HLH, a cytokine-mediated hyperinflammation syndrome, causes fever, pancytopenia, and hemophagocytosis and is often fatal. Antiinflammatory agents, etoposide, and interferon-γ antibody are the main treatments. Learn more in a new review: nej.md/40Jps19
#MedSky #Oncology
#MedSky #Oncology
Hemophagocytic Lymphohistiocytosis | NEJM
HLH, a cytokine-mediated hyperinflammation syndrome, causes fever, pancytopenia, and
hemophagocytosis and is often fatal. Antiinflammatory agents, etoposide, and interferon-γ
antibody are the main ...
nej.md
February 8, 2025 at 1:38 PM
HLH, a cytokine-mediated hyperinflammation syndrome, causes fever, pancytopenia, and hemophagocytosis and is often fatal. Antiinflammatory agents, etoposide, and interferon-γ antibody are the main treatments. Learn more in a new review: nej.md/40Jps19
#MedSky #Oncology
#MedSky #Oncology
"Erkältung" könnte COVID sein – die Herbstwelle ist angelaufen. Allgemein: Maske tragen hilft bei Viren – und bei postviralen Folgen, die wegen Hyperinflammation (unter anderem im Gehirn) depressive Symptome auslösen können. Bleibt gesund, liebe Leute!
September 29, 2026 at 10:38 AM
"Erkältung" könnte COVID sein – die Herbstwelle ist angelaufen. Allgemein: Maske tragen hilft bei Viren – und bei postviralen Folgen, die wegen Hyperinflammation (unter anderem im Gehirn) depressive Symptome auslösen können. Bleibt gesund, liebe Leute!
In a sample of SARS-CoV-2-infected children with MISC, TGFβ overproduction is shown to trigger impaired T cell cytotoxicity (facet of immune dysfunction). This led to reactivation of Epstein Barr virus (EBV) and subsequent hyperinflammation
#LongCovid Goetzke, C.C., Massoud, M. et al Nature
#LongCovid Goetzke, C.C., Massoud, M. et al Nature
March 13, 2025 at 3:54 PM
In a sample of SARS-CoV-2-infected children with MISC, TGFβ overproduction is shown to trigger impaired T cell cytotoxicity (facet of immune dysfunction). This led to reactivation of Epstein Barr virus (EBV) and subsequent hyperinflammation
#LongCovid Goetzke, C.C., Massoud, M. et al Nature
#LongCovid Goetzke, C.C., Massoud, M. et al Nature
Caspase-11–mediated hyperinflammation impairs CD8+ T cell immunity and viral clearance in severe SARS-CoV-2 infection @insight.jci.org @ohiostatemed.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
September 27, 2026 at 6:56 PM
Caspase-11–mediated hyperinflammation impairs CD8+ T cell immunity and viral clearance in severe SARS-CoV-2 infection @insight.jci.org @ohiostatemed.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
New study: “SARS-CoV-2 infection can induce persistent immune dysregulation characterized by hyperinflammation [and] lymphopenia… Post-COVID autoimmune manifestations involve multiple systems, including neurological, hematological, endocrine…”
That sure doesn’t sound like a cold to me.
That sure doesn’t sound like a cold to me.
June 24, 2026 at 5:40 PM
New study: “SARS-CoV-2 infection can induce persistent immune dysregulation characterized by hyperinflammation [and] lymphopenia… Post-COVID autoimmune manifestations involve multiple systems, including neurological, hematological, endocrine…”
That sure doesn’t sound like a cold to me.
That sure doesn’t sound like a cold to me.
uns Einblicke in die Ursachen der Hyperinflammation bei PASC, einschließlich MIS-C und Long COVID, geben und uns zu gezielteren und wirksameren Therapien führen.”
Bislang wurde lediglich die Zusammenfassung veröffentlicht, die Veröffentlichung der Studie steht noch aus.
#LongCovidKids #COVID19
Bislang wurde lediglich die Zusammenfassung veröffentlicht, die Veröffentlichung der Studie steht noch aus.
#LongCovidKids #COVID19
June 23, 2024 at 12:03 PM
uns Einblicke in die Ursachen der Hyperinflammation bei PASC, einschließlich MIS-C und Long COVID, geben und uns zu gezielteren und wirksameren Therapien führen.”
Bislang wurde lediglich die Zusammenfassung veröffentlicht, die Veröffentlichung der Studie steht noch aus.
#LongCovidKids #COVID19
Bislang wurde lediglich die Zusammenfassung veröffentlicht, die Veröffentlichung der Studie steht noch aus.
#LongCovidKids #COVID19
How a single viral protein hijacks immune cells to supercharge COVID-19 infection
Researchers found SARS-CoV-2 protein ORF8 can hijack immune cells, driving serious lung inflammation. Blocking ORF8 reduced lung inflammation and damage in infected mice, pointing to a potential target for treatments.
Researchers found SARS-CoV-2 protein ORF8 can hijack immune cells, driving serious lung inflammation. Blocking ORF8 reduced lung inflammation and damage in infected mice, pointing to a potential target for treatments.
How a single viral protein hijacks immune cells to supercharge COVID-19 infection
In the sickest COVID-19 patients, SARS-CoV-2 doesn't just cause severe damage by directly infecting airway cells. The virus can also trigger hyperinflammation—a cycle in which immune cells themselves ...
medicalxpress.com
September 20, 2026 at 12:29 AM
How a single viral protein hijacks immune cells to supercharge COVID-19 infection
Researchers found SARS-CoV-2 protein ORF8 can hijack immune cells, driving serious lung inflammation. Blocking ORF8 reduced lung inflammation and damage in infected mice, pointing to a potential target for treatments.
Researchers found SARS-CoV-2 protein ORF8 can hijack immune cells, driving serious lung inflammation. Blocking ORF8 reduced lung inflammation and damage in infected mice, pointing to a potential target for treatments.
Proposed mechanism of hyperinflammation due to MMF
#ECNeph @brammahin @myadla @Dilushiwijay @dra_miliflores
@acssjr.bsky.social
#ECNeph @brammahin @myadla @Dilushiwijay @dra_miliflores
@acssjr.bsky.social
July 31, 2025 at 12:53 PM
Proposed mechanism of hyperinflammation due to MMF
#ECNeph @brammahin @myadla @Dilushiwijay @dra_miliflores
@acssjr.bsky.social
#ECNeph @brammahin @myadla @Dilushiwijay @dra_miliflores
@acssjr.bsky.social
Why is obesity often associated with dysregulated, low-grade chronic inflammation?
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity
Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and e...
www.science.org
January 16, 2026 at 6:14 PM
Why is obesity often associated with dysregulated, low-grade chronic inflammation?
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
Impaired T cell cytotoxicity triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation in SARS-CoV-2 MIS-C
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
March 12, 2025 at 6:47 PM
Impaired T cell cytotoxicity triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation in SARS-CoV-2 MIS-C
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
SARS-CoV-2 evades early immune defenses and triggers delayed hyperinflammation, leading to acute damage and chronic immune dysfunction that underlies Long COVID.
davidlingenfelter.substack.com/p/the-immuno...
davidlingenfelter.substack.com/p/the-immuno...
August 2, 2025 at 2:31 PM
SARS-CoV-2 evades early immune defenses and triggers delayed hyperinflammation, leading to acute damage and chronic immune dysfunction that underlies Long COVID.
davidlingenfelter.substack.com/p/the-immuno...
davidlingenfelter.substack.com/p/the-immuno...
New in 2020 via Afrin, Weinstock and Molderings: Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome - implications for treatment if true
buff.ly/39RyJK1
#MCAS #MCAD #EDS #MedTwitter #COVID19 #MECFS #NEISvoid #LongCOVID
buff.ly/39RyJK1
#MCAS #MCAD #EDS #MedTwitter #COVID19 #MECFS #NEISvoid #LongCOVID
Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome
One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activat…
buff.ly
March 27, 2026 at 1:11 PM
New in 2020 via Afrin, Weinstock and Molderings: Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome - implications for treatment if true
buff.ly/39RyJK1
#MCAS #MCAD #EDS #MedTwitter #COVID19 #MECFS #NEISvoid #LongCOVID
buff.ly/39RyJK1
#MCAS #MCAD #EDS #MedTwitter #COVID19 #MECFS #NEISvoid #LongCOVID
When you suspect MMF-hyperinflammation
dont forget to exclude these
#ECNeph @brammahin @myadla @Dilushiwijay
@dra_miliflores
@acssjr.bsky.social
dont forget to exclude these
#ECNeph @brammahin @myadla @Dilushiwijay
@dra_miliflores
@acssjr.bsky.social
July 31, 2025 at 12:54 PM
When you suspect MMF-hyperinflammation
dont forget to exclude these
#ECNeph @brammahin @myadla @Dilushiwijay
@dra_miliflores
@acssjr.bsky.social
dont forget to exclude these
#ECNeph @brammahin @myadla @Dilushiwijay
@dra_miliflores
@acssjr.bsky.social
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications
Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...
www.nature.com
June 1, 2025 at 1:16 AM
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
CD62L marks a progenitor subset of the progenitor-exhausted CD8 T-cell in mice with chronic LCMV infection and the transcription factor MYB is important for this state. Conditional MYB -/- leads to hyperinflammation, illustrating exhaustion as an adaptive state.
doi.org/10.1038/s415... 🧪
doi.org/10.1038/s415... 🧪
April 13, 2025 at 5:54 PM
CD62L marks a progenitor subset of the progenitor-exhausted CD8 T-cell in mice with chronic LCMV infection and the transcription factor MYB is important for this state. Conditional MYB -/- leads to hyperinflammation, illustrating exhaustion as an adaptive state.
doi.org/10.1038/s415... 🧪
doi.org/10.1038/s415... 🧪
ROS-responsive nanogels enable inhaled CD24 immunotherapy for selective hyperinflammation suppression in severe pneumonia
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 20, 2026 at 3:45 AM
ROS-responsive nanogels enable inhaled CD24 immunotherapy for selective hyperinflammation suppression in severe pneumonia
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
unterstreichen die zunehmende Bedeutung von Virusreaktivierungen, heben deren potenziellen Beitrag zu Hyperinflammation hervor und lassen die Möglichkeit offen, dass ein Management von Virusreaktivierungen bei Erkrankungen wie akuter COVID-19 und Long COVID die
August 6, 2026 at 4:03 PM
unterstreichen die zunehmende Bedeutung von Virusreaktivierungen, heben deren potenziellen Beitrag zu Hyperinflammation hervor und lassen die Möglichkeit offen, dass ein Management von Virusreaktivierungen bei Erkrankungen wie akuter COVID-19 und Long COVID die
Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-κB Response
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
October 30, 2025 at 7:35 PM
Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-κB Response
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
Because they can regulate powerful immune responses, inflammatory cytokines can themselves cause injury if they are uncontrolled. They cause hyperinflammation of any cell that is in contact with the bloodstream or lymphatic system.
May 27, 2026 at 5:09 PM
Because they can regulate powerful immune responses, inflammatory cytokines can themselves cause injury if they are uncontrolled. They cause hyperinflammation of any cell that is in contact with the bloodstream or lymphatic system.
Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 4, 2025 at 5:36 PM
Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
while #covid is out here causing hyperinflammation.
August 28, 2026 at 11:29 PM
while #covid is out here causing hyperinflammation.
Ohio State researchers found that in mice, removing the inflammasome protein Caspase-11 reduced lung inflammation, boosted CD8⁺ T cell responses, and cleared SARS-CoV-2 more effectively, suggesting a new target to treat severe COVID.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection
Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired interferon responses, and defective T-cell activation, yet the molecular drivers of these immune dysregulations remain ...
www.biorxiv.org
November 5, 2025 at 1:33 PM
Ohio State researchers found that in mice, removing the inflammasome protein Caspase-11 reduced lung inflammation, boosted CD8⁺ T cell responses, and cleared SARS-CoV-2 more effectively, suggesting a new target to treat severe COVID.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
"The immune molecule TGFβ has been found to weaken immune defences against latent viruses". In MISC, the multi-system inflammatory syndrome seen in children post SARS-CoV-2 infection, TGFβ could trigger EBV reactivation and contribute to hyperinflammation [easy to read report]
t.co/a9LoyDQCWv
t.co/a9LoyDQCWv
https://www.nature.com/articles/d41586-025-00735-7
t.co
March 13, 2025 at 3:55 PM
"The immune molecule TGFβ has been found to weaken immune defences against latent viruses". In MISC, the multi-system inflammatory syndrome seen in children post SARS-CoV-2 infection, TGFβ could trigger EBV reactivation and contribute to hyperinflammation [easy to read report]
t.co/a9LoyDQCWv
t.co/a9LoyDQCWv
DPEP2 suppresses hyperinflammation via metabolic reprogramming of macrophages in sepsis
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com
March 10, 2026 at 1:55 AM
DPEP2 suppresses hyperinflammation via metabolic reprogramming of macrophages in sepsis
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com