Our first post here.
Tim’s newest work on the reactivity of phosphaalumenes is out. When P=Al meets it’s smaller sibling a unique B,N,Al,P-heterocycle is formed. Congrats Tim and Leonie!
#chemsky @chemcomm.bsky.social @likat.bsky.social #31p
pubs.rsc.org/en/content/a...
Tim’s newest work on the reactivity of phosphaalumenes is out. When P=Al meets it’s smaller sibling a unique B,N,Al,P-heterocycle is formed. Congrats Tim and Leonie!
#chemsky @chemcomm.bsky.social @likat.bsky.social #31p
pubs.rsc.org/en/content/a...
A BNAlP-heterocycle
We report the [2+2]-cyclization reaction of a phosphaalumene with its lighter analog, an iminoborane, to give a species with a four-membered BNAlP-heterocycle with alternating Lewis basic and acidic c...
pubs.rsc.org
February 13, 2025 at 5:08 PM
Our first post here.
Tim’s newest work on the reactivity of phosphaalumenes is out. When P=Al meets it’s smaller sibling a unique B,N,Al,P-heterocycle is formed. Congrats Tim and Leonie!
#chemsky @chemcomm.bsky.social @likat.bsky.social #31p
pubs.rsc.org/en/content/a...
Tim’s newest work on the reactivity of phosphaalumenes is out. When P=Al meets it’s smaller sibling a unique B,N,Al,P-heterocycle is formed. Congrats Tim and Leonie!
#chemsky @chemcomm.bsky.social @likat.bsky.social #31p
pubs.rsc.org/en/content/a...
Frodo at the heterocycle conference is lord of th... wait a minute, I think I did something wrong
Frodo in the command prompt is lord of the pings
frodo at wing stop is lord of the wings.
February 4, 2026 at 4:41 PM
Frodo at the heterocycle conference is lord of th... wait a minute, I think I did something wrong
Check out another recent ChemComm article:
Holger Braunschweig, @hering-lab.bsky.social and colleagues synthesised a four-membered BNAlP-heterocycle with alternating Lewis basic and acidic centres in the ring.
#OpenAccess 🔓
pubs.rsc.org/en/cont...
Holger Braunschweig, @hering-lab.bsky.social and colleagues synthesised a four-membered BNAlP-heterocycle with alternating Lewis basic and acidic centres in the ring.
#OpenAccess 🔓
pubs.rsc.org/en/cont...
A BNAlP-heterocycle
We report the [2+2]-cyclization reaction of a phosphaalumene with its lighter analog, an iminoborane, to give a species with a four-membered BNAlP-heterocycle with alternating Lewis basic and acidic centers in the ring. The reactivity of this heterocycle towards alkenes and alkynes is described, giving chain molecu
pubs.rsc.org
March 1, 2025 at 11:00 AM
Check out another recent ChemComm article:
Holger Braunschweig, @hering-lab.bsky.social and colleagues synthesised a four-membered BNAlP-heterocycle with alternating Lewis basic and acidic centres in the ring.
#OpenAccess 🔓
pubs.rsc.org/en/cont...
Holger Braunschweig, @hering-lab.bsky.social and colleagues synthesised a four-membered BNAlP-heterocycle with alternating Lewis basic and acidic centres in the ring.
#OpenAccess 🔓
pubs.rsc.org/en/cont...
Inventing the heterocycle
June 20, 2024 at 7:26 AM
Inventing the heterocycle
🚀 Our team's latest: "A Dual-Metal Strategy for N-Heterocycle Coordination Using Nickel and Aluminum”
Now out in @chemcomm.rsc.org
Work done by PhD student, Gabe! 💪
pubs.rsc.org/en/content/a...
Now out in @chemcomm.rsc.org
Work done by PhD student, Gabe! 💪
pubs.rsc.org/en/content/a...
May 7, 2026 at 10:23 AM
🚀 Our team's latest: "A Dual-Metal Strategy for N-Heterocycle Coordination Using Nickel and Aluminum”
Now out in @chemcomm.rsc.org
Work done by PhD student, Gabe! 💪
pubs.rsc.org/en/content/a...
Now out in @chemcomm.rsc.org
Work done by PhD student, Gabe! 💪
pubs.rsc.org/en/content/a...
Medchem heterocycles:
Dislike: oxetane (closely followed by oxazole)
Overrated: BCP (yes I know it’s not a heterocycle)
Underrated: THF
Like: Pyrazole
Trust: Piperidine
#Chemsky
(Disclaimer: post is copied from the other place but a fun way to start…something)
Dislike: oxetane (closely followed by oxazole)
Overrated: BCP (yes I know it’s not a heterocycle)
Underrated: THF
Like: Pyrazole
Trust: Piperidine
#Chemsky
(Disclaimer: post is copied from the other place but a fun way to start…something)
December 20, 2024 at 4:48 AM
Medchem heterocycles:
Dislike: oxetane (closely followed by oxazole)
Overrated: BCP (yes I know it’s not a heterocycle)
Underrated: THF
Like: Pyrazole
Trust: Piperidine
#Chemsky
(Disclaimer: post is copied from the other place but a fun way to start…something)
Dislike: oxetane (closely followed by oxazole)
Overrated: BCP (yes I know it’s not a heterocycle)
Underrated: THF
Like: Pyrazole
Trust: Piperidine
#Chemsky
(Disclaimer: post is copied from the other place but a fun way to start…something)
Don’t get me started on heterocycle nomenclature Scott😭 It’s the devil’s tool
March 20, 2026 at 12:07 AM
Don’t get me started on heterocycle nomenclature Scott😭 It’s the devil’s tool
Asymmetric catalysis is very challenging. Here's a couple of screen shots of a proposal from my job applications, and the link is maybe the thing closest to it that we did in my lab, 6 years later!
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
January 28, 2025 at 3:15 AM
Asymmetric catalysis is very challenging. Here's a couple of screen shots of a proposal from my job applications, and the link is maybe the thing closest to it that we did in my lab, 6 years later!
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Bicycle is what happens when you crash a heterocycle into a homocycle
May 1, 2025 at 7:56 PM
Bicycle is what happens when you crash a heterocycle into a homocycle
First post, first publication!
I’m over the moon to share the first publication from our small research group! 🚀 pubs.rsc.org/en/content/a... @chemcomm.rsc.org
Jan explored a funky P=P-containing heterocycle and its reversible! bond activation chemistry, with DFT insights from Francesco. #newPI
I’m over the moon to share the first publication from our small research group! 🚀 pubs.rsc.org/en/content/a... @chemcomm.rsc.org
Jan explored a funky P=P-containing heterocycle and its reversible! bond activation chemistry, with DFT insights from Francesco. #newPI
September 29, 2025 at 7:55 AM
First post, first publication!
I’m over the moon to share the first publication from our small research group! 🚀 pubs.rsc.org/en/content/a... @chemcomm.rsc.org
Jan explored a funky P=P-containing heterocycle and its reversible! bond activation chemistry, with DFT insights from Francesco. #newPI
I’m over the moon to share the first publication from our small research group! 🚀 pubs.rsc.org/en/content/a... @chemcomm.rsc.org
Jan explored a funky P=P-containing heterocycle and its reversible! bond activation chemistry, with DFT insights from Francesco. #newPI
January 14, 2026 at 12:42 AM
"450kg of snails"
TIL high end snails go for $200/KG
about the global price of a reasonably complex heterocycle (on the ton scale)
TIL high end snails go for $200/KG
about the global price of a reasonably complex heterocycle (on the ton scale)
Thieves have stolen €90,000 worth of fine French snails destined for some of the country’s most prestigious restaurants
Thieves take €90,000 of snails meant for Michelin-starred restaurants
French police are on the trail of ‘experienced’ criminals who stole a whole year’s worth of produce from Jean-Mathieu Dauvergne’s L’Escargot des Grands Crus
www.thetimes.com
November 28, 2025 at 12:32 AM
"450kg of snails"
TIL high end snails go for $200/KG
about the global price of a reasonably complex heterocycle (on the ton scale)
TIL high end snails go for $200/KG
about the global price of a reasonably complex heterocycle (on the ton scale)
Chemistry never stops. Bravo to the master Heterocycle Manipulator, Mark Levin and co.
Now online as an accepted article, a novel hypervalent iodine reagent that functions as a source of electrophilic "N". My first student, Patrick Kelly's swan song (now a postdoc with the Stahl lab), done in collaboration with scientists at GSK.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
November 13, 2024 at 3:23 AM
Chemistry never stops. Bravo to the master Heterocycle Manipulator, Mark Levin and co.
• Includes a nitrogen heterocycle (potential RNA/DNA precursor) + benzothiophene
• Big boost for evidence of prebiotic chemistry on ancient Mars
Read more here: www.nasa.gov/missions/mar...
• Big boost for evidence of prebiotic chemistry on ancient Mars
Read more here: www.nasa.gov/missions/mar...
NASA’s Curiosity Finds Organic Molecules Never Seen Before on Mars - NASA
After years of lab work, the results are in: A rock that NASA’s Curiosity Mars rover drilled and analyzed in 2020 includes the most diverse collection of
www.nasa.gov
April 21, 2026 at 6:04 PM
• Includes a nitrogen heterocycle (potential RNA/DNA precursor) + benzothiophene
• Big boost for evidence of prebiotic chemistry on ancient Mars
Read more here: www.nasa.gov/missions/mar...
• Big boost for evidence of prebiotic chemistry on ancient Mars
Read more here: www.nasa.gov/missions/mar...
Sometime simple solutions are best: Have a look at the last work of Emma Robert on the synthesis of N-Heterocycle substituted cyclobutanes via Michael addition now available at Chem. Eur. J.
doi.org/10.1002/chem...
doi.org/10.1002/chem...
November 27, 2024 at 7:26 AM
Sometime simple solutions are best: Have a look at the last work of Emma Robert on the synthesis of N-Heterocycle substituted cyclobutanes via Michael addition now available at Chem. Eur. J.
doi.org/10.1002/chem...
doi.org/10.1002/chem...
Pd-catalyzed asymmetric hydroalkylation of heterocycle-embedded dienes
January 14, 2026 at 1:55 AM
Pd-catalyzed asymmetric hydroalkylation of heterocycle-embedded dienes
Pd-catalyzed asymmetric hydroalkylation of heterocycle-embedded dienes
January 14, 2026 at 9:24 AM
Pd-catalyzed asymmetric hydroalkylation of heterocycle-embedded dienes
Medchem #ChemSky question:
Isostere: amide to heterocycle swap
Yes? Yes.
Acid to sulfonamide or tetrazole
Yes? Yes.
F to Cl swap - isostere?
Imidazole to triazole - isostere?
Phenyl to pyridyl?
Isostere: amide to heterocycle swap
Yes? Yes.
Acid to sulfonamide or tetrazole
Yes? Yes.
F to Cl swap - isostere?
Imidazole to triazole - isostere?
Phenyl to pyridyl?
August 10, 2026 at 11:51 PM
Medchem #ChemSky question:
Isostere: amide to heterocycle swap
Yes? Yes.
Acid to sulfonamide or tetrazole
Yes? Yes.
F to Cl swap - isostere?
Imidazole to triazole - isostere?
Phenyl to pyridyl?
Isostere: amide to heterocycle swap
Yes? Yes.
Acid to sulfonamide or tetrazole
Yes? Yes.
F to Cl swap - isostere?
Imidazole to triazole - isostere?
Phenyl to pyridyl?
I see someone post something about pozole and all I can think is "Which nitrogen heterocycle is that?"
Grad school scarred me.
Grad school scarred me.
August 25, 2024 at 10:53 PM
I see someone post something about pozole and all I can think is "Which nitrogen heterocycle is that?"
Grad school scarred me.
Grad school scarred me.
Big Hétérocycle strikes again
August 11, 2026 at 12:07 AM
Big Hétérocycle strikes again
About me:
Favourite element: nitrogen
Favourite reaction: Diels-Alder
Favourite heterocycle : benzimidazole
Favourite functional group: ester
Favourite piece of glassware: Kugelrohr
Favourite natural product: morphine
Chemsky
Favourite element: nitrogen
Favourite reaction: Diels-Alder
Favourite heterocycle : benzimidazole
Favourite functional group: ester
Favourite piece of glassware: Kugelrohr
Favourite natural product: morphine
Chemsky
Found an old post on Twix that sums up my chemistry
About me:
Favourite element: gold
Favourite reaction: Bargellini
Favourite het: pyrazole
Favourite functional group: sulfonamide
Favourite piece of glassware: clean 125 ml sep funnel Favourite natural product: sucrose
Chemsky
About me:
Favourite element: gold
Favourite reaction: Bargellini
Favourite het: pyrazole
Favourite functional group: sulfonamide
Favourite piece of glassware: clean 125 ml sep funnel Favourite natural product: sucrose
Chemsky
September 16, 2023 at 11:26 PM
About me:
Favourite element: nitrogen
Favourite reaction: Diels-Alder
Favourite heterocycle : benzimidazole
Favourite functional group: ester
Favourite piece of glassware: Kugelrohr
Favourite natural product: morphine
Chemsky
Favourite element: nitrogen
Favourite reaction: Diels-Alder
Favourite heterocycle : benzimidazole
Favourite functional group: ester
Favourite piece of glassware: Kugelrohr
Favourite natural product: morphine
Chemsky
Congrats to Daniil & collabs from the Liu group at NTU on the #HOTpaper in @angewandtechemie.bsky.social bit.ly/4ncBOJm where we show how heterocycle basicity and H-bonding ability affect the photoswitching and thermal isomerization mechanism of hydrazone switches 🧪⚗️#chemsky #NSFfunded #molswitch
Hetero‐Hydrazone Photoswitches
Heterocycles dramatically change the performance of hydrazone photoswitches. Basic rings cause rapid thermal isomerization via tautomerization, while ones that can participate in H-bonding lower swit...
bit.ly
September 15, 2025 at 2:38 PM
Congrats to Daniil & collabs from the Liu group at NTU on the #HOTpaper in @angewandtechemie.bsky.social bit.ly/4ncBOJm where we show how heterocycle basicity and H-bonding ability affect the photoswitching and thermal isomerization mechanism of hydrazone switches 🧪⚗️#chemsky #NSFfunded #molswitch
Our recent work on aliphatic CO-to-N atom swap enabled by NAHA chemistry, now online in
@science.org ! Congratulations to Zining, Zhehan and Rong!
www.science.org/doi/10.1126/...
@science.org ! Congratulations to Zining, Zhehan and Rong!
www.science.org/doi/10.1126/...
Scanning nitrogen in sp3-rich scaffolds enabled by carbonyl-to-nitrogen atom swap
Medicinal chemistry campaigns routinely require access to series of saturated nitrogen heterocycle (SNH)–based analogs that place nitrogen at different positions to probe structure-activity relationsh...
www.science.org
April 30, 2026 at 7:01 PM
Our recent work on aliphatic CO-to-N atom swap enabled by NAHA chemistry, now online in
@science.org ! Congratulations to Zining, Zhehan and Rong!
www.science.org/doi/10.1126/...
@science.org ! Congratulations to Zining, Zhehan and Rong!
www.science.org/doi/10.1126/...
