While screening for motifs, we discovered that locally scrambled IDRs were functional, and found conformational dynamics rather than linear sequence predicted function. We then used IDR dynamics as a design target and generated functional IDRs de novo.
October 28, 2026 at 12:39 PM
While screening for motifs, we discovered that locally scrambled IDRs were functional, and found conformational dynamics rather than linear sequence predicted function. We then used IDR dynamics as a design target and generated functional IDRs de novo.
A study found that 3' UTRs of 2,700+ human mRNAs with conserved nucleotides regulate protein activity by co-translationally folding IDRs, enhancing JMJD3 function. PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3
No description available
www.cell.com
October 31, 2026 at 4:00 AM
CRV Science Wiki
🧬 Short Linear Motif — Short Linear Motifs (SLiMs) are compact 3-to-12-amino-acid interaction modules embedded within Intrinsically Disordered Regions (IDRs) that mediate transient cell signaling, post-translational modification, an…
https://crvscience.com/wiki/short-linear-motif
🧬 Short Linear Motif — Short Linear Motifs (SLiMs) are compact 3-to-12-amino-acid interaction modules embedded within Intrinsically Disordered Regions (IDRs) that mediate transient cell signaling, post-translational modification, an…
https://crvscience.com/wiki/short-linear-motif
CRV Science Wiki
🧬 Short Linear Motif — Short Linear Motifs (SLiMs) are compact 3-to-12-amino-acid interaction modules embedded within Intrinsically Disordered Regions (IDRs) that mediate transient cell signaling, post-translational modification, and rapid evolutionary rewiring.
crvscience.com
November 4, 2026 at 11:20 PM
CRV Science Wiki
🧬 Short Linear Motif — Short Linear Motifs (SLiMs) are compact 3-to-12-amino-acid interaction modules embedded within Intrinsically Disordered Regions (IDRs) that mediate transient cell signaling, post-translational modification, an…
https://crvscience.com/wiki/short-linear-motif
🧬 Short Linear Motif — Short Linear Motifs (SLiMs) are compact 3-to-12-amino-acid interaction modules embedded within Intrinsically Disordered Regions (IDRs) that mediate transient cell signaling, post-translational modification, an…
https://crvscience.com/wiki/short-linear-motif
The IRS IDRS system that holds all the data on taxpayers for the last 10 years written in cobalt I’ve added to my list and I still can’t replace it. 
October 31, 2026 at 8:02 PM
The IRS IDRS system that holds all the data on taxpayers for the last 10 years written in cobalt I’ve added to my list and I still can’t replace it. 
REMINDER: IDP Trainee Symposium deadline is THIS WEEK. Are you a PhD/postdoc studying IDRs? If so, sign up today for a chance to present your work to a global audience in a 15-minute talk! 300-word abstract required - apply here!
docs.google.com/forms/d/e/1F...
docs.google.com/forms/d/e/1F...
November 2, 2026 at 11:38 AM
REMINDER: IDP Trainee Symposium deadline is THIS WEEK. Are you a PhD/postdoc studying IDRs? If so, sign up today for a chance to present your work to a global audience in a 15-minute talk! 300-word abstract required - apply here!
docs.google.com/forms/d/e/1F...
docs.google.com/forms/d/e/1F...
My group will scale this system and build AI models connecting IDR sequence, dynamics and function. We'll then write synthetic IDRs into genomes to understand how specificity and pleiotropy constrain IDR evolution. We think this approach will shed light on the dark matter of the proteome.
October 28, 2026 at 12:39 PM
My group will scale this system and build AI models connecting IDR sequence, dynamics and function. We'll then write synthetic IDRs into genomes to understand how specificity and pleiotropy constrain IDR evolution. We think this approach will shed light on the dark matter of the proteome.
Folded protein design is now routine, but ~35% of the human proteome lacks stable 3D structure. Synthetic intrinsically disordered regions (IDRs) could be used for cell engineering. However, without structure, the target for biologically functional disordered protein design is not obvious.
October 28, 2026 at 12:39 PM
Folded protein design is now routine, but ~35% of the human proteome lacks stable 3D structure. Synthetic intrinsically disordered regions (IDRs) could be used for cell engineering. However, without structure, the target for biologically functional disordered protein design is not obvious.
idrsさん、ヴァレさんのこと何も話さなかったけどもしや知らないのかな。半身はともかく白ヴェールさんの顔も知らなかったようだし…。単にあの場に居なかったからかもしれないけど
November 2, 2026 at 12:22 PM
idrsさん、ヴァレさんのこと何も話さなかったけどもしや知らないのかな。半身はともかく白ヴェールさんの顔も知らなかったようだし…。単にあの場に居なかったからかもしれないけど
ノ兄貴を救う判断した時に手に入るのがidrsの驕りなんだよな。1周目はなんも思わなかったけど。傲慢でも驕りでも救いに行くんじゃよ。ただidrsさんはこの術式作った時は苦しんでそう。幾度も時間遡行してこれは驕りなのではないか？と苦しみつつ一人で世界を救おうとしてたのかな。傲慢の血族はこれだからよぉ〜！一人で！背負うな！！
October 29, 2026 at 2:06 PM
ノ兄貴を救う判断した時に手に入るのがidrsの驕りなんだよな。1周目はなんも思わなかったけど。傲慢でも驕りでも救いに行くんじゃよ。ただidrsさんはこの術式作った時は苦しんでそう。幾度も時間遡行してこれは驕りなのではないか？と苦しみつつ一人で世界を救おうとしてたのかな。傲慢の血族はこれだからよぉ〜！一人で！背負うな！！
ICYMI: IDPForge: deep learning of proteins with global and local regions of disorder @natcomms.nature.com
IDPForge: deep learning of proteins with global and local regions of disorder
Nature Communications, Published online: 30 October 2026; doi:10.1038/s41467-026-79191-4Intrinsically disordered proteins and regions (IDPs/IDRs) are defined by diverse structural ensembles. We present IDPForge that exploits a transformer protein language diffusion model to create all-atom IDP and IDR ensembles that maintain folded domains with options to conform to experimental data.
dlvr.it
November 1, 2026 at 2:08 AM
ICYMI: IDPForge: deep learning of proteins with global and local regions of disorder @natcomms.nature.com
IDPForge: deep learning of proteins with global and local regions of disorder @natcomms.nature.com
IDPForge: deep learning of proteins with global and local regions of disorder
Nature Communications, Published online: 30 October 2026; doi:10.1038/s41467-026-79191-4Intrinsically disordered proteins and regions (IDPs/IDRs) are defined by diverse structural ensembles. We present IDPForge that exploits a transformer protein language diffusion model to create all-atom IDP and IDR ensembles that maintain folded domains with options to conform to experimental data.
dlvr.it
October 30, 2026 at 7:08 PM
IDPForge: deep learning of proteins with global and local regions of disorder @natcomms.nature.com
IDPForge: deep learning of proteins with global and local regions of disorder @natcomms.nature.com
IDPForge: deep learning of proteins with global and local regions of disorder
Nature Communications, Published online: 30 October 2026; doi:10.1038/s41467-026-79191-4Intrinsically disordered proteins and regions (IDPs/IDRs) are defined by diverse structural ensembles. We present IDPForge that exploits a transformer protein language diffusion model to create all-atom IDP and IDR ensembles that maintain folded domains with options to conform to experimental data.
dlvr.it
October 30, 2026 at 7:08 PM
IDPForge: deep learning of proteins with global and local regions of disorder @natcomms.nature.com
Over 2,700 human mRNA 3' UTRs show conserved sequences that regulate proteins with long intrinsically disordered regions (IDRs). KDM6B 3' UTR alters JMJD3 folding, enhancing IDR interactions, thereby… PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3
No description available
www.cell.com
October 26, 2026 at 2:00 AM
Over 2,700 human mRNA 3' UTRs show conserved sequences that regulate proteins with long intrinsically disordered regions (IDRs). KDM6B 3' UTR alters JMJD3 folding, enhancing IDR interactions, thereby… PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky 🧪
New research reveals that 3' UTRs of over 2,700 human mRNAs influence protein activity via co-translational folding of IDRs, seen in KDM6B affecting JMJD3. Fascinating link! PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3
No description available
www.cell.com
October 24, 2026 at 10:00 AM
Fitch Ratings confirmó que las calificaciones de incumplimiento a largo plazo del emisor (IDRs) de Perú se encuentran en ‘BBB’ con una perspectiva estable.
Fitch Ratings mantiene la calificación soberana de Perú en ‘BBB’ con perspectiva estable
elcomercio.pe
October 23, 2026 at 7:35 PM
Fitch Ratings confirmó que las calificaciones de incumplimiento a largo plazo del emisor (IDRs) de Perú se encuentran en ‘BBB’ con una perspectiva estable.
Huntingtin (HTT:p), apart from its hilariously bad name, is a large scaffold protein with multiple tightly structured Armadillo helical repeat domains (more bad naming) interspersed with pS-IDRs that presumably control its ability to form heteromeric […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 22, 2026 at 12:03 PM
Huntingtin (HTT:p), apart from its hilariously bad name, is a large scaffold protein with multiple tightly structured Armadillo helical repeat domains (more bad naming) interspersed with pS-IDRs that presumably control its ability to form heteromeric […]
[Original post on mastodon.social]
[Original post on mastodon.social]
New research reveals that 3' UTRs of >2,700 human mRNAs control protein activity by influencing folding of intrinsically disordered regions (IDRs), impacting JMJD3 function. PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Cell Press article: mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
www.cell.com
October 21, 2026 at 8:00 AM
Really interested in this process of creating agentic decision logs and change batches (ala openspec.dev).
IDRs as records of intent
In Writing the Docs: 2026 Edition , I talked a little bit about IDRs (Implementation Decision Records, a pun on
wrla.ch
October 18, 2026 at 5:52 PM
Really interested in this process of creating agentic decision logs and change batches (ala openspec.dev).
Here’s another cool one where mRNA 3’UTRs facilitate the folding of specific classes of host proteins…
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
www.cell.com
October 16, 2026 at 12:01 PM
Here’s another cool one where mRNA 3’UTRs facilitate the folding of specific classes of host proteins…
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
IDRs as Records of Intent
https://wrla.ch/log/2026/10/idrs-as-records-of-intent/
[comments] [7 points]
https://wrla.ch/log/2026/10/idrs-as-records-of-intent/
[comments] [7 points]
IDRs as records of intent
wrla.ch
October 13, 2026 at 10:03 PM
IDRs as Records of Intent
https://wrla.ch/log/2026/10/idrs-as-records-of-intent/
[comments] [7 points]
https://wrla.ch/log/2026/10/idrs-as-records-of-intent/
[comments] [7 points]
October 13, 2026 at 9:30 PM
October 13, 2026 at 9:24 PM
Asked an agent for an IDR. It restated the diff, vaguer and longer.
https://wrla.ch/log/2026/10/idrs-as-records-of-intent/
https://wrla.ch/log/2026/10/idrs-as-records-of-intent/
October 14, 2026 at 3:25 AM
Asked an agent for an IDR. It restated the diff, vaguer and longer.
https://wrla.ch/log/2026/10/idrs-as-records-of-intent/
https://wrla.ch/log/2026/10/idrs-as-records-of-intent/
October 13, 2026 at 9:26 PM