Sex Differences in #FFR Guided PCI vs. CABG in FAME 3 Trial
#CardioSky #MedSky
@accintouch.bsky.social @jaccjournals.bsky.social @mmamas1973.bsky.social
www.acc.org/Latest-in-Ca...
#CardioSky #MedSky
@accintouch.bsky.social @jaccjournals.bsky.social @mmamas1973.bsky.social
www.acc.org/Latest-in-Ca...
December 6, 2024 at 2:32 AM
Sex Differences in #FFR Guided PCI vs. CABG in FAME 3 Trial
#CardioSky #MedSky
@accintouch.bsky.social @jaccjournals.bsky.social @mmamas1973.bsky.social
www.acc.org/Latest-in-Ca...
#CardioSky #MedSky
@accintouch.bsky.social @jaccjournals.bsky.social @mmamas1973.bsky.social
www.acc.org/Latest-in-Ca...
New issue ONLINE!
✅ FFR-guided PCI of non-culprit lesions in NSTE-ACS;
✅ Radial wall strain and residual risk after PCI;
✅ Sex-based differences in antiplatelet therapy;
✅ Cardiogenic shock phenotyping after OHCA;
and more 👇
eurointervention.pcronline.com/issue/volume...
✅ FFR-guided PCI of non-culprit lesions in NSTE-ACS;
✅ Radial wall strain and residual risk after PCI;
✅ Sex-based differences in antiplatelet therapy;
✅ Cardiogenic shock phenotyping after OHCA;
and more 👇
eurointervention.pcronline.com/issue/volume...
September 25, 2026 at 3:34 PM
New issue ONLINE!
✅ FFR-guided PCI of non-culprit lesions in NSTE-ACS;
✅ Radial wall strain and residual risk after PCI;
✅ Sex-based differences in antiplatelet therapy;
✅ Cardiogenic shock phenotyping after OHCA;
and more 👇
eurointervention.pcronline.com/issue/volume...
✅ FFR-guided PCI of non-culprit lesions in NSTE-ACS;
✅ Radial wall strain and residual risk after PCI;
✅ Sex-based differences in antiplatelet therapy;
✅ Cardiogenic shock phenotyping after OHCA;
and more 👇
eurointervention.pcronline.com/issue/volume...
Now available at @jaccjournals.bsky.social: CT-guided bifurcation PCI: role of FFR-CT virtual PCI and myocardial mass for pre-procedural planning bit.ly/40xI5Gw by
Dr. Pedro Carvalho CCAD at MHIF #CT4PCI
January 15, 2025 at 9:27 PM
Now available at @jaccjournals.bsky.social: CT-guided bifurcation PCI: role of FFR-CT virtual PCI and myocardial mass for pre-procedural planning bit.ly/40xI5Gw by
Dr. Pedro Carvalho CCAD at MHIF #CT4PCI
Among patients with NSTEMI and multivessel disease, FFR-guided complete revascularization reduced the risk of death, nonfatal myocardial infarction, revascularization, and stroke at 1 year vs culprit-only revascularization.
ja.ma/43oKPqR
ja.ma/43oKPqR
November 11, 2025 at 4:15 PM
Among patients with NSTEMI and multivessel disease, FFR-guided complete revascularization reduced the risk of death, nonfatal myocardial infarction, revascularization, and stroke at 1 year vs culprit-only revascularization.
ja.ma/43oKPqR
ja.ma/43oKPqR
FAVOR III Europe subanalysis showed QFR-guided deferral leads to higher 1-year MACE vs. FFR. QFR may be less safe for intermediate coronary stenosis, with further studies needed to assess a hybrid QFR-FFR approach. #Cardiology #PCI #FFR #QFR #EAPCI
ow.ly/SHLH50UUQGi
ow.ly/SHLH50UUQGi
February 12, 2025 at 3:20 PM
FAVOR III Europe subanalysis showed QFR-guided deferral leads to higher 1-year MACE vs. FFR. QFR may be less safe for intermediate coronary stenosis, with further studies needed to assess a hybrid QFR-FFR approach. #Cardiology #PCI #FFR #QFR #EAPCI
ow.ly/SHLH50UUQGi
ow.ly/SHLH50UUQGi
Among patients with intermediate coronary lesions, angiography-guided revascularization was noninferior to pressure-wire–based guidance with respect to death, myocardial infarction, or revascularization. Full FAST III trial results and Research Summary: https://nej.md/41rkAyp
July 6, 2026 at 4:00 PM
Among patients with intermediate coronary lesions, angiography-guided revascularization was noninferior to pressure-wire–based guidance with respect to death, myocardial infarction, or revascularization. Full FAST III trial results and Research Summary: https://nej.md/41rkAyp
FFR-guided PCI slashes long-term risks in stable CAD, outperforming medical therapy by reducing urgent revascularizations significantly.
by Collet C, Mahendiran T (...) Jüni P et 27 al. in Nat Med #MedSky
👉 get more here
📖 read the article:
by Collet C, Mahendiran T (...) Jüni P et 27 al. in Nat Med #MedSky
👉 get more here
📖 read the article:
Fractional flow reserve-guided percutaneous coronary intervention versus medical therapy for stable coronary artery disease: long-term results of the FAME 2 trial - Nature Medicine
In a long-term follow-up of the FAME 2 trial, fractional flow reserve-guided percutaneous coronary intervention plus medical therapy in patients with stable coronary artery disease reduced cardiovascular events compared to medical therapy alone, primarily due to a decrease in urgent revascularization events.
www.nature.com
January 24, 2026 at 8:41 AM
FFR-guided #PCI using zotarolimus DES provides significantly better long-term value than CABG for treatment of patients with multivessel CAD, with equivalent clinical outcomes at substantially lower cost. https://bit.ly/47vJgJS
#TCT2025 #JACC #cvCABG #cvCAD #CardioSky
#TCT2025 #JACC #cvCABG #cvCAD #CardioSky
October 25, 2025 at 3:20 PM
FFR-guided #PCI using zotarolimus DES provides significantly better long-term value than CABG for treatment of patients with multivessel CAD, with equivalent clinical outcomes at substantially lower cost. https://bit.ly/47vJgJS
#TCT2025 #JACC #cvCABG #cvCAD #CardioSky
#TCT2025 #JACC #cvCABG #cvCAD #CardioSky
Fractional flow reserve-guided renal artery stenting in atherosclerotic renovascular hypertension: the FAIR randomized trial by Drs. Li, Li et al.
academic.oup.com/eurheartj/ar...
BP and antihypertensive medication usage decreased significantly after stenting in patients with FFR < 0.80
academic.oup.com/eurheartj/ar...
BP and antihypertensive medication usage decreased significantly after stenting in patients with FFR < 0.80
October 16, 2025 at 6:48 PM
Fractional flow reserve-guided renal artery stenting in atherosclerotic renovascular hypertension: the FAIR randomized trial by Drs. Li, Li et al.
academic.oup.com/eurheartj/ar...
BP and antihypertensive medication usage decreased significantly after stenting in patients with FFR < 0.80
academic.oup.com/eurheartj/ar...
BP and antihypertensive medication usage decreased significantly after stenting in patients with FFR < 0.80
#EuroPCR #JACC LBCT: #FFR-guided complete #revascularization reduced future and repeated events compared with infarct-related artery only after 10 years. The risk was mainly driven by revasc, with no reduction in MIs or death. www.jacc.org/doi/10.1016/... #cvMI #revasc
10-Year Outcome of Complete or Infarct–Artery-Only Revascularization in STEMI with Multivessel Disease (DANAMI-3-PRIMULTI):
www.jacc.org
May 20, 2025 at 6:34 PM
#EuroPCR #JACC LBCT: #FFR-guided complete #revascularization reduced future and repeated events compared with infarct-related artery only after 10 years. The risk was mainly driven by revasc, with no reduction in MIs or death. www.jacc.org/doi/10.1016/... #cvMI #revasc
Deferred Revascularization Safer When Guided by FFR vs QFR: FAVOR III Europe
Deferred Revascularization Safer When Guided by FFR vs QFR: FAVOR III Europe
Deferred Revascularization Safer When Guided by FFR vs QFR: FAVOR III Europe
sciprian@crf.org
Thu, 01/09/2025 - 14:07
Caitlin E. Cox
The subanalysis points to the possibility that it’s not just false positives—but false negatives—driving MACE…
www.tctmd.com
January 9, 2025 at 7:23 PM
Deferred Revascularization Safer When Guided by FFR vs QFR: FAVOR III Europe
William Fearon and C. Michael Gibson break down the final 5-year follow-up of the study comparing FFR-guided PCI vs CABG for patients with three-vessel CAD. Listen to the full discussion: www.tctmd.com/audio/fame-3...
September 16, 2026 at 7:29 PM
William Fearon and C. Michael Gibson break down the final 5-year follow-up of the study comparing FFR-guided PCI vs CABG for patients with three-vessel CAD. Listen to the full discussion: www.tctmd.com/audio/fame-3...
FFR-guided PCI plus TAVI showed superior outcomes compared to surgical options for severe aortic stenosis and complex coronary disease.
by Kedhi E, Hermanides RS (...) Modine T et 25 al. in Lancet #MedSky
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0140673624021007
by Kedhi E, Hermanides RS (...) Modine T et 25 al. in Lancet #MedSky
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0140673624021007
December 13, 2024 at 8:31 PM
FFR-guided PCI plus TAVI showed superior outcomes compared to surgical options for severe aortic stenosis and complex coronary disease.
by Kedhi E, Hermanides RS (...) Modine T et 25 al. in Lancet #MedSky
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0140673624021007
by Kedhi E, Hermanides RS (...) Modine T et 25 al. in Lancet #MedSky
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0140673624021007
FAST III: For patients with intermediate coronary lesions, whether outcomes of percutaneous revascularization guided by angiography-derived FFR are comparable to those guided by pressure-wire–derived FFR is unknown. Research findings are summarized in a new Quick Take video. https://nej.md/4y5W8Sv
July 3, 2026 at 7:00 PM
FAST III: For patients with intermediate coronary lesions, whether outcomes of percutaneous revascularization guided by angiography-derived FFR are comparable to those guided by pressure-wire–derived FFR is unknown. Research findings are summarized in a new Quick Take video. https://nej.md/4y5W8Sv
FLAVOUR trial post hoc analysis:
FFR-guided PCI resulted in fewer interventions than IVUS for intermediate coronary stenosis with low lesion complexity, without impacting MACE or TVF rates, regardless of diabetes status. #Cardiology #PCI #FFR
shorturl.at/OOCPk
FFR-guided PCI resulted in fewer interventions than IVUS for intermediate coronary stenosis with low lesion complexity, without impacting MACE or TVF rates, regardless of diabetes status. #Cardiology #PCI #FFR
shorturl.at/OOCPk
February 6, 2025 at 1:45 PM
FLAVOUR trial post hoc analysis:
FFR-guided PCI resulted in fewer interventions than IVUS for intermediate coronary stenosis with low lesion complexity, without impacting MACE or TVF rates, regardless of diabetes status. #Cardiology #PCI #FFR
shorturl.at/OOCPk
FFR-guided PCI resulted in fewer interventions than IVUS for intermediate coronary stenosis with low lesion complexity, without impacting MACE or TVF rates, regardless of diabetes status. #Cardiology #PCI #FFR
shorturl.at/OOCPk
🚨 TCW Trial: TAVI + FFR-guided PCI outperforms SAVR + CABG in severe aortic stenosis + complex CAD!
Lower mortality (0% vs. 10%) & major bleeding (2% vs. 12%) at 1 year. A safer, less invasive alternative?
#MedEd #CardioEd
youtu.be/18akIlaz7S8?... via @accintouch.bsky.social
Lower mortality (0% vs. 10%) & major bleeding (2% vs. 12%) at 1 year. A safer, less invasive alternative?
#MedEd #CardioEd
youtu.be/18akIlaz7S8?... via @accintouch.bsky.social
Transcatheter Aortic Valve Implantation (TAVI) and FFR-Guided PCI vs. Surgical AVR and CABG in...
YouTube video by The Support Team MasterMedFacts
youtu.be
February 11, 2025 at 4:20 PM
🚨 TCW Trial: TAVI + FFR-guided PCI outperforms SAVR + CABG in severe aortic stenosis + complex CAD!
Lower mortality (0% vs. 10%) & major bleeding (2% vs. 12%) at 1 year. A safer, less invasive alternative?
#MedEd #CardioEd
youtu.be/18akIlaz7S8?... via @accintouch.bsky.social
Lower mortality (0% vs. 10%) & major bleeding (2% vs. 12%) at 1 year. A safer, less invasive alternative?
#MedEd #CardioEd
youtu.be/18akIlaz7S8?... via @accintouch.bsky.social
@jama.com: Among patients w/ NSTEMI and multivessel disease, FFR-guided complete revascularization reduced risk of death, nonfatal myocardial infarction, revascularization, and stroke at 1 year compared with culprit-only revascularization.
#ESCCongress #WCCardio
ja.ma/3VqoBQB
#ESCCongress #WCCardio
ja.ma/3VqoBQB
August 31, 2025 at 3:45 PM
@jama.com: Among patients w/ NSTEMI and multivessel disease, FFR-guided complete revascularization reduced risk of death, nonfatal myocardial infarction, revascularization, and stroke at 1 year compared with culprit-only revascularization.
#ESCCongress #WCCardio
ja.ma/3VqoBQB
#ESCCongress #WCCardio
ja.ma/3VqoBQB
The FAME 3 Trial
The FAME 3 Trial
The FAME 3 Trial
mosbey@crf.org
Wed, 09/16/2026 - 08:56
36 minutes 44 seconds hence
William Fearon and C. Michael Gibson break down the final 5-year follow-up of the study comparing FFR-guided PCI vs CABG for patients with three-vessel CAD.
www.tctmd.com
September 16, 2026 at 1:04 PM
The FAME 3 Trial
Just published in The Lancet: in the TCW randomized trial, TAVR plus FFR-guided PCR proved better than SAVR plus CABG in patients with severe aortic stenosis and concomitant multivessel CAD www.thelancet.com/journals/lan... #TAVR
December 11, 2024 at 9:52 AM
Just published in The Lancet: in the TCW randomized trial, TAVR plus FFR-guided PCR proved better than SAVR plus CABG in patients with severe aortic stenosis and concomitant multivessel CAD www.thelancet.com/journals/lan... #TAVR
NEW ISSUE OUT
➡️ A state-of-the-art on mechanical circulatory support for high-risk PCI
➡️ Safety data of revascularisation deferral by QFR vs FFR from the FAVOR III EU trial
➡️ Outcomes of intravascular imaging-guided PCI based on lesion complexity
eurointervention.pcronline.com/issue/volume...
➡️ A state-of-the-art on mechanical circulatory support for high-risk PCI
➡️ Safety data of revascularisation deferral by QFR vs FFR from the FAVOR III EU trial
➡️ Outcomes of intravascular imaging-guided PCI based on lesion complexity
eurointervention.pcronline.com/issue/volume...
February 3, 2025 at 11:51 AM
NEW ISSUE OUT
➡️ A state-of-the-art on mechanical circulatory support for high-risk PCI
➡️ Safety data of revascularisation deferral by QFR vs FFR from the FAVOR III EU trial
➡️ Outcomes of intravascular imaging-guided PCI based on lesion complexity
eurointervention.pcronline.com/issue/volume...
➡️ A state-of-the-art on mechanical circulatory support for high-risk PCI
➡️ Safety data of revascularisation deferral by QFR vs FFR from the FAVOR III EU trial
➡️ Outcomes of intravascular imaging-guided PCI based on lesion complexity
eurointervention.pcronline.com/issue/volume...
3 ways FFR-guided diagnosis is changing cardiology: (1) Reduces unnecessary coronary interventions by 20–30% (2) Improves diagnostic accuracy in intermediate lesions (…
https://news.gmj.ge/briefs/takeaway-functional-testing-reshapes-coronary-artery-disease-diagnosis-what-cardiologists-need-to-know/
https://news.gmj.ge/briefs/takeaway-functional-testing-reshapes-coronary-artery-disease-diagnosis-what-cardiologists-need-to-know/
Takeaway: Functional Testing Reshapes Coronary Artery Disease Diagnosis: What Cardiologists Need to Know
3 ways FFR-guided diagnosis is changing cardiology: (1) Reduces unnecessary coronary interventions by 20–30% (2) Improves diagnostic accuracy in intermediate lesions (…
news.gmj.ge
September 19, 2026 at 7:30 AM
3 ways FFR-guided diagnosis is changing cardiology: (1) Reduces unnecessary coronary interventions by 20–30% (2) Improves diagnostic accuracy in intermediate lesions (…
https://news.gmj.ge/briefs/takeaway-functional-testing-reshapes-coronary-artery-disease-diagnosis-what-cardiologists-need-to-know/
https://news.gmj.ge/briefs/takeaway-functional-testing-reshapes-coronary-artery-disease-diagnosis-what-cardiologists-need-to-know/
Among patients with NSTEMI and multivessel disease, FFR-guided complete revascularization reduced the risk of death, nonfatal myocardial infarction, revascularization, and stroke at 1 year vs culprit-only revascularization.
#ESCCongress #WCCardio
ja.ma/4g53c9g
#ESCCongress #WCCardio
ja.ma/4g53c9g
August 31, 2025 at 3:45 PM
Among patients with NSTEMI and multivessel disease, FFR-guided complete revascularization reduced the risk of death, nonfatal myocardial infarction, revascularization, and stroke at 1 year vs culprit-only revascularization.
#ESCCongress #WCCardio
ja.ma/4g53c9g
#ESCCongress #WCCardio
ja.ma/4g53c9g
Clinical and economic impact of FFR-CT–guided management in moderate coronary artery disease: an interventional simulation study #recintervcardiol https://ow.ly/Y5vj50ZA71J
September 2, 2026 at 7:00 PM
Clinical and economic impact of FFR-CT–guided management in moderate coronary artery disease: an interventional simulation study #recintervcardiol https://ow.ly/Y5vj50ZA71J
【非責任領域FFR>0.8でPCIを見送ったSTEMI例の長期CV転帰は？/Int J Caridol】Aug.01
STEMIに対しFFRガイドPCI施行の280例、10.5年観察——
・非責任領域「FRR≦0.80」か「CAD狭窄≧90%」でPCIを「施行」
した群では、「FFR＞0.8」でPCR「見送り」群よりも「死亡・
MI・緊急血行再建」リスクが有意に低 [補正後HR 0.64]。発生率
は36 vs. 47%。
・PCI「見送り」群では「施行」群に比べ「CV死亡リスク」も有
意に高。
抄録🔗. x.gd/ZbHCH
STEMIに対しFFRガイドPCI施行の280例、10.5年観察——
・非責任領域「FRR≦0.80」か「CAD狭窄≧90%」でPCIを「施行」
した群では、「FFR＞0.8」でPCR「見送り」群よりも「死亡・
MI・緊急血行再建」リスクが有意に低 [補正後HR 0.64]。発生率
は36 vs. 47%。
・PCI「見送り」群では「施行」群に比べ「CV死亡リスク」も有
意に高。
抄録🔗. x.gd/ZbHCH
10-year outcome of fractional flow reserve-guided complete revascularization in patients with ST-segment elevation myocardial infarction – A DANAMI-3 PRIMULTI substudy
Complete revascularization is recommended in patients with ST-segment elevation myocardial
infarction (STEMI) and multivessel disease. However, whether the non-culprit lesions
should be evaluated usin...
x.gd
August 3, 2026 at 1:21 AM
【非責任領域FFR>0.8でPCIを見送ったSTEMI例の長期CV転帰は？/Int J Caridol】Aug.01
STEMIに対しFFRガイドPCI施行の280例、10.5年観察——
・非責任領域「FRR≦0.80」か「CAD狭窄≧90%」でPCIを「施行」
した群では、「FFR＞0.8」でPCR「見送り」群よりも「死亡・
MI・緊急血行再建」リスクが有意に低 [補正後HR 0.64]。発生率
は36 vs. 47%。
・PCI「見送り」群では「施行」群に比べ「CV死亡リスク」も有
意に高。
抄録🔗. x.gd/ZbHCH
STEMIに対しFFRガイドPCI施行の280例、10.5年観察——
・非責任領域「FRR≦0.80」か「CAD狭窄≧90%」でPCIを「施行」
した群では、「FFR＞0.8」でPCR「見送り」群よりも「死亡・
MI・緊急血行再建」リスクが有意に低 [補正後HR 0.64]。発生率
は36 vs. 47%。
・PCI「見送り」群では「施行」群に比べ「CV死亡リスク」も有
意に高。
抄録🔗. x.gd/ZbHCH
'Women had similar outcomes after FFR-guided #PCI compared to #CABG.
Men had better outcomes with CABG compared with PCI, although the interaction term didnt show statistical signficnce.
For PCI, women had a similar risk of #MACCE at 3 yrs compared 2 men' #MACE #cardiosky
www.acc.org/Latest-in-Ca...
Men had better outcomes with CABG compared with PCI, although the interaction term didnt show statistical signficnce.
For PCI, women had a similar risk of #MACCE at 3 yrs compared 2 men' #MACE #cardiosky
www.acc.org/Latest-in-Ca...
Sex Differences in FFR-Guided PCI vs. CABG in the FAME 3 Trial - American College of Cardiology
Elizabeth A. Jackson, MD, FACC
www.acc.org
December 6, 2024 at 2:17 PM
'Women had similar outcomes after FFR-guided #PCI compared to #CABG.
Men had better outcomes with CABG compared with PCI, although the interaction term didnt show statistical signficnce.
For PCI, women had a similar risk of #MACCE at 3 yrs compared 2 men' #MACE #cardiosky
www.acc.org/Latest-in-Ca...
Men had better outcomes with CABG compared with PCI, although the interaction term didnt show statistical signficnce.
For PCI, women had a similar risk of #MACCE at 3 yrs compared 2 men' #MACE #cardiosky
www.acc.org/Latest-in-Ca...