YOU KNOW WHAT TO DO
December 10, 2025 at 7:36 PM
YOU KNOW WHAT TO DO
I just find out that Friedel in Friedel-Crafts reaction is father of Friedel in Friedel's law. And mineral Friedelite is named after first Friedel.
www.mindat.org/min-1609.html
#crystallography #mineral
www.mindat.org/min-1609.html
#crystallography #mineral
Friedelite
May be regarded as a disordered equivalent of mcgillite (Ozawa et al., 1983).
Chemically very similar to pyrosmalite-(Mn) (trigonal).
The possible ...
www.mindat.org
September 2, 2025 at 6:58 PM
I just find out that Friedel in Friedel-Crafts reaction is father of Friedel in Friedel's law. And mineral Friedelite is named after first Friedel.
www.mindat.org/min-1609.html
#crystallography #mineral
www.mindat.org/min-1609.html
#crystallography #mineral
Now online:
Article by X Pu, Y Lu, Z Zhou, Y Yang, C Zhang, P Yu, Y S Zhao, J Lan & J You
Chirality retention in Friedel–Crafts spiroannulation for iterative synthesis of spiro-bridged conjugated carbocycles
www.nature.com/articles/s44... ($)
#ChemSky
Article by X Pu, Y Lu, Z Zhou, Y Yang, C Zhang, P Yu, Y S Zhao, J Lan & J You
Chirality retention in Friedel–Crafts spiroannulation for iterative synthesis of spiro-bridged conjugated carbocycles
www.nature.com/articles/s44... ($)
#ChemSky
Chirality retention in Friedel–Crafts spiroannulation for iterative synthesis of spiro-bridged conjugated carbocycles - Nature Synthesis
A strategy that preserves stereochemistry in intramolecular Friedel–Crafts alkylation is reported. An iterative synthetic approach to extend spiro-bridged molecular skeletons via C–H activation–annula...
www.nature.com
June 3, 2025 at 12:15 PM
Now online:
Article by X Pu, Y Lu, Z Zhou, Y Yang, C Zhang, P Yu, Y S Zhao, J Lan & J You
Chirality retention in Friedel–Crafts spiroannulation for iterative synthesis of spiro-bridged conjugated carbocycles
www.nature.com/articles/s44... ($)
#ChemSky
Article by X Pu, Y Lu, Z Zhou, Y Yang, C Zhang, P Yu, Y S Zhao, J Lan & J You
Chirality retention in Friedel–Crafts spiroannulation for iterative synthesis of spiro-bridged conjugated carbocycles
www.nature.com/articles/s44... ($)
#ChemSky
The Morgenstern group reports the detailed investigation of a Friedel-Crafts reaction on a Ag surface, to which Christoph contributed the starting material: onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
September 30, 2026 at 6:23 PM
The Morgenstern group reports the detailed investigation of a Friedel-Crafts reaction on a Ag surface, to which Christoph contributed the starting material: onlinelibrary.wiley.com/doi/10.1002/...
maybe we should put in some refresher organic chemistry in there as well, maybe go over the Friedel-Crafts, maybe some molecular orbital theory, nomenclature, ya know, the basics
April 3, 2026 at 9:20 PM
maybe we should put in some refresher organic chemistry in there as well, maybe go over the Friedel-Crafts, maybe some molecular orbital theory, nomenclature, ya know, the basics
Check out this week’s #ChemSciPicks from Gerard Roelfes (@roelfesgroup.bsky.social, @stratinghinst.bsky.social) et al.!
‘Genetically Encoded 3-Aminotyrosine as Catalytic Residue in a Designer Friedel-Crafts Alkylase’
Read it here for free: doi.org/10.1039/D5SC...
#ChemSky 🧪
‘Genetically Encoded 3-Aminotyrosine as Catalytic Residue in a Designer Friedel-Crafts Alkylase’
Read it here for free: doi.org/10.1039/D5SC...
#ChemSky 🧪
April 23, 2025 at 9:00 AM
Check out this week’s #ChemSciPicks from Gerard Roelfes (@roelfesgroup.bsky.social, @stratinghinst.bsky.social) et al.!
‘Genetically Encoded 3-Aminotyrosine as Catalytic Residue in a Designer Friedel-Crafts Alkylase’
Read it here for free: doi.org/10.1039/D5SC...
#ChemSky 🧪
‘Genetically Encoded 3-Aminotyrosine as Catalytic Residue in a Designer Friedel-Crafts Alkylase’
Read it here for free: doi.org/10.1039/D5SC...
#ChemSky 🧪
You’ve just opened a Chemistry themed pub. What are you calling it?
Friedel–Crafts & Drafts
The Wittig Bar
Swern & Stir
Chiral (two mirror-image happy hours)
Suzuki Coupling (great for dates)
#ChemSky
Friedel–Crafts & Drafts
The Wittig Bar
Swern & Stir
Chiral (two mirror-image happy hours)
Suzuki Coupling (great for dates)
#ChemSky
December 29, 2025 at 6:06 AM
You’ve just opened a Chemistry themed pub. What are you calling it?
Friedel–Crafts & Drafts
The Wittig Bar
Swern & Stir
Chiral (two mirror-image happy hours)
Suzuki Coupling (great for dates)
#ChemSky
Friedel–Crafts & Drafts
The Wittig Bar
Swern & Stir
Chiral (two mirror-image happy hours)
Suzuki Coupling (great for dates)
#ChemSky
Spiro-bridged conjugated carbocycles www.nature.com/articles/s44... #PiSky
Chirality retention in Friedel–Crafts spiroannulation for iterative synthesis of spiro-bridged conjugated carbocycles - Nature Synthesis
A strategy that preserves stereochemistry in intramolecular Friedel–Crafts alkylation is reported. An iterative synthetic approach to extend spiro-bridged molecular skeletons via C–H activation–annula...
www.nature.com
June 3, 2025 at 4:11 PM
Spiro-bridged conjugated carbocycles www.nature.com/articles/s44... #PiSky
Looks like somebody was studying for my exam. They have neater boardwork than me!
April 21, 2026 at 2:26 PM
Looks like somebody was studying for my exam. They have neater boardwork than me!
Was het leven maar alleen maar alpaca's, poezen en friedel crafts acylering
November 9, 2023 at 7:58 PM
Was het leven maar alleen maar alpaca's, poezen en friedel crafts acylering
Gallium? In Process Chemistry?New #OPRD from my #PfizerChemistry colleagues in Bothell WA using a Ga-mediated Friedel-Crafts toward a highly substituted dihydro benzofuran
Process Development to Synthesize SGD-11275 Utilizing a Pd-Catalyzed Acetamide Arylation and Gallium-Mediated Friedel–Crafts Acylation
An improved synthesis of SGD-11275 was developed to address inefficiencies in cost, time, and safety associated with the previous supply route. The new route features a Buchwald-Hartwig amination with...
pubs.acs.org
November 26, 2024 at 8:26 PM
Gallium? In Process Chemistry?New #OPRD from my #PfizerChemistry colleagues in Bothell WA using a Ga-mediated Friedel-Crafts toward a highly substituted dihydro benzofuran
El-Aal et al. reported efficient synthesis of indole-fused N-heterocycles via Jourdan–Ullmann and Friedel–Crafts approaches, yielding scaffolds with potential pharmacological value for medicinal chemistry applications. #AusJChem @csiropublishing.bsky.social
www.publish.csiro.au/CH/CH25003
www.publish.csiro.au/CH/CH25003
Friedel–Crafts chemistry. Part 64. Facile syntheses of fused azepinoindoles by Jourdan–Ullmann and Friedel–Crafts approaches
Facile and concise procedures for the construction of indole fused N-heterocyclic systems were described. A series of benzo-, pyrido-, thieno-, naphtho-fused azepinoindolones and indolo-azepinoquinoli...
www.publish.csiro.au
August 13, 2025 at 11:25 AM
El-Aal et al. reported efficient synthesis of indole-fused N-heterocycles via Jourdan–Ullmann and Friedel–Crafts approaches, yielding scaffolds with potential pharmacological value for medicinal chemistry applications. #AusJChem @csiropublishing.bsky.social
www.publish.csiro.au/CH/CH25003
www.publish.csiro.au/CH/CH25003
De mooiste acylering vind ik friedel crafts acylering
November 29, 2024 at 7:24 PM
De mooiste acylering vind ik friedel crafts acylering
Controlled photocatalysis hits the limitation of Friedel–Crafts alkylation - an inspiration for further exploration of nitroarenes and their utility in synthetic and medicinal chemistry. Congrats to the team!
@jacs.acspublications.org
pubs.acs.org/jacsat/artic...
@jacs.acspublications.org
pubs.acs.org/jacsat/artic...
Reactivity
of Nitroarenes toward Alkyl Radicals Enables
Direct C–H Alkylation
Abstract. Friedel–Crafts
alkylation is a cornerstone transformation
for arene functionalization; however, strongly electron-deficient
nitroarenes fail to u
pubs.acs.org
August 3, 2026 at 9:04 AM
Controlled photocatalysis hits the limitation of Friedel–Crafts alkylation - an inspiration for further exploration of nitroarenes and their utility in synthetic and medicinal chemistry. Congrats to the team!
@jacs.acspublications.org
pubs.acs.org/jacsat/artic...
@jacs.acspublications.org
pubs.acs.org/jacsat/artic...
Have a look at our photoacid system tailored for small-molecule organocatalysis! Photo-promoted proton release efficiently enables Friedel–Crafts alkylation. Congrats to Armaz, Dana and @indrajitghosh85.bsky.social @chemcomm.rsc.org 🧪 #Chemsky #photocatalysis
doi.org/10.1039/D5CC...
doi.org/10.1039/D5CC...
Merocyanine-based photoacids as recyclable catalysts in visible-light-driven transformations
Visible light-driven proton transfer is crucial in nature and catalysis. Here, we report that protic merocyanine-based photoswitches act as efficient and recyclable homogeneous Brønsted acid catalysts...
doi.org
April 9, 2025 at 1:09 PM
Have a look at our photoacid system tailored for small-molecule organocatalysis! Photo-promoted proton release efficiently enables Friedel–Crafts alkylation. Congrats to Armaz, Dana and @indrajitghosh85.bsky.social @chemcomm.rsc.org 🧪 #Chemsky #photocatalysis
doi.org/10.1039/D5CC...
doi.org/10.1039/D5CC...
Just in time for under the Christmas tree🎄our paper on Friedel-Crafts acylation of bicyclo[1.1.1]pentane ketones out in @JOC_OL pubs.acs.org/doi/10.1021/.... Great work by Karolina and Freya; collaboration with #PavelMykhailiuk @EnamineLtd. Funded by @researchireland.ie @tum.de @ias-tum.bsky.social
Bicyclo[1.1.1]pentane Ketones via Friedel–Crafts Acylation
Bicyclo[1.1.1]pentane (BCP) is a rigid aliphatic hydrocarbon with a three-dimensional (3D), propeller-like shape and a molecular size that makes it a targeted bioisosteric replacement for phenylene an...
https://pubs.acs.org/doi/10.1021/acs.joc.5c01754📢
December 23, 2025 at 8:47 AM
Just in time for under the Christmas tree🎄our paper on Friedel-Crafts acylation of bicyclo[1.1.1]pentane ketones out in @JOC_OL pubs.acs.org/doi/10.1021/.... Great work by Karolina and Freya; collaboration with #PavelMykhailiuk @EnamineLtd. Funded by @researchireland.ie @tum.de @ias-tum.bsky.social
#Saints of #Organicchemistry:
#Cannizzaro #Clemmensen #Darzen #Étard #Finkelstein #Friedel- #Crafts #Gabriel #Gattermann- #Koch #Grignard #Hell- #Volhard- #Zelinsky #Hoffmann #Kolbe #Riemer- #Tiemann #Rosenmund #Sandmeyer #Stephen #Swarts #Williamson #Wolff- #Kishner #Wurtz- #Fittig
#Cannizzaro #Clemmensen #Darzen #Étard #Finkelstein #Friedel- #Crafts #Gabriel #Gattermann- #Koch #Grignard #Hell- #Volhard- #Zelinsky #Hoffmann #Kolbe #Riemer- #Tiemann #Rosenmund #Sandmeyer #Stephen #Swarts #Williamson #Wolff- #Kishner #Wurtz- #Fittig
December 21, 2024 at 4:54 AM
Updated link:
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Genetically encoded 3-aminotyrosine as catalytic residue in a designer Friedel–Crafts alkylase
Genetic incorporation of noncanonical amino acids (ncAAs) harbouring catalytic side chains into proteins allows the creation of enzymes able to catalyse reactions that have no equivalent in nature. He...
pubs.rsc.org
April 23, 2025 at 9:59 AM
Updated link:
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Charles Friedel and the Accidental Discovery of an Important Reaction:
French chemist co-discovered the Friedel–Crafts reactions with James Mason Crafts
www.chemistryviews.org/charles-frie...
#chemistry #chemistryviews #chemviews #historyofchemistry #charlesfriedel #FriedelCrafts
French chemist co-discovered the Friedel–Crafts reactions with James Mason Crafts
www.chemistryviews.org/charles-frie...
#chemistry #chemistryviews #chemviews #historyofchemistry #charlesfriedel #FriedelCrafts
Charles Friedel and the Accidental Discovery of an Important Reaction - ChemistryViews
French chemist co-discovered the Friedel–Crafts reactions with James Mason Crafts
www.chemistryviews.org
May 5, 2024 at 7:26 PM
Charles Friedel and the Accidental Discovery of an Important Reaction:
French chemist co-discovered the Friedel–Crafts reactions with James Mason Crafts
www.chemistryviews.org/charles-frie...
#chemistry #chemistryviews #chemviews #historyofchemistry #charlesfriedel #FriedelCrafts
French chemist co-discovered the Friedel–Crafts reactions with James Mason Crafts
www.chemistryviews.org/charles-frie...
#chemistry #chemistryviews #chemviews #historyofchemistry #charlesfriedel #FriedelCrafts
Now online and open access:
Article by Max García-Melchor, Erwin Reisner & co-workers @reisnerlab.bsky.social
Anti-Friedel–Crafts alkylation via electron donor–acceptor photoinitiation
www.nature.com/articles/s44...
#Chemsky
Article by Max García-Melchor, Erwin Reisner & co-workers @reisnerlab.bsky.social
Anti-Friedel–Crafts alkylation via electron donor–acceptor photoinitiation
www.nature.com/articles/s44...
#Chemsky
Anti-Friedel–Crafts alkylation via electron donor–acceptor photoinitiation - Nature Synthesis
A transition-metal-free synthetic strategy for C–H alkylation of electron-poor aromatics is reported, which selectively alkylates the most electrophilic position of electron-deficient aromatics to exh...
www.nature.com
March 13, 2026 at 6:11 PM
Now online and open access:
Article by Max García-Melchor, Erwin Reisner & co-workers @reisnerlab.bsky.social
Anti-Friedel–Crafts alkylation via electron donor–acceptor photoinitiation
www.nature.com/articles/s44...
#Chemsky
Article by Max García-Melchor, Erwin Reisner & co-workers @reisnerlab.bsky.social
Anti-Friedel–Crafts alkylation via electron donor–acceptor photoinitiation
www.nature.com/articles/s44...
#Chemsky
Charles Friedel and the Accidental Discovery of an Important Reaction:
French chemist co-discovered the Friedel–Crafts reactions with James Mason Crafts
www.chemistryviews.org/charles-frie...
French chemist co-discovered the Friedel–Crafts reactions with James Mason Crafts
www.chemistryviews.org/charles-frie...
April 20, 2024 at 10:12 AM
Charles Friedel and the Accidental Discovery of an Important Reaction:
French chemist co-discovered the Friedel–Crafts reactions with James Mason Crafts
www.chemistryviews.org/charles-frie...
French chemist co-discovered the Friedel–Crafts reactions with James Mason Crafts
www.chemistryviews.org/charles-frie...
🔬 We used NMR to rationalize the role of two mutations that increase the catalytic activity towards the Friedel-Crafts Alkylation of indoles in an artificial metalloenzyme. The catalyst is based on a copper-phenanthroline complex bound within the hydrophobic pocket of the versatile LmrR protein.
2/5
2/5
July 4, 2025 at 9:19 AM
🔬 We used NMR to rationalize the role of two mutations that increase the catalytic activity towards the Friedel-Crafts Alkylation of indoles in an artificial metalloenzyme. The catalyst is based on a copper-phenanthroline complex bound within the hydrophobic pocket of the versatile LmrR protein.
2/5
2/5
Forgot to post that I finished that video...finally:
youtu.be/o4pGAp6oxVw
#ENVtuber #ChemistVtuber #VtuberUprising
youtu.be/o4pGAp6oxVw
#ENVtuber #ChemistVtuber #VtuberUprising
1,4-di-tert-butyl-2,5-dimethoxybenzene (and the Friedel-Crafts alkylation)
YouTube video by Zenzicubic
youtu.be
January 10, 2025 at 1:40 AM
Forgot to post that I finished that video...finally:
youtu.be/o4pGAp6oxVw
#ENVtuber #ChemistVtuber #VtuberUprising
youtu.be/o4pGAp6oxVw
#ENVtuber #ChemistVtuber #VtuberUprising