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AdiaHR is a corporate SaaS HRMS platform for employee management, attendance, leave, payroll, recruitment, compliance and employee self service.

Educational institutions manage much more than students and academic programmes. Behind every college, university, school, or training institution is a large workforce of faculty members, administrative employees, support staff, and other professionals who keep daily operations running. Managing employee attendance, payroll information, performance records, leave, and staff data manually can become increasingly difficult as an institution grows. This is where…

Educational institutions manage a large workforce that can include teaching faculty, administrative staff, department heads, support teams and other employees. Managing employee records, attendance, leave, performance and HR processes across different departments can become challenging as an institution grows. A Human Resource Management System (HRMS) can help educational institutions organise workforce-related processes through a centralised digital platform. Instead of managing employee information across spreadsheets, physical records and separate systems, institutions can use HR technology to create more structured HR workflows.

Operação de crédito com o BID tem garantia do Governo Federal e será destinada ao projeto do HRMS

Human resource teams manage many activities every day, including employee records, attendance, leave, payroll coordination, recruitment and performance management. As organisations grow, managing these activities manually can become difficult. A Human Resource Management System (HRMS) can bring multiple HR processes together within a centralised digital environment. Different HRMS platforms provide different modules, allowing organisations to select functionality according to their workforce and operational requirements.

Managing employees with spreadsheets can work when a business has only a few people. As the workforce grows, however, HR administration quickly becomes more

ABSTRACT Introduction Ripretinib is an innovative multitargeted kinase inhibitor introduced for the treatment of advanced gastrointestinal stromal tumors, was investigated to elucidate its degradation behavior and structural transformation pathways under forced stress conditions. Although degradation studies are essential for evaluating the intrinsic stability of pharmaceutical compounds, the degradation products of ripretinib have not been comprehensively characterized. The present work focuses on LC–HRMS/MS-based structural elucidation of degradation products arising from photolytic and hydrolytic stress conditions. Methods In accordance with International Council for Harmonisation guidelines, ripretinib was subjected to acidic, alkaline, oxidative, thermal, and photolytic stress conditions. Liquid chromatography was employed to separate the degradation products, which were subsequently characterized by high-resolution tandem mass spectrometry (LC–HRMS/MS) operated in positive electrospray ionization mode. Structural assignments were established using accurate mass measurements, isotopic pattern analysis, elemental composition determination, and collision-induced dissociation pathways. Degradation kinetics under photolytic conditions were also evaluated. An in silico toxicity assessment of degradation products was performed using DEREK and SARAH prediction platforms. Results Ripretinib exhibited degradation predominantly under photolytic and hydrolytic stress conditions, leading to the formation of five degradation products. The protonated molecule of ripretinib at m/z 510 displayed a characteristic bromine isotopic distribution that facilitated differentiation between brominated and debrominated products. Hydrolytic degradation generated two products through cleavage of the urea linkage, whereas photolytic degradation produced three products involving intramolecular cyclization with concomitant debromination, hydroxylation, and N–C bond cleavage pathways. Collision-induced dissociation of protonated molecules generated diagnostic product ions that enabled structural elucidation of all degradation products. Photodegradation followed apparent first-order kinetics with a half-life of 4.2 min. One hydrolytic degradation product containing a primary aromatic amine moiety was predicted to possess mutagenic potential. Conclusion This investigation elucidates the degradation pathways of ripretinib and highlights the utility of LC–HRMS/MS in the structural characterization of degradation products generated under stress conditions.

AbstractThe atmospheric gas phase is underrepresented in non-target screening of environmental organic chemicals, partly due to limited evidence on sorbent suitability. Here, we developed a workflow for non-target analysis (NTA) of styrene-divinylbenzene copolymeric (XAD) resin-based air samples that involves both gas (GC) and liquid chromatography (LC) high-resolution mass spectrometry (HRMS). More than 60 000 features were detected in passive air samplers (PAS) deployed over 4–48 weeks. Of ∼34 000 features retained after blank filtration, ∼14 000 (41%) showed an increasing signal with deployment time, suggesting that they represent substances with volatility and degradability sufficiently low for accumulation on XAD without substantial re-evaporation or degradation during the prolonged sampling period. Such linear uptake is a prerequisite for comparing PAS-derived signals across deployments and chemical classes. Chemical identification by reference standards (level 1) and spectral library matching (level 2) initially identified/annotated 116 compounds, many of which were bioactive and/or brown carbon species. Combining advanced downstream computational workflows of feature-based molecular networking (FBMN) and in silico prediction (Network Annotation Propagation/MetFrag) allowed for the structural annotation (level 3) of >8300 LC-HRMS features, including several compounds of natural and anthropogenic origin which were not previously reported in the atmospheric gas phase. Several long-chain fatty acids showed rapid early increases implausible with atmospheric origins and are likely to originate from microbial growth on the resin. Overall, our results demonstrated that XAD is a sorbent compatible with comprehensive NTA and suitable for time-integrated passive sampling of a diverse range of gas-phase organic chemicals from the atmosphere.

Human resource management involves many activities, from employee information and attendance to leave management, payroll coordination and reporting. As organisations grow, managing these processes manually or across multiple disconnected systems can become difficult. A Human Resource Management System (HRMS) can bring different HR processes together within a centralised digital platform. However, selecting HRMS software is only one part of the process.

Human resource management has changed significantly as organizations adopt digital tools to manage everyday employee activities. From maintaining employee records to managing attendance, leave, payroll and workforce information, HR teams increasingly depend on software to organize their operations. One technology gaining attention is cloud-based HRMS software. Instead of relying entirely on systems installed and maintained on local servers, organizations can use cloud-based platforms to access HR information and processes through an internet-connected environment.