#HMOX1
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angelifriedmann.bsky.social
(1) New preprint from our lab!
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis
Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...
doi.org
October 16, 2025 at 3:20 AM
angelifriedmann.bsky.social
News from the lab!

HMOX1 controls a heme-ferritin switch that protects cells from ferroptosis | Science Advances www.science.org/doi/10.1126/...
HMOX1 controls a heme-ferritin switch that protects cells from ferroptosis
Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...
www.science.org
August 19, 2026 at 6:20 PM
haoyin.bsky.social
Aortic Medial HMOX1 protein ⬆️in Ascending #AorticDissection & ➕corr. Age in dissected aortas

Ex vivo Aortic Failure/Cauchy Stress ⬇️(Circumferential ~40%; Axial ~30%) in #AorticDissection across all ages

33 case + 33 control

#AortaEd
#BioMMB 2026
link.springer.com/article/10.1...
April 27, 2026 at 6:49 PM
genesndiseases.bsky.social
Researchers developed a human retinal degeneration model that simulates the key pathological processes of human dry #AgeRelatedMacularDegeneration (AMD) and identified the role of #HMOX1 in the protective effects of drugs against retinal degeneration. #medsky

#OpenAccess: buff.ly/hBdinjM
Human Retinal Organoids for Modelling Dry Age-Related Macular Degeneration and Screening Drugs
March 16, 2025 at 10:30 PM
angelifriedmann.bsky.social
(3) Our data reveal a heme/HMOX1/ferritin axis that fine-tunes ferroptosis sensitivity.
Targeting this switch could offer new ways to modulate redox balance and iron metabolism in cancer.
October 16, 2025 at 3:20 AM
abozec.bsky.social
Excited to share our latest publication in Bone Research: This study uncovers how melanoma induces osteocyte ferroptosis through the HIF1α-HMOX1 pathway. #Research #Bone #Melanoma #Ferroptosis
www.nature.com/articles/s41...
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis - Bone Research
Bone Research - Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis
www.nature.com
January 21, 2025 at 1:30 PM
biorxivpreprint.bsky.social
Curcumin Analogues Trigger HMOX1-Mediated Ferroptosis to Halt Endometrial Cancer Growth https://www.biorxiv.org/content/10.1101/2025.11.18.689080v1
November 19, 2025 at 9:47 PM
cp-cellrepmed.bsky.social
Online now: Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis
Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis
Zhou et al. identify vorapaxar, an FDA-approved antiplatelet agent, as an enhancer of ferroptosis and ferroptosis-mediated immunotherapy. Mechanistically, vorapaxar directly binds FOXO1, inhibits Ser256 phosphorylation to promote nuclear translocation, and transcriptionally upregulates HMOX1, thereby promoting mitochondrial iron overload and mitochondria-associated ferroptosis.
dlvr.it
September 29, 2025 at 12:27 PM
biorxivpreprint.bsky.social
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis https://www.biorxiv.org/content/10.1101/2025.10.14.682408v1
October 15, 2025 at 10:49 PM
myscivoice.bsky.social
Then we found that those VCAM1 changes increased its promoter region activity. This leads to more VCAM-1 protein being produced. The protein responds to inflamation and low oxygen, so more VCAM-1 hints to unhealthy blood vessel environment

www.sciencedirect.com/science/arti...

🧪👩🏾‍🔬🧬
December 4, 2024 at 7:05 PM
devbiol.bsky.social
#DBfeature #ICYMI

A comparative analysis of VEGF and its receptors revealed tissue-specific disruptions in angiogenic signaling and endothelial integrity in Hmox1-deficient mouse embryos

By Meenakshi Rana, Gouri Nandi, Sidhant Jain, Divya Bajaj

tinyurl.com/4dcw5aph
Immunolocalization of VEGF was altered in 16.5 dpc Hmox1-KO mouse embryos. (a–f) Representative images of VEGF immunostaining in para- and mid-sagittal sections of 16.5 dpc wWT (a and b), WT (c and d), and KO (e and f) embryos. VEGF protein was visualized using DAB substrate for enzyme-linked detection. A no-primary-antibody control is included as an inset within the wWT sections, and the areas of the organs imaged at higher magnification to reveal cellular details are marked in the whole-mount images. (g–i) The region of forebrain imaged was thalamus which is a diencephalon derivative. (j–l) Cardiac muscle cells of the muscular region of the ventricles are visible and the nuclei (N) of the same are indicated with black arrows. (m–o) The epithelial cells of bronchiole (Br) and distal lung epithelial cells (DE) are indicated by black and red arrows respectively. (p–r) Individually scattered megakaryocytes (Me) are indicated with black arrows, and the liver parenchyma is marked as P. (s–u) The tubules (T) and collecting ducts (CD) are indicated by red and yellow arrows respectively, whereas glomeruli (G) are indicated by black arrows. The cortex parenchyma is marked as P. Scale bars: a to f—2 mm; g to u—50 μm. Semi-Semi-quantitative analysis of VEGF signal intensity (bottom-left corner of the figure) in wWT, WT and KO embryos.
August 26, 2026 at 1:46 PM
ajkd.bsky.social
In the Literature commentary by Zhouqi Tang & Fadi Lakkis:

Pig Kidney Xenotransplantation: Immune Insights From a Landmark Human Case

bit.ly/3SBZYTa (FREE)
Genomic Modifications in the Donor Pig. Abbreviations: GGTA1, alpha-1,3-galactosyltransferase 1; αGal, galactose-α-1,3-galactose; CMAH, cytidine monophospho-N-acetylneuraminic acid hydroxylase; Neu5Gc, N-glycolylneuraminic acid; B4GALNT2, beta-1,4-N-acetyl-galactosaminyltransferase 2; PERV, porcine endogenous retrovirus; CD46, cluster of differentiation 46; CD55, cluster of differentiation 55; THBD, thrombomodulin; PROCR, endothelial protein C receptor; CD47, cluster of differentiation 47; HMOX1, heme oxygenase 1; TNFAIP3, TNF alpha induced protein 3; PERV, Porcine Endogenous Retrovirus; CRISPR, clustered regularly interspaced short palindromic repeats; Cas9, CRISPR-associated protein 9.
July 2, 2026 at 4:08 PM
rridrobot.bsky.social
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #RRID #methodsmatter #STMpublishing
IPO9 Promotes Ovarian Cancer Progression by Suppressing HMOX1‐Dependent Ferroptosis
doi.org
February 1, 2026 at 8:03 AM
biorxivpreprint.bsky.social
Homeostatic, phagocytic, NRF2/Hmox1, Apoc1 and chemokine microglia transcriptional programmes in naive mouse cerebral cortex from embryo to adulthood https://www.biorxiv.org/content/10.64898/2026.08.20.746090v1
August 25, 2026 at 6:15 PM
rridrobot.bsky.social
RRID:AB_2091723 from @proteintech.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #methodsmatter #ReproducibleResearch #OpenScience
HMOX1 drives dihydroartemisinin-sensitized ferroptosis antagonized by mitochondrial fusion
doi.org
January 6, 2026 at 8:00 AM
rridrobot.bsky.social
RRID:Addgene_13032, was just reported to be used in "Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis". We appreciate the author's support of reproducibility. #ReproducibleResearch #methodsmatter
doi.org
February 7, 2025 at 8:02 AM
rridrobot.bsky.social
RRID:AB_2118685 from @proteintech.bsky.social was used by authors in their paper. RRIDs improve reproducibility in scientific research. #STMpublishing #ReproducibleResearch #ReproducibleResearch
Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis
doi.org
October 2, 2025 at 7:00 AM
rridrobot.bsky.social
RRID:Addgene_10878, was just reported to be used in "Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells". RRIDs like this improve reproducibility in scientific research. #RRID #STMpublishing
doi.org
February 8, 2025 at 8:02 AM
rridrobot.bsky.social
Cell Signaling Technology's resource, RRID:AB_2099233, was just reported to be used in "Downregulation of Hmox1 and Rpgrip1l Expression Linked to Risk-Taking Behavior, Reduced Depressive Symptoms, and Diminished Novelty Socializati…". Thank you for making your methods matter! #OpenScience
doi.org
April 10, 2025 at 7:00 AM
rridrobot.bsky.social
RRID:AB_2085424 was used by the authors of the Developmental Cell paper "HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosi…".We appreciate the author's support of reproducibility. #OpenScience #RRID
doi.org
January 5, 2025 at 12:34 PM
imetascience.bsky.social
Decidual macrophage-mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion
doi.org/10.1002/imt2...
Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion
Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF-κB/HMOX1 axis mediates this...
doi.org
June 15, 2026 at 12:23 PM
biorxiv-immuno.bsky.social
Effect of heme oxygenase-1 on the expression of interferon-stimulated genes https://www.biorxiv.org/content/10.1101/2024.11.04.620611v1
Effect of heme oxygenase-1 on the expression of interferon-stimulated genes https://www.biorxiv.org/content/10.1101/2024.11.04.620611v1
Heme oxygenase-1 (HO1, Hmox1) degrades excess heme and is considered an anti-oxidative and anti-infl
www.biorxiv.org
November 7, 2024 at 8:16 AM
niinasandholm.bsky.social
See our study on HMXO1 GTn repeat and heme oxogenase-1 concentrations in #FinnDiane participants with #T1D, collaboration with Lakkisto Lab! HMOX1 LL genotype was associated with cardiac events and mortality in men with #T1D, but not in women. #FolkhälsanResearch @finndiane.bsky.social rdcu.be/eBh3i
Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes
rdcu.be
August 21, 2025 at 10:59 AM
nicolasmerle.bsky.social
Excited to share my first last-author paper! Using in vivo models, transcriptomic analyses, and cellular assays, we demonstrate that HCAR2 acts as a receptor for heme, potentially forming a novel negative feedback loop that promotes Hmox1 expression.
www.sciencedirect.com/science/arti...
HCAR2 is a novel receptor for heme
Extracellular heme, released during intravascular hemolysis in sickle cell disease (SCD) and hemolytic anemia acts as a pro-inflammatory danger signal…
www.sciencedirect.com
May 16, 2025 at 10:30 AM
cp-cellreports.bsky.social
Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells
Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells
Med20 safeguards peripheral myelination by suppressing Schwann cell ferroptosis. Loss of Med20 in Schwann cells triggers ferroptosis via the DDB1-UHRF1-BACH1-Hmox1 axis, disrupting myelin sheath formation. Pharmacological inhibition of HO-1 (ZnPP) or ferroptosis (Fer-1) rescues myelination defects, revealing a therapeutic strategy for PNS disorders linked to Med20 dysfunction.
dlvr.it
November 1, 2025 at 12:35 PM