Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults with HSV encephalitis (5%) compared with the general population rupress.org/jem/article/...
September 28, 2026 at 4:00 PM
Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults with HSV encephalitis (5%) compared with the general population rupress.org/jem/article/...
In @jem.org, Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults w/ HSV encephalitis (5%) compared w/ the general population rupress.org/jem/article/...
September 28, 2026 at 4:00 PM
In @jem.org, Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults w/ HSV encephalitis (5%) compared w/ the general population rupress.org/jem/article/...
Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
September 26, 2026 at 10:01 AM
Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
September 26, 2026 at 7:15 AM
Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
September 26, 2026 at 7:15 AM
Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain https://www.biorxiv.org/content/10.64898/2026.09.23.753833v1
AAN-I-IFNs in COVID-19 pts linked to 🔺nasopharyngeal viral load (P=1.4x10⁻³) & delayed clearance (P=.013). These + high viral load = risk factors for critical disease.⚠️
High Nasopharyngeal SARS-CoV-2 Load and Delayed Clearance in Hospitalized Patients With Blood Autoantibodies Neutralizing Type I Interferons
AbstractAutoantibodies neutralizing type I interferon (AAN-I-IFNs) underlie life-threatening COVID-19. In hospitalized COVID-19 patients of the DisCoVeRy trial (NCT-04315948), AAN-I-IFNs were associated with higher nasopharyngeal viral load at inclusion (P = 1.4 × 10−3) and delayed viral clearance (P = .013). Blood AAN-I-IFNs, high viral load and delayed clearance were also independent risk factors for critical COVID-19.
academic.oup.com
September 25, 2026 at 6:00 AM
AAN-I-IFNs in COVID-19 pts linked to 🔺nasopharyngeal viral load (P=1.4x10⁻³) & delayed clearance (P=.013). These + high viral load = risk factors for critical disease.⚠️
High prevalence of #autoantibodies neutralizing type I IFNs in Japanese patients with #hepatitis C. New study from Maki Taniguchi, Satoshi Okada and colleagues (Hiroshima University):
rupress.org/jhi/article/...
#Autoimmunity #Infections #InbornErrorsOfImmunity
rupress.org/jhi/article/...
#Autoimmunity #Infections #InbornErrorsOfImmunity
September 23, 2026 at 1:45 PM
High prevalence of #autoantibodies neutralizing type I IFNs in Japanese patients with #hepatitis C. New study from Maki Taniguchi, Satoshi Okada and colleagues (Hiroshima University):
rupress.org/jhi/article/...
#Autoimmunity #Infections #InbornErrorsOfImmunity
rupress.org/jhi/article/...
#Autoimmunity #Infections #InbornErrorsOfImmunity
Beyond immunity: hematopoietic involvement in nonhematological inborn errors of immunity #immunology
Beyond immunity: hematopoietic involvement in nonhematological inborn errors of immunity
Inborn errors of immunity (IEIs) are a group of disorders caused by defects in the immune system. Emerging evidence indicates that dysregulated interferon (IFN) signaling can perturb hematopoietic stem cells in nonhematological IEIs. This forum examines the role of IFNs in regulating hematopoiesis to inform prognosis and therapeutic strategies in IEI.
dlvr.it
September 23, 2026 at 11:16 AM
Beyond immunity: hematopoietic involvement in nonhematological inborn errors of immunity #immunology
Bassin d’Arcachon : l’ensemble Colcanto interprète le « Stabat Mater » de Karl Jenkins à l’église d’Arès
🔗https://l.sudouest.fr/iFNS
🔗https://l.sudouest.fr/iFNS
September 22, 2026 at 11:34 PM
Bassin d’Arcachon : l’ensemble Colcanto interprète le « Stabat Mater » de Karl Jenkins à l’église d’Arès
🔗https://l.sudouest.fr/iFNS
🔗https://l.sudouest.fr/iFNS
Autoantibodies against type-I interferons (AAN-I-IFNs) are key in severe viral infections like life-threatening COVID-19, revealing diverse B cell responses even before severe symptoms. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1
No description available
www.cell.com
September 22, 2026 at 4:00 PM
Autoantibodies against type-I interferons (AAN-I-IFNs) are key in severe viral infections like life-threatening COVID-19, revealing diverse B cell responses even before severe symptoms. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA 🧪
🧨Interferon Production: Upstream kinases like MST1/2 can directly enhance the activation of IRF3 (Interferon Regulatory Factor 3). IRF3 then enters the nucleus to trigger the production of Type I Interferons (IFNs), which are the body's premier first-line defense chemicals against viruses
September 22, 2026 at 5:23 AM
🧨Interferon Production: Upstream kinases like MST1/2 can directly enhance the activation of IRF3 (Interferon Regulatory Factor 3). IRF3 then enters the nucleus to trigger the production of Type I Interferons (IFNs), which are the body's premier first-line defense chemicals against viruses
Endogenous and/or exogenous type I IFNs may contribute to the development of auto-Abs neutralizing type I IFNs:
High prevalence of autoantibodies neutralizing type I IFNs in Japanese patients with hepatitis C rupress.org/jhi/article/...
High prevalence of autoantibodies neutralizing type I IFNs in Japanese patients with hepatitis C rupress.org/jhi/article/...
High prevalence of autoantibodies neutralizing type I IFNs in Japanese patients with hepatitis C
The prevalence of autoantibodies neutralizing type I IFNs is significantly higher in Japanese patients with hepatitis C (2.7%) than in age-matched healthy
rupress.org
September 16, 2026 at 8:03 PM
Endogenous and/or exogenous type I IFNs may contribute to the development of auto-Abs neutralizing type I IFNs:
High prevalence of autoantibodies neutralizing type I IFNs in Japanese patients with hepatitis C rupress.org/jhi/article/...
High prevalence of autoantibodies neutralizing type I IFNs in Japanese patients with hepatitis C rupress.org/jhi/article/...
In @jhumimmunity.org, Taniguchi et al find the prevalence of autoantibodies neutralizing type I IFNs is significantly higher in Japanese patients w/ hepatitis C than in age-matched healthy controls, & is even higher in those treated w/ IFN-α than in untreated individuals rupress.org/jhi/article/...
September 16, 2026 at 5:30 PM
In @jhumimmunity.org, Taniguchi et al find the prevalence of autoantibodies neutralizing type I IFNs is significantly higher in Japanese patients w/ hepatitis C than in age-matched healthy controls, & is even higher in those treated w/ IFN-α than in untreated individuals rupress.org/jhi/article/...
Taniguchi et al. find the prevalence of #autoantibodies neutralizing type I IFNs is significantly higher in Japanese patients w/ #hepatitis C (2.7%) than in age-matched healthy controls (0.7%), and is even higher in those treated w/ IFN-α than in untreated individuals. rupress.org/jhi/article/...
September 16, 2026 at 4:00 PM
Taniguchi et al. find the prevalence of #autoantibodies neutralizing type I IFNs is significantly higher in Japanese patients w/ #hepatitis C (2.7%) than in age-matched healthy controls (0.7%), and is even higher in those treated w/ IFN-α than in untreated individuals. rupress.org/jhi/article/...
Study reveals that AAN-I-IFNs+ COVID-19 patients exhibit a robust, diverse B cell response, similar to those with genetic T cell tolerance defects, impacting severe viral infections. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1
No description available
www.cell.com
September 16, 2026 at 4:00 PM
Study reveals that AAN-I-IFNs+ COVID-19 patients exhibit a robust, diverse B cell response, similar to those with genetic T cell tolerance defects, impacting severe viral infections. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA 🧪
AAN-I-IFNs+ patients with severe COVID-19 show robust type-I IFN-specific B cells, marking a strong link between autoantibodies and viral severity. This diverse B cell response appears before critical illness… PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1
https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1
No description available
www.cell.com
September 11, 2026 at 12:00 PM
AAN-I-IFNs+ patients with severe COVID-19 show robust type-I IFN-specific B cells, marking a strong link between autoantibodies and viral severity. This diverse B cell response appears before critical illness… PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1
Chronic type II interferon promotes tumor growth through mitochondrial RNA–induced type I interferon and prostaglandin synthesis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Chronic type II interferon promotes tumor growth through mitochondrial RNA–induced type I interferon and prostaglandin synthesis
Interferons (IFNs) are proinflammatory cytokines that promote immune cell engagement to eliminate malignant cells. Paradoxically, chronic interferon signaling can also activate anti-inflammatory mecha...
www.science.org
September 10, 2026 at 11:21 PM
Chronic type II interferon promotes tumor growth through mitochondrial RNA–induced type I interferon and prostaglandin synthesis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
University of British Columbia researchers found SARS-CoV-2 3CLpro cuts glycosylated IFN-λ1, suppressing STAT1 and antiviral genes.
IFN-λ2 stayed active, while host MMPs degraded 3CLpro.
www.biorxiv.org/content/10.6...
IFN-λ2 stayed active, while host MMPs degraded 3CLpro.
www.biorxiv.org/content/10.6...
Interferon redundancy counteracts proteolytic inactivation by SARS-CoV-2 3CL main protease
Interferons (IFNs) are secreted during virus infection and induce antiviral responses through receptor-mediated phosphorylation of signal transducer and activator of transcription (STAT) proteins, lea...
www.biorxiv.org
September 8, 2026 at 8:49 PM
University of British Columbia researchers found SARS-CoV-2 3CLpro cuts glycosylated IFN-λ1, suppressing STAT1 and antiviral genes.
IFN-λ2 stayed active, while host MMPs degraded 3CLpro.
www.biorxiv.org/content/10.6...
IFN-λ2 stayed active, while host MMPs degraded 3CLpro.
www.biorxiv.org/content/10.6...
AAN-I-IFNs+ patients with severe COVID-19 show a stable, diverse B cell response that neutralizes type-I interferons, indicating a connection to T cell tolerance defects. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1
No description available
www.cell.com
September 7, 2026 at 7:00 AM
Since TBK1/IKKe also function downstream of viral sensors to induce type I IFNs, this is likely an evolutionary adaptation to infection by pathogens that encode TBK1/IKKe antagonists. This would enable the infected cells to be eliminated by IFNg secreted by T and NK cells.
September 7, 2026 at 5:24 AM
Since TBK1/IKKe also function downstream of viral sensors to induce type I IFNs, this is likely an evolutionary adaptation to infection by pathogens that encode TBK1/IKKe antagonists. This would enable the infected cells to be eliminated by IFNg secreted by T and NK cells.
Study reveals that AAN-I-IFNs in severe COVID-19 patients trigger a diverse B cell response similar to genetic T cell tolerance defects, shedding light on viral disease mechanisms. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1
No description available
www.cell.com
September 2, 2026 at 4:00 PM
Study reveals that AAN-I-IFNs in severe COVID-19 patients trigger a diverse B cell response similar to genetic T cell tolerance defects, shedding light on viral disease mechanisms. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA #ASHG 🧪
AAN-I-IFNs+ patients with critical COVID-19 show diverse, stable type-I IFN-specific B cells, resembling those in T cell tolerance defects, linking autoantibodies to severe viral infections. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1
No description available
www.cell.com
August 30, 2026 at 7:00 AM
AAN-I-IFNs+ patients with critical COVID-19 show diverse, stable type-I IFN-specific B cells, resembling those in T cell tolerance defects, linking autoantibodies to severe viral infections. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky 🧪
We’re excited to welcome our speakers and sharing their insights with you 😊 www.immunology-conference.de/scientific-p...
@zielinskilab.bsky.social @uni-wuerzburg.de @efis-immunology.bsky.social @dgfi-yi.bsky.social @iuis-online.bsky.social
#immunology26 #dgfi #SkinScience #Dermatology
@zielinskilab.bsky.social @uni-wuerzburg.de @efis-immunology.bsky.social @dgfi-yi.bsky.social @iuis-online.bsky.social
#immunology26 #dgfi #SkinScience #Dermatology
August 26, 2026 at 9:40 AM
We’re excited to welcome our speakers and sharing their insights with you 😊 www.immunology-conference.de/scientific-p...
@zielinskilab.bsky.social @uni-wuerzburg.de @efis-immunology.bsky.social @dgfi-yi.bsky.social @iuis-online.bsky.social
#immunology26 #dgfi #SkinScience #Dermatology
@zielinskilab.bsky.social @uni-wuerzburg.de @efis-immunology.bsky.social @dgfi-yi.bsky.social @iuis-online.bsky.social
#immunology26 #dgfi #SkinScience #Dermatology