In desert ecosystems, microbial activity is driven by brief hydration pulses but is severely limited by persistent nutrient scarcity. Cyanobacteria...

Guanidine is well known as a denaturing agent. However, recent studies have demonstrated both the widespread synthesis of guanidine, e.g., in plant...

Guanidine is a well-known chaotropic agent used to denature proteins and nucleic acids. However, recent studies have demonstrated both the widespread synthesis of guanidine, e.g. in plants and mammals...

Guanidine is well known as a denaturing agent. However, recent studies have demonstrated both the widespread synthesis of guanidine, e.g., in plant...

More than two decades ago, the first naturally occurring mRNA elements regulating gene expression by directly binding target ligands, termed riboswitches, were discovered in bacteria (1–4). Since then, more than 55 classes of riboswitches have been characterized (5, 6), advancing our general knowledge of gene regulation and stress response, but also unveiling unexpected biological roles for compounds whose relevance had remained elusive. A notable example is the discovery of riboswitches recognizing c-di-AMP and c-AMP-GMP (7, 8), which hinted at important biological functions for the two molecules that were later revealed to act as second messengers in key cellular processes such as biofilm formation, chemotaxis, sporulation, and virulence (9–11).

The origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine-containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines....

Malaria is a disease caused by pathogenic protozoa Plasmodium spp., with a significant global impact on human health. Increasing resistance of P. falciparum strains to drugs treating malaria highlight...

Copper complexes of tripodal ligands have been used as model systems for electron transfer proteins for decades, displaying a broad range of electron self-exchange rates. We herein report a group of s...

150 years ago, guanidine was found to affect muscle function via unknown mechanisms. Here, Kavita et al. provide evidence that guanine-sensing RNAs are present in many eukaryotic transcripts relevant ...

Guanidine is a protein denaturant that is a widely used constituent in explosives, plastics, and resins. Its effects on muscle contraction were initially reported in 1876, which eventually led to the use of guanidine as a treatment for certain ataxia symptoms such as those caused by Lambert-Eaton disease. However, its mechanisms of therapeutic action remained unknown. Guanidine was recently found to be a widespread natural metabolite through the discovery of four bacterial riboswitch classes that selectively recognize this compound. Here, we report the discovery and biochemical validation of vertebrate members of guanidine-I and -II riboswitch aptamer classes that are associated with numerous genes relevant to neuromuscular function, mostly involved in Ca2+ transport or signaling. These findings suggest that guanidine is a widely used signaling molecule that serves as an additional layer of regulation of genes relevant to neuromuscular disorders. 150 years ago, guanidine was found to a

A comprehensive understanding of RNA-based gene regulation is a fundamental aspect for the development of innovative therapeutic options in medicine and for a more targeted response to environmental p...

We present a bifunctional catalyst consisting of a copper(I)/N-heterocyclic carbene and an organocatalytic guanidine moiety that enables, for the first time, a copper(I)-catalyzed reduction of amides ...

Guanidine is an organic compound primarily used as a denaturing reagent to disrupt the structures of proteins and nucleic acids.

The antihypertensive effect of the guanidine derivative BS 100-141 (N-amidino-2-(2,6-dichlorphenyl)acetamide hydrochloride) has been studied in 11 hospitalized patients suffering from essential hypert...

What’s in Your Tube?: A Quick Guide to Measuring DNA by Spectrophotometry

Guanidine is an organic compound primarily used as a denaturing reagent to disrupt the structures of proteins and nucleic acids. Together with partner institutions, scientists at the Helmholtz Centre ...