#IFNL4
LightNews LightNews
connorggbamford.bsky.social
Very nice study from @benhale.bsky.social group on impact of human genetic variation on IFNbeta activity www.science.org/doi/10.1126/... similar to our work on IFNL4 journals.plos.org/plospathogen... but would be neat to compare
Functional diversity of natural human IFNB1 variants in innate immunity
Human interferon-β (IFN-β), a type I IFN, is critical for effective innate immunity and is also an approved disease-modifying therapeutic. While genetic variations in several components of the type I ...
www.science.org
September 18, 2026 at 8:18 PM
ttorrearagones.bsky.social
PUBMED - IFNL4-rs12979860 CC genotype predisposes to accelerated terminal exhaustion and senescence in HIV/HCV-chronic infection pubmed.ncbi.nlm.nih.gov/41466297/
#produccionhuil #PabloRyan #MarianoMatarranz
IFNL4-rs12979860 CC genotype predisposes to accelerated terminal exhaustion and senescence in HIV/HCV-chronic infection - PubMed
CC-carriage may result in premature cellular activation and senescence or impaired functionality during HCV chronic infection in PWH, which may be masked by their maintained plasma immune homeostasis…
pubmed.ncbi.nlm.nih.gov
January 7, 2026 at 10:01 AM
drdeannasanter.bsky.social
New #IFNL publication answering some key Qs about the enigma that is #IFNL4. Great work by Mendoza lab et al 🥂👏🏻
Cytokines 2025 is far away in Nov, but @ramlabuw.bsky.social we should really have an #IFNL satellite symposium again🤞Hawaii was fun & I see ur a co-chair...
www.nature.com/articles/s41...
Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering - Nature Communications
IFNλ4 has posed a conundrum in human immunology, leading to structural and functional questions about the protein. Here, the authors use protein engineering and cryoEM to determine the cytokine-recept...
www.nature.com
January 18, 2025 at 7:11 PM
tomkindlon.bsky.social
[Clinical characteristics and cytokine gene expression in patients with post-COVID-19 syndrome] Article in Spanish

zenodo.org/records/1420...

Screenshot is from the latest Science for ME weekly update

#LongCovid #PASC
Zenodo Características clínicas y expresión génica de citocinas en pacientes con síndrome post-COVID-19 — Valencia-Gutiérrez et al. Article in Spanish. "Protective factors for fatigue were serotonin expression with an OR of 0.238 (95% CI 0.060-0.949); for concentration problems, SOCS3 with an OR of 0.188 (95% CI 0.037-0.946), and for memory impairment IFNL4 OR 0.094 (95% CI 0.015-0.586)."
May 2, 2025 at 1:14 AM
stigmabase.bsky.social
Study Links IFNL4-rs12979860 CC Genotype to Faster Immune Decline in Chronic HIV and ...
This research adds to the understanding of how genetic factors influence disease progression in chronic conditions like HIV and HCV. Newsflash | ... View article...
dlvr.it
December 31, 2025 at 12:41 AM
vasculitides.bsky.social
IFNL4 Genotype is Associated with Hepatitis A Virus InfectionFindings from a Focused Phenotype Study in the UK Biobank Cohort
IFNL4 Genotype is Associated with Hepatitis A Virus InfectionFindings from a Focused Phenotype Study in the UK Biobank Cohort - PubMed
We report a novel protective association between the IFNL4-ΔG allele, which generates IFN-λ4 protein, and HAV infection. Future studies might examine the mechanism for this association and the therapeutic potential of IFN-λ4 for treating infection with HAV.
pubmed.ncbi.nlm.nih.gov
February 26, 2026 at 5:49 AM