CD8+ Tem GZMK+ to GZMB+ ratio distinguishes healthy from disease-associated trajectories and predicts mortality risk @cp-immunity.bsky.social
www.cell.com/immunity/ful... @washumedicine.bsky.social @nationwidekids.bsky.social @kingscollegelondon.bsky.social
www.cell.com/immunity/ful... @washumedicine.bsky.social @nationwidekids.bsky.social @kingscollegelondon.bsky.social
October 10, 2026 at 11:10 PM
CD8+ Tem GZMK+ to GZMB+ ratio distinguishes healthy from disease-associated trajectories and predicts mortality risk @cp-immunity.bsky.social
www.cell.com/immunity/ful... @washumedicine.bsky.social @nationwidekids.bsky.social @kingscollegelondon.bsky.social
www.cell.com/immunity/ful... @washumedicine.bsky.social @nationwidekids.bsky.social @kingscollegelondon.bsky.social
RRIDs were included in this in Immunity paper. RRIDs improve reproducibility in scientific research. #RRID #methodsmatter #OpenResearch
Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories
Read the full paper: Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories
doi.org
October 11, 2026 at 7:00 AM
RRIDs were included in this in Immunity paper. RRIDs improve reproducibility in scientific research. #RRID #methodsmatter #OpenResearch
Online now: Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories
Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories
Terekhova et al. assemble a single-cell PBMC atlas of 8 datasets, 2,609 individuals, and over 12 million cells to dissect variable and conserved features of human immune aging. CD8+ Tem GZMK+ to GZMB+ ratio distinguishes healthy from disease-associated trajectories and predicts mortality risk. This work provides a clinically relevant marker for monitoring human aging.
dlvr.it
October 9, 2026 at 2:48 PM
Online now: Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories
A study of 2,600 individuals found that the ratio of GZMK+ to GZMB+ T cells predicts health outcomes. Genetic and environmental factors drive differences in immune aging between people of the same age.
#ImmuneAging #Gzmk #Gzmb
#ImmuneAging #Gzmk #Gzmb
Study of 12.4 million immune cells reveals determinants of immune aging
Source: GEN (Genetic Eng News)
realfeedapp.com
October 10, 2026 at 12:40 PM
A study of 2,600 individuals found that the ratio of GZMK+ to GZMB+ T cells predicts health outcomes. Genetic and environmental factors drive differences in immune aging between people of the same age.
#ImmuneAging #Gzmk #Gzmb
#ImmuneAging #Gzmk #Gzmb
Researchers mapped immune cells from 2,609 adults. The GZMK-to-GZMB T-cell balance tracked health, while protein signatures linked to later disease risk. Observational evidence, not a clinical aging test.
thelifespanbrief.com/2026/10/09/i...
thelifespanbrief.com/2026/10/09/i...
October 9, 2026 at 7:00 PM
Researchers mapped immune cells from 2,609 adults. The GZMK-to-GZMB T-cell balance tracked health, while protein signatures linked to later disease risk. Observational evidence, not a clinical aging test.
thelifespanbrief.com/2026/10/09/i...
thelifespanbrief.com/2026/10/09/i...
New research suggests a simple immune-cell ratio, the balance between GZMB+ and GZMK+ memory T cells, could become a new biomarker for biological aging. A history of CMV infection is a major risk factor.
More: addhealth.cpc.unc.edu/news/persist...
More: addhealth.cpc.unc.edu/news/persist...
A Tale of Two T Cells
A Landmark Study of Our Immune System Aging With A Promising Blood Test
erictopol.substack.com
October 11, 2026 at 9:38 PM
New research suggests a simple immune-cell ratio, the balance between GZMB+ and GZMK+ memory T cells, could become a new biomarker for biological aging. A history of CMV infection is a major risk factor.
More: addhealth.cpc.unc.edu/news/persist...
More: addhealth.cpc.unc.edu/news/persist...
Fantastic preprint showing how circulating EBV-specific CD8+ T cells in MS adopt a GZMK+ effector–memory state that is primed to migrate to the CNS & may drive neuroinflammation through non-cytolytic interactions with B cells & myeloid cells. 🧵👇 1/
New preprint from our lab, now on bioRxiv! We are VERY excited about this one!
www.biorxiv.org/content/10.6...
How does Epstein–Barr virus (EBV) immunity become linked to multiple sclerosis (MS)?
(1/8)
www.biorxiv.org/content/10.6...
How does Epstein–Barr virus (EBV) immunity become linked to multiple sclerosis (MS)?
(1/8)
A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity
T and B cell-mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein-Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-s...
www.biorxiv.org
October 2, 2026 at 9:48 AM
Fantastic preprint showing how circulating EBV-specific CD8+ T cells in MS adopt a GZMK+ effector–memory state that is primed to migrate to the CNS & may drive neuroinflammation through non-cytolytic interactions with B cells & myeloid cells. 🧵👇 1/
Functionally, activated CD8⁺ T cells promoted atypical B cell and plasmablast formation, while GZMK-enriched effector-memory cells induced inflammatory IL-6 and IL-8 responses in myeloid cells.
(5/8)
(5/8)
October 2, 2026 at 6:45 AM
Functionally, activated CD8⁺ T cells promoted atypical B cell and plasmablast formation, while GZMK-enriched effector-memory cells induced inflammatory IL-6 and IL-8 responses in myeloid cells.
(5/8)
(5/8)
We found that CNS accumulation was not random. T cell clones carrying a GZMK⁺ effector-memory program already in peripheral blood were strongly biased toward the CSF. Strikingly, EBV-specific T cells were particularly enriched for this tissue-oriented state.
(3/8)
(3/8)
October 2, 2026 at 6:45 AM
We found that CNS accumulation was not random. T cell clones carrying a GZMK⁺ effector-memory program already in peripheral blood were strongly biased toward the CSF. Strikingly, EBV-specific T cells were particularly enriched for this tissue-oriented state.
(3/8)
(3/8)
Incredible to see this elegant antigen-resolved approach converge on the same B cell-dependent GZMK-effector CNS-trafficking T cell state we triangulated via a reverse translational approach using B cell depletion & trafficking blockade in our recent @brain1878.bsky.social paper. 2/
October 2, 2026 at 9:48 AM
Incredible to see this elegant antigen-resolved approach converge on the same B cell-dependent GZMK-effector CNS-trafficking T cell state we triangulated via a reverse translational approach using B cell depletion & trafficking blockade in our recent @brain1878.bsky.social paper. 2/
Efficacy of anti-BCMA CAR-T is linked to an EF1α-driven GZMK⁺ transcriptional trajectory that supports both persistence and effector function
www.nature.com/articles/s41...
@natcomms.nature.com @mskcancercenter.bsky.social
www.nature.com/articles/s41...
@natcomms.nature.com @mskcancercenter.bsky.social
September 21, 2026 at 2:42 PM
Efficacy of anti-BCMA CAR-T is linked to an EF1α-driven GZMK⁺ transcriptional trajectory that supports both persistence and effector function
www.nature.com/articles/s41...
@natcomms.nature.com @mskcancercenter.bsky.social
www.nature.com/articles/s41...
@natcomms.nature.com @mskcancercenter.bsky.social
🧬 CAR design includes its promoter. In 87 myeloma patients, cilta-cel tracked with a GZMK+ state; mouse experiments implicated EF1α in expansion and tumour control. Human comparison was non-randomised. doi.org/10.1038/s414... #CART
The EF1α promoter of cilta-cel drives a highly effective GZMK+ transcriptional program - Nature Communications
Chimaeric antigen receptors (CAR) approved for the treatment of multiple myeloma have been reported to have different therapeutic efficacies. In this study, the authors demonstrate that this differenc...
doi.org
September 21, 2026 at 11:25 AM
🧬 CAR design includes its promoter. In 87 myeloma patients, cilta-cel tracked with a GZMK+ state; mouse experiments implicated EF1α in expansion and tumour control. Human comparison was non-randomised. doi.org/10.1038/s414... #CART
The authors included RRIDs in their in Cancer Discovery paper! RRIDs improve reproducibility in scientific research. #STMpublishing #methodsmatter #OpenScience
Glioblastoma-infiltrating CD8+ T cells are predominantly a clonally expanded GZMK+ effector population
Read the full paper: Glioblastoma-infiltrating CD8+ T cells are predominantly a clonally expanded GZMK+ effector population
doi.org
August 20, 2026 at 7:00 AM
The authors included RRIDs in their in Cancer Discovery paper! RRIDs improve reproducibility in scientific research. #STMpublishing #methodsmatter #OpenScience
Cool recent paper on immune triads.
As other papers have suggested, Cxcl13 and Gzmk are uber important for beneficial anti tumor interactions between T cells and APC. Also, triads are apparently common even without therapy!
aacrjournals.org/cancerimmuno...
As other papers have suggested, Cxcl13 and Gzmk are uber important for beneficial anti tumor interactions between T cells and APC. Also, triads are apparently common even without therapy!
aacrjournals.org/cancerimmuno...
Intratumoral Three-Cell-Type Clusters Are a Conserved Feature of Endogenous Antitumor Immunity
The authors show that dendritic cells commonly interact with both CD4+ T cells and CD8+ T cells, often simultaneously, within the tumor microenvironment of pancreatic adenocarcinoma and that the frequ...
aacrjournals.org
August 12, 2026 at 3:18 PM
Cool recent paper on immune triads.
As other papers have suggested, Cxcl13 and Gzmk are uber important for beneficial anti tumor interactions between T cells and APC. Also, triads are apparently common even without therapy!
aacrjournals.org/cancerimmuno...
As other papers have suggested, Cxcl13 and Gzmk are uber important for beneficial anti tumor interactions between T cells and APC. Also, triads are apparently common even without therapy!
aacrjournals.org/cancerimmuno...
TAU, martedì 4 agosto a Falerone "Itaca per sempre" con Enrico Lo Verso e Chiara Dimaggio
https://vivere.me/gZMk-k
https://vivere.me/gZMk-k
July 31, 2026 at 9:41 AM
TAU, martedì 4 agosto a Falerone "Itaca per sempre" con Enrico Lo Verso e Chiara Dimaggio
https://vivere.me/gZMk-k
https://vivere.me/gZMk-k
GZMK-expressing tissue-resident memory CD8+ T cells participate in human intestinal acute graft-versus-host disease @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
July 24, 2026 at 2:17 AM
GZMK-expressing tissue-resident memory CD8+ T cells participate in human intestinal acute graft-versus-host disease @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
GZMK deficiency alleviates target-organ pathological injury in murine aGVHD.
July 22, 2026 at 4:06 PM
GZMK deficiency alleviates target-organ pathological injury in murine aGVHD.
GZMK-expressing tissue-resident memory CD8+ T cells participate in human intestinal acute graft-versus-host disease: doi.org/10.1172/jci....
July 22, 2026 at 4:06 PM
GZMK-expressing tissue-resident memory CD8+ T cells participate in human intestinal acute graft-versus-host disease: doi.org/10.1172/jci....
This issue’s cover features work by Hua Jin & team on the discovery of a GZMK-expressing CD8+ T cell subset linked to severe intestinal GVHD and poorer patient outcomes after stem cell transplantation: doi.org/10.1172/jci....
Image generated using ChatGPT.
Image generated using ChatGPT.
July 22, 2026 at 4:06 PM
This issue’s cover features work by Hua Jin & team on the discovery of a GZMK-expressing CD8+ T cell subset linked to severe intestinal GVHD and poorer patient outcomes after stem cell transplantation: doi.org/10.1172/jci....
Image generated using ChatGPT.
Image generated using ChatGPT.
So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases - Nature
Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...
www.nature.com
February 13, 2025 at 6:54 PM
So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
However, in contrast to GZMK+ cells, the ISG population was transcriptionally inert. i.e they poorly responded (at a transcriptional level) to ex vivo stimulation. Meanwhile, GZMK+ cells quickly up-regulated an effector profile.
November 17, 2024 at 12:57 PM
However, in contrast to GZMK+ cells, the ISG population was transcriptionally inert. i.e they poorly responded (at a transcriptional level) to ex vivo stimulation. Meanwhile, GZMK+ cells quickly up-regulated an effector profile.
Leveraging scTCRseq we could track TCR clones before and after stimulation to understand their transcriptional response. We found that these Interferon-stimulated gene (ISG) cells were clonally related to a subset of CD8+ cells characterised by high GZMK expression.
November 17, 2024 at 12:55 PM
Leveraging scTCRseq we could track TCR clones before and after stimulation to understand their transcriptional response. We found that these Interferon-stimulated gene (ISG) cells were clonally related to a subset of CD8+ cells characterised by high GZMK expression.
Single-cell immunophenotyping identifies CD8+GZMK+IFNG+ T cells as a key immune population in cutaneous Lyme disease
March 4, 2026 at 9:01 PM
Single-cell immunophenotyping identifies CD8+GZMK+IFNG+ T cells as a key immune population in cutaneous Lyme disease
An SPP1+ Macrophage / GZMK+ CD8 T-Cell Axis Mediates Immune Escape and Defines a Therapeutic Target in Non-Small Cell Lung Cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-10202716/latest
https://www.researchsquare.com/article/rs-10202716/latest
July 2, 2026 at 8:59 AM
An SPP1+ Macrophage / GZMK+ CD8 T-Cell Axis Mediates Immune Escape and Defines a Therapeutic Target in Non-Small Cell Lung Cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-10202716/latest
https://www.researchsquare.com/article/rs-10202716/latest