#GATA2
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ipopi.bsky.social
🧬 Living with GATA2 deficiency? Your experience matters.

Your perspective can help contribute to a better understanding of GATA2 deficiency and support more personalised care.
📅 Survey closes: 31 October 2026

👉 Take the survey: www.surveymonkey.com/r/V7B9F83

🔗 Learn more: gata2project.eu
September 15, 2026 at 11:07 AM
jazzergoalie.bsky.social
Great piece!
gata2
Alt: Blade Runner clip of Pris smiling.
static.klipy.com
September 14, 2026 at 1:26 AM
shihcheng.bsky.social
ZEB1, crucial for erythroid maturation, modulates the GATA2-KLF1 switch. Its loss hinders progenitor proliferation in mice and humans. PMID:42331751, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag613 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1093/nar/gkag613
No description available
doi.org
September 5, 2026 at 3:00 AM
wimi-bio-tech.bsky.social
UPenn researchers developed a pooled mammalian screening framework for AI-designed ubiquibodies, using FACS and NGS to identify functional peptide-guided degraders targeting beta-catenin, GFAP, EWS::FLI1, and endogenous GATA2. 🧬🤖 #ProteinDegradation #TPD#bioRxiv2026 #AIProteinDesign #Ubiquibody
August 28, 2026 at 8:15 AM
kyra919.bsky.social
GATA2
August 14, 2026 at 9:19 AM
chang-m-yun.bsky.social
5) Now we explore through a different modality: TF ChIP-seq. Using 5 BPNet models trained on ChIP for GATA2, SP1, CEBPB, JUND, GABPB1 in K562 and its scores, we see that the models highlight the same bases, specific to each TF, orthogonally confirming the key seqs and binders. 9/
August 10, 2026 at 7:00 PM
helena.bio
We are excited to share our new preprint with Academician Draga Toncheva and Vasil Sgurev.

Across 507 TCGA-UCEC and 230 CPTAC-UCEC tumours, GATA2 and SOX9 retained direction across cohorts, but neither passed the universal single-target-deletion gate.

doi.org/10.5281/zeno...
August 7, 2026 at 7:12 PM
htlin.bsky.social
CEBPA 雙突變唯一的好朋友
Biallelic CEBPA 合併 GATA2 突變仍維持 favorable —— 這是少數不會拉低預後的共突變。
其餘都往壞的方向走：NPM1 加 DNMT3A、CEBPA 加 WT1、t(8;21) 加 KIT。
記法：壞朋友一堆，好朋友只有 GATA2。
#血液專科
https://hema-2026.hsiehting.com/q/110-019
August 4, 2026 at 5:57 AM
htlin.bsky.social
哪個 IBMFS 以純紅血球再生不良表現
Diamond-Blackfan anemia —— 白血球與血小板生成正常，只有紅血球前驅細胞在 proerythroblast 階段被阻斷。
Fanconi anemia、dyskeratosis congenita、Shwachman-Diamond、GATA2 症候群則多隨病程進展為三系全血球低下。
記法：Diamond-Blackfan 只有紅血球倒下。
#血液專科
https://hema-2026.hsiehting.com/q/111-054
August 4, 2026 at 4:05 AM
ahmad-ayadi.bsky.social
The Inner Rhythm of Life

ZEB1 guides KLF1 into the cell’s heart to find maturity, turning fragile beginnings into the red cells that sustain our every breath.

academic.oup.com/nar/article/...
ZEB1 drives terminal erythroid maturation by controlling the GATA2–KLF1 regulatory switch
Abstract. Erythropoiesis is a highly coordinated process governed by lineage-defining transcription factors. While several master regulators have been char
academic.oup.com
July 23, 2026 at 9:10 AM
oneinanarmy.bsky.social
75% of blood cancer patients don't find a matching donor in their family. That match could be you. Joining the NMDP Registry is free, painless, and takes just a cheek swab. If you're 18-35 and based in the US, visit: my.nmdp.org/BTSARMY
A purple poster featuring an open spiral bound diary. The diary has a BTS 💜 ARMY bookmark, and the page is framed by a neon green border, the words "Bone Marrow" and "Stem cell" are across the top border, and orange-yellow heart stickers are scattered around the other sides. The diary entry reads: "Every 27 seconds, someone in the world is diagnosed with blood cancer. For many of these patients, a blood stem cell transplant is their best or only shot at survival, but 75% of patients don't have a fully matched donor in their family. That match could be you. In the US, NMDP runs the world's most diverse blood stem cell donor registry, with over 9 million potential donors. Joining is free and simple; all it takes is a cheek swab. If you're between 18-35 and based in the US, you're eligible. NMDP covers all donor expenses including medical costs, travel, lost wages, and even childcare." A small rectangular banner in a darker purple color hovers over the bottom of the page: #ArmyMemoryBox / OIAA July 2026 Campaign. The current campaign OIAA logo is at the top left of the poster, while the general socials address (@oneinanarmy) and website (oneinanarmy.org) are at the bottom right. A purple poster featuring an open spiral bound diary. The diary has a BTS 💜 ARMY bookmark, and the page is framed by a neon green border, the words "Bone Marrow" and "Stem cell" are across the top border, and orange-yellow heart stickers are scattered around the other sides. The diary entry reads: "HOW TO JOIN ▪ Step 1: https://my.nmdp.org/BTSARMY ▪ Step 2: Complete a health history form ▪ Step 3 Receive your cheek swab kit by mail, complete it and send it back" A small rectangular banner in a darker purple color hovers over the bottom of the page: #ArmyMemoryBox / OIAA July 2026 Campaign. The current campaign OIAA logo is at the top left of the poster, while the general socials address (@oneinanarmy) and website (oneinanarmy.org) are at the bottom right. A purple poster featuring an open spiral bound diary. The diary has a BTS 💜 ARMY bookmark, and the page is framed by a neon green border, the words "PATIENT STORY" are across the top border, and orange-yellow heart stickers are scattered around the other sides. The diary entry reads: "Bayleigh is a 29-year-old from Pocatello, Idaho, with Northern European Dutch and Native American heritage. She is living with GATA2 deficiency, a condition with no current treatment option, and is preparing for a bone marrow transplant through a clinical study at the National Institutes of Health in Maryland. Bayleigh’s connection to the transplant journey began early, when she was 12 years old, she served as her sister’s donor. Tragically, her sister passed away from MDS with monosomy 7. Today, Bayleigh is searching for her own donor. That donor could be you." A small rectangular banner in a darker purple color hovers over the bottom of the page: #ArmyMemoryBox / OIAA July 2026 Campaign. The current campaign OIAA logo is at the top left of the poster, while the general socials address (@oneinanarmy) and website (oneinanarmy.org) are at the bottom right.
July 12, 2026 at 3:02 PM
cgconsortium.bsky.social
Q42. What gene mutations are associated transient abnormal myelopoiesis (TAM) and myeloid leukemia associated with Down syndrome (ML-DS)?
A. GATA1
B. GATA2
C. RUNX1
D. CEBPA
July 9, 2026 at 2:02 PM
cgconsortium.bsky.social
Q42. What gene mutations are associated transient abnormal myelopoiesis (TAM) and myeloid leukemia associated with Down syndrome (ML-DS)?
A. GATA1
B. GATA2
C. RUNX1
D. CEBPA

Type your answer in the chat and come back next week for the answer and explination!
July 2, 2026 at 4:00 PM
cgconsortium.bsky.social
Q41. Which of these heme malignancy genes has a GOF mechanism?
A. ANKRD26
B. GATA2
C. CEBPA
D. DDX41
June 23, 2026 at 2:06 PM
cgconsortium.bsky.social
Q41. Which of these heme malignancy genes has a GOF mechanism?
A. ANKRD26
B. GATA2
C. CEBPA
D. DDX41

Type your answer in the chat below and come back next week for the answer and explanation!
June 16, 2026 at 2:05 PM
bencekover.bsky.social
We find large-scale sex-bias across the board, and that this is mostly driven by sex hormones, as nicely shown by several perturbation datasets. In addition, GATA2 seems to implement an additional layer of male-biased expression in gonadotrophs. 6/19
June 5, 2026 at 8:16 AM
research-er.jp
【注目プレスリリース】白血病の進行と先天性骨髄不全の発症を制御する新たなメカニズムを解明 ――転写因子MECOMとGATA2の「機能的競合」が造血異常の鍵を握る―― / 東京大学
https://research-er.jp/articles/view/155790
白血病の進行と先天性骨髄不全の発症を制御する新たなメカニズムを解明 ――転写因子MECOMとGATA2の「機能的競合」が造血異常の鍵を握る――
2026.05.11 東京大学 プレスリリース 発表のポイント難治性白血病原因遺伝子MECOMのC末端領域が主要なDNA結合部位であること、そしてMECOMがCtBPと協調して転...
research-er.jp
May 11, 2026 at 8:14 AM
rridrobot.bsky.social
The authors included RRIDs in their in Blood paper! Thanks for making your methods matter! #OpenScience #BetterScience #accelerateopenscience
GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia
Read the full paper: GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia
doi.org
May 10, 2026 at 7:01 AM
rridrobot.bsky.social
The authors included RRIDs in their in JCI Insight paper! RRIDs improve reproducibility in scientific research. #methodsmatter #ReproducibleResearch #accelerateopenscience
GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function
Read the full paper: GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function
doi.org
May 6, 2026 at 7:02 AM
isehsociety.bsky.social
Germline genetic variation can alter inflammation sensitivity. This review by @vulehuytran.bsky.social and Emery Bresnick dissects mechanisms connecting GATA2, RUNX1, and blood pathogenesis—bone marrow failure and leukemia. Read more on www.exphem.org/article/S030...
April 16, 2026 at 7:05 PM
pitt-immunology.bsky.social
New research from @gottschalklab.bsky.social, @satarupa2025.bsky.social and their team identifies GATA2 as an important regulator of inflammatory responses and metabolism in alveolar macrophages, providing new insights into pulmonary diseases driven by GATA2 deficiency.
April 13, 2026 at 2:15 PM
insight.jci.org
Rachel A. Gottschalk @gottschalklab.bsky.social, Satarupa Ganguly @satarupa2025.bsky.social & team show lung macrophages lacking GATA2 during inflammation promote metabolic dysfunction & profibrotic gene expression in mice: doi.org/10.1172/jci....
April 13, 2026 at 11:02 AM
longtail-news.bsky.social
Feed: "JCI Insight -- New Articles"
GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function
Alveolar macrophages (AMs) catabolize lipid-rich pulmonary surfactant to support gas exchange and have antiinflammatory programming to limit tissue damage in response to minor challenges. GATA transcription factors (TFs) shape immune cell fates, and GATA2 is expressed in a lung-specific manner in macrophages. GATA2 mutations and lung macrophage downregulation of GATA2 have been associated with chronic pulmonary pathologies in humans, but the role of GATA2 in coordinating AM function is not well defined. Using mice with myeloid-specific deletion of the GATA2 DNA binding C-terminal zinc finger domain, we show that GATA2 deficiency promotes enhanced inflammatory gene expression and metabolic dysfunction in AMs in response to type 2 stimuli. Although homeostatic functions of AMs remain largely intact, GATA2 deficiency increases expression of type 2 response genes during IL-33–induced inflammation. Coincident with GATA2-dependent expression of genes in metabolic pathways, Seahorse metabolic flux analysis indicates that AM metabolism is compromised in the absence of GATA2. AM GATA2-dependent gene networks are enriched for targets of TFs previously demonstrated to interact with GATA2 in other cellular contexts, including PU.1, PPARγ, and other regulators of AM function. Our data suggest that GATA2 modulates AM metabolic and transcriptomic programming to restrain responses and maintain AM identity during inflammation.
insight.jci.org
April 12, 2026 at 2:33 AM
onclive.bsky.social
🧬 Emerging data show GATA2 variants don’t fully lose function—instead, they retain selective enhancer activity, skew hematopoietic differentiation, and may activate inflammatory pathways that contribute to leukemogenesis.
Read more ➡️ www.onclive.com/view/gata2-g...
#Leukemia #MDS #oncology
GATA2 Genetic Variants Drive Processes That May Link Germline Predisposition to Hematologic Malignancies | OncLive
GATA2 variants retain enhancer activity, alter differentiation, and may link inflammation to hematologic malignancy risk.
www.onclive.com
April 8, 2026 at 10:25 PM
rridrobot.bsky.social
A paper using RRID:AB_2236705 from @proteintech.bsky.social was just published. We value the author's support of reproducibility. #accelerateopenscience #RRID #methodsmatter
Müllerian duct maintenance at the cranial region is promoted by <i>Gata2</i>
Read the full paper: Müllerian duct maintenance at the cranial region is promoted by <i>Gata2</i>
doi.org
April 3, 2026 at 7:00 AM