Excited to share the most recent work from our lab! In which we seek out the cellular source of homeostatic IFNL in the gut and find that gut pDC are ‘rewired’ to produce IFNL over type I IFNs.
Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responses https://www.biorxiv.org/content/10.1101/2025.08.25.672167v1
August 30, 2025 at 1:35 AM
Excited to share the most recent work from our lab! In which we seek out the cellular source of homeostatic IFNL in the gut and find that gut pDC are ‘rewired’ to produce IFNL over type I IFNs.
Officially official 🥳🎉🥂
5yr #CIHR grant celebrations today with #SanterLab & Murooka lab who also got their grant (as co-I some #IFNL too 😉)
#IBD #IFNs #immunology
So thankful to our co-Is, collabs & all in our lab + #sisterlab who worked hard to help get this funded🙏🏻
@umanitoba.bsky.social
5yr #CIHR grant celebrations today with #SanterLab & Murooka lab who also got their grant (as co-I some #IFNL too 😉)
#IBD #IFNs #immunology
So thankful to our co-Is, collabs & all in our lab + #sisterlab who worked hard to help get this funded🙏🏻
@umanitoba.bsky.social
January 29, 2025 at 9:18 PM
Officially official 🥳🎉🥂
5yr #CIHR grant celebrations today with #SanterLab & Murooka lab who also got their grant (as co-I some #IFNL too 😉)
#IBD #IFNs #immunology
So thankful to our co-Is, collabs & all in our lab + #sisterlab who worked hard to help get this funded🙏🏻
@umanitoba.bsky.social
5yr #CIHR grant celebrations today with #SanterLab & Murooka lab who also got their grant (as co-I some #IFNL too 😉)
#IBD #IFNs #immunology
So thankful to our co-Is, collabs & all in our lab + #sisterlab who worked hard to help get this funded🙏🏻
@umanitoba.bsky.social
The fact that we have not done a good job of arming Ukraine with the weapons it needs is explicitly a consequence of the weakness of European defence.
Ifnl we actually had an arms race they wouldn't have any shortage of artillery ammunition.
Ifnl we actually had an arms race they wouldn't have any shortage of artillery ammunition.
I don’t want to be really rude here, but do you have any basic reading comprehension?
1) I’ve supported arming Ukraine throughout, so what are you talking about?
2) I don’t support a European arms race based on the fantasy that Russia is going to otherwise conquer Europe
1) I’ve supported arming Ukraine throughout, so what are you talking about?
2) I don’t support a European arms race based on the fantasy that Russia is going to otherwise conquer Europe
December 16, 2025 at 9:38 PM
The fact that we have not done a good job of arming Ukraine with the weapons it needs is explicitly a consequence of the weakness of European defence.
Ifnl we actually had an arms race they wouldn't have any shortage of artillery ammunition.
Ifnl we actually had an arms race they wouldn't have any shortage of artillery ammunition.
CIHR grant results day & so excited to see we will be funded for our #IFNL #immunology #IBD 5yr grant! Very thankful to coAs, those in the lab who got key new data + multiple people who spent the time to provide critiques to really improve the grant. Still in shock, but 🥳🥳😀😀🎉🎉
Dancing Ducks GIF
ALT: Dancing Ducks GIF
media.tenor.com
January 15, 2025 at 3:25 PM
CIHR grant results day & so excited to see we will be funded for our #IFNL #immunology #IBD 5yr grant! Very thankful to coAs, those in the lab who got key new data + multiple people who spent the time to provide critiques to really improve the grant. Still in shock, but 🥳🥳😀😀🎉🎉
Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!
IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (rupress.org/jem/article/...) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal #fibrosis. @lozanzi.bsky.social highlights the findings: rupress.org/jem/article/...
July 7, 2026 at 9:24 PM
Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!
Congrats to Olamide on her successful #Immunology MSc defense today! 🎉🥳
She was the 1st member of the #SanterLab as a co-op student, to then tech & now MSc.
I couldn't have got the lab going without her. Thank u Olamide for choosing my lab & all your dedication to #IFNL research!🙏🏻
She was the 1st member of the #SanterLab as a co-op student, to then tech & now MSc.
I couldn't have got the lab going without her. Thank u Olamide for choosing my lab & all your dedication to #IFNL research!🙏🏻
July 15, 2025 at 11:10 PM
Congrats to Olamide on her successful #Immunology MSc defense today! 🎉🥳
She was the 1st member of the #SanterLab as a co-op student, to then tech & now MSc.
I couldn't have got the lab going without her. Thank u Olamide for choosing my lab & all your dedication to #IFNL research!🙏🏻
She was the 1st member of the #SanterLab as a co-op student, to then tech & now MSc.
I couldn't have got the lab going without her. Thank u Olamide for choosing my lab & all your dedication to #IFNL research!🙏🏻
ifnl ur butler doesn't lactate then what are you even on, I mean clearly not the fortune 500 list
August 13, 2024 at 2:07 AM
ifnl ur butler doesn't lactate then what are you even on, I mean clearly not the fortune 500 list
A l'échelle mondiale, 12% des conducteurs de voitures électriques mentionnent également la Chine comme un pays de production de véhicules électriques qu'ils éviteraient d'acheter 🚗⚡️
https://l.bfmtv.com/iFnl
https://l.bfmtv.com/iFnl
November 17, 2025 at 6:30 PM
A l'échelle mondiale, 12% des conducteurs de voitures électriques mentionnent également la Chine comme un pays de production de véhicules électriques qu'ils éviteraient d'acheter 🚗⚡️
https://l.bfmtv.com/iFnl
https://l.bfmtv.com/iFnl
Rugby en Dordogne : les résultats de Régionales 1, 2 et 3 du week-end
🔗https://l.sudouest.fr/iFNl
🔗https://l.sudouest.fr/iFNl
September 21, 2026 at 10:50 AM
Rugby en Dordogne : les résultats de Régionales 1, 2 et 3 du week-end
🔗https://l.sudouest.fr/iFNl
🔗https://l.sudouest.fr/iFNl
Thanks to everyone who joined us for #CSI2026 in Winnipeg! The awards dinner/gala was the perfect way to celebrate the #internationaldayofimmunology & all the awesome #immunology research presented over 3.5 days incl 6 #IFNL posters & top award to our postdoc Monireh 😀
🙏🏻 to all our sponsors too!
🙏🏻 to all our sponsors too!
May 1, 2026 at 5:07 PM
Thanks to everyone who joined us for #CSI2026 in Winnipeg! The awards dinner/gala was the perfect way to celebrate the #internationaldayofimmunology & all the awesome #immunology research presented over 3.5 days incl 6 #IFNL posters & top award to our postdoc Monireh 😀
🙏🏻 to all our sponsors too!
🙏🏻 to all our sponsors too!
New #IFNL publication answering some key Qs about the enigma that is #IFNL4. Great work by Mendoza lab et al 🥂👏🏻
Cytokines 2025 is far away in Nov, but @ramlabuw.bsky.social we should really have an #IFNL satellite symposium again🤞Hawaii was fun & I see ur a co-chair...
www.nature.com/articles/s41...
Cytokines 2025 is far away in Nov, but @ramlabuw.bsky.social we should really have an #IFNL satellite symposium again🤞Hawaii was fun & I see ur a co-chair...
www.nature.com/articles/s41...
Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering - Nature Communications
IFNλ4 has posed a conundrum in human immunology, leading to structural and functional questions about the protein. Here, the authors use protein engineering and cryoEM to determine the cytokine-recept...
www.nature.com
January 18, 2025 at 7:11 PM
New #IFNL publication answering some key Qs about the enigma that is #IFNL4. Great work by Mendoza lab et al 🥂👏🏻
Cytokines 2025 is far away in Nov, but @ramlabuw.bsky.social we should really have an #IFNL satellite symposium again🤞Hawaii was fun & I see ur a co-chair...
www.nature.com/articles/s41...
Cytokines 2025 is far away in Nov, but @ramlabuw.bsky.social we should really have an #IFNL satellite symposium again🤞Hawaii was fun & I see ur a co-chair...
www.nature.com/articles/s41...
#WeekendRead! #InterferonFriendOrFoe?! Ding, Hou &co show @co-cellhostmicrobe.bsky.social that rota & reovirus induce diarrhea (in neonate mice) via MAVS-IFN lambda downregulating a ion exchanger! IFNL is increased in human IBD biopsies as we also recently showed👉 doi.org/10.1016/j.cell.2024.10.010
March 9, 2025 at 4:56 PM
#WeekendRead! #InterferonFriendOrFoe?! Ding, Hou &co show @co-cellhostmicrobe.bsky.social that rota & reovirus induce diarrhea (in neonate mice) via MAVS-IFN lambda downregulating a ion exchanger! IFNL is increased in human IBD biopsies as we also recently showed👉 doi.org/10.1016/j.cell.2024.10.010
Great lab meeting today welcoming co-op undergraduate student Junel for his summer work term & celebrating some great news Testimony (PhD student) received recently 🥳🥳🎉🎉
Lots of fun #IFNL work planned for the rest of 2025 😀😀😀
#newlabgroupphoto
Lots of fun #IFNL work planned for the rest of 2025 😀😀😀
#newlabgroupphoto
May 5, 2025 at 8:37 PM
Great lab meeting today welcoming co-op undergraduate student Junel for his summer work term & celebrating some great news Testimony (PhD student) received recently 🥳🥳🎉🎉
Lots of fun #IFNL work planned for the rest of 2025 😀😀😀
#newlabgroupphoto
Lots of fun #IFNL work planned for the rest of 2025 😀😀😀
#newlabgroupphoto
Very thankful that another Murooka/Santer lab project was funded 3 weeks later for our #CIHR Catalyst grant with Dr Ali Ashkar as fellow coPI & coA @annablakney.bsky.social expanding on #IFNL #antiviral effects in the STBBI field. Super excited to work with this awesome team across 3 universities🥳🙌
February 21, 2025 at 9:07 PM
Very thankful that another Murooka/Santer lab project was funded 3 weeks later for our #CIHR Catalyst grant with Dr Ali Ashkar as fellow coPI & coA @annablakney.bsky.social expanding on #IFNL #antiviral effects in the STBBI field. Super excited to work with this awesome team across 3 universities🥳🙌
#HappyCanadaDay 🇨🇦
Also the 1st day of my research study leave/sabbatical!
While I enjoy teaching & serve on many committees at UM, I am excited to focus on research for 6 months when we have lots of exciting #IFNL work ongoing plus I can collect data myself here + with collaborators outside MB 🥳👩🔬🔬
Also the 1st day of my research study leave/sabbatical!
While I enjoy teaching & serve on many committees at UM, I am excited to focus on research for 6 months when we have lots of exciting #IFNL work ongoing plus I can collect data myself here + with collaborators outside MB 🥳👩🔬🔬
July 1, 2026 at 6:05 PM
#HappyCanadaDay 🇨🇦
Also the 1st day of my research study leave/sabbatical!
While I enjoy teaching & serve on many committees at UM, I am excited to focus on research for 6 months when we have lots of exciting #IFNL work ongoing plus I can collect data myself here + with collaborators outside MB 🥳👩🔬🔬
Also the 1st day of my research study leave/sabbatical!
While I enjoy teaching & serve on many committees at UM, I am excited to focus on research for 6 months when we have lots of exciting #IFNL work ongoing plus I can collect data myself here + with collaborators outside MB 🥳👩🔬🔬
It keeps occurring to me since the election how much I'll hate hearing it and how do I take in news while avoiding him. I had hoped so much to never hear him again and to know he'll be covered by journalists as ifnl he isnt colossally inept, incompetent, and ill informed is dreadful.
December 17, 2024 at 4:37 AM
It keeps occurring to me since the election how much I'll hate hearing it and how do I take in news while avoiding him. I had hoped so much to never hear him again and to know he'll be covered by journalists as ifnl he isnt colossally inept, incompetent, and ill informed is dreadful.
Cinq pays de l'UE appellent à taxer les profits exceptionnels des groupes énergétiques
➡️ https://l.euronews.com/iFNl
➡️ https://l.euronews.com/iFNl
April 4, 2026 at 1:23 PM
Cinq pays de l'UE appellent à taxer les profits exceptionnels des groupes énergétiques
➡️ https://l.euronews.com/iFNl
➡️ https://l.euronews.com/iFNl
We found that upon recruitment to the gut pDC ‘open’ their IFNL gene locus and express other marks of TGFbeta response. Remarkably, treatment of a pDC cell line with TGFb amplifies its otherwise meager IFNL production
August 30, 2025 at 1:42 AM
We found that upon recruitment to the gut pDC ‘open’ their IFNL gene locus and express other marks of TGFbeta response. Remarkably, treatment of a pDC cell line with TGFb amplifies its otherwise meager IFNL production
www.youtube.com/watch?v=IFNl... Das Rad in dem Video von EnjoyYourBike kostet locker 10k EURO, allein der Rahmen 6000 €.
Aber ich finde es immer toll, wie sich de Ingo hier für die Räder begeistert, so ansteckend!
Aber ich finde es immer toll, wie sich de Ingo hier für die Räder begeistert, so ansteckend!
July 12, 2024 at 1:32 PM
www.youtube.com/watch?v=IFNl... Das Rad in dem Video von EnjoyYourBike kostet locker 10k EURO, allein der Rahmen 6000 €.
Aber ich finde es immer toll, wie sich de Ingo hier für die Räder begeistert, so ansteckend!
Aber ich finde es immer toll, wie sich de Ingo hier für die Räder begeistert, so ansteckend!
Happy International #DayofImmunology!🥳🎉
I am currently 🛫 & will visit McMaster for the 1st time tomorrow to present in their Infection & Immunity seminar series 😀 🙏🏻 to @koenigjfe.bsky.social for the invite
Looking forward to chatting science & presenting a couple stories from our #IFNL projects
I am currently 🛫 & will visit McMaster for the 1st time tomorrow to present in their Infection & Immunity seminar series 😀 🙏🏻 to @koenigjfe.bsky.social for the invite
Looking forward to chatting science & presenting a couple stories from our #IFNL projects
April 29, 2025 at 4:48 PM
Happy International #DayofImmunology!🥳🎉
I am currently 🛫 & will visit McMaster for the 1st time tomorrow to present in their Infection & Immunity seminar series 😀 🙏🏻 to @koenigjfe.bsky.social for the invite
Looking forward to chatting science & presenting a couple stories from our #IFNL projects
I am currently 🛫 & will visit McMaster for the 1st time tomorrow to present in their Infection & Immunity seminar series 😀 🙏🏻 to @koenigjfe.bsky.social for the invite
Looking forward to chatting science & presenting a couple stories from our #IFNL projects
#InterferonPower! Zhou &co show @elife.baky.social that a phospholipid scramblase is upregulated in response to interferon lambda #IFNL, and works as a transcription factor to upreg IFNLR in lung epithelial cells, protecting against influenza A virus! doi.org/10.7554/eLif...
Phospholipid Scramblase 1 (PLSCR1) Regulates Interferon-Lambda Receptor 1 (IFN-λR1) and IFN-λ Signaling in Influenza A Virus (IAV) Infection
doi.org
March 12, 2025 at 5:36 PM
#InterferonPower! Zhou &co show @elife.baky.social that a phospholipid scramblase is upregulated in response to interferon lambda #IFNL, and works as a transcription factor to upreg IFNLR in lung epithelial cells, protecting against influenza A virus! doi.org/10.7554/eLif...
Would love to see fellow #IFNL enthusiasts in Scotland🏴 in October! Abstract submission is due early July and is separate from #Cytokines2026. 1 day free add on so register and submit an abstract soon 👇👇👇 Thanks @achillebro.bsky.social Rune and Charlotte for the talk invitation 😀
#BestIFN
#BestIFN
Which is the best #IFN, and why is it IFN-λ?
If you are also interested in this amazing #cytokine, and you're planning to attend the @cytokinesociety.bsky.social meeting in Glasgow this fall, we have you covered with a #free satellite workshop on the 22nd of october.
ifnlworkshop.org
If you are also interested in this amazing #cytokine, and you're planning to attend the @cytokinesociety.bsky.social meeting in Glasgow this fall, we have you covered with a #free satellite workshop on the 22nd of october.
ifnlworkshop.org
IFN lambda Satellite Workshop 2026 | CRUK Glasgow
Join the IFN lambda Satellite Workshop 2026 in Glasgow. Free registration, keynote speakers, and research collaborations.
ifnlworkshop.org
June 24, 2026 at 1:52 PM
Would love to see fellow #IFNL enthusiasts in Scotland🏴 in October! Abstract submission is due early July and is separate from #Cytokines2026. 1 day free add on so register and submit an abstract soon 👇👇👇 Thanks @achillebro.bsky.social Rune and Charlotte for the talk invitation 😀
#BestIFN
#BestIFN
I'm honoured to be a Science Co-op supervisor of the year!🙏🏻😀
I have mentored 7 @umanitoba.bsky.social co-op undergrads thus far & all have been a pleasure to work with- whether est. new protocols or getting 😎 #IFNL data!
Thank you to Cedric for the nomination & kind words🙏🏻
#luckyPI
I have mentored 7 @umanitoba.bsky.social co-op undergrads thus far & all have been a pleasure to work with- whether est. new protocols or getting 😎 #IFNL data!
Thank you to Cedric for the nomination & kind words🙏🏻
#luckyPI
March 27, 2025 at 11:10 PM
I'm honoured to be a Science Co-op supervisor of the year!🙏🏻😀
I have mentored 7 @umanitoba.bsky.social co-op undergrads thus far & all have been a pleasure to work with- whether est. new protocols or getting 😎 #IFNL data!
Thank you to Cedric for the nomination & kind words🙏🏻
#luckyPI
I have mentored 7 @umanitoba.bsky.social co-op undergrads thus far & all have been a pleasure to work with- whether est. new protocols or getting 😎 #IFNL data!
Thank you to Cedric for the nomination & kind words🙏🏻
#luckyPI