zirkulierenden Serotoninspiegeln verbunden
➡️ Der Serotoninabbau wird durch virale RNA-induzierte Typ-I-Interferone (IFNs) angetrieben
➡️ IFNs reduzieren Serotonin durch verminderte Tryptophanaufnahme und Hyperkoagulabilität
➡️ Peripherer Serotoninmangel beeinträchtigt
➡️ Der Serotoninabbau wird durch virale RNA-induzierte Typ-I-Interferone (IFNs) angetrieben
➡️ IFNs reduzieren Serotonin durch verminderte Tryptophanaufnahme und Hyperkoagulabilität
➡️ Peripherer Serotoninmangel beeinträchtigt
October 16, 2023 at 5:56 PM
zirkulierenden Serotoninspiegeln verbunden
➡️ Der Serotoninabbau wird durch virale RNA-induzierte Typ-I-Interferone (IFNs) angetrieben
➡️ IFNs reduzieren Serotonin durch verminderte Tryptophanaufnahme und Hyperkoagulabilität
➡️ Peripherer Serotoninmangel beeinträchtigt
➡️ Der Serotoninabbau wird durch virale RNA-induzierte Typ-I-Interferone (IFNs) angetrieben
➡️ IFNs reduzieren Serotonin durch verminderte Tryptophanaufnahme und Hyperkoagulabilität
➡️ Peripherer Serotoninmangel beeinträchtigt
In #Science #Immunology, researchers at @stanfordmedicine.bsky.social studied #IFNs in human #fetal #thymus development. They found type I & II IFNs play distinct but critical roles in cortical & medullary thymic #EpithelialCell differentiation!
Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development
Single-cell transcriptomics identifies type I and II interferons as regulators of cortical and medullary thymic epithelial differentiation.
www.science.org
May 26, 2025 at 10:06 PM
In #Science #Immunology, researchers at @stanfordmedicine.bsky.social studied #IFNs in human #fetal #thymus development. They found type I & II IFNs play distinct but critical roles in cortical & medullary thymic #EpithelialCell differentiation!
#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity
ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.
www.science.org
March 7, 2025 at 10:32 PM
#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!
What I love about interferons is their simplicity ;-)
But seriously a great @cellcellpress.bsky.social new review of IFNs that are our 1st line of defense vs infections and have a critical role in many inflammatory an autoimmune diseases www.cell.com/cell/fulltex...
But seriously a great @cellcellpress.bsky.social new review of IFNs that are our 1st line of defense vs infections and have a critical role in many inflammatory an autoimmune diseases www.cell.com/cell/fulltex...
August 21, 2025 at 3:42 PM
What I love about interferons is their simplicity ;-)
But seriously a great @cellcellpress.bsky.social new review of IFNs that are our 1st line of defense vs infections and have a critical role in many inflammatory an autoimmune diseases www.cell.com/cell/fulltex...
But seriously a great @cellcellpress.bsky.social new review of IFNs that are our 1st line of defense vs infections and have a critical role in many inflammatory an autoimmune diseases www.cell.com/cell/fulltex...
Since @altssa.altgov.info asked nicely, here’s a an explainer that is hopefully useful.
Interferons (IFNs) are proteins made by our bodies. They are really helpful in fighting viruses, so viruses try to turn off their production.
Interferons (IFNs) are proteins made by our bodies. They are really helpful in fighting viruses, so viruses try to turn off their production.
This has the potential to be huge! RFKkr and Bhattacharya can eat dirt.
A human inborn error of immunity guided discovery and development of a prophylactic, mRNA-based antiviral
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 15, 2025 at 3:03 AM
Since @altssa.altgov.info asked nicely, here’s a an explainer that is hopefully useful.
Interferons (IFNs) are proteins made by our bodies. They are really helpful in fighting viruses, so viruses try to turn off their production.
Interferons (IFNs) are proteins made by our bodies. They are really helpful in fighting viruses, so viruses try to turn off their production.
Increasing evidence that innate immune pattern recognition receptors do not sense productive infections.
DeRisi lab finds that RSV does not induce IFNs in productively infected cells. Only bystander/non-productively infected cells produce IFNs.
journals.asm.org/doi/10.1128/...
DeRisi lab finds that RSV does not induce IFNs in productively infected cells. Only bystander/non-productively infected cells produce IFNs.
journals.asm.org/doi/10.1128/...
Defining the host dependencies and the transcriptional landscape of RSV infection | mBio
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection
in infants and the elderly. Despite its substantial global health burden, RSV-targeted
treatments remain unava...
journals.asm.org
August 26, 2025 at 2:25 PM
Increasing evidence that innate immune pattern recognition receptors do not sense productive infections.
DeRisi lab finds that RSV does not induce IFNs in productively infected cells. Only bystander/non-productively infected cells produce IFNs.
journals.asm.org/doi/10.1128/...
DeRisi lab finds that RSV does not induce IFNs in productively infected cells. Only bystander/non-productively infected cells produce IFNs.
journals.asm.org/doi/10.1128/...
Review @jimmunol.bsky.social @kingofpathogens.bsky.social
Getting on your last nerve: IFNs and resistance to infection
academic.oup.com/jimmunol/art...
Getting on your last nerve: IFNs and resistance to infection
academic.oup.com/jimmunol/art...
July 2, 2026 at 5:24 PM
Review @jimmunol.bsky.social @kingofpathogens.bsky.social
Getting on your last nerve: IFNs and resistance to infection
academic.oup.com/jimmunol/art...
Getting on your last nerve: IFNs and resistance to infection
academic.oup.com/jimmunol/art...
Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
September 26, 2026 at 10:01 AM
Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
We often talk about IFNa and IFNb interchangeably as type I IFNs but it's becoming more and more clear that they're not at all interchangeable, and that they may even have opposing functions. IFNb seems to be surprisingly toleragenic in certain contexts. @lozanzi.bsky.social
#WeekendRead! #InterferonPower! Stunnenberg Pickkers Kox, Keramati &co show @natimmunol.bsky.org that 2 LPS injections in volunteers mimic the proinflammatory & immunosuppressive phases of #sepsis & found that IFNb treatment restores immune responsiveness in the suppressive phase!
Systemic inflammation impairs myelopoiesis and interferon type I responses in humans - Nature Immunology
Stunnenberg et al. use a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune cells during the hyperinflammatory and immunosuppr...
www.nature.com
May 10, 2025 at 3:13 PM
We often talk about IFNa and IFNb interchangeably as type I IFNs but it's becoming more and more clear that they're not at all interchangeable, and that they may even have opposing functions. IFNb seems to be surprisingly toleragenic in certain contexts. @lozanzi.bsky.social
Study: Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections.
Published: May 6, 2026
www.cell.com/cell/abstrac...
Published: May 6, 2026
www.cell.com/cell/abstrac...
Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections
By integrating functional and structural approaches with AI-based analysis of autoantibodies
against type-I IFNs, these neutralizing autoantibodies—linked to severe viral diseases
in humans—are shown ...
www.cell.com
July 20, 2026 at 6:04 AM
Study: Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections.
Published: May 6, 2026
www.cell.com/cell/abstrac...
Published: May 6, 2026
www.cell.com/cell/abstrac...
Type I interferons (IFNs) play an important role in cutaneous lupus erythematosus and dermatomyositis skin inflammation, which could potentially be treated with IFN-targeted therapies.
Victoria Werth, MD, tackles IFNs in this summary in The Rheumatologist
www.the-rheumatologist.org/article/type...
Victoria Werth, MD, tackles IFNs in this summary in The Rheumatologist
www.the-rheumatologist.org/article/type...
Type I IFNs in Cutaneous Lupus & Dermatomyositis - The Rheumatologist
Type I interferons (IFNs) play an important role in the immunopathogenesis of cutaneous lupus erythematosus and dermatomyositis skin inflammation, which could potentially be treated with IFN-targeted ...
www.the-rheumatologist.org
October 20, 2024 at 1:14 PM
Type I interferons (IFNs) play an important role in cutaneous lupus erythematosus and dermatomyositis skin inflammation, which could potentially be treated with IFN-targeted therapies.
Victoria Werth, MD, tackles IFNs in this summary in The Rheumatologist
www.the-rheumatologist.org/article/type...
Victoria Werth, MD, tackles IFNs in this summary in The Rheumatologist
www.the-rheumatologist.org/article/type...
Review: Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases @jhumimmunity.org @casanovalab.bsky.social @shenyingzhang1.bsky.social rupress.org/jhi/article/...
November 10, 2025 at 5:03 PM
Review: Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases @jhumimmunity.org @casanovalab.bsky.social @shenyingzhang1.bsky.social rupress.org/jhi/article/...
But each cell has additional brakes. When immune cells get highly activated, they start making IL-10, a cytokine that reduces immune activity. When there is a lot of interferons (IFNs), this dampens response, again to protect you, but it risks secondary infections.
7/10
7/10
November 5, 2025 at 7:04 AM
But each cell has additional brakes. When immune cells get highly activated, they start making IL-10, a cytokine that reduces immune activity. When there is a lot of interferons (IFNs), this dampens response, again to protect you, but it risks secondary infections.
7/10
7/10
1/ We are thrilled to share our collaborative study of B cells producing auto-Abs neutralizing type I IFNs in @cellpress.bsky.social (www.cell.com/cell/abstrac... ).
Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections
By integrating functional and structural approaches with AI-based analysis of autoantibodies
against type-I IFNs, these neutralizing autoantibodies—linked to severe viral diseases
in humans—are shown ...
www.cell.com
May 7, 2026 at 12:18 PM
1/ We are thrilled to share our collaborative study of B cells producing auto-Abs neutralizing type I IFNs in @cellpress.bsky.social (www.cell.com/cell/abstrac... ).
My graduate student @besshoshingo.bsky.social gave an oral presentation on the role of Type I IFNs and Salmonella mediated autoimmunity at #MAMPM. Thank you organizers for a wonderful meeting in beautiful VA @lawrenzlab.bsky.social @davislabjhu.bsky.social
February 7, 2025 at 5:53 PM
My graduate student @besshoshingo.bsky.social gave an oral presentation on the role of Type I IFNs and Salmonella mediated autoimmunity at #MAMPM. Thank you organizers for a wonderful meeting in beautiful VA @lawrenzlab.bsky.social @davislabjhu.bsky.social
14/ Patients with AAN-I-IFN should not be given LAV, including YFV and CHIKV vaccines. People over 65 years of age should be screened for AA-IFN-I, as their prevalence is about 4% (doi.org/10.1126/scii...).
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Autoantibodies neutralizing type I IFNs increase in prevalence over 60 years of age and underlie about 20% of all fatal COVID-19 cases.
doi.org
January 26, 2026 at 9:30 PM
14/ Patients with AAN-I-IFN should not be given LAV, including YFV and CHIKV vaccines. People over 65 years of age should be screened for AA-IFN-I, as their prevalence is about 4% (doi.org/10.1126/scii...).
Autoantibodies against type-I IFNs linked to severe viral diseases in humans arise from pre-existing autoimmunity driven by prolonged germinal center affinity maturation
www.cell.com/cell/fulltex... @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @cellcellpress.bsky.social
May 6, 2026 at 3:38 PM
Autoantibodies against type-I IFNs linked to severe viral diseases in humans arise from pre-existing autoimmunity driven by prolonged germinal center affinity maturation
www.cell.com/cell/fulltex... @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @cellcellpress.bsky.social
@pbsnews.org covers @brennancenter.org's poll of election officials. It's a harrowing account of what election officials are facing right now, but also inspiring as so many officials remain committed to secure, free and fair elections. Everyone should watch it. www.youtube.com/watch?v=iFNs...
Election officials sound alarm over political interference in midterms
YouTube video by PBS NewsHour
www.youtube.com
April 23, 2026 at 3:53 PM
@pbsnews.org covers @brennancenter.org's poll of election officials. It's a harrowing account of what election officials are facing right now, but also inspiring as so many officials remain committed to secure, free and fair elections. Everyone should watch it. www.youtube.com/watch?v=iFNs...
Officially official 🥳🎉🥂
5yr #CIHR grant celebrations today with #SanterLab & Murooka lab who also got their grant (as co-I some #IFNL too 😉)
#IBD #IFNs #immunology
So thankful to our co-Is, collabs & all in our lab + #sisterlab who worked hard to help get this funded🙏🏻
@umanitoba.bsky.social
5yr #CIHR grant celebrations today with #SanterLab & Murooka lab who also got their grant (as co-I some #IFNL too 😉)
#IBD #IFNs #immunology
So thankful to our co-Is, collabs & all in our lab + #sisterlab who worked hard to help get this funded🙏🏻
@umanitoba.bsky.social
January 29, 2025 at 9:18 PM
Officially official 🥳🎉🥂
5yr #CIHR grant celebrations today with #SanterLab & Murooka lab who also got their grant (as co-I some #IFNL too 😉)
#IBD #IFNs #immunology
So thankful to our co-Is, collabs & all in our lab + #sisterlab who worked hard to help get this funded🙏🏻
@umanitoba.bsky.social
5yr #CIHR grant celebrations today with #SanterLab & Murooka lab who also got their grant (as co-I some #IFNL too 😉)
#IBD #IFNs #immunology
So thankful to our co-Is, collabs & all in our lab + #sisterlab who worked hard to help get this funded🙏🏻
@umanitoba.bsky.social
On commence bien à distinguer les IFNs ainsi que la faible couleur rouge au centre :)
April 10, 2026 at 9:14 PM
On commence bien à distinguer les IFNs ainsi que la faible couleur rouge au centre :)
We are currently in the process of recruiting a technician. 🥼🐭🔬
If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!
If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!
October 2, 2025 at 5:41 PM
We are currently in the process of recruiting a technician. 🥼🐭🔬
If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!
If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!
A Review of auto-Abs neutralizing type I IFN in patients with arboviral diseases:
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases url: rupress.org/jhi/article/...
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases url: rupress.org/jhi/article/...
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases | Journal of Human Immunity | Rockefeller University Press
Autoantibodies neutralizing antiviral type I IFNs (AAN-I-IFN) underlie a small but growing number of severe arboviral diseases. These auto-Abs are strong,
rupress.org
October 24, 2025 at 1:19 PM
A Review of auto-Abs neutralizing type I IFN in patients with arboviral diseases:
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases url: rupress.org/jhi/article/...
Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases url: rupress.org/jhi/article/...
Wrap-up of Innate Immunity I: Jakob Ankerhold from Freiburg presented the role of autoantibodies against type I IFNs in patients with zoonotic H7N9 infections. #GfV2025
(HMB)
(HMB)
March 6, 2025 at 10:30 AM
Wrap-up of Innate Immunity I: Jakob Ankerhold from Freiburg presented the role of autoantibodies against type I IFNs in patients with zoonotic H7N9 infections. #GfV2025
(HMB)
(HMB)
Lies come so easy to some.
-I post science and even politics, nothing exclusive.
-I highlight science in context and meaning.
-I have not captured anyone.
-Immunesuppression is a thing, HIV, FKB506, CsA, steroids, etc. It should not ve confounded with immune feedback mechanisms, such as high IFNs
-I post science and even politics, nothing exclusive.
-I highlight science in context and meaning.
-I have not captured anyone.
-Immunesuppression is a thing, HIV, FKB506, CsA, steroids, etc. It should not ve confounded with immune feedback mechanisms, such as high IFNs
Well, there's this Dutch guy, who posts exclusively about evidence that suggests immune suppression isn't a thing; and he's captured a certain high profile opinion leader, whose assessments frequent the pages of the contemptible @nytimes.com...
👇🤷🏻♀️🥴
bsky.app/profile/marc...
👇🤷🏻♀️🥴
bsky.app/profile/marc...
More severe symptoms = more SC2-specific antibodies. No difference for LC.
Any immune suppression/damage/dysregulation? No, all cytokine levels and cell numbers are comparable.
But, looking in more detail, some modest alterations can be seen. You would expect some, considering some report LC.
5/10
Any immune suppression/damage/dysregulation? No, all cytokine levels and cell numbers are comparable.
But, looking in more detail, some modest alterations can be seen. You would expect some, considering some report LC.
5/10
April 12, 2025 at 1:15 PM
Lies come so easy to some.
-I post science and even politics, nothing exclusive.
-I highlight science in context and meaning.
-I have not captured anyone.
-Immunesuppression is a thing, HIV, FKB506, CsA, steroids, etc. It should not ve confounded with immune feedback mechanisms, such as high IFNs
-I post science and even politics, nothing exclusive.
-I highlight science in context and meaning.
-I have not captured anyone.
-Immunesuppression is a thing, HIV, FKB506, CsA, steroids, etc. It should not ve confounded with immune feedback mechanisms, such as high IFNs
Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts @jhumimmunity.org @esibor.bsky.social
@shenyingzhang1.bsky.social @casanovalab.bsky.social
rupress.org/jhi/article/...
@shenyingzhang1.bsky.social @casanovalab.bsky.social
rupress.org/jhi/article/...
March 18, 2026 at 2:19 AM
Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts @jhumimmunity.org @esibor.bsky.social
@shenyingzhang1.bsky.social @casanovalab.bsky.social
rupress.org/jhi/article/...
@shenyingzhang1.bsky.social @casanovalab.bsky.social
rupress.org/jhi/article/...