Background Duchenne Muscular Dystrophy (DMD) is a progressive neuromuscular disorder characterized by impaired muscle repair. Forskolin (FSK), an adenylyl cyclase activator, has shown potential in enh...

Researchers from the University of Surrey say the compound could help fight an aggressive leukaemia.

Forskolin, a plant-derived compound, shows surprising potential against one of the most aggressive forms of leukemia. Researchers discovered that it not only stops cancer cells from growing but also m...

Hemispheric asymmetries in NMDAR-dependent synaptic plasticity have been described in hippocampal area CA1, but it remains unclear whether similar lateralized mechanisms exist for cyclic adenosine monophosphate (cAMP)-dependent plasticity. Here, we investigated whether cAMP-mediated potentiation of synaptic transmission in mouse CA1 exhibits hemisphere-specific properties. In recordings with electrical stimulation of CA1 inputs, a subset of recordings in the left, but not in the right hemisphere CA1, exhibited a pronounced cAMP-induced potentiation of field excitatory postsynaptic potentials (fEPSPs). To isolate input-specific contributions, we expressed the optogenetic actuator ChrimsonR unilaterally in the CA3/CA2 region of wild-type mice. Light-evoked glutamate release from ipsilateral Schaffer collaterals showed no cAMP sensitivity in either hemisphere, while commissures originating from the right (COR) exhibited cAMP-mediated potentiation of transmission in a subset of experiments. Notably, this effect was absent at commissures originating from the left (COL). The selective presence of the effect prompted us to further investigate the underlying cell population using CA3-specific (G32-4 Cre) and CA2-specific (Amigo2-Cre) driver lines. Recordings from synapses of CA3 COR recapitulated the cAMP-induced potentiation of transmitter release observed in wild-type animals. However, the effect was again restricted to a subset of experiments, did not correlate with the age or the sex of the mice, and was absent in recordings with specific stimulation of CA2 COR. Our results demonstrate a variable cAMP sensitivity of synaptic transmission at COR synapses in the left CA1. Altogether, we reveal a hemisphere-specific cAMP-mediated synaptic plasticity at CA3 COR onto CA1, underscoring hidden heterogeneity and lateralization in hippocampal circuit function.

Cytochrome B5s, or CytB5s, are small heme-binding proteins, ubiquitous across all kingdoms of life that serve mainly as electron donors to enzymes eng…

Read the full paper: Astrocyte targeted SMN1 gene therapy and forskolin application improves astrocyte filopodia actin defects and motor neuron synaptic dysfunction in human SMA disease pathology

Glioblastoma (GBM) is the deadliest brain cancer in adults, and all patients succumb to the tumor. While surgery followed by chemoradiotherapy dela...

Forskolin, a plant-derived compound, may offer a meaningful improvement in therapies for a highly aggressive leukemia known as KMT2A-rearranged Acute Myeloid Leukemia (KMT2A-r AML). Researchers at the University of Surrey report that this natural molecule could play a valuable role in enhancing patient outcomes. According to findings published in the British Journal of Pharmacology, forskolin not only slows the growth of leukemia cells but also increases how well chemotherapy drugs work. The Surrey team discovered that forskolin activates Protein Phosphatase 2A (PP2A) and reduces the activity of several cancer-linked genes (MYC, HOXA9 and HOXA10).