Excitation enables neuronal function; however, overexcitation and calcium overload can be deadly. This study reveals a cellular resilience program in which reduced expression of electron transport cha...

It is clear that ketamine at a sufficient dose & frequency can and does kill neurons through NMDA-driven excitotoxicity. However, what does a sufficient dose & frequency mean? There is a common myth t...

Scientific Reports - L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

It is clear that ketamine at a sufficient dose & frequency can and does kill neurons through NMDA-driven excitotoxicity. However, what does a sufficient dose & frequency mean? There is a common myth t...

Excitotoxicity and altered RNA regulation by RNA-binding proteins (RBPs) are two prevalent hallmarks in multiple neurodegenerative disorders. However,…

Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the central and peripheral nervous systems. Other than the previousl...

Nature Reviews Immunology, Published online: 27 August 2026; doi:10.1038/s41577-026-01348-5Excessive glutamate receptor signalling contributes to central nervous system pathology in different neurological settings, including in epilepsy, Parkinson disease and multiple sclerosis. Here, the authors discuss the need to integrate the immune system along with glutamate-centric mechanisms as a core driver of excitotoxic pathology. They suggest that this concept of ‘immune-mediated excitotoxicity’ can help us develop better therapeutic interventions for various neurological conditions.

Excitation enables neuronal function; however, overexcitation and calcium overload can be deadly. This study reveals a cellular resilience program in which reduced expression of electron transport chain components protects against excitotoxic death, as seen in pain-sensing primary afferent neurons (nociceptors).