#Foxp3
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research-er.jp
【注目プレスリリース】制御性 T 細胞の安定性を支える Foxp3 エピゲノム制御機構を解明 ――TCR–mTORC1–TET 経路が Foxp3 発現の安定化を促進する―― / 東京大学
https://research-er.jp/articles/view/160373
制御性 T 細胞の安定性を支える Foxp3 エピゲノム制御機構を解明 ――TCR–mTORC1–TET 経路が Foxp3 発現の安定化を促進する――
2026.09.29 東京大学 プレスリリース 発表のポイント制御性 T 細胞(Treg)の分化と機能を司る転写因子 Foxp3 の発現を安定化するエピジェネティック制御機構を...
research-er.jp
September 29, 2026 at 2:00 AM
bigearthdata.ai
Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate
->Nature | More on "Regulatory T cell reprogramming mechanisms" at BigEarthData.ai
Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate
To investigate whether human Treg cells are susceptible to losing lineage identity, CD4+CD25+CD127lo/− fluorescence-activated cell sorting (FACS)-isolated primary human Treg cells (Extended Data Fig. 1a) were subjected to repeated cycles of in vitro CD3/CD28 stimulation in the presence or absence of proinflammatory cytokines (Fig. 1a). As a preliminary gauge of Treg cell identity, we focused on FOXP3 and HELIOS, a key pair of TFs with well-established, complementary roles in regulating Treg cell fitness and suppressive function13,14 (Extended Data Fig. 1b). As human conventional CD4+ T (Tconv) cells transiently express FOXP3 following T cell receptor (TCR) activation, expression profiles were evaluated 7 days into each stimulation cycle, after FOXP3 levels had mostly waned in non-Treg cells15. Previous studies on the impact of inflammatory cytokines on human Treg cell lineage stability have implicated a negative role of IL-1214,16, whereas the effects of IL-6 have been more controversial17,18,19,20. We thus started with unbiased comparisons of Th1-, Th2- and Th17-driving cytokines, singly and in combinations (Extended Data Fig. 1c). We found that the Th17-promoting combination of IL-6, IL-1β and IL-23 was the most consistent at inducing FOXP3 and HELIOS silencing (Extended Data Fig. 1c). The extent of Treg cell destabilization by this triple cytokine...
www.nature.com
September 21, 2026 at 8:22 PM
davidusharauli.bsky.social
This paper is a good example of the “if all you have is a hammer, everything looks like a nail” mindset. In an allograft setting,the authors observed that Tregs do not migrate to the graft unless Teff cells go there first, & they interpret this as something that needs to be fixed..

buff.ly/ViD5vvd
Regulatory CD4 T cells minimally migrate to inflamed allografts in the absence of effector T cell responses
CD4+Foxp3+ regulatory T cells (Treg) are essential for maintaining immune tolerance in both lymphoid and non-lymphoid tissues, including transplanted organs. Understanding the mechanisms that…
buff.ly
September 19, 2026 at 7:10 PM
allergy-eaaci.bsky.social
Tezepelumab Reverses TSLP-Driven Immunometabolic Rewiring in Human cDC2s Underlying Pathogenic Th2 and Dysfunctional Treg Responses. First author: Leticia Martín-Cruz; corresponding author: Oscar Palomares
🌟 doi.org/10.1111/all.70470
This study aimed to determine whether thymic stromal lymphopoietin (TSLP) induces a pathogenic immunometabolic program in human type 2 conventional dendritic cells (cDC2s) and whether tezepelumab can directly reverse this process. TSLP rewires human cDC2 metabolism by increasing both glycolysis and mitochondrial oxidative phosphorylation. This metabolic shift drives a pro-type 2 phenotype required to generate pathogenic Th2 cells and functionally impaired FOXP3+ Tregs. Tezepelumab effectively restores normal metabolic and functional properties in cDC2s, inhibiting Th2 polarization and rescuing Treg function. #Allergy_journal Read more articles published in #Allergy on basic and clinical immunology here: https://journalallergy.com/Basic-and-Translational
September 17, 2026 at 4:31 PM
scholarcast.bsky.social
Mechanical cues at the immunological synapse: Foxp3-driven cytoskeletal mechanics may stabilize synapses, advancing autoimmune/transplant/cancer therapy.
link.springer.com/article/10.1...
#Immunology #Treg #Foxp3
The long-lived immunological synapse: mechanical perspective of regulatory T cell-mediated peripheral immune tolerance - Acta Mechanica Sinica
The 2025 Nobel Prize in Physiology or Medicine honors the discovery of regulatory T cells (Tregs) and the Foxp3 gene as the key regulator of peripheral immune tolerance, preventing autoimmunity by sup...
link.springer.com
September 16, 2026 at 8:13 AM
ryanlab.bsky.social
📢 Last weeks #immunometabolism discoveries Biomed News mitoworld.org ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency–mediated disease
September 14, 2026 at 8:14 PM
labwaggoner.bsky.social
Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency–mediated disease @insight.jci.org @bostonchildrens.bsky.social
insight.jci.org/articles/vie...
September 11, 2026 at 4:32 PM
acr-journals.bsky.social
In posttraumatic osteoarthritis mouse models, synovial Foxp3+ Treg cells accumulated early after injury and acquired tissue-adapted features.

IL-2–mediated enrichment was associated with less synovitis & cartilage damage and partial preservation of load-bearing function

A&R
doi.org/10.1002/art....
Systemic IL-2/anti-IL-2 preferentially expands synovial Treg cells and improves gait and joint pathology in the DMM model. Day-49 H&E and Safranin O/Fast Green sections with synovitis scores (n = 7–9) and OARSI grades (n = 8–9). Arrows denote lining enlargement (green), stromal cellularity (orange), proteoglycan loss (yellow), reparative tissue (purple), mid-zone erosion (black), and superficial fibrillation (blue). Scale bars, 100 μm (H&E) and 200 μm (Safranin O/Fast Green).
September 8, 2026 at 11:47 AM
labwaggoner.bsky.social
Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity
www.nature.com/articles/s41...
Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity - Cellular & Molecular Immunology
Cellular & Molecular Immunology - Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity
www.nature.com
September 4, 2026 at 1:16 AM
vasculitides.bsky.social
Dissociated FoxP3 Up-regulation With Functional Surface Marker Loss Defines a Convergent Treg Paradox Across Immunological Archetypes of IgA Nephropathy and IgA Vasculitis
Dissociated FoxP3 Up-regulation With Functional Surface Marker Loss Defines a Convergent Treg Paradox Across Immunological Archetypes of IgA Nephropathy and IgA Vasculitis - PubMed
IgAN and IgAV are not uniform immunological entities. The Treg Paradox, a dissociation between regulatory commitment and functional capacity may represent a shared pathogenic feature across clinically diverse phenotypes, warranting further validation as a potential basis for immunotype-guided precis …
pubmed.ncbi.nlm.nih.gov
September 3, 2026 at 1:03 AM
davidusharauli.bsky.social
We need to look at the other plots as well. Here, Foxp3+ cells remain dominant, with no clear emergence of T-bet+ T cells. The Tregs are RORγt+ here (top plot), so a T-bet shift within the Treg population, as you suggested, seems unlikely.
September 1, 2026 at 3:37 PM
davidusharauli.bsky.social
7/ Even more interesting: these antigen-specific Tregs remained stable after DSS-induced inflammation or infection. Foxp3-negative cells emerged substantially only when IL-10 deficiency was combined with DSS.
August 31, 2026 at 10:50 PM
davidusharauli.bsky.social
6/ The current study's tetramer experiments showed a similar story: whether targeting a microbiota antigen or a corn antigen, antigen-specific cells were almost entirely Foxp3+.
August 31, 2026 at 10:50 PM
davidusharauli.bsky.social
5/ But is this really a new observation? Previous work already pointed in this direction. Mark Jenkins' lab found that gliadin-specific gut T cells were predominantly Foxp3+ Tregs, with essentially no conventional effector population.

pmc.ncbi.nlm.nih.gov/articles/PMC...
August 31, 2026 at 10:50 PM
prepub-neurodegen.bsky.social
Bioactive dietary polyphenols modulate hippocampal inflammasome activation and sex- specific affective behavioral deficits following peripheral Foxp3 + regulatory T cell depletion #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10425197/latest
August 25, 2026 at 1:02 AM
cerebrodigital.net
El Premio Nobel de Medicina 2025 reconoció el descubrimiento de la tolerancia periférica y el gen Foxp3, claves en enfermedades autoinmunes.

DOI: 10.1172/JCI202216

Te contamos más aquí:
cerebrodigital.net/premio-n...
August 21, 2026 at 6:00 PM
shrinelongevity.bsky.social
Common belief: air pollution mostly affects lungs. Truth? PM2.5 particles can speed up aging by triggering histone methyltransferase, hypermethylating genes like FOXP3 and CDKN2A. Yikes! Why

📄 Full article: https://longevityprotocol.substack.com/p/untitled-39d

#ShrineLongevity
August 20, 2026 at 4:31 PM
pulsercheck.bsky.social
Roinflammatory macrophage infiltration, enhanced FoxP3+ Treg recruitment and less profibrotic signaling are interesting, but "the AI told me" leaves zero traceability or audit trail, cant drive automated CAPAs or reviewability in teh QMS.
August 19, 2026 at 2:22 AM
plosbiology.org
miRNAs regulate CD4+ #Tcell differentiation, but how they shape #autoimmunity in vivo remains unclear. This study maps miRNAs in experimental autoimmune encephalomyelitis (EAE) and identifies miR-122-5p and miR-1247 as regulators of T cell pathogenicity.
🧪 #AcademicSky
plos.io/3Uqa9uA
miR-122-5p inhibition anticipates EAE onset, while miR-1247-5p upregulation limits EAE severity. Top: Experimental setup: triple Foxp3-hCD2.Ifng-YFP.Il17a-GFP reporter mice were immunized s.c. in both flanks with 100 µg of myelin oligodendrocyte glicoprotein (MOG)35-55 peptide emulsified in CFA solution (day 0). On the day of immunization and 2 days later, mice received a retro-orbital injection of 200 ng of pertussis toxin. At days 7, 9 and 11, mice received 5 µmol/kg of specific antagomiRs (retro-orbital injection). AntagomiR for cel-miR-67-3p was used as control. Bottom: Mice treated with control and miR-1247-5p antagomiRs were scored for EAE clinical signs and weighed daily for 28 days. Results are mean ± SD from 3 independent experiments (n = 10–11). *p < 0.05 and **p < 0.01 (two-way ANOVA followed by Sidak’s multiple comparisons test).
August 13, 2026 at 4:10 PM
msuskiewicz.eurosky.social
We are currently writing a review ourselves - on various filament-forming transcription factors, so it was nice to brush up on FOXP3 and AIRE through this review.
August 13, 2026 at 11:12 AM
msuskiewicz.eurosky.social
FOXP3's DNA-binding domain (FKH), together with its partly flexible extension called the RBR, multimerises in a strictly DNA-dependent manner, on TnG repeat DNA supports. Interestingly, depending on the type of repeat (T2G, T3G, T4G), the multimerisation modes are different, because...
August 13, 2026 at 11:01 AM
msuskiewicz.eurosky.social
Just finished reading this. A very interesting review summarising a series of recent studies, largely from the Sun Hur team, on two immunity-related transcription-related proteins, FOXP3 and AIRE, both of which homo-multimerise in interesting ways.
August 13, 2026 at 10:58 AM
plosbiology.org
miRNAs regulate CD4+ #Tcell differentiation, but how they shape #autoimmunity in vivo remains unclear. This study maps miRNAs in experimental autoimmune encephalomyelitis (EAE) and identifies miR-122-5p and miR-1247 as regulators of T cell pathogenicity.
🧪 #AcademicSky
plos.io/3Uqa9uA
miR-122-5p inhibition anticipates EAE onset, while miR-1247-5p upregulation limits EAE severity. Top: Experimental setup: triple Foxp3-hCD2.Ifng-YFP.Il17a-GFP reporter mice were immunized s.c. in both flanks with 100 µg of myelin oligodendrocyte glicoprotein (MOG)35-55 peptide emulsified in CFA solution (day 0). On the day of immunization and 2 days later, mice received a retro-orbital injection of 200 ng of pertussis toxin. At days 7, 9 and 11, mice received 5 µmol/kg of specific antagomiRs (retro-orbital injection). AntagomiR for cel-miR-67-3p was used as control. Bottom: Mice treated with control and miR-1247-5p antagomiRs were scored for EAE clinical signs and weighed daily for 28 days. Results are mean ± SD from 3 independent experiments (n = 10–11). *p < 0.05 and **p < 0.01 (two-way ANOVA followed by Sidak’s multiple comparisons test).
August 12, 2026 at 12:10 PM
labwaggoner.bsky.social
TIF1γ is a critical regulator of Treg cell stability that restrains β-catenin–TCF7 signaling, thereby preserving Foxp3 expression and preventing inflammatory reprogramming @natimmunol.nature.com
www.nature.com/articles/s41...
August 11, 2026 at 6:55 PM
l2plabs.bsky.social
TIF1γ regulates stability of regulatory T cells during inflammation
Nature Immunology, Published online: 11 August 2026; doi:10.1038/s41590-026-02603-6This study identifies TIF1γ as a critical regulator of regulatory T cell stability during inflammation. By restraining β-catenin–TCF7 signaling, TIF1γ preserves Foxp3 expression, prevents inflammatory reprogramming and maintains immune tolerance.
dlvr.it
August 11, 2026 at 10:00 AM