We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗
@ibc2-gu.bsky.social @goetheuni.bsky.social
@ibc2-gu.bsky.social @goetheuni.bsky.social
ProxiCapture Reveals Context-Dependent CRBN Interactore Landscape of Molecular Glue Degraders https://www.biorxiv.org/content/10.64898/2026.01.05.697692v1
January 6, 2026 at 8:54 PM
We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗
@ibc2-gu.bsky.social @goetheuni.bsky.social
@ibc2-gu.bsky.social @goetheuni.bsky.social
🥁 We are live on BlueSky!! Stay tuned for more news and updates from our lab. We are looking forward to connecting with you here again.
@ibc2-gu.bsky.social @idikic.bsky.social #GoetheUniversity #IBC2
@ibc2-gu.bsky.social @idikic.bsky.social #GoetheUniversity #IBC2
December 6, 2024 at 12:45 PM
🥁 We are live on BlueSky!! Stay tuned for more news and updates from our lab. We are looking forward to connecting with you here again.
@ibc2-gu.bsky.social @idikic.bsky.social #GoetheUniversity #IBC2
@ibc2-gu.bsky.social @idikic.bsky.social #GoetheUniversity #IBC2
🥳Excited to join the Bsky Science community! 🥳
Today marks 8 years at Goethe University—an incredible journey from group leader @ibc2-gu.bsky.social to full professor and Director of the Institute of Molecular Systems Medicine. Grateful for the invaluable support and amazing people along the way!
Today marks 8 years at Goethe University—an incredible journey from group leader @ibc2-gu.bsky.social to full professor and Director of the Institute of Molecular Systems Medicine. Grateful for the invaluable support and amazing people along the way!
December 1, 2024 at 3:01 PM
🥳Excited to join the Bsky Science community! 🥳
Today marks 8 years at Goethe University—an incredible journey from group leader @ibc2-gu.bsky.social to full professor and Director of the Institute of Molecular Systems Medicine. Grateful for the invaluable support and amazing people along the way!
Today marks 8 years at Goethe University—an incredible journey from group leader @ibc2-gu.bsky.social to full professor and Director of the Institute of Molecular Systems Medicine. Grateful for the invaluable support and amazing people along the way!
Getting all set up for the conference!! We are looking forward to 4 days of exciting science 🤗 #FCQC25 #autophagy #proteostasis @ibc2-gu.bsky.social @sfb1177.bsky.social
March 24, 2025 at 8:39 AM
Getting all set up for the conference!! We are looking forward to 4 days of exciting science 🤗 #FCQC25 #autophagy #proteostasis @ibc2-gu.bsky.social @sfb1177.bsky.social
🏆 Congratulations to @adricovapinto.bsky.social for being awarded the @elife.bsky.social poster prize at the #FCQC2025 #autophagy #remodelling
@ibc2-gu.bsky.social
@ibc2-gu.bsky.social
March 27, 2025 at 12:44 PM
🏆 Congratulations to @adricovapinto.bsky.social for being awarded the @elife.bsky.social poster prize at the #FCQC2025 #autophagy #remodelling
@ibc2-gu.bsky.social
@ibc2-gu.bsky.social
As a golden closing chapter to 2025 ✨ thanks @idikic.bsky.social Đikić for the invitation to IBC2. 🙏🏼 #ProxiDrugs & whole team: fantastic in every sense—science 🧠 & humanity ❤️. Crashing your Xmas party was the perfect bonus 🎄😄 Thank you all for making me feel part of the team♥️ #ProfLife #ChemBio
December 20, 2025 at 9:51 AM
As a golden closing chapter to 2025 ✨ thanks @idikic.bsky.social Đikić for the invitation to IBC2. 🙏🏼 #ProxiDrugs & whole team: fantastic in every sense—science 🧠 & humanity ❤️. Crashing your Xmas party was the perfect bonus 🎄😄 Thank you all for making me feel part of the team♥️ #ProfLife #ChemBio
Last week at the 1st Symposium on Advances in Therapeutic Approaches, Uxía presented some of her PhD work. @uxiagestal.bsky.social @ibc2-gu.bsky.social @proxidrugs.bsky.social #EnableFrankfurt #BMBF #hmwk_hessen
Thanks to @doroteaartscience.bsky.social for the great illustration! #ScienceArt
Thanks to @doroteaartscience.bsky.social for the great illustration! #ScienceArt
December 9, 2024 at 11:11 AM
Last week at the 1st Symposium on Advances in Therapeutic Approaches, Uxía presented some of her PhD work. @uxiagestal.bsky.social @ibc2-gu.bsky.social @proxidrugs.bsky.social #EnableFrankfurt #BMBF #hmwk_hessen
Thanks to @doroteaartscience.bsky.social for the great illustration! #ScienceArt
Thanks to @doroteaartscience.bsky.social for the great illustration! #ScienceArt
🧪 E3 ligases are enzymes that are implicated in protein degradation and in ubiquitin signaling. Researchers @ibc2-gu.bsky.social at Goethe University have now elucidated the relationships among all 462 catalytic human E3 ligases: 🔗 aktuelles.uni-frankfurt.de/english/the-...
@idikic.bsky.social
@idikic.bsky.social
January 16, 2026 at 9:34 AM
🧪 E3 ligases are enzymes that are implicated in protein degradation and in ubiquitin signaling. Researchers @ibc2-gu.bsky.social at Goethe University have now elucidated the relationships among all 462 catalytic human E3 ligases: 🔗 aktuelles.uni-frankfurt.de/english/the-...
@idikic.bsky.social
@idikic.bsky.social
This 11–13 May, EMBO is hosting the 91st meeting of the EMBO Council. The Council is the governing body of EMBO and ensures the development of the organization. The EMBO Council Chair is Marta Miączyńska, Director @iimcb.bsky.social and Vice Chair is Ivan Dikic, Director IBC2. 🧪
May 12, 2026 at 4:10 PM
This 11–13 May, EMBO is hosting the 91st meeting of the EMBO Council. The Council is the governing body of EMBO and ensures the development of the organization. The EMBO Council Chair is Marta Miączyńska, Director @iimcb.bsky.social and Vice Chair is Ivan Dikic, Director IBC2. 🧪
April 7, 2025 at 12:36 PM
🧪🧬 Wenn das DNA-Reparaturenzym SPRTN ausfällt, häufen sich DNA-Schäden, Entzündungen werden ausgelöst und Alterungsprozesse beschleunigt. Das zeigt eine #Studie unter Leitung von @idikic.bsky.social vom @ibc2-gu.bsky.social an der #GoetheUni. | 🔗 aktuelles.uni-frankfurt.de/forschung/ka...
January 30, 2026 at 9:12 AM
🧪🧬 Wenn das DNA-Reparaturenzym SPRTN ausfällt, häufen sich DNA-Schäden, Entzündungen werden ausgelöst und Alterungsprozesse beschleunigt. Das zeigt eine #Studie unter Leitung von @idikic.bsky.social vom @ibc2-gu.bsky.social an der #GoetheUni. | 🔗 aktuelles.uni-frankfurt.de/forschung/ka...
Honored to receive the RMU Award for Pharmaceutical Research & Innovative Medical Therapies for our discovery of proteotoxic RNA splicing!
Huge thanks to RMU @goetheuni.bsky.social @ibc2-gu.bsky.social & @idikic.bsky.social ! 🧬
#RMU #Science
www.rhein-main-universitaeten.de/en/news/rmu-...
Huge thanks to RMU @goetheuni.bsky.social @ibc2-gu.bsky.social & @idikic.bsky.social ! 🧬
#RMU #Science
www.rhein-main-universitaeten.de/en/news/rmu-...
RMU END OF YEAR GET TOGETHER WITH PRESENTATION OF RMU AWARDS - REGISTER NOW! | Rhein-Main Universitäten (RMU)
www.rhein-main-universitaeten.de
October 24, 2025 at 5:16 PM
Honored to receive the RMU Award for Pharmaceutical Research & Innovative Medical Therapies for our discovery of proteotoxic RNA splicing!
Huge thanks to RMU @goetheuni.bsky.social @ibc2-gu.bsky.social & @idikic.bsky.social ! 🧬
#RMU #Science
www.rhein-main-universitaeten.de/en/news/rmu-...
Huge thanks to RMU @goetheuni.bsky.social @ibc2-gu.bsky.social & @idikic.bsky.social ! 🧬
#RMU #Science
www.rhein-main-universitaeten.de/en/news/rmu-...
🧪🧬 When the DNA repair enzyme SPRTN fails, DNA damage accumulates, inflammation is triggered, and aging processes are accelerated. This is shown by a #study led by @idikic.bsky.social from @ibc2-gu.bsky.social at #GoetheUni. | 🔗 aktuelles.uni-frankfurt.de/english/a-br...
January 30, 2026 at 9:13 AM
🧪🧬 When the DNA repair enzyme SPRTN fails, DNA damage accumulates, inflammation is triggered, and aging processes are accelerated. This is shown by a #study led by @idikic.bsky.social from @ibc2-gu.bsky.social at #GoetheUni. | 🔗 aktuelles.uni-frankfurt.de/english/a-br...
Great kick off of our #FCQC2025! Inspiring sessions, meaningful conversations, and exciting new connections. 🙌Can’t wait for the next days!
@enablefrankfurt.bsky.social @dfg.de @proxidrugs.bsky.social @ibc2-gu.bsky.social
@enablefrankfurt.bsky.social @dfg.de @proxidrugs.bsky.social @ibc2-gu.bsky.social
March 24, 2025 at 5:03 PM
Great kick off of our #FCQC2025! Inspiring sessions, meaningful conversations, and exciting new connections. 🙌Can’t wait for the next days!
@enablefrankfurt.bsky.social @dfg.de @proxidrugs.bsky.social @ibc2-gu.bsky.social
@enablefrankfurt.bsky.social @dfg.de @proxidrugs.bsky.social @ibc2-gu.bsky.social
Another day, another poster session 🪧 Come and chat with us tonight about ER-phagy, membrane remodelling, bacterial infection, #ubiquitin, #autophagy, and microproteins #FCQC2025 @ibc2-gu.bsky.social @idikic.bsky.social
Getting ready for day 3 of #FCQC2025! Excited to learn what is new in the fields of “Proteinopathies & neurodegeneration” and “Emerging therapeutics”.
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
March 26, 2025 at 2:05 PM
Another day, another poster session 🪧 Come and chat with us tonight about ER-phagy, membrane remodelling, bacterial infection, #ubiquitin, #autophagy, and microproteins #FCQC2025 @ibc2-gu.bsky.social @idikic.bsky.social
#IBC week is here — and Ceeblue is back! ⚡
See how #WebRTS delivers sub-second streaming with DRM, SSAI and standard CDN scale — without rebuilding your workflow.
📍 Booth 5.C43
📅 calendly.com/ceeblue/ibc2...
#RealTimeStreaming
See how #WebRTS delivers sub-second streaming with DRM, SSAI and standard CDN scale — without rebuilding your workflow.
📍 Booth 5.C43
📅 calendly.com/ceeblue/ibc2...
#RealTimeStreaming
September 7, 2026 at 2:27 PM
#IBC week is here — and Ceeblue is back! ⚡
See how #WebRTS delivers sub-second streaming with DRM, SSAI and standard CDN scale — without rebuilding your workflow.
📍 Booth 5.C43
📅 calendly.com/ceeblue/ibc2...
#RealTimeStreaming
See how #WebRTS delivers sub-second streaming with DRM, SSAI and standard CDN scale — without rebuilding your workflow.
📍 Booth 5.C43
📅 calendly.com/ceeblue/ibc2...
#RealTimeStreaming
Read the full story here ➡️ "IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion" www.cell.com/cell/fulltex...
#autophagy #CancerResearch #Immunity @cellpress.bsky.social @ibc2-gu.bsky.social @uxiagestal.bsky.social @idikic.bsky.social
#autophagy #CancerResearch #Immunity @cellpress.bsky.social @ibc2-gu.bsky.social @uxiagestal.bsky.social @idikic.bsky.social
IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion
IRGQ acts in the quality control of MHC class I molecules through autophagy, mediating tumor immune evasion.
www.cell.com
December 9, 2024 at 11:11 AM
Read the full story here ➡️ "IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion" www.cell.com/cell/fulltex...
#autophagy #CancerResearch #Immunity @cellpress.bsky.social @ibc2-gu.bsky.social @uxiagestal.bsky.social @idikic.bsky.social
#autophagy #CancerResearch #Immunity @cellpress.bsky.social @ibc2-gu.bsky.social @uxiagestal.bsky.social @idikic.bsky.social
learning from the pinned comment of a great animation www.youtube.com/watch?v=iBC2... that Art Fight is a website!? ofc that makes sense but i never went to look
Larping the Rooms | 2026 Artfight Mass Attack
YouTube video by berry_xi
www.youtube.com
August 20, 2026 at 5:58 AM
learning from the pinned comment of a great animation www.youtube.com/watch?v=iBC2... that Art Fight is a website!? ofc that makes sense but i never went to look
After an inspiring first day, we’re excited to dive into the second day of #FCQC2025 filled with amazing talks on „Organelles in biology and disease“ and „RNA and protein quality control“.
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
March 25, 2025 at 9:30 AM
After an inspiring first day, we’re excited to dive into the second day of #FCQC2025 filled with amazing talks on „Organelles in biology and disease“ and „RNA and protein quality control“.
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
Check out our latest paper: #Legionella SidE effectors phosphoribosyl-ubiquitinate SNAREs STX17 & SNAP29, stalling #autophagy and fueling bacterial growth. Dive into how pathogens hijack #ubiquitin driven autophagy @embojournal.org @ibc2-gu.bsky.social @idikic.bsky.social doi.org/10.1038/s443...
Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection | The EMBO Journal
imageimageAmong the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) during infection, the SidE class of
effectors modify host proteins b...
doi.org
June 18, 2025 at 7:47 AM
Check out our latest paper: #Legionella SidE effectors phosphoribosyl-ubiquitinate SNAREs STX17 & SNAP29, stalling #autophagy and fueling bacterial growth. Dive into how pathogens hijack #ubiquitin driven autophagy @embojournal.org @ibc2-gu.bsky.social @idikic.bsky.social doi.org/10.1038/s443...
Real-time streaming will be front and center at #IBC2026.
Meet Ceeblue at Booth 5.C43 to see how #WebRTS delivers secure, DRM-protected, SSAI-enabled, sub-second streaming over standard CDNs—no proprietary infrastructure.
📅 Book a meeting: calendly.com/ceeblue/ibc2...
Meet Ceeblue at Booth 5.C43 to see how #WebRTS delivers secure, DRM-protected, SSAI-enabled, sub-second streaming over standard CDNs—no proprietary infrastructure.
📅 Book a meeting: calendly.com/ceeblue/ibc2...
August 13, 2026 at 1:55 PM
Real-time streaming will be front and center at #IBC2026.
Meet Ceeblue at Booth 5.C43 to see how #WebRTS delivers secure, DRM-protected, SSAI-enabled, sub-second streaming over standard CDNs—no proprietary infrastructure.
📅 Book a meeting: calendly.com/ceeblue/ibc2...
Meet Ceeblue at Booth 5.C43 to see how #WebRTS delivers secure, DRM-protected, SSAI-enabled, sub-second streaming over standard CDNs—no proprietary infrastructure.
📅 Book a meeting: calendly.com/ceeblue/ibc2...
I am deeply excited and proud of this paper you have just published in #ScienceMagacine 📗 🧬🧫
It is very commendable .
🎉 I congratulations to all collaborators inside and outside of
#IBC2
🤩 Bravo! 🤩
👨🏻🔬 @prieto-garcia.bsky.social
doi.org/10.1126/scie...
It is very commendable .
🎉 I congratulations to all collaborators inside and outside of
#IBC2
🤩 Bravo! 🤩
👨🏻🔬 @prieto-garcia.bsky.social
doi.org/10.1126/scie...
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
doi.org
November 17, 2024 at 7:17 AM
I am deeply excited and proud of this paper you have just published in #ScienceMagacine 📗 🧬🧫
It is very commendable .
🎉 I congratulations to all collaborators inside and outside of
#IBC2
🤩 Bravo! 🤩
👨🏻🔬 @prieto-garcia.bsky.social
doi.org/10.1126/scie...
It is very commendable .
🎉 I congratulations to all collaborators inside and outside of
#IBC2
🤩 Bravo! 🤩
👨🏻🔬 @prieto-garcia.bsky.social
doi.org/10.1126/scie...
🧪 E3-Ligasen sind Enzyme, die am Proteinabbau und an Signalübertragungsprozessen beteiligt sind. Forscher*innen @ibc2-gu.bsky.social haben jetzt erstmals die Verwandtschaftsverhältnisse aller 462 E3-Ligasen des Menschen aufgeklärt: 🔗 aktuelles.uni-frankfurt.de/forschung/fa...
@idikic.bsky.social
@idikic.bsky.social
January 16, 2026 at 9:31 AM
🧪 E3-Ligasen sind Enzyme, die am Proteinabbau und an Signalübertragungsprozessen beteiligt sind. Forscher*innen @ibc2-gu.bsky.social haben jetzt erstmals die Verwandtschaftsverhältnisse aller 462 E3-Ligasen des Menschen aufgeklärt: 🔗 aktuelles.uni-frankfurt.de/forschung/fa...
@idikic.bsky.social
@idikic.bsky.social
Getting ready for day 3 of #FCQC2025! Excited to learn what is new in the fields of “Proteinopathies & neurodegeneration” and “Emerging therapeutics”.
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
March 26, 2025 at 7:35 AM
Getting ready for day 3 of #FCQC2025! Excited to learn what is new in the fields of “Proteinopathies & neurodegeneration” and “Emerging therapeutics”.
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
@sfb1177.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social
Getting ready for day 3 of #FCQC2025! Excited to learn what is new in the fields of “Proteinopathies & neurodegeneration” and “Emerging therapeutics”.
@enablefrankfurt.bsky.social @ibc2-gu.bsky.social @proxidrugs.bsky.social
@enablefrankfurt.bsky.social @ibc2-gu.bsky.social @proxidrugs.bsky.social
March 26, 2025 at 7:36 AM
Getting ready for day 3 of #FCQC2025! Excited to learn what is new in the fields of “Proteinopathies & neurodegeneration” and “Emerging therapeutics”.
@enablefrankfurt.bsky.social @ibc2-gu.bsky.social @proxidrugs.bsky.social
@enablefrankfurt.bsky.social @ibc2-gu.bsky.social @proxidrugs.bsky.social