Hypoxia-induced expression of the zinc-finger transcription factor EGR1 drives immunosuppression in tumor-infiltrating neutrophils.

MicroRNAs (miRNAs) are short sequences of single-stranded non-coding RNAs that target messenger RNAs, leading to their repression or decay. Interestingly, miRNAs play a role in the cellular response t...

Ishiguro et al. identify stereoselective ribose-backbone methylations in the peptidyl-transferase center of E. coli ribosomes, installed by the cobalamin-dependent enzyme RlmX. These methylations, together with ho5C2501, are specifically induced under hypoxia. The hypoxia-induced modifications activate ribosomes, enhancing translational capacity and thereby promoting bacterial fitness in anaerobic conditions.

Transfer RNA-derived small RNAs (tsRNAs, or tDRs) perform a range of cellular functions. Here, we showed that a hypoxia-induced tDR, derived from the 3′ end of tRNA-Asp-GTC (tRNA-Asp-GTC-3′tDR), activ...

Sanchez-Garcia et al. report that systemic hypoxia-induced epigenetic reprogramming of neutrophil progenitors in the bone marrow reduces their effector function to limit lung tissue damage.

Hypoxia is both a physiological and pathological signal in cells. Changes in gene expression play a critical role in the cellular response to hypoxia, enabling cells to adapt to reduced oxygen availab...

Ciliary flows buffer coral O2 supply under heat stress until a tipping point, above which hypoxia and tissue failure are induced.

Experiments in Arabidopsis demonstrate that group VII ethylene response factors show differential responses to different stimuli, enabling plants in flood-prone environments to adapt to both submergence-induced hypoxia and reoxygenation upon desubmergence.

Experiments in Arabidopsis demonstrate that group VII ethylene response factors show differential responses to different stimuli, enabling plants in flood-prone environments to adapt to both submergence-induced hypoxia and reoxygenation upon desubmergence.

Background Globally, temperate lakes are experiencing increases in surface water temperatures, extended periods of summer stratification, and decreases of both surface and deep water dissolved oxygen ...