Brii Bio recently shared groundbreaking data from its Phase 2 studies on BRII-179, showcasing its role in enhancing HBV treatments at AASLD 2026.

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As more people with HIV (PWH) transition to tenofovir (TXF)-sparing antiretroviral therapy (ART), the risk of hepatitis B virus (HBV) reactivation (HBVr) and new infection (HBVi) is a concern.MethodsWe conducted a retrospective study of 5,776 PWH in the Centers for AIDS Research Network of Integrated Clinical Systems cohort without active HBV infection with ≥1 TXF-sparing ART regimen prescribed after 5/1/2014 and examined episodes of HBVi/r defined as new HBV surface antigen (HBsAg) positivity or HBV viremia. We calculated rate of HBVi/r over total time on TXF-sparing ART per 10,000 person-years.ResultsWe identified 17 cases of HBVi/r over a median 5.3 years of follow up. The rate of HBVi was 3.9 per 10,000 person-years, and rate of HBVr was 6.0 per 10,000 person-years, with possible higher risk for those who were HBV surface antibody (HBsAb) negative at cohort entry and among those not on ART with no anti-HBV activity. Liver injury, defined as alanine aminotransferase lab value ≥ 100 U/L, occurred within 3 months in only one HBVi case.ConclusionsHBVi/r on TXF-sparing ART was rare in this U.S. cohort. HBVi/r occurred in some with prior HBsAb positivity, but significant hepatic flares were not observed. When starting TXF-sparing ART, providers should check complete HBV serologies, offer initial or additional vaccination as needed, and monitor for potential HBVi/r.

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Guinea-Bissau’s Judicial Police raided Bandim Health Project offices on October 19, and the proposed vaccine trial will not go ahead. The officers seized a

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Voor HBV Falcons stond afgelopen zaterdag opnieuw een pittige wedstrijd op het programma thuis tegen de nummer 2 van de competitie. Met de eindstand 54-60 was het team tevreden over het getoonde spel.

Older adults and patients with ALD are less likely to receive HBV vaccination prior to liver transplantation.

Tonight's digest has 31 articles: 7 medchem, 9 pharmacology, 8 computational and 7 industry. Highlights include AbbVie's up-to-$1.47B gut-targeted EP4 IBD licence, Compass's imminent COMP360 FDA filing, and Servier's sevasemten Phase 2 miss.

Guinea-Bissau has reportedly halted a controversial US-funded hepatitis B virus vaccine (HBV) trial that drew global scrutiny when experts said it involved withholding life-saving shots from thousands of babies. The trial failed to receive the necessary authorization from the government, one researcher involved in the project said in a statement, adding that the trial's end was a "significant setback" for African science.

Guinea-Bissau has reportedly halted a controversial US-funded hepatitis B virus vaccine (HBV) trial that drew global scrutiny when experts said it involved withholding life-saving shots from thousands of babies. The trial failed to receive the necessary authorization from the government, one researcher involved in the project said in a statement, adding that the trial's end was a "significant setback" for African science.

In this Diabetes in Real Life column, Susan Weiner, MS, RDN, CDN, CDCES, FADCES, talks with Arpan Mohanty, MD, MSc, about why hepatitis B warrants greater attention in diabetes care and what to know a...