G&M’s Andrew Coyne showed full HC transfers aren’t spent on HC by provinces.
In AB, UCP ‘refocus’, Dynalife, fake studies, corp virtual & primary care, #CorruptCare (Tylenot, poor PPE, overpriced CSF), all come from limited HC budgets.
How much is left for critical HC, after UCP grift?
#abpoli
In AB, UCP ‘refocus’, Dynalife, fake studies, corp virtual & primary care, #CorruptCare (Tylenot, poor PPE, overpriced CSF), all come from limited HC budgets.
How much is left for critical HC, after UCP grift?
#abpoli
March 18, 2025 at 5:35 PM
G&M’s Andrew Coyne showed full HC transfers aren’t spent on HC by provinces.
In AB, UCP ‘refocus’, Dynalife, fake studies, corp virtual & primary care, #CorruptCare (Tylenot, poor PPE, overpriced CSF), all come from limited HC budgets.
How much is left for critical HC, after UCP grift?
#abpoli
In AB, UCP ‘refocus’, Dynalife, fake studies, corp virtual & primary care, #CorruptCare (Tylenot, poor PPE, overpriced CSF), all come from limited HC budgets.
How much is left for critical HC, after UCP grift?
#abpoli
Hot off the press. We observed elevated levels of G-CSF in AMD human donor RPE-Choroid tissue and identified c-reactive protein as an AMD associated stressor responsible for increased G-CSF levels. @choroidlab.bsky.social @adnankhan.bsky.social @stemcellseh.bsky.social.
Elevation of Granulocyte Colony Stimulating Factor in Human AMD Donor RPE-Choroid | IOVS | ARVO Journals
iovs.arvojournals.org
December 6, 2024 at 4:51 PM
Hot off the press. We observed elevated levels of G-CSF in AMD human donor RPE-Choroid tissue and identified c-reactive protein as an AMD associated stressor responsible for increased G-CSF levels. @choroidlab.bsky.social @adnankhan.bsky.social @stemcellseh.bsky.social.
Real-world use of G-CSF primary prophylaxis in small cell #LungCancer: secondary data analysis from the French national cohorts KBP-2020-CPHG and ESCAP-2020-CPHG. link.springer.com/article/10.1...
Real-world use of G-CSF primary prophylaxis in small cell lung cancer: secondary data analysis from the French national cohorts KBP-2020-CPHG and ESCAP-2020-CPHG - Supportive Care in Cancer
Purpose Small-cell lung cancer (SCLC) is an aggressive malignancy frequently associated with chemotherapy-induced febrile neutropenia (FN), particularly with etoposide-platinum-based regimens. G-CSF p...
link.springer.com
September 25, 2026 at 9:44 AM
Real-world use of G-CSF primary prophylaxis in small cell #LungCancer: secondary data analysis from the French national cohorts KBP-2020-CPHG and ESCAP-2020-CPHG. link.springer.com/article/10.1...
☺️ Welcome! 😊
You can now also follow us here on Bluesky.
Spearheaded by EF CLIF, 13 partners joined forces for the A-TANGO project in March 2021 to develop G-TAK, a novel combinatorial therapy for #ACLF (acute-on-chronic #LiverFailure) by using the synergistic actions of G-CSF + TAK-242. #LiverSky
You can now also follow us here on Bluesky.
Spearheaded by EF CLIF, 13 partners joined forces for the A-TANGO project in March 2021 to develop G-TAK, a novel combinatorial therapy for #ACLF (acute-on-chronic #LiverFailure) by using the synergistic actions of G-CSF + TAK-242. #LiverSky
January 16, 2025 at 4:46 PM
☺️ Welcome! 😊
You can now also follow us here on Bluesky.
Spearheaded by EF CLIF, 13 partners joined forces for the A-TANGO project in March 2021 to develop G-TAK, a novel combinatorial therapy for #ACLF (acute-on-chronic #LiverFailure) by using the synergistic actions of G-CSF + TAK-242. #LiverSky
You can now also follow us here on Bluesky.
Spearheaded by EF CLIF, 13 partners joined forces for the A-TANGO project in March 2021 to develop G-TAK, a novel combinatorial therapy for #ACLF (acute-on-chronic #LiverFailure) by using the synergistic actions of G-CSF + TAK-242. #LiverSky
Tomorrow at #Immunology2025, Jonah Stephan, a PhD student from Dr. Wysoczynski Marcin's lab, will present a poster on his recent work on G-CSF-induced Emergency Granulopoiesis and the modulation of Neutrophil Effector Function. #cardiosky @aai.org
May 4, 2025 at 2:28 PM
Tomorrow at #Immunology2025, Jonah Stephan, a PhD student from Dr. Wysoczynski Marcin's lab, will present a poster on his recent work on G-CSF-induced Emergency Granulopoiesis and the modulation of Neutrophil Effector Function. #cardiosky @aai.org
1年前の今日 白血球足りなくてG-CSF製剤打ってた
July 3, 2026 at 1:26 AM
1年前の今日 白血球足りなくてG-CSF製剤打ってた
🚨 Our newest manuscript is out in Nature Communications:
Hypersialylation in breast cancer immunoregulation: uncovering novel mechanisms and highlighting major therapeutic potential.
+6 years in the making.
Dive into: tinyurl.com/sialic
@meduniwien.ac.at
Hypersialylation in breast cancer immunoregulation: uncovering novel mechanisms and highlighting major therapeutic potential.
+6 years in the making.
Dive into: tinyurl.com/sialic
@meduniwien.ac.at
Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer - Nature Communications
Tumor sialylation has been associated with different mechanisms of immune evasion. Here the authors show that tumor sialylation regulates G-CSF stability to promote neutrophil-mediated immunosuppression as well dampens tumor cell immunogenicity by limiting MHC-I surface expression, limiting anti-tumor immunity in breast cancer.
tinyurl.com
June 2, 2026 at 3:07 PM
🚨 Our newest manuscript is out in Nature Communications:
Hypersialylation in breast cancer immunoregulation: uncovering novel mechanisms and highlighting major therapeutic potential.
+6 years in the making.
Dive into: tinyurl.com/sialic
@meduniwien.ac.at
Hypersialylation in breast cancer immunoregulation: uncovering novel mechanisms and highlighting major therapeutic potential.
+6 years in the making.
Dive into: tinyurl.com/sialic
@meduniwien.ac.at
Some paper showed that to achieve better CSF penetration/levels one must go higher up to 2 g, q6h or 8-10 g/day in continuous infusion.
February 22, 2025 at 6:38 PM
Some paper showed that to achieve better CSF penetration/levels one must go higher up to 2 g, q6h or 8-10 g/day in continuous infusion.
白血病患者とマッチしたので5日前から毎日G-CSFを注射して、今日は造血幹細胞提供するため入院
動脈の針は結構痛い(；´Д｀)
動脈の針は結構痛い(；´Д｀)
June 25, 2025 at 3:39 AM
白血病患者とマッチしたので5日前から毎日G-CSFを注射して、今日は造血幹細胞提供するため入院
動脈の針は結構痛い(；´Д｀)
動脈の針は結構痛い(；´Д｀)
Skin-derived G-CSF activates pathological granulopoiesis upon psoriasis https://www.biorxiv.org/content/10.1101/2025.10.10.681054v1
October 12, 2025 at 3:16 AM
Skin-derived G-CSF activates pathological granulopoiesis upon psoriasis https://www.biorxiv.org/content/10.1101/2025.10.10.681054v1
🌟 POSTER THU-182 by Supachaya S. (UCL, @rajivjalan.bsky.social) featured in a #PosterTour at #EASLCongress! 👏
👉 Transcriptomic & metabolic insights into #hyperammonemia: The complementary therapeutic roles of #TLR4 inhibitor (#TAK242) + ornithine phenylacetate
👍 In A-TANGO, we use #TAK242 + G-CSF
👉 Transcriptomic & metabolic insights into #hyperammonemia: The complementary therapeutic roles of #TLR4 inhibitor (#TAK242) + ornithine phenylacetate
👍 In A-TANGO, we use #TAK242 + G-CSF
May 9, 2025 at 3:05 PM
🌟 POSTER THU-182 by Supachaya S. (UCL, @rajivjalan.bsky.social) featured in a #PosterTour at #EASLCongress! 👏
👉 Transcriptomic & metabolic insights into #hyperammonemia: The complementary therapeutic roles of #TLR4 inhibitor (#TAK242) + ornithine phenylacetate
👍 In A-TANGO, we use #TAK242 + G-CSF
👉 Transcriptomic & metabolic insights into #hyperammonemia: The complementary therapeutic roles of #TLR4 inhibitor (#TAK242) + ornithine phenylacetate
👍 In A-TANGO, we use #TAK242 + G-CSF
New AGIHO guideline update on G-CSF prophylaxis in adult cancer patients! Evidence-based recommendations incl. immunotherapy settings, biosimilars & risk stratification to support clinical decision-making.
🔗 pubmed.ncbi.nlm.nih.gov/41570611/
@rosannesprute.bsky.social
#Oncology #Guidelines
🔗 pubmed.ncbi.nlm.nih.gov/41570611/
@rosannesprute.bsky.social
#Oncology #Guidelines
Evidence-based AGIHO guideline update on prophylaxis of infectious complications with granulocyte-stimulating factors (G-CSF) for the treatment of adult patients with cancer - PubMed
Comprehensive literature search and expert panel consensus confirm most of the key recommendations of 2014. New recommendations on the use of G-CSF in immunotherapy settings provide insight and support for day-by-day clinical decision making in the care of patients with cancer.
pubmed.ncbi.nlm.nih.gov
February 3, 2026 at 10:02 AM
New AGIHO guideline update on G-CSF prophylaxis in adult cancer patients! Evidence-based recommendations incl. immunotherapy settings, biosimilars & risk stratification to support clinical decision-making.
🔗 pubmed.ncbi.nlm.nih.gov/41570611/
@rosannesprute.bsky.social
#Oncology #Guidelines
🔗 pubmed.ncbi.nlm.nih.gov/41570611/
@rosannesprute.bsky.social
#Oncology #Guidelines
This phenotype is driven by inflammatory cues (TGF-β/GM-CSF) and enhanced by G-CSF priming—highlighting tissue-driven immune heterogeneity. Way to go, Team. Check out the paper here: pubmed.ncbi.nlm.nih.gov/42019709/
SiglecF-expressing neutrophils differentiate from mature neutrophils locally in the heart after myocardial infarction - PubMed
Myocardial infarction (MI) triggers an immune response marked by rapid infiltration of neutrophils. Although once considered a uniform population, neutrophils display remarkable heterogeneity post-MI,...
pubmed.ncbi.nlm.nih.gov
June 9, 2026 at 10:37 PM
This phenotype is driven by inflammatory cues (TGF-β/GM-CSF) and enhanced by G-CSF priming—highlighting tissue-driven immune heterogeneity. Way to go, Team. Check out the paper here: pubmed.ncbi.nlm.nih.gov/42019709/
A bit of Pumpkin Lore right there, and the tale of the floating G.
Now, with a TBI, brain fog, and a CSF leak, stuff like that flusters and upsets me. My brain cannot understand how anyone could possibly think that way and argue about something like that, and I get what I call a brain tangle.
Now, with a TBI, brain fog, and a CSF leak, stuff like that flusters and upsets me. My brain cannot understand how anyone could possibly think that way and argue about something like that, and I get what I call a brain tangle.
September 18, 2026 at 11:38 PM
A bit of Pumpkin Lore right there, and the tale of the floating G.
Now, with a TBI, brain fog, and a CSF leak, stuff like that flusters and upsets me. My brain cannot understand how anyone could possibly think that way and argue about something like that, and I get what I call a brain tangle.
Now, with a TBI, brain fog, and a CSF leak, stuff like that flusters and upsets me. My brain cannot understand how anyone could possibly think that way and argue about something like that, and I get what I call a brain tangle.
Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer @natcomms.nature.com @smereiter.bsky.social @meduniwien.ac.at @penningerlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 24, 2026 at 2:28 AM
Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer @natcomms.nature.com @smereiter.bsky.social @meduniwien.ac.at @penningerlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Introducing StorybookGPT, a GPT that automatically generates stories for React + TypeScript components! 💥
Incredible work by by our community member, Kaelig 👏 Check it out!
chat.openai.com/g/g-Ev8pDjD1...
Incredible work by by our community member, Kaelig 👏 Check it out!
chat.openai.com/g/g-Ev8pDjD1...
ChatGPT - React / TypeScript StorybookGPT
Creates React Storybook stories (in TypeScript and CSF v2)
chat.openai.com
November 16, 2023 at 3:41 PM
Introducing StorybookGPT, a GPT that automatically generates stories for React + TypeScript components! 💥
Incredible work by by our community member, Kaelig 👏 Check it out!
chat.openai.com/g/g-Ev8pDjD1...
Incredible work by by our community member, Kaelig 👏 Check it out!
chat.openai.com/g/g-Ev8pDjD1...
Rothaarige Menschen machen nach G-CSF Mobilisation weniger CD34+ als dunkelhaarige Menschen. Kann es nicht ohne weiteres belegen aber irgendwie ist es ein Ding.
April 3, 2024 at 3:47 PM
Rothaarige Menschen machen nach G-CSF Mobilisation weniger CD34+ als dunkelhaarige Menschen. Kann es nicht ohne weiteres belegen aber irgendwie ist es ein Ding.
🆕 Study hints at potential benefits of G-CSF in treating severe alcoholic hepatitis
👍 90-day survival beats no treatment, matches steroids
⚠️ Limited data, cause of death & long-term effects unknown
⚖️ Sepsis & encephalopathy rates similar between groups
🔓 doi.org/10.1111/liv....
#LiverSky #MedSky
👍 90-day survival beats no treatment, matches steroids
⚠️ Limited data, cause of death & long-term effects unknown
⚖️ Sepsis & encephalopathy rates similar between groups
🔓 doi.org/10.1111/liv....
#LiverSky #MedSky
November 16, 2024 at 7:43 PM
🆕 Study hints at potential benefits of G-CSF in treating severe alcoholic hepatitis
👍 90-day survival beats no treatment, matches steroids
⚠️ Limited data, cause of death & long-term effects unknown
⚖️ Sepsis & encephalopathy rates similar between groups
🔓 doi.org/10.1111/liv....
#LiverSky #MedSky
👍 90-day survival beats no treatment, matches steroids
⚠️ Limited data, cause of death & long-term effects unknown
⚖️ Sepsis & encephalopathy rates similar between groups
🔓 doi.org/10.1111/liv....
#LiverSky #MedSky
👏 1st Site Visit Completed for A-TANGO's #ClinicalTrial: Thanks to big efforts by Yaqrit + Royal Free Hospital, we have kicked off our Phase 2a trial, evaluating the safety of #TLR4 antagonist in combination with #G-CSF for the treatment of #ACLF!
#BenchToBedside #cirrhosis
@rajivjalan.bsky.social
#BenchToBedside #cirrhosis
@rajivjalan.bsky.social
October 4, 2025 at 5:03 AM
👏 1st Site Visit Completed for A-TANGO's #ClinicalTrial: Thanks to big efforts by Yaqrit + Royal Free Hospital, we have kicked off our Phase 2a trial, evaluating the safety of #TLR4 antagonist in combination with #G-CSF for the treatment of #ACLF!
#BenchToBedside #cirrhosis
@rajivjalan.bsky.social
#BenchToBedside #cirrhosis
@rajivjalan.bsky.social
New paper out: Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration.: De Houwer, Julie F H; Dopper, Elise G; van Buuren, Renee; et al.
Brain Vol. 149, no. 8, p. 2816 - 2830 | Thanks for sharing #dzne #papers
Brain Vol. 149, no. 8, p. 2816 - 2830 | Thanks for sharing #dzne #papers
Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration.
De Houwer, Julie F H; Dopper, Elise G; van Buuren, Renee; et al.
Brain Vol. 149, no. 8, p. 2816 - 2830
dlvr.it
August 8, 2026 at 5:41 AM
Doch, das „boostern“ geht schon.
Über ein teures, subcutan zu verabreichendes Medikament namens G-CSF, damit mehr weiße Blutkörperchen ausgeschüttet werden.
Das wird aber dann doch eher nicht von Voelkel pharmaceuticals hergestellt.
Über ein teures, subcutan zu verabreichendes Medikament namens G-CSF, damit mehr weiße Blutkörperchen ausgeschüttet werden.
Das wird aber dann doch eher nicht von Voelkel pharmaceuticals hergestellt.
February 6, 2026 at 12:36 PM
Doch, das „boostern“ geht schon.
Über ein teures, subcutan zu verabreichendes Medikament namens G-CSF, damit mehr weiße Blutkörperchen ausgeschüttet werden.
Das wird aber dann doch eher nicht von Voelkel pharmaceuticals hergestellt.
Über ein teures, subcutan zu verabreichendes Medikament namens G-CSF, damit mehr weiße Blutkörperchen ausgeschüttet werden.
Das wird aber dann doch eher nicht von Voelkel pharmaceuticals hergestellt.
I wrote about how neuroscience advances not only through new data, but through new language.
“Glymphatic system” (introduced in 2012), E–I imbalance in epilepsy, mirror neurons, channelopathies — all useful frameworks.
But frameworks are not mechanisms.
epilepsygenetics.blog/2026/02/15/g...
“Glymphatic system” (introduced in 2012), E–I imbalance in epilepsy, mirror neurons, channelopathies — all useful frameworks.
But frameworks are not mechanisms.
epilepsygenetics.blog/2026/02/15/g...
February 16, 2026 at 1:57 AM
I wrote about how neuroscience advances not only through new data, but through new language.
“Glymphatic system” (introduced in 2012), E–I imbalance in epilepsy, mirror neurons, channelopathies — all useful frameworks.
But frameworks are not mechanisms.
epilepsygenetics.blog/2026/02/15/g...
“Glymphatic system” (introduced in 2012), E–I imbalance in epilepsy, mirror neurons, channelopathies — all useful frameworks.
But frameworks are not mechanisms.
epilepsygenetics.blog/2026/02/15/g...