Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!
IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (rupress.org/jem/article/...) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal #fibrosis. @lozanzi.bsky.social highlights the findings: rupress.org/jem/article/...
July 7, 2026 at 9:24 PM
Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!
#FriendsOrFoes?! Lee, Naora &co show @cp-cancercell.bsky.social that neutrophils produce NETs in peritoneal fat during ovarian cancer favoring metastasis formation. NETs displace CD22 from SHP1 in innate-like B cells driving IL10 production, Treg differentiation, & metastasis formation!
Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10
Lee et al. show that neutrophil extracellular traps (NETs) establish the pre-metastatic niche in the omentum by recruiting innate-like B cells and eliciting IL-10 production in these cells through inactivating SHP-1 and generating reactive oxygen species, thereby expanding Tregs. These findings underscore the potential of inhibiting NETs for metastasis prevention.
dlvr.it
January 3, 2025 at 4:00 PM
#FriendsOrFoes?! Lee, Naora &co show @cp-cancercell.bsky.social that neutrophils produce NETs in peritoneal fat during ovarian cancer favoring metastasis formation. NETs displace CD22 from SHP1 in innate-like B cells driving IL10 production, Treg differentiation, & metastasis formation!
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February 19, 2025 at 6:00 PM
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🧟♂️ Ready to scare your friends... or yourselves? UNDERWARD drops on Feb 5, 2025! Dive in for spine-tingling fun & special discounts! 💀💰 #HorrorGames #Underward #FriendsOrFoes - https://nerdburglars.net/?p=65823
February 19, 2025 at 4:00 PM
🧟♂️ Ready to scare your friends... or yourselves? UNDERWARD drops on Feb 5, 2025! Dive in for spine-tingling fun & special discounts! 💀💰 #HorrorGames #Underward #FriendsOrFoes - https://nerdburglars.net/?p=65823