Nature Reviews Gastroenterology & Hepatology, Published online: 02 November 2026; doi:10.1038/s41575-026-01277-7Timing matters in hepatic artery thrombosis after paediatric liver transplantation

Nature Reviews Gastroenterology & Hepatology, Published online: 02 November 2026; doi:10.1038/s41575-026-01277-7Timing matters in hepatic artery thrombosis after paediatric liver transplantation

Abstract. Minor intron retention resulting from dysregulation of minor intron splicing factors is an emerging risk factor for the metabolic dysfunction–ass

We thank Xie and colleagues for discussing our Cell Metabolism study in their letter “From liver to L-cell: Clinical considerations for translating hepatic ALP signaling.” In their secondary analyses of clinical studies, the authors question whether fasting plasma glucagon-like peptide-1 (GLP-1) reflects L-cell abundance, differentiation, or endogenous incretin function, and they suggest that circulating ALP-GLP-1 relationships may vary across populations. We agree that fasting GLP-1 is not a quantitative surrogate for total intestinal L-cell abundance, differentiation, or endogenous GLP-1 function.

We identify a TECR palmitoylation-dependent necrotic cell death (TPNCD) pathway. Blocking TPNCD genetically or pharmacologically protects against immune- and drug-induced liver injury, revealing a therapeutic strategy for hepatic injury.

Alveolar echinococcosis (AE), caused by Echinococcus multilocularis (E.multilocularis), is a life-threatening zoonotic disease with limited therapeutic options, and reliable biomarkers of disease a...

Schistosomiasis morbidity and mortality are primarily driven by egg-triggered granulomas with subsequent fibrosis. However, the dynamics of cellular composition within these granulomas, particularly the identity and function of key immune cells that orchestrate their formation and evolution, remain poorly understood. Here, we combine single-cell RNA sequencing with multiplex immunofluorescence to characterize the hepatic immune landscape in Schistosoma japonicum-infected mice and further validate the functional roles of two neutrophil subsets. We find that eggs alter hepatic immune cell composition, which is characterized by extensive neutrophil recruitment and differentiation. Neutrophil recruitment correlates with CXCL2 derived from both an autocrine loop and paracrine signaling from monocytes. Cellular localization analysis reveals that granulomas progress through three distinct developmental stages: early Ly6GhiF4/80loDesminlo, developing Ly6GmidF4/80hiDesminmid, and advanced Ly6Gl