#FGFR1
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toriherridge.bsky.social
[though as an aside, honestly Colossal missed a trick not going for the Fgfr1/2 double mutant -- I mean, have you seen a more mammothy-mouse?!]

*MAMMOUSE KLAXON*

www.nature.com/articles/s41...
a wild-type short haired mouse next to a Fgfr1/2 double mutant mouse, which has long luxuriant fur
March 5, 2025 at 12:20 AM
dev-journal.bsky.social
Issue 3 is complete!

On the cover: Immunofluorescence staining of phosphorylated FGFR1 (magenta), TBXT (yellow) and β-catenin (cyan) in 2D human gastruloids.

See the Research Article by Idse Heemskerk and colleagues (@heemskerklab.bsky.social) here: doi.org/10.1242/dev....
Cover: Immunofluorescence staining of phosphorylated FGFR1 (magenta), TBXT (yellow) and β-catenin (cyan) in 2D human gastruloids. The spatial pattern of phosphorylated FGFR1 matches ERK activity observed during primitive streak-like differentiation. See Research Article by Jo, Liu et al. (dev205459).
February 20, 2026 at 1:04 PM
natcomms.nature.com
The brain microenvironment modulates FGFR1 activity in a host age-dependent manner to promote estrogen receptor-positive #breastcancer #brainmetastases @cittellylab.bsky.social @morgan-fox.bsky.social @cucancerbio.bsky.social @cucancercenter.bsky.social doi.org/10.1038/s414...
Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases - Nature Communications
FGFR1 amplifications are associated with risk of late recurrence for estrogen receptor-positive breast cancer. Here, the authors show that the brain microenvironment modulates FGFR1 activity in a host...
doi.org
June 5, 2026 at 11:09 AM
mariagoobs.bsky.social
In honor of upcoming Valentine’s Day here is a classic example of rosette-forming glioneuronal tumor. These grade 1 tumors typically show a hotspot mutation in FGFR1 along with PIK3R1 or PIK3CA alterations and are usually found in the fourth ventricle 🌹 ♥️ 🥀 🧠 🔬 #pathsky #neuropath #medsky
February 11, 2025 at 9:35 PM
57kev.bsky.social
HEALTH NEWS 💉
Oral Drug Highly Active in Rare Blood Cancers With FGFR1 Rearrangements (MedPage Today)
Most patients with myeloid/lymphoid neoplasms with FGFR1 rearrangements receiving pemigatinib (Pemazyre) experienced complete responses in the phase II FIGHT...
l.smartnews.com
August 27, 2025 at 4:59 AM
taraska.bsky.social
It’s incredibly exciting when a completely different approach supports an unexpected finding from your group. Recently, we published that LDLR is captured with EGFR and FGFR1 at clathrin sites after EGF stimulation. I love science.

www.molbiolcell.org/doi/full/10....

bsky.app/profile/scie...
December 13, 2024 at 6:21 PM
megeblad.bsky.social
Graduate student Morgan Fox gave a very nice talk on how the non-canonical activation of FGFR1 drives brain metastasis of ER+ breast cancer in aged mice (or “non-young” as Devon Lawson diplomatically put it for those of us over 40!)

KSMetastasis25
January 21, 2025 at 1:30 AM
haoyin.bsky.social
#SpatialTranscriptomics #ParkinsonsDisease

A role of #FGF9 in Glia #Ferroptosis in PD?😁

+snRNAseq
MPTP🐭 #SubstantiaNigra

FGF9 ⏬in PD Neuron ⏫in PD Ependymal cell

FGF9-to-FGFR1/2/3 (CellChat, likely Neuron-to-Oligodendrocyte/Astrocyte) ⏬in PD

#NPJParkinsonsDis 2025
www.nature.com/articles/s41...
July 2, 2025 at 12:08 PM
katesears.bsky.social
💡 #MWClinicalTips
FGFR1-amplified colorectal cancer: a distinct prognostic subtype

✅ Large-scale profiling (n=7606) → FGFR1 amplification = predominant FGFR alteration in CRC (≈4%).
✨ Independent marker of poor prognosis: ↓DFS (HR 2.91) & ↓PFS (HR 2.52).
September 3, 2025 at 5:47 PM
biorxiv-cancer.bsky.social
Multiple FGFR1 mutations modulate tumorigenic mechanisms in glioneuronal tumors. https://www.biorxiv.org/content/10.1101/2025.05.27.654799v1
May 29, 2025 at 3:52 AM
medicine.stitches.today
Targeting mutant FGFR1 in high-risk neuroblastoma could reverse treatment failures, offering hope through FGFR-directed therapies in resistant cases.

by Werr L, Boland J (...) Fischer M et 44 al. in J Clin Invest #MedSky

👉 get more here

📖 read the article: https://www.jci.org/articles/view/189152
February 21, 2026 at 2:47 AM
haoyin.bsky.social
#SpatialTranscriptomics
Comprehensive mapping of Oral Squamous Cell Carcinoma tumor progression over a 23-wk time course of🐭+4-NQO

cellSpat➡️ spatially co-localized L-R pairs
pypi.org/project/cell...
Sema4a-Plxnb2
Fgf7-Fgfr1
App-Cd74

@jalees.bsky.social bioRxiv 2025
www.biorxiv.org/content/10.1...
January 21, 2026 at 9:11 PM
salzmoritz.eurosky.social
The most commonly known genes involved are ANOS1 (formerly KAL1) and FGFR1.
Other frequently implicated genes include FGF8, PROK2, PROKR2, and CHD7.
November 13, 2025 at 9:58 PM
shihcheng.bsky.social
Oral infigratinib, a FGFR1-3 inhibitor, shows promise in improving growth in children aged 3-11 with achondroplasia. Phase 2: 72 kids. #GrowthBreakthrough PMID:39555818, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2411790 #Medsky 🧪
https://doi.org/10.1056/NEJMoa2411790
No description available
doi.org
March 10, 2025 at 11:10 AM
nscbraindamage.bsky.social
Thrilled to start new collaborative project between
@idibell.bsky.social and @idibaps.bsky.social, funded by Lindonlight Collective! 🚀
We will develop human stem cell-based models to investigate FGFR1 mutations in pediatric low-grade gliomas using CRISPR and brain organoids. 🧠🧬
lnkd.in/p/ek8vz4_X
July 29, 2026 at 8:42 AM
sciencex.bsky.social
Altered FGFR1 signaling in the hippocampus may contribute to depression, particularly in the elderly, with increased Numb protein expression blocking antidepressant effects in aged brains. doi.org/g9zfpw
Altered FGFR1 pathway in hippocampus may underlie depression, especially in elderly
Major depressive disorder (MDD) is one of the most common psychiatric illnesses worldwide, but its molecular causes have still not been clearly identified.
medicalxpress.com
August 26, 2025 at 8:29 AM
adameykolab.bsky.social
(16) Some perturbed clones showed completely novel behavior (in the case of Ptch1 knock-out) or distortion of already existing clonal programs (Fgfr1, Fzd2, and other knock-outs) — it wasn't possible to distinguish these cases without clonal information.
November 25, 2024 at 10:47 PM
edonato.bsky.social
Let's start the 2025 with a blast 🎇. Out today on @naturecancer.bsky.social Würth et al., on HER3/NRG1 and FGFR1 compensatory mechanism in CTCs and how to hijack that for long term in vitro culture.
#CTC #breastcancer #liquidbiopsies #NGS #personalizedmedicine @dkfz.bsky.social #HISTEM
rdcu.be/d5pGe
Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling
Nature Cancer - Trumpp and colleagues develop a method to obtain long-term circulating tumor cell-derived organoids from individuals with metastatic breast cancer and identify the neuregulin...
rdcu.be
January 3, 2025 at 6:49 PM
onco404.bsky.social
The phase II FIGHT-202 trial’s final results reveal pemigatinib, a selective FGFR1-3 inhibitor, shows 37% ORR in patients with advanced/metastatic #CCA harboring #FGFR2 fusions/rearrangements (cohort A) 🌟

@myesmo.bsky.social #esmoopen

#Onco404 #Cancer #Kanser #Cholangiocarcinoma #Pemigatinib
May 8, 2025 at 5:49 PM
katesears.bsky.social
💡 Clinical Tip: FGFR1 amplification defines a high-risk CRC subset. IRS-based IHC scoring may serve as practical biomarker to identify candidates for novel FGFR1-targeted strategies.

#ColorectalCancer #FGFR1 #Biomarkers #PrecisionOncology #OncoTwitter #Medicalwatch
www.esmoopen.com/article/S205...
FGFR1-amplified colorectal cancer: a distinct prognostic subtype identified through integrated genomic and immunohistochemical profiling
Fibroblast growth factor receptor (FGFR) alterations are established therapeutic targets in cholangiocarcinoma and urothelial carcinoma but remain understudied in colorectal cancer (CRC). This study i...
www.esmoopen.com
September 3, 2025 at 5:47 PM
genesdev.bsky.social
Clark and Soriano describe the developmental defects arising from FGFR1 signaling deficiencies and reveal a non-canonical mechanism for FGFR1 in regulating early mesoderm development.

Learn more here:
➡️ tinyurl.com/gd351593
July 9, 2024 at 9:00 PM
nshahlab.bsky.social
We characterized the substate specificity of a common FGFR-family oncogenic mutant (K656E in FGFR1). This mutation alters specificity (not prev. known!), and we used this information to design a mutant-selective inhibitor.

Lots of neat stuff not shown in this short thread - read the paper for more!
Left: structural model of a peptide substrate bound to FGFR1, highlighting the proximity of K656 to the substrate. Right: mass spec data showing covalent labeling of FGFR1 K656E by a designer peptide, with little labeling of FGFR1 wild-type under the same conditions.
May 14, 2026 at 8:10 PM
onco404.bsky.social
The phase 2 FIGHT-207 basket trial evaluated pemigatinib, a selective oral FGFR1-3 inhibitor, in previously treated patients with advanced solid tumors harboring activating FGFR1-3 alterations.

@natureportfolio.nature.com

#Onco404 #MedSky #OncSky #Cancer #Kanser #ClinicalTrials #Oncology #FGFR
April 26, 2025 at 4:56 PM
haoyin.bsky.social
How 18 FGF ligands signal through 4 FGF receptors differentially?

Quantitative example on FGF4/8/9-FGFR1c in cultured HEK 293T, RCS chondrogenic cells

FRET➡️FGF8 binding creates a wider distance (60±1 Å) b/w FGFR1 dimer C-termini than FGF4/9 (55~56±1 Å)

#eLife 2024
elifesciences.org/articles/88144
April 9, 2024 at 7:23 PM
biorxiv-cancer.bsky.social
FGFR1 inhibition prevents metabolic adaptation associated with therapy resistance in glioblastoma https://www.biorxiv.org/content/10.1101/2025.01.11.632515v1
January 14, 2025 at 2:13 PM