#HLH
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ambaile.org.uk
#Corpach Hotel, late-19th century

[photo: George Washington Wilson; source: HLH Archives, D1751/2/2/4]
November 7, 2026 at 5:07 PM
ambaile.org.uk
The slipway at Kyleakin, c1960, with the ruins of Caisteal Maol on the right. I think the ferry is the Caledonian Steam Packet Company's MV Lochalsh

[source: HLH Libraries]
November 6, 2026 at 5:36 PM
ambaile.org.uk
Women carrying peat, early 20th century. The location is somewhere in the #Orkney Islands, but I don't know exactly where

[photo: Charles Reid; source: HLH Archives, D1751/2/1/22]
November 3, 2026 at 6:12 PM
ambaile.org.uk
Making a scoo (creel) at #Cromarty, circa early 20th century. I think the matierial is willow

[source: HLH Archives, D1751/2/1/04]
November 3, 2026 at 2:09 PM
ambaile.org.uk
A modified Blackburn Iris flying boat at #Invergordon, 1920s

[source: HLH Archives, D1751/2/1/04]
November 1, 2026 at 10:14 AM
olmedo-lab.bsky.social
So how does HLH-30 prevent inappropriate developmental activity? Removing either BLMP-1 and CEBP-1, which become overactivated in the absence of HLH-30, partially suppresses the cell-cycle defects of hlh-30 mutants. This places HLH-30 upstream of a developmental brake during starvation. 7/8
November 4, 2026 at 12:59 PM
olmedo-lab.bsky.social
Our results point to HLH-30, the C. elegans ortholog of TFEB. Without HLH-30, starved larvae inappropriately activate cell-cycle markers and seam cells can divide when they should remain arrested. In other words, HLH-30 is critical for enforcing quiescence during complete starvation. 4/8
November 4, 2026 at 12:59 PM
olmedo-lab.bsky.social
New paper from our lab!
Work led by
@amatacabana.bsky.social and Marta Muñoz Barrera.
How do cells prevent division when development has to stop during starvation? HLH-30/TFEB is a key factor maintaining cellular quiescence during complete starvation in C. elegans. 1/8
doi.org/10.1093/nar/...
Validate User
doi.org
November 4, 2026 at 12:59 PM
olmedo-lab.bsky.social
And HLH-30 does much more than control cell division. Loss of hlh-30 causes extensive transcriptional deregulation during starvation, particularly affecting genes involved in cell division and chromosome organization. 5/8
November 4, 2026 at 12:59 PM
cancers-mdpi.bsky.social
🎯Editor's Choice
Hemophagocytic Lymphohistiocytosis Associated with Immune Checkpoint Inhibitors: A Pharmacovigilance Analysis of Spontaneous Reports
🧑‍⚕️by Suleyman Sami Guzel, Kubilay Tay et al.
📊Citations: 5
www.mdpi.com/2072-6694/18...

#ImmuneCheckpointInhibitors #HemophagocyticLymphohistiocytosis
Flow diagram of case selection for hemophagocytic lymphohistiocytosis (HLH) in the FAERS database. Adverse event reports related to ICIs were retrieved from the FAERS. Duplicate records were removed, HLH-related reports were identified using MedDRA Preferred Terms, and duplicate HLH reports were excluded. The final analytical cohort consisted of 733 unique HLH cases.
November 4, 2026 at 6:48 AM
olmedo-lab.bsky.social
We also found a striking effect on nuclear organization. Starvation induces a characteristic reorganization of intestinal chromatin into two concentric rings. With the help of @daphne-cabianca.bsky.social we observed that without HLH-30, this architecture is disrupted. 6/8
November 4, 2026 at 12:59 PM
ambaile.org.uk
In October 1910, Simon Joseph Fraser, Lord Lovat and 23rd Chief of Clan Fraser of Lovat, married the Hon. Laura Lister in London. After their honeymoon they went to live at Beaufort Castle, Beauly where they arrived on 5 November 1910

[photo: F.W. Urquhart; source: HLH Archives, D1751/2/1/03]
November 5, 2026 at 1:37 PM
amatacabana.bsky.social
We are happy to share the new paper from @olmedo-lab.bsky.social, published in @narjournal.bsky.social and carried out at the Genetics Department of @unisevilla.us.es, in collaboration with @daphne-cabianca.bsky.social lab in Munich.
@divulgaus.bsky.social

doi.org/10.1093/nar/...
November 5, 2026 at 8:20 AM
unaruppokkmajinyan.bsky.social
Nov #promosky !
28, mdni

Special month of going on a trip, meeting friends, + seeing PLAVE live so expect pics + freakouts 🥰

💙Reading, maybesorta writing
💜Music (PLAVE, HLH, Epic, BMTH, IDOLiSH7, TALK, RAYE, etc)
🩷Movies
❤️Games (Pokemon, FoM, etc)
🖤Plushies

♡/⟳ appreciated!
Me holding up a big Turtwig plushie in front of my face, sparkle stickers Selfie of me with a sprout sticker on top of my head PLAVE posing for their Hyperdrive album in racing outfits Cute art of a squirrel carrying books back to its hole/home in a tree, which is already filled with books
November 2, 2026 at 1:23 AM
needtoknow.co.uk.web.brid.gy
My daughter’s flu-like symptoms turned DEADLY and killed her within a MONTH
A mum shares how her 25-year-old daughter's flu-like symptoms triggered hemophagocytic lymphohistiocytosis (HLH), a rare deadly disease that killed her within a month and ravaged her body.</p>
needtoknow.co.uk
November 5, 2026 at 10:39 AM
olmedo-lab.bsky.social
Together, our work helps resolve a long-standing question:
What maintains cellular quiescence during complete starvation? Our results identify HLH-30/TFEB as a central part of that answer, linking nutrient deprivation to transcriptional regulation, chromatin organization and cell-cycle arrest. 8/8
November 4, 2026 at 12:59 PM
ambaile.org.uk
Overlooking #Farr Bay, #Bettyhil, c1920s

[source: HLH Archives, D1751/2/2/11]
October 28, 2026 at 5:17 PM
ambaile.org.uk
The view across Gruinard Bay, circa late-1950s

[]photo: William S. Thomson; source: HLH Libraries]
October 27, 2026 at 6:43 PM
virusesmdpi.bsky.social
🦠 EBV is more than infectious mononucleosis. This new review in Viruses explores how #EBV drives #autoimmunity (MS, RA, SLE), lymphoproliferative disorders, HLH/CAEBV in children, and possibly long COVID — and what this means for future therapies and vaccines.🔗 www.mdpi.com/1999-4915/18...
#Virology
www.mdpi.com
October 29, 2026 at 2:01 AM
arimrrow.bsky.social
Puppy I know the context of the tweet makes the guy an HLH (Huge Larping Hypocrite) but let’s call out people without discounting how debilitating sensory problems can be for some <3
October 29, 2026 at 12:21 AM
bloodsparasites.bsky.social
Metagenomic next-generation sequencing rescues a case of imported visceral leishmaniasis masquerading as hemophagocytic lymphohistiocytosis PubMed
Metagenomic next-generation sequencing rescues a case of imported visceral leishmaniasis masquerading as hemophagocytic lymphohistiocytosis
This paper reports a case of imported visceral leishmaniasis (VL; also known as kala-azar) in a nonendemic area (Wuhan). The patient was a 63-year-old male who had recurrent fever for more than 5 months and failed to respond to multiple treatments for hemophagocytic syndrome (HLH). No pathogen was detected by traditional bone marrow aspiration smear microscopy. Finally, 12347 standardized sequence count of Leishmania species complex were detected in peripheral blood via metagenomic...
dlvr.it
October 31, 2026 at 1:54 PM
ambaile.org.uk
Farm workers with horses ready for ploughing, early 20th century. I don't know the name of the farm but the image was captured by an #Invergordon-based photographer. If you recognise it, I would love to know...

[source: HLH Archives, D1751/2/2/7]
October 26, 2026 at 5:17 PM
thecurbau.bsky.social
Small medical update for those interested. Am in hospital at the moment getting some treatment and care. I don't usually talk about health stuff because A) it's boring, B) it doesn't really give anyone much to respond to other than 'hope you feel better soon' and C) it makes people feel bad. Sorry.
Another day. Going ok. Medication doing its thing. Doctors doing their thing. A MAS/HLH event. Link in comment for those interested, but effectively it's where your body - or rather, someone with Still's Disease - looks at your red blood cells and says 'hey, they shouldn't be here, let's get rid of them'. Ideally, if medication is doing its thing, this shouldn't happen, but due to an infection I've been off my medication. Back on it now. I'm rather blase about it now as I've lived with this all my life and have gone through a few MAS/HLH events. None of them are fun, especially because it often means that you're at a very high risk of dying. Speed is of the essence otherwise organs start also abandoning ship. Not a positive thing. Anyhow. Not dying this time round, but certainly shaved some time off my scorecard. Will no doubt be back to the turmeric/yoga/positive thinking/meditation/insert useless fucking treatment that is often recommended by those who don't know what living with a chronic illness is like. If there's a big positive about this it's that I'm getting to see some of the younger rheumo doctors who remember me from five years ago and who wrote papers about me back then. Then there's the new generation of younger doctors equally excited to read up about a rare disease and the treatment for it. Curiosity is a beautiful creature that must be nurtured, supported, and nourished. Understanding that we are not all monoliths and are sometimes genuine zebras is important. Nice view too. Can almost see home from here. A photo of my hospital window which overlooks a lake, a construction site, a native park, and the top of the ICU. It's a sunny, blue sky, cloud free day.
October 28, 2026 at 7:16 AM
ambaile.org.uk
The Banff-registered fishing boat, Progress II, on the Rose Street Foundry's Thornbush Slipway at #Inverness. She was launched in 1907 but the slipway didn't open until 1908 so she's likely in for a refit or undergoing modification prior to being used as a patrol boat during #WWII 

[HLH Archives]
October 24, 2026 at 4:22 PM
ambaile.org.uk
Residents of the #Aultbea Hotel being driven around the local area, c1910

[HLH Archives, D1751/2/1/06]
October 22, 2026 at 3:56 PM