ICYMI: New content online: Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment
Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment
Nature Reviews Endocrinology, Published online: 27 February 2025; doi:10.1038/s41574-025-01099-8Anti-PIT1 hypophysitis is a form of paraneoplastic autoimmune hypophysitis. The condition is attributable to the ectopic expression of pituitary-specific…
www.nature.com
March 1, 2025 at 2:30 PM
ICYMI: New content online: Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment
So easy to forget that new therapies, as marvellous as they might be, can present with a myriad side effects. 6/12 of Pembrolizumab and I’m now thyrotoxic, with +/- hypophysitis. Rx by a second specialty service has commenced. I’m hopeful of symptom resolution. #Sèzary
December 13, 2024 at 10:31 AM
So easy to forget that new therapies, as marvellous as they might be, can present with a myriad side effects. 6/12 of Pembrolizumab and I’m now thyrotoxic, with +/- hypophysitis. Rx by a second specialty service has commenced. I’m hopeful of symptom resolution. #Sèzary
That can lead to:
- pneumonitis
- thyroiditis
- myocarditis
- hypophysitis
- hepatitis
- colitis
etc.,
Some of which have extremely poor prognosis, e.g., ICI myocarditis.
- pneumonitis
- thyroiditis
- myocarditis
- hypophysitis
- hepatitis
- colitis
etc.,
Some of which have extremely poor prognosis, e.g., ICI myocarditis.
Immune checkpoint inhibitor–associated myocarditis: Incidence, risk factors, and clinical outcomes in a global real-world cohort.
11177Background: Immune checkpoint inhibitor (ICI)-associated myocarditis is a rare but life-threatening
immune-related adverse event (irAE), with a mortality rate of 30–50%. Most available
evidence c...
ascopubs.org
January 7, 2026 at 1:53 AM
That can lead to:
- pneumonitis
- thyroiditis
- myocarditis
- hypophysitis
- hepatitis
- colitis
etc.,
Some of which have extremely poor prognosis, e.g., ICI myocarditis.
- pneumonitis
- thyroiditis
- myocarditis
- hypophysitis
- hepatitis
- colitis
etc.,
Some of which have extremely poor prognosis, e.g., ICI myocarditis.
ICYMI: New content online: An update on hypophysitis
An update on hypophysitis
Nature Reviews Endocrinology, Published online: 27 November 2025; doi:10.1038/s41574-025-01200-1Hypophysitis is a rare disease characterized by inflammation of the pituitary gland that can cause hypopituitarism-related symptoms, headaches and visual disturbances. This Review discusses the current understanding of the epidemiology, pathophysiology, diagnosis and clinical management of hypophysitis.
www.nature.com
November 30, 2025 at 7:20 AM
ICYMI: New content online: An update on hypophysitis
Rare but real. Hypophysitis www.nature.com/articles/s41... 🧪
An update on hypophysitis - Nature Reviews Endocrinology
Hypophysitis is a rare disease characterized by inflammation of the pituitary gland that can cause hypopituitarism-related symptoms, headaches and visual disturbances. This Review discusses the curren...
www.nature.com
November 27, 2025 at 11:07 AM
Rare but real. Hypophysitis www.nature.com/articles/s41... 🧪
Endocrine disorders commonly occur after cancer #immunotherapy:
🔹Hypothyroidism
🔹Thyroiditis
🔹Hypophysitis
🔹Type 1 Diabetes
Monitor thyroid, pituitary/adrenal, glycemic control initially and periodically in all patients on immunotherapy.
#medtwitter
pubmed.ncbi.nlm.nih.gov/35477029/
🔹Hypothyroidism
🔹Thyroiditis
🔹Hypophysitis
🔹Type 1 Diabetes
Monitor thyroid, pituitary/adrenal, glycemic control initially and periodically in all patients on immunotherapy.
#medtwitter
pubmed.ncbi.nlm.nih.gov/35477029/
December 25, 2023 at 4:26 AM
Endocrine disorders commonly occur after cancer #immunotherapy:
🔹Hypothyroidism
🔹Thyroiditis
🔹Hypophysitis
🔹Type 1 Diabetes
Monitor thyroid, pituitary/adrenal, glycemic control initially and periodically in all patients on immunotherapy.
#medtwitter
pubmed.ncbi.nlm.nih.gov/35477029/
🔹Hypothyroidism
🔹Thyroiditis
🔹Hypophysitis
🔹Type 1 Diabetes
Monitor thyroid, pituitary/adrenal, glycemic control initially and periodically in all patients on immunotherapy.
#medtwitter
pubmed.ncbi.nlm.nih.gov/35477029/
New content online: An update on hypophysitis
An update on hypophysitis
Nature Reviews Endocrinology, Published online: 27 November 2025; doi:10.1038/s41574-025-01200-1Hypophysitis is a rare disease characterized by inflammation of the pituitary gland that can cause hypopituitarism-related symptoms, headaches and visual disturbances. This Review discusses the current understanding of the epidemiology, pathophysiology, diagnosis and clinical management of hypophysitis.
www.nature.com
November 28, 2025 at 7:19 AM
New content online: An update on hypophysitis
#Pembrolizumab effective also for CTCL (Sézary Syndrome - in my case). Significant s/es however… hypophysitis, thyroiditis, pneumonitis. But, I live!
June 1, 2025 at 2:29 AM
#Pembrolizumab effective also for CTCL (Sézary Syndrome - in my case). Significant s/es however… hypophysitis, thyroiditis, pneumonitis. But, I live!
"In cases of severe, refractory or worsening #hypophysitis after initial therapy with #glucocorticoids, non-glucocorticoids immunosuppressive therapy could be a safe and effective alternative to control symptoms and #pituitary stalk thickening." -- Janaki Vakharia, MD. #ENDO2025 #EndoSky
July 13, 2025 at 6:34 PM
"In cases of severe, refractory or worsening #hypophysitis after initial therapy with #glucocorticoids, non-glucocorticoids immunosuppressive therapy could be a safe and effective alternative to control symptoms and #pituitary stalk thickening." -- Janaki Vakharia, MD. #ENDO2025 #EndoSky
Here, Castinetti and colleagues discuss the current understanding of the epidemiology, pathophysiology, diagnosis and clinical management of hypophysitis. (£) go.nature.com/3Xq37o6 #EndoSky #Medsky
November 28, 2025 at 10:51 AM
Here, Castinetti and colleagues discuss the current understanding of the epidemiology, pathophysiology, diagnosis and clinical management of hypophysitis. (£) go.nature.com/3Xq37o6 #EndoSky #Medsky
Concomitant Immune Checkpoint Inhibitors Induced Central and Primary Adrenal Insufficiency: A Diagnostic Challenge. Read more in #JCEMCaseReports: bit.ly/42UM6pd #ImmuneCheckpointInhibitors #Hypophysitis #Adrenalitis
November 10, 2025 at 9:02 PM
Concomitant Immune Checkpoint Inhibitors Induced Central and Primary Adrenal Insufficiency: A Diagnostic Challenge. Read more in #JCEMCaseReports: bit.ly/42UM6pd #ImmuneCheckpointInhibitors #Hypophysitis #Adrenalitis
#Pembrolizumab -induced #thyroiditis, hypophysitis and adrenalitis: a case of triple endocrine dysfunction. doi.org/10.1210/jcem...
Featured in #JCEMCaseReports #OpenAccess
#adrenal #pituitary #CheckpointInhibitors
@endocrinesociety.bsky.social
Featured in #JCEMCaseReports #OpenAccess
#adrenal #pituitary #CheckpointInhibitors
@endocrinesociety.bsky.social
Pembrolizumab-induced Thyroiditis, Hypophysitis and Adrenalitis: A Case of Triple Endocrine Dysfunction
Abstract. Immune checkpoint inhibitor drugs can trigger autoimmune endocrine reactions as a known side effect. Several cases of immunotherapy-induced autoi
doi.org
January 13, 2025 at 1:40 PM
#Pembrolizumab -induced #thyroiditis, hypophysitis and adrenalitis: a case of triple endocrine dysfunction. doi.org/10.1210/jcem...
Featured in #JCEMCaseReports #OpenAccess
#adrenal #pituitary #CheckpointInhibitors
@endocrinesociety.bsky.social
Featured in #JCEMCaseReports #OpenAccess
#adrenal #pituitary #CheckpointInhibitors
@endocrinesociety.bsky.social
Response to commentary: "Primary #Hypophysitis and the benefits of Glucocorticoids, a still unresolved question’’ by Aysa Hacioglu et al
EJE Volume 192, Issue 1, January 2025
👉 doi.org/10.1093/ejen...
ESE Members free access via 👉 my.ese-hormones.org
EJE Volume 192, Issue 1, January 2025
👉 doi.org/10.1093/ejen...
ESE Members free access via 👉 my.ese-hormones.org
March 26, 2025 at 2:25 PM
Response to commentary: "Primary #Hypophysitis and the benefits of Glucocorticoids, a still unresolved question’’ by Aysa Hacioglu et al
EJE Volume 192, Issue 1, January 2025
👉 doi.org/10.1093/ejen...
ESE Members free access via 👉 my.ese-hormones.org
EJE Volume 192, Issue 1, January 2025
👉 doi.org/10.1093/ejen...
ESE Members free access via 👉 my.ese-hormones.org
COVID-19 mRNA Jabs Can Cause An Array Of Rare Pituitary Disorders Including Hypophysitis, Pituitary Apoplexy And Even Enlarge Pituitary Adenomas!
www.thailandmedical.news/news/covid-1...
www.thailandmedical.news/news/covid-1...
COVID-19 mRNA Jabs Can Cause An Array Of Rare Pituitary Disorders Including Hypophysitis, Pituitary Apoplexy And Even Enlarge Pituitary Adenomas! - Thailand Medical News
www.thailandmedical.news
February 29, 2024 at 10:34 AM
COVID-19 mRNA Jabs Can Cause An Array Of Rare Pituitary Disorders Including Hypophysitis, Pituitary Apoplexy And Even Enlarge Pituitary Adenomas!
www.thailandmedical.news/news/covid-1...
www.thailandmedical.news/news/covid-1...
We know that the pituitary gets clobbered. The drop in GnRH and reduced libido and performance in men... That's been demonstrated.
Hypophisitis yep!
doi.org/10.1007/s111...
Hypophisitis yep!
doi.org/10.1007/s111...
Hypophysitis in COVID-19: a systematic review - Pituitary
Purpose This systematic review aims to collect and examine recent research findings regarding hypophysitis in COVID-19 patients. Method We conducted a comprehensive literature review in English on the...
doi.org
December 3, 2024 at 6:42 AM
We know that the pituitary gets clobbered. The drop in GnRH and reduced libido and performance in men... That's been demonstrated.
Hypophisitis yep!
doi.org/10.1007/s111...
Hypophisitis yep!
doi.org/10.1007/s111...
From our May issue: Frederic Castinetti & colleagues discuss the current understanding of the epidemiology, pathophysiology, diagnosis and clinical management of hypophysitis (£) go.nature.com/3OKkqzk #MedSky #EndoSky
April 23, 2026 at 9:58 AM
From our May issue: Frederic Castinetti & colleagues discuss the current understanding of the epidemiology, pathophysiology, diagnosis and clinical management of hypophysitis (£) go.nature.com/3OKkqzk #MedSky #EndoSky
New content online: Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment
Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment
Nature Reviews Endocrinology, Published online: 27 February 2025; doi:10.1038/s41574-025-01099-8Anti-PIT1 hypophysitis is a form of paraneoplastic autoimmune hypophysitis. The condition is attributable to the ectopic expression of pituitary-specific…
www.nature.com
February 27, 2025 at 2:29 PM
New content online: Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment
Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid - Nature Communications
Cytotoxic T lymphocytes (CTL) have been implicated in anti-PIT-1 hypophysitis, an autoimmune disease, but direct evidence is lacking. Here the authors use induced pluripotent stem cells to generate pi...
www.nature.com
August 27, 2025 at 9:24 PM
Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Another key factor is the development of autoimmune diseases (such as autoimmune hypophysitis) as a consequence of infection. Autoimmune hypophysitis causes a cortisol deficit, which leads to increased immune hyperactivity and consequently aggravates immune exhaustion.
December 4, 2024 at 1:55 PM
Another key factor is the development of autoimmune diseases (such as autoimmune hypophysitis) as a consequence of infection. Autoimmune hypophysitis causes a cortisol deficit, which leads to increased immune hyperactivity and consequently aggravates immune exhaustion.
Immune Checkpoint Inhibitor Endocrinopathies—Insights From 3 Unusual Cases. Read more in #JCEMCaseReports: bit.ly/494cHnO #Hypophysitis #Type1Diabetes #primaryadrenalinsufficiency @endocrinesociety.bsky.social
Immune Checkpoint Inhibitor Endocrinopathies—Insights From 3 Unusual Cases
Immune checkpoint inhibitors (ICIs) are monoclonal antibody drugs that have revolutionized cancer therapy and led to dramatically improved survival for agg
bit.ly
November 16, 2025 at 10:17 PM
Immune Checkpoint Inhibitor Endocrinopathies—Insights From 3 Unusual Cases. Read more in #JCEMCaseReports: bit.ly/494cHnO #Hypophysitis #Type1Diabetes #primaryadrenalinsufficiency @endocrinesociety.bsky.social
❌ The use of ICIs in patients with autoimmune diseases increases the risk of aggravating autoimmunity, especially increasing the risk of autoimmune hypophysitis.
December 4, 2024 at 1:55 PM
❌ The use of ICIs in patients with autoimmune diseases increases the risk of aggravating autoimmunity, especially increasing the risk of autoimmune hypophysitis.
RRIDs were included in this in Hormones paper. RRIDs improve reproducibility in scientific research. #RRID #OpenResearch #reproducibility
Transient adrenocorticotropic hormone elevation with a disproportionate cortisol response prior to the onset of immune checkpoint inhibitor-related hypophysitis - Hormones
Read the full paper: Transient adrenocorticotropic hormone elevation with a disproportionate cortisol response prior to the onset of immune checkpoint inhibitor-related hypophysitis
doi.org
April 1, 2026 at 7:01 AM
RRIDs were included in this in Hormones paper. RRIDs improve reproducibility in scientific research. #RRID #OpenResearch #reproducibility
💡 𝐈𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐜𝐞 𝐨𝐟 𝐭𝐡𝐞 𝐬𝐚𝐥𝐢𝐯𝐚 𝐜𝐨𝐫𝐭𝐢𝐬𝐨𝐥 𝐜𝐮𝐫𝐯𝐞 𝐟𝐨𝐫 𝐋𝐨𝐧𝐠 𝐂𝐎𝐕𝐈𝐃 𝐚𝐧𝐝 𝐌𝐄/𝐂𝐅𝐒..
📊 𝐖𝐡𝐲 𝐩𝐞𝐫𝐟𝐨𝐫𝐦 𝐢𝐭?
The blood cortisol tests I had done in the morning (at 11 o'clock) always came out within normal ranges, even after the EBV-caused hypophysitis I had at the onset of my disease in 2013
#LongCOVID #MECFS #Health
📊 𝐖𝐡𝐲 𝐩𝐞𝐫𝐟𝐨𝐫𝐦 𝐢𝐭?
The blood cortisol tests I had done in the morning (at 11 o'clock) always came out within normal ranges, even after the EBV-caused hypophysitis I had at the onset of my disease in 2013
#LongCOVID #MECFS #Health
November 15, 2024 at 1:38 PM
💡 𝐈𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐜𝐞 𝐨𝐟 𝐭𝐡𝐞 𝐬𝐚𝐥𝐢𝐯𝐚 𝐜𝐨𝐫𝐭𝐢𝐬𝐨𝐥 𝐜𝐮𝐫𝐯𝐞 𝐟𝐨𝐫 𝐋𝐨𝐧𝐠 𝐂𝐎𝐕𝐈𝐃 𝐚𝐧𝐝 𝐌𝐄/𝐂𝐅𝐒..
📊 𝐖𝐡𝐲 𝐩𝐞𝐫𝐟𝐨𝐫𝐦 𝐢𝐭?
The blood cortisol tests I had done in the morning (at 11 o'clock) always came out within normal ranges, even after the EBV-caused hypophysitis I had at the onset of my disease in 2013
#LongCOVID #MECFS #Health
📊 𝐖𝐡𝐲 𝐩𝐞𝐫𝐟𝐨𝐫𝐦 𝐢𝐭?
The blood cortisol tests I had done in the morning (at 11 o'clock) always came out within normal ranges, even after the EBV-caused hypophysitis I had at the onset of my disease in 2013
#LongCOVID #MECFS #Health
🧠 In der aktuellen Notfall+Rettungsmedizin Ausgabe wird ein interessanter Fall präsentiert: Notfall-MRT bei Hyponatriämie? – Immunvermittelte Hypophysitis.
Sandra Kleinfeld, Christiane Lange, Ullrich Graeven und Sebastian Bergrath berichten über den seltenen Kasus.
Sandra Kleinfeld, Christiane Lange, Ullrich Graeven und Sebastian Bergrath berichten über den seltenen Kasus.
May 26, 2026 at 2:39 PM
🧠 In der aktuellen Notfall+Rettungsmedizin Ausgabe wird ein interessanter Fall präsentiert: Notfall-MRT bei Hyponatriämie? – Immunvermittelte Hypophysitis.
Sandra Kleinfeld, Christiane Lange, Ullrich Graeven und Sebastian Bergrath berichten über den seltenen Kasus.
Sandra Kleinfeld, Christiane Lange, Ullrich Graeven und Sebastian Bergrath berichten über den seltenen Kasus.
Read interesting case history: 73-year-old man presenting with hypotension of 95/73 mm Hg, reduced left ventricular ejection fraction 30%. Severe adrenal insufficiency and depressed HPA via idiopathic hypophysitis. Resolved with hydrocortisone.
doi: 10.1001/jamainternmed.2025.6324
doi: 10.1001/jamainternmed.2025.6324
December 2, 2025 at 10:17 PM
Read interesting case history: 73-year-old man presenting with hypotension of 95/73 mm Hg, reduced left ventricular ejection fraction 30%. Severe adrenal insufficiency and depressed HPA via idiopathic hypophysitis. Resolved with hydrocortisone.
doi: 10.1001/jamainternmed.2025.6324
doi: 10.1001/jamainternmed.2025.6324