapy for enteric infection in mice #MicroSky
The NREVSS dashboard is back up and running and includes data from the last 7 weeks when it was not updating. 🙌
www.cdc.gov/nrevss/php/d...
www.cdc.gov/nrevss/php/d...
The National Respiratory and Enteric Virus Surveillance System (NREVSS)
NREVSS is a laboratory-based system that monitors respiratory and enteric virus activity.
www.cdc.gov
November 15, 2025 at 3:52 PM
The NREVSS dashboard is back up and running and includes data from the last 7 weeks when it was not updating. 🙌
www.cdc.gov/nrevss/php/d...
www.cdc.gov/nrevss/php/d...
A lot of claims are being made about new technologies to reduce enteric methane emissions from cattle and sheep. Some of the leading researchers in the field compiled a set of recommendations for testing enteric methane-mitigating feed additives in ruminant studies.
Feed additives for methane mitigation: Recommendations for testing enteric methane-mitigating feed additives in ruminant studies
The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes.
www.journalofdairyscience.org
December 29, 2024 at 8:50 PM
A lot of claims are being made about new technologies to reduce enteric methane emissions from cattle and sheep. Some of the leading researchers in the field compiled a set of recommendations for testing enteric methane-mitigating feed additives in ruminant studies.